{"id":14220,"date":"2018-08-29T10:52:06","date_gmt":"2018-08-29T08:52:06","guid":{"rendered":"https:\/\/news.embl.de\/?p=14220"},"modified":"2024-03-22T10:57:13","modified_gmt":"2024-03-22T09:57:13","slug":"cohesin-glue-for-dna","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/cohesin-glue-for-dna\/","title":{"rendered":"Cohesin: a glue for DNA"},"content":{"rendered":"\n

Before cell division begins, a newly replicated chromosome consists of two identical threadlike strands that are joined together. Responsible for holding these sister chromatids together is a ring-shaped protein complex called cohesin<\/a>, possibly by embracing them within its ring. However, how cohesin might directly recognise DNA was unknown. Now, Yan Li and co-workers from the group of Daniel Panne at EMBL Grenoble<\/a> have published the crystal structure of a cohesin subcomplex. The study shows that this complex directly engages the double helix. A stretch of amino acids on the surface of the cohesin component effectively \u2018glues\u2019 to the DNA.<\/p>\n\n\n\n

Furthermore, in collaboration with the group of Christian Haering<\/a> at EMBL Heidelberg, the scientists artificially altered these amino acids. This modified cohesin ring does not engage chromatids, thus preventing normal cell division. The results \u2013 published in eLife<\/em> \u2013 therefore reveal a direct DNA attachment site in the cohesin complex. Further studies on cohesin and its engagement to chromatids will lead to deeper mechanistic insights into how this machinery contributes to cell division.<\/p>\n\n\n\n

Daniel Panne is now working as a group leader at the University of Leicester, UK<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

EMBL scientists discover how a component of the cohesin ring binds DNA<\/p>\n","protected":false},"author":63,"featured_media":14221,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[535,700,537,37,699,701,539,35],"embl_taxonomy":[],"class_list":["post-14220","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-chromosome","tag-cohesin","tag-dna","tag-grenoble","tag-panne","tag-protein-complex","tag-research-highlight","tag-structural-biology"],"acf":{"article_intro":"

EMBL scientists discover how a component of the cohesin ring binds DNA<\/p>\n","related_links":[{"link_description":"Panne group","link_url":"https:\/\/www2.le.ac.uk\/institutes\/liscb\/research-groups\/structural-biology-of-signal-transduction-and-epigenetic-gene-regulation"},{"link_description":"H\u00e4ring group","link_url":"https:\/\/www.embl.de\/research\/units\/cbb\/haering\/"},{"link_description":"Looping the loops: How chromosomes form","link_url":"https:\/\/news.embl.de\/science\/looping-loops-chromosomes-form\/"},{"link_description":"A cohesive structure","link_url":"https:\/\/news.embl.de\/science\/1603-cohesin\/"},{"link_description":"Loops, loops and loops: how DNA gets organised","link_url":"https:\/\/news.embl.de\/science\/loops-loops-loops-dna-gets-organised\/"}],"article_sources":[{"source_description":"

Yan Li et al.,\u00a0<\/em>Structural basis for Scc3-dependent cohesin recruitment to chromatin,\u00a0eLife,<\/em>\u00a0published online 15 August 2018. DOI:\u00a010.7554\/eLife.38356<\/p>\n","source_link_url":"https:\/\/doi.org\/10.7554\/eLife.38356"}],"vf_locked":false,"featured":false,"color":"#007B53"},"embl_taxonomy_terms":[],"yoast_head":"\nCohesin: a glue for DNA | EMBL<\/title>\n<meta name=\"description\" content=\"Yan Li and co-workers from the group of Daniel Panne at EMBL Grenoble discover how a component of the cohesin ring binds DNA.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/cohesin-glue-for-dna\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cohesin: a glue for DNA | EMBL\" \/>\n<meta property=\"og:description\" content=\"Yan Li and co-workers from the group of Daniel Panne at EMBL Grenoble discover how a component of the cohesin ring binds DNA.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/science\/cohesin-glue-for-dna\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2018-08-29T08:52:06+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-22T09:57:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2018\/08\/1603-cohesin-ib1-etcissue86.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"620\" \/>\n\t<meta property=\"og:image:height\" content=\"425\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Patrick Mueller\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@embl\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Patrick Mueller\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/cohesin-glue-for-dna\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/cohesin-glue-for-dna\/\"},\"author\":{\"name\":\"Patrick Mueller\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/20e24fdaf3fdbf34c02236ad1afe73f2\"},\"headline\":\"Cohesin: a glue for DNA\",\"datePublished\":\"2018-08-29T08:52:06+00:00\",\"dateModified\":\"2024-03-22T09:57:13+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/cohesin-glue-for-dna\/\"},\"wordCount\":190,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/cohesin-glue-for-dna\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2018\/08\/1603-cohesin-ib1-etcissue86.jpg\",\"keywords\":[\"chromosome\",\"cohesin\",\"dna\",\"grenoble\",\"panne\",\"protein complex\",\"research highlight\",\"structural biology\"],\"articleSection\":[\"Science\",\"Science & Technology\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/cohesin-glue-for-dna\/\",\"url\":\"https:\/\/www.embl.org\/news\/science\/cohesin-glue-for-dna\/\",\"name\":\"Cohesin: a glue for DNA | EMBL\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/cohesin-glue-for-dna\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/cohesin-glue-for-dna\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2018\/08\/1603-cohesin-ib1-etcissue86.jpg\",\"datePublished\":\"2018-08-29T08:52:06+00:00\",\"dateModified\":\"2024-03-22T09:57:13+00:00\",\"description\":\"Yan Li and co-workers from the group of Daniel Panne at EMBL Grenoble discover how a component of the cohesin ring binds DNA.\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.embl.org\/news\/science\/cohesin-glue-for-dna\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/cohesin-glue-for-dna\/#primaryimage\",\"url\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2018\/08\/1603-cohesin-ib1-etcissue86.jpg\",\"contentUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2018\/08\/1603-cohesin-ib1-etcissue86.jpg\",\"width\":620,\"height\":425,\"caption\":\"During cell division, cohesin directly engages DNA (purple) and holds the replicated chromosome together. 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