{"id":58719,"date":"2023-05-15T12:00:00","date_gmt":"2023-05-15T10:00:00","guid":{"rendered":"https:\/\/www.embl.org\/news\/?post_type=embletc&p=58719"},"modified":"2023-05-17T20:49:08","modified_gmt":"2023-05-17T18:49:08","slug":"celebrating-100-issues-of-embletc","status":"publish","type":"embletc","link":"https:\/\/www.embl.org\/news\/embletc\/issue-100\/celebrating-100-issues-of-embletc\/","title":{"rendered":"Celebrating 100 issues of EMBLetc."},"content":{"rendered":"\n

Founded in 1974, EMBL is Europe’s life science laboratory. With its six European sites, EMBL is a world leader in cutting-edge molecular biology research, services, training, technology transfer, and policy development. <\/p>\n\n\n\n

In the 1990s, as the organisation grew, so did the need for a common and reliable platform for sharing news about EMBL both within and outside the institution. Thus, in 1999, EMBLetc., <\/em>a newsletter that would be circulated among the institute\u2019s staff and alumni, was created to fulfil this need. <\/p>\n\n\n\n

As the editors wrote in the introduction to the first edition<\/a>, \u201cA newsletter can be of great value in raising awareness of what is going on in EMBL as a whole\u2026it can provide an important means of keeping our Alumni linked to the life of the Laboratory, and it will provide a forum for voicing issues which don\u2019t fit easily into EMBL\u2019s other publications.\u201d<\/p>\n\n\n\n

First created as an 8-page black-and-white newsletter, EMBLetc.<\/em> received its first major makeover in 2009, transitioning to a full-colour layout with its 50th issue<\/a>. In 2014, EMBL\u2019s 40th anniversary year, EMBLetc.<\/em> evolved into a full-colour, 40-page magazine<\/a>, with sections dedicated to discussing the institute\u2019s research, people, and culture. Finally, with Issue 99<\/a>, released in November last year, the magazine took a new digital-first direction, representing EMBL\u2019s move towards more sustainable publications. <\/p>\n\n\n\n

Today, as we release its 100th issue<\/a>, we can see a microcosm of EMBL\u2019s history captured in the pages of this very special magazine\/newsletter. Browsing through its issues, we come across defining moments, important achievements, triumphs and challenges, overcoming adversity and building community. In memorialising EMBL\u2019s story, EMBLetc.<\/em> tells a tale of persistent innovation, collaboration, creativity, connection, resilience, and intellectual curiosity that cannot be dampened. <\/p>\n\n\n\n

EMBLetc.<\/em> has been instrumental in celebrating the achievements of EMBL\u2019s broad community and in serving as a platform for its many diverse voices.<\/p>Edith Heard, Director General, EMBL<\/cite><\/blockquote><\/figure>\n\n\n\n

In this 100th issue, we take a trip down memory lane<\/a> to witness the history of the most recent 24 years of EMBL\u2019s history through the lens of EMBLetc. <\/em>issues. We also celebrate recent advances in research and services across EMBL\u2019s sites and units. We discover how EMBL Barcelona researchers are using ‘organ-on-chip’ and organoid models<\/a> to understand health and disease. We look at novel insights from EMBL Rome researchers regarding the inheritance of epigenetic traits<\/a>. We peek behind the scenes to see how engineers and scientists collaborate<\/a> at EMBL Grenoble to build innovative fully-automated pipelines for structural biology experiments. We learn how EMBL researchers have been building accessible tools to deal with the challenge of big data analysis in biological imaging<\/a>.<\/p>\n\n\n\n

We also take a sneak peek at EMBL\u2019s upcoming science and society conference<\/a>, Terra Incognita<\/em>, which has invited a stellar lineup of speakers to examine and discuss ethical standards in life science research. We hear from past and present stalwarts of EMBL, including Professor Dame Janet Thornton<\/a>, former Director of EMBL-EBI, Des Higgins<\/a>, one of the early pioneers of bioinformatics, and Veli Vural Uslu<\/a>, who has been instrumental in combining science and theatre <\/strong>to aid public engagement in science.\u00a0<\/p>\n\n\n\n

