{"id":13019,"date":"2018-04-09T16:24:21","date_gmt":"2018-04-09T14:24:21","guid":{"rendered":"https:\/\/news.embl.de\/?p=13019"},"modified":"2024-03-22T23:06:14","modified_gmt":"2024-03-22T22:06:14","slug":"counting-condensins-chromosomes","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/counting-condensins-chromosomes\/","title":{"rendered":"Counting condensins on chromosomes"},"content":{"rendered":"\n<p>Chromosomes are highly organised, dense arrangements of DNA that form every time our cells duplicate themselves. Two protein complexes, condensins I and II, are known to help organise DNA strands into chromosomes during this process of mitosis, but it is uncertain how. In a paper published in the <em>Journal of Cell Biology<\/em>, <a href=\"https:\/\/www.embl.de\/research\/units\/cbb\/ellenberg\/index.html\" target=\"_blank\" rel=\"noopener noreferrer\">Jan Ellenberg<\/a> and his group have measured how many condensin proteins are bound to the chromosomes during the different stages of mitosis, using quantitative live-cell imaging. The proteins\u2019 precise locations on the chromosome and their spacing along the DNA strand were also identified using super-resolution imaging. Based on this research, Jan Ellenberg and his team propose that condensins organise DNA into chromosomes by forming highly regulated loops of DNA. This supports <a href=\"https:\/\/news.embl.de\/science\/loops-loops-loops-dna-gets-organised\/\">previous results<\/a> published by the <a href=\"https:\/\/www.embl.de\/research\/units\/cbb\/haering\/index.html\" target=\"_blank\" rel=\"noopener noreferrer\">Haering group<\/a> at EMBL and will further our understanding of how condensins organise DNA during mitosis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>EMBL scientists count and locate chromosomal proteins during cell duplication<\/p>\n","protected":false},"author":59,"featured_media":13020,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[64,535,43,79,539],"embl_taxonomy":[],"class_list":["post-13019","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-cell-biology","tag-chromosome","tag-heidelberg","tag-microscopy","tag-research-highlight"],"acf":{"article_intro":"<p>EMBL scientists count and locate chromosomal proteins during cell duplication<\/p>\n","related_links":[{"link_description":"Ellenberg group","link_url":"https:\/\/www.embl.de\/research\/units\/cbb\/ellenberg\/index.html"},{"link_description":"Haering group","link_url":"https:\/\/www.embl.de\/research\/units\/cbb\/haering\/index.html"}],"article_sources":[{"source_description":"<p>Walther, N., <em>et al<\/em>. A quantitative map of human Condensins provides new insights into mitotic chromosome architecture<em>. Journal of Cell Biology<\/em>, published 9 April 2018. DOI: 10.1083\/jcb.201801048<\/p>\n","source_link_url":"https:\/\/doi.org\/10.1083\/jcb.201801048"}],"vf_locked":false,"featured":false,"color":"#007B53"},"embl_taxonomy_terms":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Counting condensins on chromosomes | EMBL<\/title>\n<meta name=\"description\" content=\"Jan Ellenberg and his group count and locate chromosomal proteins, Condensins I and II, during cell duplication.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/counting-condensins-chromosomes\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Counting condensins on chromosomes | EMBL\" \/>\n<meta property=\"og:description\" content=\"Jan Ellenberg and his group count and locate chromosomal proteins, Condensins I and II, during cell duplication.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/science\/counting-condensins-chromosomes\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2018-04-09T14:24:21+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-22T22:06:14+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2018\/04\/1803_highlight_ellenberg3_ib.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"620\" \/>\n\t<meta property=\"og:image:height\" content=\"425\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Emma Steer\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@embl\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Emma Steer\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/counting-condensins-chromosomes\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/counting-condensins-chromosomes\/\"},\"author\":{\"name\":\"Emma Steer\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/4c1a1fd8d38ed9a5cf0d0020048f6443\"},\"headline\":\"Counting condensins on chromosomes\",\"datePublished\":\"2018-04-09T14:24:21+00:00\",\"dateModified\":\"2024-03-22T22:06:14+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/counting-condensins-chromosomes\/\"},\"wordCount\":148,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/counting-condensins-chromosomes\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2018\/04\/1803_highlight_ellenberg3_ib.jpg\",\"keywords\":[\"cell biology\",\"chromosome\",\"heidelberg\",\"microscopy\",\"research highlight\"],\"articleSection\":[\"Science\",\"Science &amp; 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