{"id":53300,"date":"2022-11-16T12:00:00","date_gmt":"2022-11-16T11:00:00","guid":{"rendered":"https:\/\/www.embl.org\/news\/?post_type=embletc&#038;p=53300"},"modified":"2023-01-25T14:40:52","modified_gmt":"2023-01-25T13:40:52","slug":"building-bioinformatics-capacity-in-latin-america","status":"publish","type":"embletc","link":"https:\/\/www.embl.org\/news\/embletc\/issue-99\/building-bioinformatics-capacity-in-latin-america\/","title":{"rendered":"Building bioinformatics capacity in Latin America"},"content":{"rendered":"\n<p>Having one bioinformatician on a research team used to be enough, but as biology becomes more data-driven, bioinformaticians are in high demand.&nbsp;<\/p>\n\n\n\n<p>This is certainly the case in Latin America, where the data revolution is well underway in the life sciences. But one thing that is still missing is a critical mass of bioinformaticians to manage, analyse, and share the data more widely.&nbsp;<\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"614\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/AerialView_1000X600_retouched-1024x614.jpg\" alt=\"Aerial view of a riverbank with trees and boats visible.\" class=\"wp-image-53986\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/AerialView_1000X600_retouched-1024x614.jpg 1024w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/AerialView_1000X600_retouched-300x180.jpg 300w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/AerialView_1000X600_retouched-768x461.jpg 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"vf-figure__caption\">Aerial shot taken during a CABANA visit to Bel\u00e9m in Brazil. Credit: Jeff Dowling\/EMBL-EBI<\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Bioinformatics &#8211; getting insights from big data<\/strong><\/h2>\n\n\n\n<p>Bioinformatics is the science of analysing, managing, storing and sharing biological data, usually on a large scale. Discovery and innovation rely on scientists sharing the data generated by their experiments; this way, the data can be reused by others to explore different scientific questions and gain new insights.&nbsp;<\/p>\n\n\n\n<p>But as the number and scale of experiments increase \u2013 and more data are generated \u2013 the need for specialist databases, analysis tools, and data experts becomes urgent.<\/p>\n\n\n\n<p>Bioinformatics enables scientists to exploit the large datasets available in public data resources such as the ones managed by EMBL\u2019s European Bioinformatics Institute (EMBL-EBI), to answer diverse research questions, for example:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>How and why do we differ from one another?<\/li>\n\n\n\n<li>Why are some people more susceptible to disease?<\/li>\n\n\n\n<li>Why do some drugs work for certain people but not for others?<\/li>\n\n\n\n<li>How can we make crops more resistant to a changing climate?<\/li>\n\n\n\n<li>What microorganisms live in the oceans and what functions do they fulfil?<\/li>\n\n\n\n<li>How do we identify and monitor biodiversity?<\/li>\n<\/ul>\n\n\n\n<p>Bioinformatics is essential for cutting-edge research, such as drug discovery \u2013 developing new medicines or repurposing existing ones to treat different diseases \u2013 and \u2018white biotechnology\u2019, which aims to develop more useful products with less energy, while generating less waste. This could include, for example, enzymes that can degrade plastic, improve cleaning products to make them less toxic, etc.&nbsp;<\/p>\n\n\n\n<p>The applications of bioinformatics are endless, but to unlock them, researchers first need to be able to find and analyse molecular data from public databases. EMBL-EBI\u2019s Training team enables life scientists to do exactly this and make the most of the biological data that is openly available, in order to expand their science and gain new insights.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><\/strong><strong>Strengthening bioinformatics capacity<\/strong><\/h2>\n\n\n\n<div class=\"vf-embed vf-embed--16x9 | vf-u-margin__bottom--400\">\n<iframe src=\"https:\/\/www.youtube.com\/embed\/tUJ-Q4ODGbs\" frameborder=\"0\" controls allowfullscreen><\/iframe><\/div>\n\n\n\n\n\n<p>The <a href=\"https:\/\/cabana.network\/\">CABANA project<\/a> was born out of a desire to strengthen bioinformatics capacity and accelerate data-driven biology in Latin America. The project was developed by nine research organisations in the region and the EMBL-EBI Training team. Their vision resonated with UK Research and Innovation which, in 2017, funded the project through the <a href=\"https:\/\/www.ukri.org\/what-we-offer\/international-funding\/global-challenges-research-fund\/\">Global Challenges Research Fund<\/a>. Five years later, the project has come to an end, but the impact of of this EMBL-EBI collaborative work continues.