EMBLetc.<\/em> was for many pre-digital and pre-pandemic years EMBL\u2019s flagship external communications channel. In its new digital-first and multimedia-rich format, it reinforces our role as Europe\u2019s leading life sciences research and technology organisation.<\/p>\n\n\n\n

Check out the new issue here<\/a>. You can also browse through our archive of past EMBLetc. issues here<\/a>, going back 24 years. We look forward to your comments, suggestions, and feedback<\/a>!<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

First published in 1999 as a black-and-white printed newsletter for EMBL staff and alumni, EMBLetc. has undergone many transformations in its 24 years of existence.<\/p>\n","protected":false},"author":124,"featured_media":58971,"parent":0,"menu_order":0,"template":"","tags":[80,687,13956],"class_list":["post-58719","embletc","type-embletc","status-publish","has-post-thumbnail","hentry","tag-alumni","tag-celebration","tag-embletc"],"acf":{"featured":true,"show_featured_image":false,"field_target_display":"embl","field_article_language":{"value":"english","label":"English"},"article_intro":"

First published in 1999 as a black-and-white printed newsletter for EMBL staff and alumni, EMBLetc.<\/em> has undergone many transformations in its 24 years of existence.<\/p>\n","related_links":[{"link_description":"Archive of past EMBLetc. issues","link_url":"https:\/\/www.embl.org\/news\/embletc-archive\/"}],"source_article":false,"in_this_article":false,"press_contact":"None","article_translations":false,"languages":"","embletc_issue":[{"ID":58531,"post_author":"124","post_date":"2023-05-15 12:00:00","post_date_gmt":"2023-05-15 10:00:00","post_content":"","post_title":"Issue 100","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"issue-100","to_ping":"","pinged":"","post_modified":"2023-05-15 13:01:59","post_modified_gmt":"2023-05-15 11:01:59","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.embl.org\/news\/?post_type=embletc-issue&p=58531","menu_order":0,"post_type":"embletc-issue","post_mime_type":"","comment_count":"0","filter":"raw"}],"embletc_in_this_issue":[{"ID":58717,"post_author":"120","post_date":"2023-05-15 12:00:00","post_date_gmt":"2023-05-15 10:00:00","post_content":"\n

Alexander Aulehla<\/strong>, Head of Developmental Biology Unit, and Mikhail Savitski<\/strong>, Team Leader and Head of Proteomics Core Facility at EMBL Heidelberg, have received Allen Distinguished Investigator awards<\/a> this year for a project to study differences in protein ageing and lifespan. Funded by the Paul G. Allen Family Foundation, the awards support cutting-edge, early-stage research projects that promise to advance the fields of biology and medicine.<\/p>\n\n\n\n

Alba Diz-Mu\u00f1oz<\/strong>, Group Leader at EMBL Heidelberg, won the 2023 Early Career Award in Mechanobiology<\/a> from the US Biophysical Society (BPS). The award recognises a young principal investigator who has made outstanding contributions to the way we understand how mechanics shape molecular and cellular processes. <\/p>\n\n\n\n

Olivier Duss<\/strong>, Group Leader at EMBL Heidelberg, is one of the recipients of the FEBS Excellence Awards<\/a> from the Federation of European Biochemical Societies (FEBS). The prestigious programme supports early-career group leaders in molecular life sciences.<\/p>\n\n\n\n

Miki Ebisuya<\/strong>, Group Leader at EMBL Barcelona, has been awarded an Alexander von Humboldt Professorship<\/a> by the Humboldt Foundation. The professorship, one of Germany\u2019s foremost research awards, aims to bring top international researchers from all disciplines to German universities. <\/p>\n\n\n\n

Anne Ephrussi<\/strong>, Senior Scientist and Head of EICAT, has received the Lifetime Achievement Award<\/a> from the Society for Developmental Biology. The award recognises her fundamental research contributions to our understanding of RNA localisation and translation in development. <\/p>\n\n\n\n

