{"id":58717,"date":"2023-05-15T12:00:00","date_gmt":"2023-05-15T10:00:00","guid":{"rendered":"https:\/\/www.embl.org\/news\/?post_type=embletc&p=58717"},"modified":"2023-05-15T12:22:07","modified_gmt":"2023-05-15T10:22:07","slug":"awards-and-honours-issue-100","status":"publish","type":"embletc","link":"https:\/\/www.embl.org\/news\/embletc\/issue-100\/awards-and-honours-issue-100\/","title":{"rendered":"Awards and honours (Issue 100)"},"content":{"rendered":"\n

Alexander Aulehla<\/strong>, Head of Developmental Biology Unit, and Mikhail Savitski<\/strong>, Team Leader and Head of Proteomics Core Facility at EMBL Heidelberg, have received Allen Distinguished Investigator awards<\/a> this year for a project to study differences in protein ageing and lifespan. Funded by the Paul G. Allen Family Foundation, the awards support cutting-edge, early-stage research projects that promise to advance the fields of biology and medicine.<\/p>\n\n\n\n

Alba Diz-Mu\u00f1oz<\/strong>, Group Leader at EMBL Heidelberg, won the 2023 Early Career Award in Mechanobiology<\/a> from the US Biophysical Society (BPS). The award recognises a young principal investigator who has made outstanding contributions to the way we understand how mechanics shape molecular and cellular processes. <\/p>\n\n\n\n

Olivier Duss<\/strong>, Group Leader at EMBL Heidelberg, is one of the recipients of the FEBS Excellence Awards<\/a> from the Federation of European Biochemical Societies (FEBS). The prestigious programme supports early-career group leaders in molecular life sciences.<\/p>\n\n\n\n

Miki Ebisuya<\/strong>, Group Leader at EMBL Barcelona, has been awarded an Alexander von Humboldt Professorship<\/a> by the Humboldt Foundation. The professorship, one of Germany\u2019s foremost research awards, aims to bring top international researchers from all disciplines to German universities. <\/p>\n\n\n\n

Anne Ephrussi<\/strong>, Senior Scientist and Head of EICAT, has received the Lifetime Achievement Award<\/a> from the Society for Developmental Biology. The award recognises her fundamental research contributions to our understanding of RNA localisation and translation in development. <\/p>\n\n\n\n

Jamie Hackett<\/strong>, Group Leader at EMBL Rome, won the first GSK-EMBL Young Entrepreneur<\/a> Award for his research on precise epigenome modifications for regulating genes. The award by EMBLEM and GSK supports EMBL scientists in testing the commercial viability of early research work. <\/p>\n\n\n\n

Edith Heard<\/strong>, EMBL Director General, has been elected member of the French Academy of Sciences<\/a> (Acad\u00e9mie des Sciences \u2013 Institut de France), under the section \u2018Human Biology and Medical Sciences\u2019, for her work on epigenetics, particularly in deciphering the process of X-chromosome inactivation. In addition to providing policymakers with a framework of expertise, the academy supports research, science education, and scientific life at the international level.<\/p>\n\n\n\n

\u200b\u200bJohn Lees<\/strong>, Group Leader, and Joel Hellewell<\/strong>, postdoctoral fellow in the Lees Group at EMBL-EBI, have received the SPI-M-O Award for Modelling and Data Support (SAMDS) from the British government, in recognition of their exceptional contributions to the Scientific Pandemic Influenza Group on Modelling (SPI-M-O) and the scientific advice which has supported the government\u2019s response to the pandemic.<\/p>\n\n\n\n

Jonas Tholen, <\/strong>postdoctoral fellow in the Galej Group at EMBL Grenoble, is the graduate student winner of the 2023 Scaringe Young Scientist Award<\/a> from the RNA Society. Open to all junior scientists from all regions of the world, the award recognises the winners\u2019 achievements in RNA research and encourages them to pursue a career in the field of RNA.<\/p>\n\n\n\n