<\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image  | vf-figure--align vf-figure--align-inline-start   size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/CABANA_partner_portraits-98_retouched-683x1024.jpg\" alt=\"Photograph of male scientist\" class=\"wp-image-53982\" width=\"256\" height=\"384\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/CABANA_partner_portraits-98_retouched-683x1024.jpg 683w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/CABANA_partner_portraits-98_retouched-200x300.jpg 200w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/CABANA_partner_portraits-98_retouched-768x1152.jpg 768w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/CABANA_partner_portraits-98_retouched.jpg 1231w\" sizes=\"auto, (max-width: 256px) 100vw, 256px\" \/><figcaption class=\"vf-figure__caption\">Alfredo Herrera-Estrella is a CABANA Co-investigator based at the National Laboratory of Genomics for Biodiversity in Mexico. Credit: Jeff Dowling\/EMBL-EBI<\/figcaption><\/figure>\n\n\n\n<p>\u201cOur aim was to help researchers in Latin America participate in large global consortia equitably, and to contribute to solving global challenges, specifically biodiversity, food security and communicable diseases,\u201d explained <a href=\"https:\/\/www.ebi.ac.uk\/people\/person\/cath-brooksbank\/\">Cath Brooksbank, Head of Training at EMBL-EBI<\/a>. \u201cThe only way to solve these big challenges is by bringing together a wealth of knowledge and experiences from all over the world; it simply cannot be done without our colleagues in Latin America.\u201d<\/p>\n\n\n\n<p>Alfredo Herrera-Estrella, CABANA Co-investigator at the National Laboratory of Genomics for Biodiversity, in Mexico said, \u201cThrough CABANA, we have the opportunity through genomics and bioinformatics in particular to find ways to contribute to solving or facing the problem of climate change.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Training with an impact<\/strong><\/h2>\n\n\n\n<p>\u201cA lot of thought went into the project planning, to ensure the impact would be widespread and long-term,\u201d explained Brooksbank. \u201cWe knew our funding was limited, so with our partners, we decided to develop a network of people and institutes across Latin America, which would continue to exist after the funding ran out.&nbsp;<\/p>\n\n\n\n<p>\u201cThis way, the network would benefit from an initial wave of bioinformatics training, supported by knowledge exchange and links to other international consortia. As the project came to an end, the network could continue to jointly apply for funding to support new initiatives in their areas of interest.\u201d<\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/UBA_group_retouched-1024x683.jpg\" alt=\"Group photograph showing workshop participants seated on a staircase\" class=\"wp-image-53988\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/UBA_group_retouched-1024x683.jpg 1024w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/UBA_group_retouched-300x200.jpg 300w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/UBA_group_retouched-768x512.jpg 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"vf-figure__caption\">Participants and trainers at a CABANA workshop held at the University of Buenos Aires. Credit: Jeff Dowling\/EMBL-EBI.<\/figcaption><\/figure>\n\n\n\n<figure class=\"vf-figure wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/CABANA_secondees_group02441_retouched-1024x683.jpg\" alt=\"Three workshop participants seated on a sofa and looking at a computer screen.\" class=\"wp-image-53990\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/CABANA_secondees_group02441_retouched-1024x683.jpg 1024w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/CABANA_secondees_group02441_retouched-300x200.jpg 300w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/CABANA_secondees_group02441_retouched-768x512.jpg 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"vf-figure__caption\">CABANA secondees at EMBL-EBI. Credit: Jeff Dowling\/EMBL-EBI<\/figcaption><\/figure>\n\n\n\n<p>CABANA enabled the delivery of many bioinformatics workshops in Latin America, as well as the creation of bespoke e-learning courses and train-the-trainer activities. At the heart of the project were secondments that enabled Latin American scientists to visit other research institutes and embed themselves in another lab. The project also supported seven collaborative research projects in the region.<\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"698\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/Cabana-Infographic-edited.jpg\" alt=\"Infographic showing the number of courses and workshops conducted by CABANA, as well as the number of scientists trained, research innovation awards, and secondments.\" class=\"wp-image-53770\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/Cabana-Infographic-edited.jpg 1000w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/Cabana-Infographic-edited-300x209.jpg 300w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/Cabana-Infographic-edited-768x536.jpg 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><figcaption class=\"vf-figure__caption\">Some of the achievements of the CABANA project. Credit: Karen Arnott\/EMBL-EBI<\/figcaption><\/figure>\n\n\n\n<p>\u201cProjects like CABANA also allow people in Latin America to build further bonds between bioinformatics groups, to be a part of this community and carry out research using bioinformatics,\u201d said Guillermo Rangel-Pi\u00f1eros, CABANA Secondee from the University of Los Andes in Colombia.