{"id":11408,"date":"2017-12-04T15:16:47","date_gmt":"2017-12-04T14:16:47","guid":{"rendered":"https:\/\/news.embl.de\/?p=11408"},"modified":"2024-03-22T11:53:20","modified_gmt":"2024-03-22T10:53:20","slug":"welcome-eva-kowalinski","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/welcome-eva-kowalinski\/","title":{"rendered":"Welcome: Eva Kowalinski"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\">Describe your work in a nutshell<\/h3>\n\n\n\n<p>In order for the cell to make sense of its genetic instructions, DNA is copied into RNA, which is then translated into proteins. This sounds very linear, but it\u2019s not. I study RNA editing, a processing step which diversifies RNA sequences by deleting, adding or modifying parts of the RNA.<\/p>\n\n\n\n<p>RNA editing is a complicated process carried out by large molecular machines that are assembled of many subunits made up of proteins. In the lab, we want first to study the structure \u2013 what these protein complexes look like \u2013 to then get to know their function. &nbsp;In some years, we will understand how these mechanisms work and, hopefully, be able to put them to use.<\/p>\n\n\n\n<blockquote class=\"vf-blockquote\"><p>There is definitely a special spirit about EMBL<\/p><\/blockquote>\n\n\n\n<h3 class=\"wp-block-heading\">Why did you choose <em>Trypanosoma brucei,<\/em> the parasite that causes sleeping sickness, as a model system to conduct your research?<\/h3>\n\n\n\n<p><em>Trypanosoma brucei<\/em> can change large parts of its RNA and has a very complicated RNA editing machinery. We want to understand how the different proteins implicated in the RNA editing process are structured to know their function and how they interact with each other. We are studying <em>Trypanosoma<\/em> because if we are able to understand its complicated machinery, we\u2019ll be able to compare it to the mechanisms used by other organisms.<\/p>\n\n\n\n<p>If we were able to control the RNA editing process in an organism, we might be able to quite specifically control which proteins result from gene activity without modifying the organism\u2019s DNA. &nbsp;This is very interesting, but at a very early stage: one day we might be able to use RNA editing as a medical tool.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">During your postdoc training at the Max Planck Institute of Biochemistry in Munich you were working on an intriguing complex, called the Ski complex. What is it and what makes it so interesting?<\/h3>\n\n\n\n<p>Inside the cell, there\u2019s a complex called exosome that breaks up RNA. The exosome precisely trims certain RNAs and contributes to regular RNA turnover in the cell. But it can also degrade RNA completely in case there are mistakes in the RNA that lead to faulty proteins. So, you can imagine the exosome as a paper shredder, where the paper is RNA and the Ski complex is the hand that feeds the paper in. We have been investigating how the Ski complex helps the exosome with its task and we found evidence for the direct contact between ribosomes, the cellular protein factory, and the Ski complex. We think this is a sort of cellular quality control, for when a defective RNA molecule gets stuck in the ribosome and has to be removed and degraded.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">How does it feel to be back at EMBL?<\/h3>\n\n\n\n<p>It is good to be back to EMBL, I think this is a great place! EMBL\u2019s Grenoble site is a small and lively European science hub. On the one hand, we have access to great European facilities: the <a href=\"http:\/\/www.esrf.eu\/about\/synchrotron-science\/synchrotron\" target=\"_blank\" rel=\"noopener noreferrer\">synchrotron<\/a>, <a href=\"https:\/\/news.embl.de\/science\/new-cryo-em-facility\/\">electron microscopes<\/a>, the <a href=\"https:\/\/www.embl.fr\/services\/ht_crystallisation\/\">high throughput crystallization facility<\/a> &#8211; there\u2019s everything you need to study protein structures! On the other hand, the site\u2019s relatively small size encourages you to get out of your bubble, seek collaborations, invite external speakers and look behind the horizon. There\u2019s definitely a special spirit about EMBL. The environment is open and collaborative, everyone gives stimulating input to everyone\u2019s research \u2013 I hope to contribute and give ideas to all of them and soak up inspiration myself.<\/p>\n\n\n\n<blockquote class=\"vf-blockquote\"><p>I want the people in my lab to be passionate about science and to love what they do<\/p><\/blockquote>\n\n\n\n<h3 class=\"wp-block-heading\">Is there anything you wish you had known before becoming a group leader?<\/h3>\n\n\n\n<p>Becoming a group leader is quite a harsh transition. As students and postdocs, we are trained to read journals, do experiments and write papers. As a group leader, there\u2019s a lot of management, organisation, interviewing and so on involved \u2013 a completely different set of tasks. Thankfully, the administrative staff at EMBL are extremely helpful, and they are very good at making life easier. I enjoy the new responsibilities, but I have to confess that I want to spend as much time as I can in the lab doing experiments!<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Is there any specific thing that you are looking for while recruiting?<\/h3>\n\n\n\n<p>I want the people in my lab to be passionate about science and to love what they do. I learnt from my own experience that there\u2019re times when everything goes well and the experiments are successful. But there are also periods when progress feels slow-moving, and that\u2019s when you need to be resilient \u2013 it takes will power and passion for what you do. There are ups and downs, so you have to love what you do and really want it.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>New group leader based in Grenoble aims to unveil the mechanisms of RNA editing<\/p>\n","protected":false},"author":55,"featured_media":11409,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[17593,2],"tags":[59,40,41,37,541,35,295,493],"embl_taxonomy":[],"class_list":["post-11408","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-people-perspectives","category-science","tag-careers","tag-gene-regulation","tag-genetics","tag-grenoble","tag-kowalinski","tag-structural-biology","tag-welcome","tag-women-in-science"],"acf":{"article_intro":"<p>New group leader based in Grenoble aims to unveil the mechanisms of RNA editing<\/p>\n","related_links":[{"link_description":"Kowalinski research group","link_url":"https:\/\/www.embl.fr\/research\/unit\/kowalinski\/"}],"article_sources":false,"vf_locked":false,"featured":false,"color":"#007B53"},"embl_taxonomy_terms":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Welcome: Eva Kowalinski | EMBL<\/title>\n<meta name=\"description\" content=\"Working at EMBL in Grenoble, Eva Kowalinski will lead a group of structural biologists to unveil the mechanisms of RNA editing.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/welcome-eva-kowalinski\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Welcome: Eva Kowalinski | EMBL\" \/>\n<meta property=\"og:description\" content=\"Working at EMBL in Grenoble, Eva Kowalinski will lead a group of structural biologists to unveil the mechanisms of RNA editing.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/science\/welcome-eva-kowalinski\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2017-12-04T14:16:47+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-22T10:53:20+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2017\/11\/171123_welcome_Kowalinski_ib.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"620\" \/>\n\t<meta property=\"og:image:height\" content=\"425\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Berta Carre\u00f1o\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@embl\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Berta Carre\u00f1o\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/welcome-eva-kowalinski\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/welcome-eva-kowalinski\/\"},\"author\":{\"name\":\"Berta Carre\u00f1o\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/3188b4d1fc563c4c62a41ab642fda2b5\"},\"headline\":\"Welcome: Eva Kowalinski\",\"datePublished\":\"2017-12-04T14:16:47+00:00\",\"dateModified\":\"2024-03-22T10:53:20+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/welcome-eva-kowalinski\/\"},\"wordCount\":798,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/welcome-eva-kowalinski\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2017\/11\/171123_welcome_Kowalinski_ib.jpg\",\"keywords\":[\"careers\",\"gene regulation\",\"genetics\",\"grenoble\",\"kowalinski\",\"structural biology\",\"welcome\",\"women in science\"],\"articleSection\":[\"People &amp; 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