Nassos Typas<\/strong>, Group Leader and Senior Scientist at EMBL Heidelberg, has been awarded the Liliane Bettencourt Prize for Life Sciences 2022<\/a> from the Fondation Bettencourt Schueller. Each year, this prize is given to a European young researcher for their outstanding work and contribution to the scientific community. <\/p>\n","protected":false},"excerpt":{"rendered":"

The work and excellence of EMBL researchers have been recognised with multiple awards and honours during the past six months. Here are some of the awardees.<\/p>\n","protected":false},"author":120,"featured_media":53992,"parent":0,"menu_order":0,"template":"","tags":[352,149,5650,1321,357,498,512,13084],"class_list":["post-58717","embletc","type-embletc","status-publish","has-post-thumbnail","hentry","tag-aulehla","tag-award","tag-diz-munoz","tag-ebisuya","tag-ephrussi","tag-hackett","tag-heard","tag-lees"],"acf":{"featured":true,"show_featured_image":false,"field_target_display":"embl","field_article_language":{"value":"english","label":"English"},"article_intro":"

The work and excellence of EMBL researchers have been recognised with multiple awards and honours during the past six months.<\/p>\n","related_links":[{"link_description":"Awards and honours (Issue 99)","link_url":"https:\/\/www.embl.org\/news\/embletc\/issue-99\/awards-honours\/"}],"source_article":false,"in_this_article":false,"press_contact":"None","article_translations":false,"languages":"","embletc_issue":[{"ID":58531,"post_author":"124","post_date":"2023-05-15 12:00:00","post_date_gmt":"2023-05-15 10:00:00","post_content":"","post_title":"Issue 100","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"issue-100","to_ping":"","pinged":"","post_modified":"2023-05-15 13:01:59","post_modified_gmt":"2023-05-15 11:01:59","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.embl.org\/news\/?post_type=embletc-issue&p=58531","menu_order":0,"post_type":"embletc-issue","post_mime_type":"","comment_count":"0","filter":"raw"}],"embletc_in_this_issue":[{"ID":58551,"post_author":"124","post_date":"2023-05-15 12:00:00","post_date_gmt":"2023-05-15 10:00:00","post_content":"\n

In the late 1980s, whenever Des Higgins received a request from a fellow scientist to share Clustal \u2013 the groundbreaking software he had developed \u2013 he would send it out in a floppy disk via the postal service. Over a period of four years, he estimates having sent two or three hundred copies. Then, in 1992, Higgins put a new version of the program on the EMBL file server, set up by EMBL IT group leader Roy Omond. <\/p>\n\n\n\n

\"And overnight, there were 400 downloads,\" said Higgins. \"It was a wonderful feeling.\"<\/p>\n\n\n\n

A lifelong learner and problem solver, Higgins joined EMBL in 1990, well before the bioinformatics boom had taken off. An avid reader of science books and a collector of wild spiders as a child, he had earlier arrived at Trinity College, Dublin, to study biology and fallen in love with computation while pursuing a PhD in zoology.<\/p>\n\n\n\n

\"Bioinformatics in the 1980s was mainly done by researchers working on their own or by very small groups, and as a sideline rather than a main focus,\u201d said Higgins. \u201cEven the word \u2018bioinformatics\u2019 wasn't much used up until 1985.\"<\/p>\n\n\n\n

However, that changed when large-scale sequencing became popular. As Higgins recalls: \u201cOnce people started sequencing genomes, you couldn't make use of the data without bioinformatics. And so, between 1990 and the year 2000, bioinformatics went from being a minor field to being of fundamental importance.\"<\/p>\n\n\n\n

Two other developments aided the growing popularity of bioinformatics. The first was the Human Genome Project, launched in 1990 and (mostly) completed in 2003 when it was the first to sequence more than 90% of the human genome. And the second was the recognition by pharmaceutical companies in the 1990s of the commercial potential of mining early data from human genomes, as well as from other biological datasets.<\/p>\n\n\n\n