Jamie Hackett<\/strong>, Group Leader at EMBL Rome, won the first GSK-EMBL Young Entrepreneur<\/a> Award for his research on precise epigenome modifications for regulating genes. The award by EMBLEM and GSK supports EMBL scientists in testing the commercial viability of early research work. <\/p>\n\n\n\n

Edith Heard<\/strong>, EMBL Director General, has been elected member of the French Academy of Sciences<\/a> (Acad\u00e9mie des Sciences \u2013 Institut de France), under the section \u2018Human Biology and Medical Sciences\u2019, for her work on epigenetics, particularly in deciphering the process of X-chromosome inactivation. In addition to providing policymakers with a framework of expertise, the academy supports research, science education, and scientific life at the international level.<\/p>\n\n\n\n

\u200b\u200bJohn Lees<\/strong>, Group Leader, and Joel Hellewell<\/strong>, postdoctoral fellow in the Lees Group at EMBL-EBI, have received the SPI-M-O Award for Modelling and Data Support (SAMDS) from the British government, in recognition of their exceptional contributions to the Scientific Pandemic Influenza Group on Modelling (SPI-M-O) and the scientific advice which has supported the government\u2019s response to the pandemic.<\/p>\n\n\n\n

Jonas Tholen, <\/strong>postdoctoral fellow in the Galej Group at EMBL Grenoble, is the graduate student winner of the 2023 Scaringe Young Scientist Award<\/a> from the RNA Society. Open to all junior scientists from all regions of the world, the award recognises the winners\u2019 achievements in RNA research and encourages them to pursue a career in the field of RNA.<\/p>\n\n\n\n

Nassos Typas<\/strong>, Group Leader and Senior Scientist at EMBL Heidelberg, has been awarded the Liliane Bettencourt Prize for Life Sciences 2022<\/a> from the Fondation Bettencourt Schueller. Each year, this prize is given to a European young researcher for their outstanding work and contribution to the scientific community. <\/p>\n","post_title":"Awards and honours (Issue 100)","post_excerpt":"The work and excellence of EMBL researchers have been recognised with multiple awards and honours during the past six months. Here are some of the awardees.","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"awards-and-honours-issue-100","to_ping":"","pinged":"","post_modified":"2023-05-15 12:22:07","post_modified_gmt":"2023-05-15 10:22:07","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.embl.org\/news\/?post_type=embletc&p=58717","menu_order":0,"post_type":"embletc","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":58533,"post_author":"94","post_date":"2023-05-15 12:00:00","post_date_gmt":"2023-05-15 10:00:00","post_content":"\n

Our body is influenced greatly by the context within which it lives. The food we eat, the air we breathe, and the environment around us, all affect the way our body functions and responds to challenges. Researchers at EMBL Barcelona aim to understand the importance of such context in disease development. To achieve this, they are increasingly making use of groundbreaking technologies like organs-on-chip and organoids, which have the potential to revolutionise the way we study, diagnose, and treat diseases.<\/p>\n\n\n\n

Organs-on-chip \u2013 also called microphysiological systems (MPS) \u2013  are small cell-based devices, which can range from the size of a one-cent coin to that of a credit card. They allow researchers to recreate the structures and functions of human organs on a miniature scale. <\/p>\n\n\n\n

Organoids, on the other hand, are three-dimensional cell aggregates which can grow up to a couple of millimetres in size. They mimic aspects of the architecture or function of real organs, such as the heart or the brain. <\/p>\n\n\n\n

Together, these technologies offer a powerful new way to study how diseases develop, test drugs, and potentially develop personalised therapeutic treatments.<\/p>\n\n\n\n

A toolbox to study diseases<\/strong><\/h2>\n\n\n\n

Since organoids and MPS can mimic organ and tissue function in the laboratory, they are an invaluable tool for researchers trying to understand organ function and dysfunction under controlled conditions. At EMBL Barcelona, Maria Bernabeu, Talya Dayton, Miki Ebisuya, and Kristina Haase lead research groups that study cerebral malaria, cancer, spinal deformation, and microvascular dysfunction, respectively, using these systems.<\/p>\n\n\n\n