<\/p>\n\n\n\n<p>Guillermo Rangel-Pi\u00f1eros, CABANA secondee from University of Los Andes, Columbia, now a postdoctoral researcher at the University of Copenhagen. Credit:&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Supporting the pandemic response<\/strong><\/h2>\n\n\n\n<p>When COVID-19 was declared a global pandemic, the CABANA partners were among the many scientists who wanted to support the local and international response. CABANA allocated five of its partners a large innovation award for this purpose. Under the coordination of Alfredo Herrera in Mexico, they supported the sequencing and analysis of COVID-19 samples from the region.&nbsp;<\/p>\n\n\n\n<p>Despite some of the institutes not previously specialising in infectious disease, they built on their genomics and bioinformatics expertise to develop the open source <a href=\"https:\/\/peerj.com\/articles\/13300\/\">PiPeCov pipeline<\/a> to analyse COVID-19 genomic data. The project aimed to help understand the evolution and distribution of the virus in Latin America and contribute data from the region to international databases such as the <a href=\"https:\/\/www.covid19dataportal.org\/\">European COVID-19 Platform<\/a>, which was set up by EMBL-EBI in 2020.&nbsp;<\/p>\n\n\n\n<p>\u201cThe pandemic was a stress test of the CABANA network,\u201d said Brooksbank. \u201cIt was amazing to see our partners spring into action, and use their skills and expertise to address the unfolding global health crisis.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>A case for open data<\/strong><\/h2>\n\n\n\n<p>The Latin America and Carribean region is home to <a href=\"https:\/\/www.cbd.int\/gbo\/gbo4\/outlook-grulac-en.pdf\">60% of terrestrial life<\/a>, many freshwater and marine species, as well as a multiethnic human population. But despite this diversity, the continent isn\u2019t well represented in <a href=\"https:\/\/www.ebi.ac.uk\/services\">open biological databases<\/a> such as those managed by EMBL-EBI.&nbsp;<\/p>\n\n\n\n<p>By involving Latin American researchers in large, collaborative projects and supporting them to generate and submit data to open databases whenever possible, EMBL hopes to make biological data generated in Latin America more easily accessible to everyone, while also enabling Latin American researchers to make the most of data generated elsewhere. Open access to data and tools has the potential to accelerate the rate of research and discovery worldwide.<\/p>\n\n\n\n<figure class=\"wp-block-gallery has-nested-images columns-default is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"vf-figure wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" class=\"vf-figure__image\" data-id=\"53996\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/All_Hands_CIP-46-1_retouched-1024x683.jpg\" alt=\"Group photograph of conference participants standing in a circle and discussing something.\" class=\"wp-image-53996\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/All_Hands_CIP-46-1_retouched-1024x683.jpg 1024w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/All_Hands_CIP-46-1_retouched-300x200.jpg 300w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/All_Hands_CIP-46-1_retouched-768x512.jpg 768w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/All_Hands_CIP-46-1_retouched.jpg 1846w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<figure class=\"vf-figure wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" class=\"vf-figure__image\" data-id=\"53998\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/All_Hands_USMP-17-1_retouched-1024x683.jpg\" alt=\"Photograph of four workshop participants seated or standing around a desk. \" class=\"wp-image-53998\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/All_Hands_USMP-17-1_retouched-1024x683.jpg 1024w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/All_Hands_USMP-17-1_retouched-300x200.jpg 300w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/All_Hands_USMP-17-1_retouched-768x512.jpg 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<figcaption class=\"blocks-gallery-caption wp-element-caption\">2019 CABANA all-hands in Lima, Peru. Credit: Jeff Dowling\/EMBL-EBI<\/figcaption><\/figure>\n\n\n\n<p>\u201cWhat we\u2019ve learned from the COVID-19 pandemic is that sharing data is important to all of us, and no one should be working alone on this. All the new COVID-19 information that researchers have generated has had an impact on the health of everyone in every country,\u201d said Josefina Campos, Coordinator of Genomics and Bioinformatic Platforms at INEI-ANLIS in Argentina.