At this crucial moment in the development of the field, EMBL was well-situated to take a leading role. The EMBL Nucleotide Sequence Database, the world\u2019s first nucleotide sequence database, was established in the early 1980s at The Data library of EMBL Heidelberg, which later developed into the European Bioinformatics Institute (EMBL-EBI) in Hinxton. When Higgins joined the EMBL Data Library, it was being led by Graham Cameron (who developed the concept for EMBL-EBI and later became its associate director). <\/p>\n\n\n\n

\"EMBL was one of the main places in Europe that championed bioinformatics,\u201d said Higgins. \u201cIt had one of the biggest collections of bioinformaticists in the world. We had very good computer facilities, and everyone had a computer on their desk connected to the EMBL mainframe computers.\u201d According to Higgins, the scientists were also fully connected to the internet, something that set them apart from most other scientists on the planet at the time.<\/p>\n\n\n\n

\"It felt pioneering,\u201d Higgins said. \u201cIt felt like we were doing something new and important and even if the rest of the world didn't think so, they would soon realise it \u2013 because what we were doing was about to become essential.\"<\/p>\n\n\n\n

A crucial collaboration<\/strong><\/h2>\n\n\n\n

One of the things Higgins appreciated most about EMBL was the academic freedom it afforded its researchers. In this environment, the problem that he turned his attention to was one he had already been working on before he came to EMBL \u2013 that of multiple sequence alignments.  <\/p>\n\n\n\n

Aligning or comparing short sequences of DNA, RNA, or protein sequences can give scientists a wealth of interesting biological information. One of the most important applications is in the field of phylogenetics \u2013 figuring out how organisms are related to each other in the evolutionary tree by comparing their genetic codes. Another application is in working out the function of an unknown protein by comparing its sequence to that of known proteins. As Higgins explains, \"It is useful to be able to pile sequences on top of each other to look for which regions are conserved and which regions are variable.\"<\/p>\n\n\n\n

However, when researchers needed to make such alignments in the 1980s, there were no easily available methods for doing so, and scientists often ended up doing them manually using word processing software \u2013 a time-consuming and error-prone process. Towards the end of the decade, quite a few researchers, including Higgins, created and released programs to speed up or automate this process. <\/p>\n\n\n\n

\"But to use these, you needed a mainframe computer,\u201d explained Higgins. \u201cYou had to work in an institute that had one and you had to know how to use it. These were big expensive boxes that required a whole computer lab to run them.\"<\/p>\n\n\n\n

While EMBL had good mainframe computers, most molecular biologists in the world didn't have easy access to mainframes. And hence, what Higgins wanted most was to make multiple sequence alignment work on old IBM and Apple Macintosh PCs, which most scientists had on their desktops for writing manuscripts. The result was \u2018Clustal\u2019 \u2013 one of the first multiple sequence alignment programs that didn\u2019t require mainframes to run.<\/p>\n\n\n\n

\u201cI figured out how to make multiple alignments work on these tiny little computers,\" said Higgins. \u201cIt meant that now anyone could make their own multiple alignments in their offices.\u201d<\/p>\n\n\n\n

It was at this stage that he ran into Toby Gibson, Team leader at EMBL who was then a staff scientist in Patrick Argos\u2019s research group. Gibson often had to do multiple sequence alignments for his work, and had been using the manual method up until then. \u201cAnd I said I've got a program that can do this. Would you like to try it?\" Higgins recalled.<\/p>\n\n\n\n

While excited by Higgins\u2019s program, Gibson was nevertheless sceptical about some aspects. And so Julie Thompson, then a programmer working with Gibson and now a senior scientist at the Institute of Genetics and Molecular and Cellular Biology (IGBMC) in Strasbourg, France, took up the task of modernising the Clustal package that Higgins had created, and making it more sensitive and accurate for protein alignments. <\/p>\n\n\n\n

\"EMBL was a wonderful place to collaborate,\u201d said Higgins. \u201cPeople were free to take on new collaborations quickly. Also, there were seminars and workshops happening constantly, so you got to meet new people all the time.\"<\/p>\n\n\n\n

The three scientists continued to meet over coffee or beer in Heidelberg, and the program was finally finished around 1994. The team described the updated software, which they called Clustal W, in a paper published in the journal Nucleic Acids Research. <\/em>Higgins had moved to EMBL-EBI by then, and this was the very first paper published from that institute. <\/p>\n\n\n\n

