{"id":12734,"date":"2018-03-21T15:04:54","date_gmt":"2018-03-21T14:04:54","guid":{"rendered":"https:\/\/news.embl.de\/?p=12734"},"modified":"2024-03-23T22:02:11","modified_gmt":"2024-03-23T21:02:11","slug":"welcome-maria-garcia-alai","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/welcome-maria-garcia-alai\/","title":{"rendered":"Welcome: Maria Garcia Alai"},"content":{"rendered":"\n<p>As Head of the <a href=\"http:\/\/www.embl-hamburg.de\/services\/spc\/?_ga=2.147200119.1370726087.1521541457-1457099627.1520441443\" target=\"_blank\" rel=\"noopener noreferrer\">Sample Preparation and Characterisation Facility<\/a> at EMBL Hamburg, Maria Garcia Alai leads one of the best-equipped facilities in Europe. With state-of-the-art biosensors and a synchrotron on site, she will help users determine protein structures using different biophysical techniques.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What will be the focus of your role?<\/h3>\n\n\n\n<p>The most important thing is providing a service. I\u2019ve learnt that I really like the interaction with users, helping them design and set up experiments. Some of the users who come to the facility aren\u2019t structural biologists, so when they come here they get support and supervision. At the end of the day you really feel like you\u2019ve done something useful and helped somebody out \u2013 that\u2019s what I really enjoy. Some scientists prefer to have one big research question that they work on, but I like working on all kinds of different problems \u2013 the truth is I have so much fun with the methodology and applying the technology! That\u2019s the part I like most. Trying to solve problems for others keeps me grounded.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What are your specific research interests?<\/h3>\n\n\n\n<p>We use biophysical techniques to solve what I like to call \u2018dynamic puzzles\u2019. These are 3D structural biology puzzles, for which we use biophysics to work out how proteins assemble, or the way they interact with cell membranes. The last puzzle that I helped solve focused on amphitropic proteins, which are proteins that can go in and out of the membrane. They bind with fat molecules (lipids) on the cell membrane and help to bring molecules into the cell from the outside world.<\/p>\n\n\n\n<blockquote class=\"vf-blockquote\"><p>I like to solve dynamic puzzles<\/p><\/blockquote>\n\n\n\n<p>I\u2019m also interested in proteins that bind with lipids generally. They\u2019re a little like Lego bricks and can form different kinds of structures. If you leave them uncontrolled, in time you can get assemblies of four proteins (tetramers), eight proteins (octamers), or something even bigger! The puzzle itself is so dynamic. It changes depending on how long you leave the protein, or which other proteins are present. In the test tube there are a mix of proteins and in the cell it\u2019s even more complex, but I really enjoy exploring those puzzles too.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Is there one tool that you can\u2019t do without?<\/h3>\n\n\n\n<p>No! With protein-protein interactions, you can\u2019t use just one technique. Even if you want to publish something based on one technique, people will ask you to check your results using different methods to support what you\u2019re saying. We need to try as many techniques as possible and sometimes one of them doesn\u2019t work. It\u2019s even better if the techniques are based on different technologies. If you can see the same interaction with different physical systems then you can put much more trust in your result. I just want to have as many tools as possible and combine them all.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What was it like to study and research in Argentina?<\/h3>\n\n\n\n<p>I was born and raised in Argentina and I lived there for 27 years. I studied Biology there but during my degree I changed specialism and ended up doing Biophysics. I also completed my PhD in Buenos Aires, researching protein folding. During my PhD, I learnt that you have to be motivated and your motivation can\u2019t let you down. It\u2019s very hard-core training, but I think it\u2019s great! You learn a lot of skills to help you survive. In Argentina I had great teachers too, who kept me motivated.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What\u2019s your philosophy for running your facility?<\/h3>\n\n\n\n<p>You have to keep on going: always give the best you can, to support your users. Also, multitasking is important. One minute you\u2019re putting a rubber band on the arm of the robot because it isn\u2019t working and you have to wait three weeks for the engineer to come. The next, you have to explain to a PhD student why his experiment isn\u2019t working!