{"id":13861,"date":"2018-07-06T15:20:48","date_gmt":"2018-07-06T13:20:48","guid":{"rendered":"https:\/\/news.embl.de\/?p=13861"},"modified":"2024-08-21T15:57:54","modified_gmt":"2024-08-21T13:57:54","slug":"melting-bacteria-to-decipher-antibiotic-resistance","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/melting-bacteria-to-decipher-antibiotic-resistance\/","title":{"rendered":"Melting bacteria to decipher antibiotic resistance"},"content":{"rendered":"\n<p>With antibiotic resistance spreading worldwide, there is a strong need for new technologies to study bacteria. EMBL researchers have adapted an existing technique to study the melting behaviour of proteins so that it can be used for the study of bacteria. <em>Molecular Systems Biology <\/em>published their results \u2013 allowing researchers worldwide to start using the technique \u2013 on July 6.<\/p>\n\n\n\n<p>Thermal proteome profiling (TPP) was developed in 2014 (<a href=\"http:\/\/science.sciencemag.org\/content\/346\/6205\/1255784.long\">Savitski et al., Science 2014<\/a>) and enables scientists to compare the melting behavior of all proteins in a cell or organism before and after a perturbation, such as the administration of a drug. By adapting TPP to bacteria, it can now be used to study the activity and architecture of most proteins in a bacterial cell while it\u2019s alive. Andr\u00e9 Mateus, a postdoc working in the Savitski and Typas groups at EMBL, led the study.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Bacteria taking the heat<\/h2>\n\n\n\n<p>While human bodies cease to function at temperatures above 42\u00b0C, E. coli bacteria still grow regularly up to 45\u00b0C. \u201cWe discovered that proteins in the middle of a bacterial cell are less tolerant to heat than those at the cell surface,\u201d says Mikhail Savitski. \u201cSurprisingly, a protein\u2019s location is more predictive for its melting behavior than which other proteins it interacts with.\u201d<\/p>\n\n\n\n<p>With TPP, researchers can also investigate the effects of drugs on bacteria. Protein-drug interactions typically increase the proteins\u2019 heat tolerance, resulting in higher melting points. Therefore, comparing the heat tolerance of drug-treated and untreated bacterial cells helps to identify targets of antimicrobial drugs, but also to decipher how the bacterial cell succumbs to the drug or tries to bypass its action.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Drug resistance mechanisms<\/h2>\n\n\n\n<p>\u201cIn one particular case, we were able to elucidate a novel drug resistance mechanism,\u201d says Andr\u00e9 Mateus. \u201cCells use proteins to pump antibiotics out of the cell. After genetically removing one such efflux pump from their chromosome, bacteria became more sensitive to many drugs, but curiously more resistant to one specific antibiotic called aztreonam. Using TPP, we found that this was due to dramatically reduced levels of a specific porin \u2013 a protein that acts as a pore \u2013 used by aztreonam to enter the cell.\u201d<\/p>\n\n\n\n<p>Compared to other techniques, TPP allows scientists to investigate the effects of perturbations on thousands of individual proteins in a short timeframe. Most of the obtained insights \u2013 like the changes in the activity of proteins in vivo &#8211; would be impossible with other conventional techniques and for so many proteins simultaneously, showing TPP\u2019s potential to study bacteria in detail.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>EMBL scientists investigate how bacteria melt to study their reaction to drugs<\/p>\n","protected":false},"author":58,"featured_media":13862,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[584,494,580,981,1748,668,45,669,670,582],"embl_taxonomy":[],"class_list":["post-13861","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-antibiotic","tag-antibiotic-resistance","tag-bacteria","tag-drug","tag-press-release","tag-proteome","tag-proteomics","tag-thermal-proteome-profiling","tag-tpp","tag-typas"],"acf":{"article_intro":"<p>EMBL scientists investigate how bacteria melt to study their reaction to drugs<\/p>\n","related_links":[{"link_description":"","link_url":""},{"link_description":"","link_url":""},{"link_description":"","link_url":""},{"link_description":"","link_url":""}],"article_sources":[{"source_description":"<p>Mateus, A., <em>et al<\/em>. Thermal proteome profiling in bacteria: probing protein state in vivo. <em>Molecular Systems Biology<\/em>, published online 6 July 2018. DOI: 10.15252\/msb.20188242<\/p>\n","source_link_url":"http:\/\/msb.embopress.org\/content\/14\/7\/e8242"}],"vf_locked":false,"featured":false,"color":"#007B53","link_color":"#fff","show_featured_image":false,"in_this_article":false,"youtube_url":"","mp4_url":"","video_caption":"","translations":false,"press_contact":"EMBL Generic","field_target_display":"embl","field_article_language":{"value":"english","label":"English"},"source_article":false,"article_translations":false,"languages":""},"embl_taxonomy_terms":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Melting bacteria to decipher antibiotic resistance | EMBL<\/title>\n<meta name=\"description\" content=\"EMBL researchers have adapted an existing technique to study the melting behaviour of proteins to be used for the study of bacteria.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/melting-bacteria-to-decipher-antibiotic-resistance\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Melting bacteria to decipher antibiotic resistance | EMBL\" \/>\n<meta property=\"og:description\" content=\"EMBL researchers have adapted an existing technique to study the melting behaviour of proteins to be used for the study of bacteria.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/science\/melting-bacteria-to-decipher-antibiotic-resistance\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2018-07-06T13:20:48+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-08-21T13:57:54+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2018\/07\/Savitski-ib.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"620\" \/>\n\t<meta property=\"og:image:height\" content=\"425\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Iris Kruijen\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@IrisKruijen\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Iris Kruijen\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/melting-bacteria-to-decipher-antibiotic-resistance\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/melting-bacteria-to-decipher-antibiotic-resistance\/\"},\"author\":{\"name\":\"Iris Kruijen\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/bdd9b4c648f9ed37311c369a20ac77e1\"},\"headline\":\"Melting bacteria to decipher antibiotic resistance\",\"datePublished\":\"2018-07-06T13:20:48+00:00\",\"dateModified\":\"2024-08-21T13:57:54+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/melting-bacteria-to-decipher-antibiotic-resistance\/\"},\"wordCount\":420,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/melting-bacteria-to-decipher-antibiotic-resistance\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2018\/07\/Savitski-ib.jpg\",\"keywords\":[\"antibiotic\",\"antibiotic resistance\",\"bacteria\",\"drug\",\"press release\",\"proteome\",\"proteomics\",\"thermal proteome profiling\",\"tpp\",\"typas\"],\"articleSection\":[\"Science\",\"Science &amp; 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