Maria Bernabeu and her team study cerebral malaria<\/strong>, a disease that causes around 400,000 deaths a year. Malarial parasites stick to small blood vessels in the brain (microvasculature) releasing toxins that disrupt the blood-brain barrier, causing vessel blockage and brain swelling. This makes cerebral malaria one of the most fatal malaria complications with a 20% mortality rate even after antimalarial drug administration. <\/p>\n\n\n\n

\u201cCurrent knowledge of cerebral malaria is based primarily on autopsy analysis, because of limitations of available animal models,\u201d said Viola Introini, postdoc in the Bernabeu Lab. \u201cWe cannot study disease onset and progression in humans because of ethical reasons. As an alternative, our group engineers 3D human brain microvessel models that incorporate crucial cells like pericytes and astrocytes to better mimic the blood-brain barrier. They can be used to study vascular dysfunctions caused by parasite infection in physiological conditions, aiming to provide a holistic understanding of cerebral malaria.\u201d<\/p>\n\n\n\n

\"Microscope
A 3D artificial blood vessel, used to study the mechanism of cerebral malaria. Endothelial cells are shown in red, astrocytes in green, and cell nuclei in blue. Credit: Bernabeu Group\/EMBL<\/figcaption><\/figure>\n\n\n\n

The COVID-19 pandemic has also shown us how important it is to understand the development of infectious diseases, and organoids and MPS devices can be incredibly helpful. During the pandemic and using both MPS devices and organoids, researchers across the world could replicate interactions between SARS-CoV-2 and organs like lungs, kidneys, or blood vessels. In addition, they could study immune responses and assess the effectiveness of therapies. <\/p>\n\n\n\n

At EMBL Barcelona, the Haase and Bernabeu group joined forces to study how SARS-CoV-2, the novel coronavirus, produces microvascular inflammation<\/strong>. <\/p>\n\n\n\n

\u201cResults from this project can help us to identify how SARS-CoV-2 travels through the human body and whether or not existing drugs can reduce the impact of severe COVID-19, and may provide evidence for new targets to treat the disease,\u201d said Marina Fortea, a joint postdoc in the Bernabeu and Haase groups.<\/p>\n\n\n\n

In addition to studying diseases and performing drug screening and toxicity assays, organoids and MPS can be developed into assays used in personalised medicine. These technologies can be used to explore the effects of drugs in individual patients, using patient-derived tissue. Nowadays, researchers can generate successful organoids from almost every patient biopsy, and this holds great hope for personalised medicine. <\/p>\n\n\n\n

Group Leader Talya Dayton generates lung organoids from patient-derived tumour tissue to study cancer<\/strong>. Her group also generates organoids from healthy tissue, and this allows them to compare healthy tissue and cancer tissue.<\/p>\n\n\n\n

\u201cThe fact that we can generate organoids from healthy cells and tumour cells in the same defined in vitro<\/em> system means that we can grow and study cancers across the entire existing range of malignancy,\u201d said Dayton. According to her, while traditional 2D cell lines can usually only be grown from highly aggressive cancers, organoids can be grown from even very early cancers, and this allows scientists to use this system to study how early cancers can become more malignant and highly aggressive. <\/p>\n\n\n\n

\u201cIn our lab, we use organoids and genetic engineering to recapitulate the transition from healthy cell to<\/em> early cancer cell to<\/em> highly aggressive cancer that is the basis of cancer formation and progression. Using this, we can try to predict therapeutic strategies that can either prevent this transition from happening or that can reverse it,\u201d added Dayton. <\/p>\n\n\n\n

At their heart, organoids and MPS devices are simplified three-dimensional in vitro <\/em>structures that mimic organ and tissue function. They can be created using stem cells, patient cells, or tissue samples and can be designed to simulate human physiology better than traditional 2D cell culture. In the case of MPS, these devices can mimic critical aspects of organs such as mechanical cues, e.g. blood flow, tissue stretch, or hydrostatic pressure.<\/p>\n\n\n\n

