{"id":14173,"date":"2018-08-23T11:54:49","date_gmt":"2018-08-23T09:54:49","guid":{"rendered":"https:\/\/news.embl.de\/?p=14173"},"modified":"2024-03-22T10:57:18","modified_gmt":"2024-03-22T09:57:18","slug":"new-approach-for-testing-cancer-drug-response","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/new-approach-for-testing-cancer-drug-response\/","title":{"rendered":"New approach for testing cancer drug response"},"content":{"rendered":"\n<p>Patients with seemingly similar cancer tumours can respond differently to the same treatment. Over the last decades, scientists have been studying the molecular signatures of tumours to predict drug sensitivity. This approach primarily focuses on understanding the molecular alternations of the tumour itself. One aspect that not many studies include is the germline \u2013 or inherited \u2013 component of a patient\u2019s genome, which includes the analysis of non-diseased cells. This approach means that the relevance of germline variants on drug susceptibility is still largely unknown.<\/p>\n\n\n\n<p>Researchers at the <a href=\"http:\/\/www.ebi.ac.uk\" target=\"_blank\" rel=\"noopener noreferrer\">European Bioinformatics Institute (EMBL-EBI)<\/a> have used a large collection of cancer cell lines to systematically test the relevance of germline variants to explain differences in drug response. The analysis, which leveraged both inherited genetic variants and variants that are caused by the tumour, was applied to 993 cell lines and 265 drugs. Surprisingly, results, published in <em><a href=\"https:\/\/www.nature.com\/articles\/s41467-018-05811-3\">Nature Communications<\/a>,<\/em> showed that the germline contribution to differences in drug susceptibility can be just as important as the contribution of somatic mutations.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">A new tool in treatment decisions?<\/h2>\n\n\n\n<p>\u201cWe combined the cancer somatic and germline genetic information, and looked at how inherited genetic predispositions influence drug sensitivity,\u201d explains Michael Menden, who worked on the analysis during his PhD in the <a href=\"https:\/\/www.ebi.ac.uk\/research\/saez-rodriguez\">Saez-Rodriguez group<\/a> at EMBL-EBI, and now part of the IMED Biotech Unit at AstraZeneca. \u201cSurprisingly, we found that the germline contribution to drug sensitivity is sometimes larger than the effects of somatic mutations. Although this paper is a proof of concept, we believe further research could help establish the germline component as an additional tool for deciding what treatment to offer cancer patients.\u201d<\/p>\n\n\n\n<p>\u201cThe germline component could be useful in multiple ways,\u201d continues Paolo Casale, previously a Predoctoral Fellow in the <a href=\"https:\/\/www.embl.de\/research\/units\/genome_biology\/stegle\/members\/?_ga=2.73461970.1171920843.1534934059-872133392.1534934059\">Stegle group<\/a> and now at the Microsoft Research New England lab. \u201cIt could help us anticipate how effectively a certain drug would work on a patient depending on their genetic background, and it could also help us identify unwanted side-effects that a drug may have on a subset of patients.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Large-scale systematic analysis explores how inherited genome affects drug response of cancer cells<\/p>\n","protected":false},"author":47,"featured_media":14179,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[38,41,247,470],"embl_taxonomy":[],"class_list":["post-14173","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-cancer","tag-genetics","tag-saez-rodriguez","tag-stegle"],"acf":{"article_intro":"<p>Large-scale systematic analysis explores how inherited genome affects drug response of cancer cells<\/p>\n","related_links":[{"link_description":"Leukaemia roots detectable years before diagnosis","link_url":"http:\/\/https:\/\/news.embl.de\/science\/acute-myleoid-leukaemia-detection\/"},{"link_description":"Personalised medicine: one data type is not enough","link_url":"http:\/\/https:\/\/news.embl.de\/science\/personalised-medicine-multi-omics-factor-analysis\/"},{"link_description":"Exploring genetic variation","link_url":"http:\/\/https:\/\/news.embl.de\/science\/exploring-genetic-variation\/"}],"article_sources":[{"source_description":"<p>Julio, Saez-Rodriguez, <em>et al.\u00a0<\/em>The germline genetic component of drug sensitivity in cancer cell lines.\u00a0<em>Nature Communications,\u00a0<\/em>published online 23 August 2018.\u00a0DOI:\u00a010.1038\/s41467-018-05811-3<\/p>\n","source_link_url":"https:\/\/doi.org\/10.1038\/s41467-018-05811-3"}],"vf_locked":false,"featured":false,"color":"#007B53"},"embl_taxonomy_terms":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>New approach for testing cancer drug response | EMBL<\/title>\n<meta name=\"description\" content=\"First large-scale systematic analysis explores how inherited genome 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