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>When the going gets tough, the tough get creative<\/strong><\/h2>\n\n\n\n<p>When the COVID-19 pandemic hit, CABANA was in full swing, with many in-person training courses and secondments left to go. This had been CABANA\u2019s selling point: opportunities for researchers to visit other labs and embed themselves into a different research group and a new approach. But pandemic travel restrictions made this impossible.&nbsp;<\/p>\n\n\n\n<p>The team had no choice but to adapt to the new pandemic reality \u2013 a world where people would be unable to travel for an unknown period of time. They put their heads together to figure out how to make the training sessions virtual, while maintaining their interactive nature, and how secondments could continue remotely.<\/p>\n\n\n\n<p>\u201cAt first, we thought the pandemic would mean we had to put CABANA on hold,\u201d explains Brooksbank. \u201cBut after the initial shock, we started to think of options to continue the project remotely, making the most of virtual collaboration tools. After a few intense months of fighting fires, everything seemed to fall into place. In fact, shifting the focus to online activities meant we could make our training accessible to a wider range of researchers.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>This is only the beginning&nbsp;<\/strong><\/h2>\n\n\n\n<p>As the project came to an end in May 2022, one question remained: Would the CABANA network continue to exist, or would it fizzle out?<\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image  | vf-figure--align vf-figure--align-inline-start   size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/CABANA_partner_portraits-115_retouched-683x1024.jpg\" alt=\"Photograph of female scientist.\" class=\"wp-image-54000\" width=\"280\" height=\"419\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/CABANA_partner_portraits-115_retouched-683x1024.jpg 683w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/CABANA_partner_portraits-115_retouched-200x300.jpg 200w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/CABANA_partner_portraits-115_retouched-768x1152.jpg 768w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/CABANA_partner_portraits-115_retouched.jpg 1231w\" sizes=\"auto, (max-width: 280px) 100vw, 280px\" \/><figcaption class=\"vf-figure__caption\">Cath Brooksbank, Head of Training at EMBL-EBI. Credit:&nbsp;Jeff Dowling\/EMBL-EBI<\/figcaption><\/figure>\n\n\n\n<p>\u201cWe were pleased to see that the appetite for new collaborations had not diminished,\u201d explains Ian Willis, CABANA Project Manager at EMBL-EBI. \u201cThe network has already submitted several funding proposals in the key interest areas. These include a project to sequence cacao species in four Latin American countries, and to improve how COVID data collected in the region is analysed locally, and shared with the world more widely.<\/p>\n\n\n\n<p>\u201cIt\u2019s excellent to see the experience gained during CABANA applied more widely. We\u2019re also hoping that the network will expand to include other countries in the region, and partnerships on other key themes. We hope to see a snowball effect as more and more bioinformaticians are trained and projects are funded.\u201d<\/p>\n\n\n\n<p>\u201cWe wanted CABANA to be a framework for future projects to build bioinformatics capacity; the idea was for it to be easily replicated in other regions\u201d explained Brooksbank. \u201cIn our experience these are the key training requirements to build capacity: focusing on thematic areas, secondments to encourage knowledge exchange, train-the-trainer sessions to improve capacity quickly, and access to e-learning materials \u2013 ideally translated into the local language.\u201d<\/p>\n\n\n\n<p>The days when entire institutes and companies only had a token bioinformatician on the team are long gone. As big data takes its place at the heart of the life sciences, computational skills are more important than ever.&nbsp;<\/p>\n\n\n\n<div class=\"vf-embed vf-embed--16x9 | vf-u-margin__bottom--400\">\n<iframe src=\"https:\/\/www.youtube.com\/embed\/DvKQ9_RL1P4\" frameborder=\"0\" controls allowfullscreen><\/iframe><\/div>\n\n\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"vf-embed vf-embed--16x9\">\n<iframe loading=\"lazy\" title=\"CABANA - 5 years of capacity building for data-driven biology in Latin America\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/DvKQ9_RL1P4?start=5&#038;feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe> \n<\/div><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>The CABANA project was born out of a desire to strengthen bioinformatics capacity and accelerate data-driven biology in Latin America.<\/p>\n","protected":false},"author":47,"featured_media":53762,"parent":0,"menu_order":0,"template":"","tags":[28,36,27],"class_list":["post-53300","embletc","type-embletc","status-publish","has-post-thumbnail","hentry","tag-bioinformatics","tag-embl-ebi","tag-training"],"acf":{"featured":true,"show_featured_image":false,"field_target_display":"embl","field_article_language":{"value":"english","label":"English"},"article_intro":"<p>The CABANA project was born out of a desire to strengthen bioinformatics capacity and accelerate data-driven biology in Latin America.