\u201cAlthough 2D cell culture systems offer a high degree of flexibility and reproducibility, they do not fully capture the 3D complexity that cells experience in vivo \u2013 <\/em>thereby limiting their ability to recapitulate tissue and organ function,\u201d said Akinola Akinbote, PhD student at the Haase Group. \u201cIn comparison, MPS have the potential to better approximate the in vivo<\/em> environment by recapitulating multicellular 3D arrangement and the extracellular microenvironments in vitro<\/em>,\u201d <\/p>\n\n\n\n

Akinbote\u2019s project seeks to harness human induced pluripotent stem cell technologies and microfluidics to generate perfusable cardiac-specific vascularised tissues<\/strong> \u2013 essentially mimicking human heart vessels on a matchbox-sized device. \u201cOur objective is to establish a representative model that enables the investigation of the coronary microvessels form and function in vitro<\/em>,\u201d said Akinbote. <\/p>\n\n\n\n

\"Microscope
Cardiac organoid. Credits: Akinola Akinbote\/EMBL<\/figcaption><\/figure>\n\n\n\n

The Ebisuya group studies how and why we humans are different from other species when it comes to embryonic development. To study this, Miki Ebisuya and her group work with organoids of different species and compare them. The researchers are already working on several mammalian species, including rabbits, cattle, and rhinoceroses, setting up a \u2018stem cell zoo\u2019 in the lab.<\/p>\n\n\n\n

\u201cOur next project will focus on creating somitoids, from different species. Somitoids are organoids that mimic the precursor structures that give rise to the spinal column form during human embryonic development. We would like to measure the cell proliferation and cell migration speed of somitoids from different mammals to establish what and how somitogenesis is different among species,\u201d said Ebisuya.<\/p>\n\n\n\n

DIY: tailor-made devices in-house<\/strong><\/h2>\n\n\n\n

MPS devices differ in size and design. Ranging from approximately the size of a USB memory stick to that of a credit card, they vary depending on need and usage. At EMBL Barcelona, one example that utilises such flexibility is the placenta-on-chip<\/strong> system developed by Marta Cherubini, postdoc in the Haase Group.<\/p>\n\n\n\n

\u201cWe use a small device made from a flexible polymer with a central port where we grow cells to create a placental barrier,\u201d said Cherubini. \u201cWith the right nutrients and environment, cells spontaneously form vessels inside the chip. Around that port, there are several channels that allow us to supply fluids and molecules to the cells and analyse fetal-like vascular development.\u201d <\/p>\n\n\n\n

\"Microscope
Artificial placental vessels on chip to study placental dysfunction due to microvascular inflammation. Credit: Kristina Haase \/EMBL<\/figcaption><\/figure>\n\n\n\n

A critical aspect of performing successful research with MPS is to be able to develop your own devices, tailored to the needs of the project. EMBL Barcelona has led a project on campus to be able to fabricate such tools \u2013 a 'maker-space' or collaborative place, with equipment to design and produce tools, from macro to micro scales. This space is called the micro Fabrication Laboratory \u2013 \u00b5FabLab<\/strong> \u2013 and is now open for the whole PRBB community.<\/p>\n\n\n\n

\u201cThe advantage of using laser cutters, 3D printers, and CNC milling machines is that you can design small parts and generally fabricate them in an afternoon,\u201d said Kristina Haase, Group Leader at EMBL Barcelona and one of the main forces behind the creation of the \u00b5FabLab. \u201cThis is a huge advantage of prototyping \u2013 being able to make several iterations of a design quickly to optimise it for your needs and get it rapidly to the lab for biological experiments.\u201d<\/p>\n\n\n\n

The future of organoid technologies<\/strong><\/h2>\n\n\n\n

Over the last 20 years, researchers have developed several types of organoids with strong resemblance to in vivo<\/em> organs. However, organoid generation can be a lengthy process in some cases, and has relatively low throughput. The challenges of this field are somewhat related to the complexity of biology itself.<\/p>\n\n\n\n