<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What\u2019s the best advice you would give to researchers?<\/h3>\n\n\n\n<p>Focus on the problem that you want to solve and keep it simple. Design the experiment in the best and most simple way, and it will be clear and beautiful.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The new head of facility at EMBL Hamburg will help users solve protein puzzles<\/p>\n","protected":false},"author":59,"featured_media":12934,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[17593,2],"tags":[48,11421,53,5744,35,295,493],"embl_taxonomy":[9596,19023,19369],"class_list":["post-12734","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-people-perspectives","category-science","tag-facility","tag-garcia-alai","tag-hamburg","tag-sample-preparation-and-characterisation-facility","tag-structural-biology","tag-welcome","tag-women-in-science","embl_taxonomy-embl-hamburg","embl_taxonomy-maria-marta-garcia-alai","embl_taxonomy-sample-preparation-and-characterisation-facility"],"acf":{"article_intro":"<p>The new head of facility at EMBL Hamburg will help users solve protein puzzles<\/p>\n","related_links":[{"link_description":"Sample Preparation and Characterisation Facility ","link_url":"https:\/\/www.embl.org\/groups\/sample-preparation-characterisation\/"}],"article_sources":false,"vf_locked":false,"featured":false,"color":"#007B53","link_color":"#fff","show_featured_image":false,"in_this_article":false,"youtube_url":"","mp4_url":"","video_caption":"","press_contact":"None","source_article":false,"field_target_display":""},"embl_taxonomy_terms":[{"uuid":"a:3:{i:0;s:36:\"b14d3f13-5670-44fb-8970-e54dfd9c921a\";i:1;s:36:\"89e00fee-87f4-482e-a801-4c3548bb6a58\";i:2;s:36:\"613c4de5-1775-447f-af71-4b07085318e9\";}","parents":[],"name":["EMBL Hamburg"],"slug":"embl-hamburg","description":"Where &gt; All EMBL sites &gt; EMBL Hamburg"},{"uuid":"a:2:{i:0;s:36:\"4428d1fd-441a-4d6d-a1c5-5dcf5665f213\";i:1;s:36:\"97f40d49-50ea-4956-b149-50bd369d23d4\";}","parents":[],"name":["Maria Marta Garcia Alai"],"slug":"maria-marta-garcia-alai","description":"Who &gt; Maria Marta Garcia Alai"},{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"42b86629-bf66-44cd-b9e0-61590f8e8584\";i:2;s:36:\"01cca59b-ea0d-4c7d-b627-4cd295f3f9bc\";}","parents":[],"name":["Sample Preparation and Characterisation Facility"],"slug":"sample-preparation-and-characterisation-facility","description":"What &gt; Services at EMBL Hamburg &gt; Sample Preparation and Characterisation Facility"}],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Welcome: Maria Garcia Alai | EMBL<\/title>\n<meta name=\"description\" content=\"Maria Garcia Alai, the new head of the Sample Preparation and Characterisation Facility at EMBL Hamburg will help users solve protein puzzles.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/welcome-maria-garcia-alai\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Welcome: Maria Garcia Alai | EMBL\" \/>\n<meta property=\"og:description\" content=\"Maria Garcia Alai, the new head of the Sample Preparation and Characterisation Facility at EMBL Hamburg will help users solve protein puzzles.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/science\/welcome-maria-garcia-alai\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2018-03-21T14:04:54+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-23T21:02:11+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2018\/03\/180321-welcome-maria-garcia-alai.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"620\" \/>\n\t<meta property=\"og:image:height\" content=\"425\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Emma Steer\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@embl\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Emma Steer\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/welcome-maria-garcia-alai\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/welcome-maria-garcia-alai\/\"},\"author\":{\"name\":\"Emma Steer\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/4c1a1fd8d38ed9a5cf0d0020048f6443\"},\"headline\":\"Welcome: Maria Garcia Alai\",\"datePublished\":\"2018-03-21T14:04:54+00:00\",\"dateModified\":\"2024-03-23T21:02:11+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/welcome-maria-garcia-alai\/\"},\"wordCount\":702,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/welcome-maria-garcia-alai\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2018\/03\/180321-welcome-maria-garcia-alai.jpg\",\"keywords\":[\"facility\",\"garcia alai\",\"hamburg\",\"sample preparation and characterisation facility\",\"structural biology\",\"welcome\",\"women in science\"],\"articleSection\":[\"People &amp; 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