<\/p>\n","related_links":false,"source_article":false,"in_this_article":false,"press_contact":"None","article_translations":false,"languages":"","embletc_issue":[{"ID":53290,"post_author":"124","post_date":"2022-11-16 12:00:00","post_date_gmt":"2022-11-16 11:00:00","post_content":"","post_title":"Issue 99","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"issue-99","to_ping":"","pinged":"","post_modified":"2022-11-17 11:34:48","post_modified_gmt":"2022-11-17 10:34:48","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.embl.org\/news\/?post_type=embletc-issue&#038;p=53290","menu_order":0,"post_type":"embletc-issue","post_mime_type":"","comment_count":"0","filter":"raw"}],"embletc_in_this_issue":[{"ID":53302,"post_author":"100","post_date":"2022-11-16 12:00:00","post_date_gmt":"2022-11-16 11:00:00","post_content":"<!-- wp:paragraph -->\n<p>The sun sets on a Thursday evening in Casalvecchio di Puglia, a remote village in rural southern Italy. Amidst a pastoral setting of vineyards, wheat fields, and olive groves, a young girl convinces her parents and siblings to watch another episode of \u201cSuperquark\u201d, a science show aired throughout Italy, but perhaps watched in few other households in this village of approximately 2,000 residents.&nbsp;<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Superquark \u2013 a science show that debuted in the \u201890s in Italy \u2013 showcases a variety of science stories and profiles of scientists.&nbsp; And for Maria Antonietta Tosches, it began a lifelong passion.&nbsp;<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Her interest piqued by&nbsp;scientific discoveries featured in every episode, Tosches ultimately went on to pursue the principles that drive evolution of neuron types and brain circuits. Her foray began with frogs, then moved onto <em>Platynereis<\/em> worms, then turtles and lizards, and now, Spanish ribbed newts (<em>Pleurodeles<\/em>). At Columbia University, Tosches is exploring newts\u2019 simple neural networks as models for more complicated ones.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Tosches\u2019 research \u2013 recognised with EMBL\u2019s 2022 John Kendrew Award for original contributions to the field of brain evolution \u2014 is testament to her commitment to a calling very different from her parents, who are farmers still in Italy. But it is also a demonstration of the work ethic and values she has held dear throughout her personal and professional life.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cMy parents put 100 % into everything they do,\u201d Tosches said. \u201cIt\u2019s from them that I learned to strive for excellence. I see this in myself when I am running my projects, setting priorities \u2013 trying to do the best things possible in the best possible way. It\u2019s been 20 years since I left my village, and I would never have imagined this kind of work for myself then.\u201d<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading -->\n<h2><strong>From worms to turtles to newts<\/strong><\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n<p>Even before Tosches earned her PhD at EMBL, she was studying the development of retinas in frogs.&nbsp; She joined Detlev Arendt\u2019s group at EMBL Heidelberg where his group was exploring the evolution of neurons, using the <em>Platynereis<\/em> worm\u2019s nervous system as a model organism.&nbsp;<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>At EMBL, Tosches took up work that Arendt had started as a postdoc when he discovered photoreceptor cells similar to those found in retinas, but in the middle of a <em>Platynereis <\/em>larva\u2019s brain. She wanted to understand why they were there. Through a series of experiments, she discovered these cells are part of a larger group that produces melatonin, a chemical that essentially helps tell a body when it\u2019s time to sleep. In the case of the worm larvae, swimming and dispersing in the sea, the melatonin is used by these photoreceptor cells to sense when it is night or day so the worm larvae\u2019s swimming circuits can slow down during night.&nbsp;&nbsp;<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cThis work showed how the same molecule is used in animals that diverged from human\u2019s evolutionary path 600 million years ago, to do something very similar \u2013 controlling circadian rhythms of locomotion,\u201d Tosches explained. \u201cThe light-dependent control of locomotion is something that has existed since the beginning of the evolution of animal nervous systems. Other researchers discovered that even jellyfish sleep, and melatonin modulates or is involved in sleep mechanisms. This link between sleep and melatonin is something very, very ancient in animals.