A revolution in multiple sequence alignments<\/strong><\/h2>\n\n\n\n
\"Male<\/figure>\n\n\n\n

The success of Clustal W exceeded all expectations. According to a 2014 analysis by Nature<\/em><\/a>, <\/em>the 1994 paper introducing Clustal W was then the most highly cited bioinformatics paper of all time, and the 10th most cited paper across all scientific fields. At its height, the program was used many thousands of times every day around the world, by everyone from undergraduate students to senior bioinformaticians. It enabled advances in fields as diverse as evolutionary biology, cancer research, and vaccine design.<\/p>\n\n\n\n

Thompson later created a graphical user interface for Clustal, making the program even easier to use and accessible to more scientists worldwide. The scientists described this version of the program \u2013 Clustal X \u2013 in a 1997 paper, which the same Nature<\/em> analysis found to be the 28th most cited paper across all fields, and the fourth most highly cited bioinformatics paper of all time.<\/p>\n\n\n\n

Ease of use was one of the guiding principles for Higgins, Gibson, and Thompson. \u201cWhen I first made the program, I wanted to ensure that you could use the program without having to read the manual,\u201d said Higgins. \u201cWe wanted it to be simple enough that undergraduates could use it in practicals or other scientists could use it without having to be trained in bioinformatics.\"<\/p>\n\n\n\n

The other major ideal was accessibility. \"We never charged for Clustal,\u201d said Higgins. \u201cThe concept of open access did not exist in those days, but the software was effectively open access, because it was free to use and we gave away the source code.\"<\/p>\n\n\n\n

The end of an era<\/strong><\/h2>\n\n\n\n

Leaving EMBL in 1996, Higgins moved to University College Cork in Ireland, where he taught biochemistry from 1997 to 2003. He was Professor of Bioinformatics at University College Dublin until his retirement last year. With his retirement, Clustal is no longer in active development, but its last released version \u2013 Clustal Omega \u2013 continues to be available to the world via EMBL-EBI. <\/p>\n\n\n\n

\u201cOmega is the last letter of the Greek alphabet,\u201d said Higgins, adding that many new programs for multiple alignment have come up in recent years, including MAFFT, also hosted by EMBL-EBI. \u201cLife goes on,\u201d he added philosophically. <\/p>\n\n\n\n

In recognition of his indisputable contributions to the field of bioinformatics research, Higgins was awarded the 2023 Lennart Philipson Award. The awards will be presented as part of the EMBL World Alumni Day celebration<\/a>, which will take place at EMBL Heidelberg on 7 July 2023.<\/p>\n\n\n","post_title":"The story of Clustal: democratising sequence alignments","post_excerpt":"Desmond Higgins, 2023 Lennart Philipson Award winner, discusses his time at EMBL and his research developing sequence alignment tools.","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"the-story-of-clustal-democratising-sequence-alignments","to_ping":"","pinged":"","post_modified":"2023-07-21 13:07:58","post_modified_gmt":"2023-07-21 11:07:58","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.embl.org\/news\/?post_type=embletc&p=58551","menu_order":0,"post_type":"embletc","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":58719,"post_author":"124","post_date":"2023-05-15 12:00:00","post_date_gmt":"2023-05-15 10:00:00","post_content":"\n

Founded in 1974, EMBL is Europe's life science laboratory. With its six European sites, EMBL is a world leader in cutting-edge molecular biology research, services, training, technology transfer, and policy development. <\/p>\n\n\n\n

In the 1990s, as the organisation grew, so did the need for a common and reliable platform for sharing news about EMBL both within and outside the institution. Thus, in 1999, EMBLetc., <\/em>a newsletter that would be circulated among the institute\u2019s staff and alumni, was created to fulfil this need. <\/p>\n\n\n\n