Building an MPS model presents the first challenge. Researchers need to capture the level of biological complexity and accuracy of the organ, as well as its size and its fluid volume. In organoids and MPS models, there are several types of cells that coexist in the same space. Creating and maintaining such cell heterogeneity is a challenge. At EMBL Barcelona, many MPS models include vasculature, which is a dynamic and complex system. In addition, obtaining sufficient cells to perform experiments is not always a straightforward process, especially if these are patient-derived.<\/p>\n\n\n\n

In spite of the above-mentioned challenges, these 3D miniaturised organs and devices present many benefits: they provide researchers with greater insights into human physiology, they can better approximate the in vivo<\/em> environment of organs, and they can be created with patient-derived tissue. <\/p>\n\n\n\n

Recently, the US Food and Drug Administration (FDA) approved the use of microfluidic devices for drug testing, ending a federal mandate from 1938 that obliged experimental drugs to be tested on animals before they were used in human clinical trials. This new law opens the door to new technologies that aim to reproduce human physiology in vitro<\/em> as a means of effective preclinical research.<\/p>\n\n\n\n

There is also growing recognition from industry that these techniques are suitable for preclinical drug screening, tissue regeneration, and toxicology\/safety evaluation. Advances in this field, including those led by EMBL Barcelona, will therefore represent a reduction in animal testing, more targeted drug evaluation, and the development of personalised medicine.<\/p>\n","post_title":"Organs-on-chip: new horizons for disease research","post_excerpt":"EMBL Barcelona researchers are studying how tissues develop in health and disease using organoids and 3D multicellular systems to mimic human organs and their functions.\n","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"organs-on-chip-new-horizons-for-disease-research","to_ping":"","pinged":"","post_modified":"2023-05-15 12:25:03","post_modified_gmt":"2023-05-15 10:25:03","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.embl.org\/news\/?post_type=embletc&p=58533","menu_order":0,"post_type":"embletc","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"\nCelebrating 100 issues of EMBLetc. | EMBL<\/title>\n<meta name=\"description\" content=\"First published in 1999 as a black-and-white printed newsletter, EMBLetc. has undergone many transformations in its 24 years of existence.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/embletc\/issue-100\/celebrating-100-issues-of-embletc\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Celebrating 100 issues of EMBLetc. | EMBL\" \/>\n<meta property=\"og:description\" content=\"First published in 1999 as a black-and-white printed newsletter, EMBLetc. has undergone many transformations in its 24 years of existence.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/embletc\/issue-100\/celebrating-100-issues-of-embletc\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:modified_time\" content=\"2023-05-17T18:49:08+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2023\/05\/20230504_EMBLetc_100_1000x600px-e1684148383734.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.embl.org\/news\/embletc\/issue-100\/celebrating-100-issues-of-embletc\/\",\"url\":\"https:\/\/www.embl.org\/news\/embletc\/issue-100\/celebrating-100-issues-of-embletc\/\",\"name\":\"Celebrating 100 issues of EMBLetc. | EMBL\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/embletc\/issue-100\/celebrating-100-issues-of-embletc\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/embletc\/issue-100\/celebrating-100-issues-of-embletc\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2023\/05\/20230504_EMBLetc_100_1000x600px-e1684148383734.jpg\",\"datePublished\":\"2023-05-15T10:00:00+00:00\",\"dateModified\":\"2023-05-17T18:49:08+00:00\",\"description\":\"First published in 1999 as a black-and-white printed newsletter, EMBLetc. has undergone many transformations in its 24 years of existence.\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.embl.org\/news\/embletc\/issue-100\/celebrating-100-issues-of-embletc\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.embl.org\/news\/embletc\/issue-100\/celebrating-100-issues-of-embletc\/#primaryimage\",\"url\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2023\/05\/20230504_EMBLetc_100_1000x600px-e1684148383734.jpg\",\"contentUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2023\/05\/20230504_EMBLetc_100_1000x600px-e1684148383734.jpg\",\"width\":1000,\"height\":600,\"caption\":\"Science illustration representing research on organoids, organs-on-chip and human health. 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