\u201d<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>In 2014, Tosches joined the group of Gilles Laurent at the Max Planck Institute for Brain Research as a postdoc. There, she used a single-cell approach to study the evolution of cerebral cortices in turtles and lizards, choosing them because they have the simplest cerebral cortex.&nbsp;<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cFor many decades, scientists have been comparing the brains of frogs, fish, turtles, and of course, mammals, and describing the neuroanatomy of these brains,\u201d Tosches said. \u201cBut what's still obscure is how the <em>differences<\/em> between these different vertebrate brains came about.\u201d<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:image {\"id\":53972,\"sizeSlug\":\"large\",\"linkDestination\":\"none\"} -->\n<figure class=\"wp-block-image size-large\"><img src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/Spanish_Ribbed_Newt_1_retouched-1024x683.jpg\" alt=\"Photo of a spanish ribbed newt on a rock with purple moss, against a dark background.\" class=\"wp-image-53972\"\/><figcaption>In five to 10 years, the EMBL alumna hopes the Spanish ribbed newt, <em>Pleurodeles waltl<\/em> will help her to create a complete, cell-by-cell description of how neural circuits are assembled and organised in a vertebrate brain. Credit: Wenze Li<\/figcaption><\/figure>\n<!-- \/wp:image -->\n\n<!-- wp:paragraph -->\n<p>Additionally, Tosches has been interested in learning more about the cognitive capacities of vertebrates besides what has been gleaned from mice, primates, and humans.&nbsp;<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cAbout 320 million years ago, one vertebrate evolutionary line led to us mammals, and another led to reptiles and birds. And in these passing years, lots of changes happened,\u201d she said. \u201cEventually, mammals and birds acquired very high cognitive abilities independently. Birds are incredibly smart and have been studied more than other vertebrates with simpler cognition, which are not understood at all yet.\u201d<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Since 2019, she has led her own research lab at Columbia University. With newts, Tosches uses genetic, genomic, developmental, and neurobiological approaches to investigate the evolution of brain cell types and neural circuits in the vertebrate brain.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cWe are trying to understand whether salamanders can use landmarks to understand their location,\u201d she explained. \u201cA part of the brain involved in navigation, the hippocampus, has an innate ability to know where you are in space. We found that cell types there that help make this happen also exist in other species.\u201d<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>In early September, her research group and collaborators published <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.abp9186\">a paper in <em>Science<\/em><\/a> exploring the similarities and differences of neuron types in the forebrains of salamanders, turtles, lizards, and mice.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading -->\n<h2><strong>Why evolutionary neuroscience is important<\/strong><\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n<p>\u201cI am driven by curiosity,\u201d Tosches said, talking about the future of her research.&nbsp;&nbsp;<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>In five to 10 years, the EMBL alumna hopes to have created a complete, cell-by-cell description of how neural circuits are assembled and organised in a vertebrate brain. It\u2019s a \u2018dream that drives\u2019 her to think about her lesser-known Spanish ribbed newt <em>Pleurodeles waltl <\/em>ultimately<em> <\/em>being recognised as a model organism in much the same way that <em>C. elegans<\/em> is extolled for its role in understanding neural circuitry.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>And in the world of fundamental scientific research, that\u2019s a very big deal.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cIf we look back at history, all the major breakthroughs in biology \u2013 and in science in general \u2013 came not because someone anticipated or planned for the societal impact or the impact on human health,\u201d she said. \u201cThat\u2019s the beauty of fundamental research. At the time many of these kinds of discoveries are made, nobody \u2013 not even the person who makes the discovery \u2013 is really aware of the influence they may have in future scientists\u2019 work or how the science can change how we think about and do things.\u201d<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading -->\n<h2><strong>Being \u2018fearless about your science\u2019<\/strong><\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n<p>Tosches\u2019 determination to reach this goal is quite evident. Her voice only grows stronger as she shares more details from her current work.&nbsp; However, she is quick to add \u2013 more than once \u2013 that this drive not only comes from her parents but a culture of risk taking at EMBL.