As the editors wrote in the introduction to the first edition<\/a>, \u201cA newsletter can be of great value in raising awareness of what is going on in EMBL as a whole\u2026it can provide an important means of keeping our Alumni linked to the life of the Laboratory, and it will provide a forum for voicing issues which don\u2019t fit easily into EMBL\u2019s other publications.\u201d<\/p>\n\n\n\n

First created as an 8-page black-and-white newsletter, EMBLetc.<\/em> received its first major makeover in 2009, transitioning to a full-colour layout with its 50th issue<\/a>. In 2014, EMBL\u2019s 40th anniversary year, EMBLetc.<\/em> evolved into a full-colour, 40-page magazine<\/a>, with sections dedicated to discussing the institute\u2019s research, people, and culture. Finally, with Issue 99<\/a>, released in November last year, the magazine took a new digital-first direction, representing EMBL\u2019s move towards more sustainable publications. <\/p>\n\n\n\n

Today, as we release its 100th issue<\/a>, we can see a microcosm of EMBL\u2019s history captured in the pages of this very special magazine\/newsletter. Browsing through its issues, we come across defining moments, important achievements, triumphs and challenges, overcoming adversity and building community. In memorialising EMBL\u2019s story, EMBLetc.<\/em> tells a tale of persistent innovation, collaboration, creativity, connection, resilience, and intellectual curiosity that cannot be dampened. <\/p>\n\n\n\n

EMBLetc.<\/em> has been instrumental in celebrating the achievements of EMBL\u2019s broad community and in serving as a platform for its many diverse voices.<\/p>Edith Heard, Director General, EMBL<\/cite><\/blockquote><\/figure>\n\n\n\n

In this 100th issue, we take a trip down memory lane<\/a> to witness the history of the most recent 24 years of EMBL\u2019s history through the lens of EMBLetc. <\/em>issues. We also celebrate recent advances in research and services across EMBL\u2019s sites and units. We discover how EMBL Barcelona researchers are using 'organ-on-chip' and organoid models<\/a> to understand health and disease. We look at novel insights from EMBL Rome researchers regarding the inheritance of epigenetic traits<\/a>. We peek behind the scenes to see how engineers and scientists collaborate<\/a> at EMBL Grenoble to build innovative fully-automated pipelines for structural biology experiments. We learn how EMBL researchers have been building accessible tools to deal with the challenge of big data analysis in biological imaging<\/a>.<\/p>\n\n\n\n

We also take a sneak peek at EMBL\u2019s upcoming science and society conference<\/a>, Terra Incognita<\/em>, which has invited a stellar lineup of speakers to examine and discuss ethical standards in life science research. We hear from past and present stalwarts of EMBL, including Professor Dame Janet Thornton<\/a>, former Director of EMBL-EBI, Des Higgins<\/a>, one of the early pioneers of bioinformatics, and Veli Vural Uslu<\/a>, who has been instrumental in combining science and theatre <\/strong>to aid public engagement in science.\u00a0<\/p>\n\n\n\n

EMBLetc.<\/em> was for many pre-digital and pre-pandemic years EMBL\u2019s flagship external communications channel. In its new digital-first and multimedia-rich format, it reinforces our role as Europe\u2019s leading life sciences research and technology organisation.<\/p>\n\n\n\n

Check out the new issue here<\/a>. You can also browse through our archive of past EMBLetc. issues here<\/a>, going back 24 years. We look forward to your comments, suggestions, and feedback<\/a>!<\/em><\/p>\n","post_title":"Celebrating 100 issues of EMBLetc.","post_excerpt":"First published in 1999 as a black-and-white printed newsletter for EMBL staff and alumni, EMBLetc. has undergone many transformations in its 24 years of existence.","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"celebrating-100-issues-of-embletc","to_ping":"","pinged":"","post_modified":"2023-05-17 20:49:08","post_modified_gmt":"2023-05-17 18:49:08","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.embl.org\/news\/?post_type=embletc&p=58719","menu_order":0,"post_type":"embletc","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"\nAwards and honours (Issue 100) | EMBL<\/title>\n<meta name=\"description\" content=\"The work and excellence of EMBL researchers have been recognised with multiple awards and honours during the past six months.\" \/>\n<meta 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