{"id":11972,"date":"2017-12-21T17:00:42","date_gmt":"2017-12-21T16:00:42","guid":{"rendered":"https:\/\/news.embl.de\/?p=11972"},"modified":"2024-03-22T11:50:38","modified_gmt":"2024-03-22T10:50:38","slug":"mapping-molecules-people-fields-atm-machines-2","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/mapping-molecules-people-fields-atm-machines-2\/","title":{"rendered":"Mapping molecules on people, fields and ATMs"},"content":{"rendered":"\n<div class=\"wp-block-image wp-image-11981 size-full\"><figure class=\"vf-figure  | vf-figure--align vf-figure--align-centered \"><img loading=\"lazy\" decoding=\"async\" width=\"620\" height=\"425\" class=\"vf-figure__image\" src=\"https:\/\/news.embl.de\/wp-content\/uploads\/2017\/12\/171221-alexandrov-metabolomics_ib.jpeg\" alt=\"\" class=\"wp-image-11981\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2017\/12\/171221-alexandrov-metabolomics_ib.jpeg 620w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2017\/12\/171221-alexandrov-metabolomics_ib-300x206.jpeg 300w\" sizes=\"auto, (max-width: 620px) 100vw, 620px\" \/><figcaption class=\"vf-figure__caption\">IMAGE: Theodore Alexandrov\/EMBL<\/figcaption><\/figure><\/div>\n\n\n\n<p>This glowing avatar is a map of molecules. Every day, every inch of skin on your body comes into contact with thousands of molecules \u2013 from skin cream, sweat, even from the microbes that call your skin home. Now scientists can create interactive 3D maps that show where each molecule lingers on our bodies, thanks to a new method that researchers at <a href=\"https:\/\/www.embl.de\" target=\"_blank\" rel=\"noopener noreferrer\">EMBL<\/a> and <a href=\"https:\/\/ucsd.edu\/\" target=\"_blank\" rel=\"noopener noreferrer\">University of California San Diego<\/a> have made available in Nature Protocols. When the team <a href=\"https:\/\/news.embl.de\/science\/1508-metabolomics\/\">first used this approach<\/a> to map the molecules on the skin of two volunteers, they found traces of sun cream and other hygiene products \u2013 three days after they\u2019d last been used.<\/p>\n\n\n<div\n  class=\"vf-embed vf-embed--custom-ratio\"\n\n  style=\"--vf-embed-max-width: 100%;\n    --vf-embed-custom-ratio-x: 640;\n    --vf-embed-custom-ratio-y: 360;\"><iframe loading=\"lazy\" width=\"640\" height=\"360\" src=\"https:\/\/ili.embl.de\/?NP_man\/model.stl;NP_man\/intensities.csv;NP_man\/sles.json\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe><\/div>\n\n\n\n<p>Theodore Alexandrov\u2019s team at EMBL and Pieter Dorrestein\u2019s at UC San Diego first developed the method to explore how molecules from our surroundings affect the microbe communities on our skin. Having been approached by colleagues from fields as diverse as forensics, cosmetics, ecology and agriculture, they have now made it into a step-by-step recipe and intuitive software.<\/p>\n\n\n\n<p>Can you guess which four digits a volunteer typed into the ATM machine in the image in the top header? If you guessed 8, 0, 1 and 7, you were right. The colour of the dots represents the amount of a molecule that was transferred from the person\u2019s finger to the keypad. \u201cThere are much easier ways of stealing someone\u2019s PIN,\u201d says Alexandrov. \u201cWe had to first clean the ATM machine with methanol, then swab it and perform mass spectrometry, so it\u2019s unlikely someone would steal your PIN this way. But it does show nicely that we transfer molecules from our skin to the objects we interact with \u2013 and that we can measure and map that. This has raised lots of interest from forensics experts.\u201d In previous work, for instance, Alexandrov and Dorrestein were able to make predictions about people\u2019s lifestyles based on the molecules found on their mobile phones.<\/p>\n\n\n\n<div class=\"wp-block-image wp-image-11977 size-full\"><figure class=\"vf-figure  | vf-figure--align vf-figure--align-centered \"><img loading=\"lazy\" decoding=\"async\" width=\"620\" height=\"425\" class=\"vf-figure__image\" src=\"https:\/\/news.embl.de\/wp-content\/uploads\/2017\/12\/171221-Alexandrov-rosemary-ib.jpeg\" alt=\"\" class=\"wp-image-11977\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2017\/12\/171221-Alexandrov-rosemary-ib.jpeg 620w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2017\/12\/171221-Alexandrov-rosemary-ib-300x206.jpeg 300w\" sizes=\"auto, (max-width: 620px) 100vw, 620px\" \/><figcaption class=\"vf-figure__caption\">IMAGE: Alexandrov Team\/EMBL &amp; Dorrenstein Team\/UC San Diego<\/figcaption><\/figure><\/div>\n\n\n\n<p>\u201cThis is just a sprig of rosemary that we collected on campus at UC San Diego, but it demonstrates that the method can be applied to agriculture,\u201d says Dorrestein. \u201cYou could use it to see if pesticides or other products applied to a field spread to neighbouring fields, and if there are patterns in that spread.\u201d In this image, you can see that the old leaves at the bottom of the rosemary plant have much higher levels of the flavonoid cirsimaretin than the newer leaves at the top. Using maps like this, scientists can study how plants transport molecules from old leaves to young ones, or how they react to stress.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Molecule mapping method raises interest in forensics, agriculture and microbiome studies<\/p>\n","protected":false},"author":58,"featured_media":11976,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[416,43,219,1748,51],"embl_taxonomy":[],"class_list":["post-11972","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-alexandrov","tag-heidelberg","tag-metabolomics","tag-press-release","tag-systems-biology"],"acf":{"article_intro":"<p>Standardised, freely available molecule mapping method is raising interest in forensics, agriculture and microbiome studies<\/p>\n","related_links":[{"link_description":"Welcome: Theodore Alexandrov","link_url":"https:\/\/news.embl.de\/science\/1508-alexandrov\/"},{"link_description":"Alexandrov research group","link_url":"https:\/\/www.embl.de\/research\/units\/scb\/alexandrov\/index.html"},{"link_description":"Dorrestein Lab","link_url":"http:\/\/dorresteinlab.ucsd.edu\/Dorrestein_Lab\/Welcome.html"}],"article_sources":[{"source_description":"<p>Protsyuk I, Melnik AV, Nothias LF <em>et al.<\/em> 3D molecular cartography using LC-MS facilitated by Optimus and `ili software. <em>Nature Protocols<\/em>, published online 21 December, 2017. DOI:10.1038\/nprot.2017.122<\/p>\n","source_link_url":"https:\/\/www.nature.com\/articles\/nprot.2017.122"}],"vf_locked":false,"featured":false,"color":"#007B53","show_featured_image":false,"in_this_article":false,"youtube_url":"","mp4_url":"","video_caption":"","translations":false,"press_contact":"EMBL Generic"},"embl_taxonomy_terms":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Mapping molecules on people, fields and ATMs | EMBL<\/title>\n<meta name=\"description\" content=\"Standardised, freely available method of mapping molecules is raising interest in forensics, agriculture and microbiome studies.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/mapping-molecules-people-fields-atm-machines-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" 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