{"id":13462,"date":"2018-06-04T15:52:09","date_gmt":"2018-06-04T13:52:09","guid":{"rendered":"https:\/\/news.embl.de\/?p=13462"},"modified":"2024-03-22T23:20:12","modified_gmt":"2024-03-22T22:20:12","slug":"welcome-simone-koehler","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/welcome-simone-koehler\/","title":{"rendered":"Welcome: Simone K\u00f6hler"},"content":{"rendered":"\n<p><a href=\"https:\/\/www.embl.de\/research\/units\/cbb\/koehler\/index.html\" target=\"_blank\" rel=\"noopener noreferrer\">Simone K\u00f6hler<\/a> will join EMBL Heidelberg in June as a group leader in the Cell Biology and Biophysics Unit. Using state-of-the-art microscopy and genome-editing techniques, she will research how chromosomes interact with each other to form the DNA within germ cells \u2013 the precursors to sperm or egg cells.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Please describe your research in a nutshell.<\/h3>\n\n\n\n<p>I\u2019m interested in meiosis, which is a very specialised cell division process. Typically, during cell division, you want to make two genetically identical daughter cells, but with meiosis you want to produce germ cells. These have only half as many chromosomes as the other cells in our bodies, which are known as somatic cells. This means that after germ cells from two individuals combine, there are a full diploid set of chromosomes again.<\/p>\n\n\n\n<p>I\u2019m particularly interested in finding out how chromosomes initially pair, are held together, and exchange genes with each other during a process known as crossover formation. There\u2019s a really fascinating structure called the synaptonemal complex that is involved in this process. During my postdoctoral fellowship I figured out that the synaptonemal complex reorganises its structure and that this is essential for crossover formation. Now I want to understand what else is regulated by this complex during meiosis \u2013 and how.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">How did you become interested in this topic?<\/h3>\n\n\n\n<p>During my PhD I researched how a combination of proteins can create an active network that is highly dynamic and constantly remodelled. This network is known as an active actin network and forms the dynamic scaffold inside cells. Once I\u2019d come to the end of this project, I really wanted to change fields dramatically and I started looking around at different research areas to see what else could be interesting. I saw some images of meiotic nuclei and they were fascinating to me \u2013 that\u2019s what initially drew me to this field. What inspires me is knowing that there\u2019s so much more to learn. We still have no idea how the chromosomes initially find each other or how crossover formation is regulated. I think it\u2019s amazing how little we understand about meiosis, even though we\u2019ve known about the concept for such a long time.<strong>&nbsp;<\/strong><\/p>\n\n\n\n<div class=\"wp-block-image wp-image-13464 size-full\"><figure class=\"vf-figure  | vf-figure--align vf-figure--align-centered \"><img loading=\"lazy\" decoding=\"async\" width=\"620\" height=\"380\" class=\"vf-figure__image\" src=\"https:\/\/news.embl.de\/wp-content\/uploads\/2018\/05\/1805_Welcome_Koehler_Meiosis.jpg\" alt=\"The heterogeneous chromosomes in meiotic cells after chromosome crossover formation has occurred.\" class=\"wp-image-13464\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2018\/05\/1805_Welcome_Koehler_Meiosis.jpg 620w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2018\/05\/1805_Welcome_Koehler_Meiosis-300x184.jpg 300w\" sizes=\"auto, (max-width: 620px) 100vw, 620px\" \/><figcaption class=\"vf-figure__caption\">In meiotic cells, a protein structure known as the synaptonemal complex holds paired homologous chromosomes in close contact. IMAGE: Simone K\u00f6hler\/University of California, Berkley.<\/figcaption><\/figure><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">What sort of skills are you looking for in your lab?<\/h3>\n\n\n\n<p>I really like using a very wide range of techniques so I\u2019m open to people from most academic backgrounds. This is probably because I changed fields pretty drastically myself, so I\u2019m very open to others doing the same thing. I think it really helps if you have a diverse background knowledge so I\u2019m looking for a group that can bring in ideas from different perspectives.<strong>&nbsp;<\/strong><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What\u2019s your philosophy for running a lab?<\/h3>\n\n\n\n<p>Stay curious and try things out. When I come up with a new idea, I do a quick experiment just to see where it goes. When I get a result that\u2019s really exciting, that opens up so many more questions for me. The day-to-day work in the lab really gives me a lot of new ideas.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Who would you like to work with at EMBL?<\/h3>\n\n\n\n<p>Literally almost any group at EMBL! That\u2019s the reason why I\u2019m so excited to come here \u2013 there are so many scientists I could collaborate with who are studying nuclear and chromatin organisation. The microscopy facilities are really great at EMBL too.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What\u2019s the best advice that you\u2019ve received?<\/h3>\n\n\n\n<p>Present your research well: talk about your work and be proactive. Sometimes that can be really difficult, as I like to be in the lab doing experiments, but that\u2019s not good enough. When you talk about your research, that\u2019s where you really learn a lot and you can get so much great input from others.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Which of our genes will be passed on to our children? Simone K\u00f6hler wants to find out<\/p>\n","protected":false},"author":59,"featured_media":13576,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[17593,2],"tags":[59,619,535,43,598,634,295],"embl_taxonomy":[],"class_list":["post-13462","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-people-perspectives","category-science","tag-careers","tag-cell-cycle","tag-chromosome","tag-heidelberg","tag-imaging","tag-kohler","tag-welcome"],"acf":{"article_intro":"<p>Which of our genes will be passed on to our children? Simone K\u00f6hler wants to find out<\/p>\n","related_links":[{"link_description":"K\u00f6hler group","link_url":"https:\/\/www.embl.de\/research\/units\/cbb\/koehler\/index.html"}],"article_sources":false,"vf_locked":false,"featured":false,"color":"#007B53"},"embl_taxonomy_terms":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Welcome: Simone K\u00f6hler | EMBL<\/title>\n<meta name=\"description\" content=\"Simone K\u00f6hler will join EMBL Heidelberg in June as a group leader in the Cell Biology and Biophysics Unit. 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