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cWhat did I learn during my time at EMBL? Not to be afraid of trying new things,\u201d she said. \u201cYou are surrounded by people doing amazing science in so many different fields; it's not like other institutes.&nbsp; The environment encourages you to talk to others even about things you yourself barely understand\u2026 you learn from each other.\u201d<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>She speaks of this experience as uniquely motivating, teaching her to \u2018dream big\u2019 and \u2018try new things\u2019.&nbsp; And her example of living this mantra comes in her own postdoc experience following EMBL.&nbsp; Upon learning of new sequencing technology available that could process thousands of cells at a time, she changed research direction, abandoning her original postdoc project to focus on a transcriptomics single-cell approach, finding herself ultimately \u2018more satisfied\u2019 in the new undertaking.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cEMBL is very special, and consequently it has aspects impossible to replicate in a single research lab,\u201d Tosches said. \u201cHowever, what I am passing down to my students and postdocs is the idea of being fearless about the science they're doing. We try new things every day because we're working on a new system, a new animal, a new model. It\u2019s important to be positive \u2013 with the attitude of open-minded explorers who seize on new, unplanned opportunities and even find unexpected results.\u201d<\/p>\n<!-- \/wp:paragraph -->","post_title":"Studying brain evolution: from worms to newts","post_excerpt":"Newts act as model organisms for Maria Tosches, winner of the 2022 John Kendrew Award, to further explore the cellular makeup of vertebrate brains.\n","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"studying-brain-evolution-from-worms-to-newts","to_ping":"","pinged":"","post_modified":"2022-11-18 11:12:17","post_modified_gmt":"2022-11-18 10:12:17","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.embl.org\/news\/?post_type=embletc&#038;p=53302","menu_order":0,"post_type":"embletc","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":53304,"post_author":"16","post_date":"2022-11-16 12:00:00","post_date_gmt":"2022-11-16 11:00:00","post_content":"<!-- wp:paragraph -->\n<p><em>By Tom Furnival-Adams<\/em><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>As she reflects on her long, successful career, it is clear that Sara A. Courtneidge has always been driven, primarily, by an innate compulsion to discover how things work.&nbsp;<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Growing up in Sussex, England, she recalls excitedly rushing to the butcher\u2019s shop on her way home one day to obtain a cow eye to dissect, having been shown the ropes by a particularly enthusiastic science teacher. She also remembers taking it upon herself to examine her family\u2019s tap water using a microscope borrowed from one of her brothers\u2019 chemistry kit.&nbsp;<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>And while these formative experiments ensured her family always boiled their water and thoroughly washed chopping boards, they also indicated early on Courtneidge\u2019s burning curiosity about the natural world that would shape the rest of her life.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>It is this extraordinary will to examine and better understand crucial mechanisms of biology that led to her <a href=\"https:\/\/www.embl.org\/news\/alumni\/2022-embl-alumni-award-winners-announced\/\">2022 Lennart Philipson Award<\/a> recognising her major contributions to foundational and translational cancer research.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>This could be perceived as her career coming almost full circle: Philipson was the Director General who recruited Courtneidge to EMBL in 1985. \u201cI had some fantastic interactions with Lennart; he was a wonderfully supportive man. I owe a lot to him,\u201d she said.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading -->\n<h2><strong>The chemistry of serendipity<\/strong><\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n<p>Courtneidge, who attended one of Britain\u2018s first comprehensive schools, attributes much of her early success to serendipity. She considers it a stroke of luck that she was taught by a PhD-level chemistry teacher, and was one of a handful of students in her year encouraged and supported to attend university.&nbsp; \u201cMy life has just been these series of fortuitous things,\u201d she said.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>In 1972, she went to the University of Leeds, having \u201cannounced\u201d that she intended to do so to parents who were both slightly bemused by, and extremely supportive of, their daughter\u2019s boldness. She was only the second member of her family to attend university and believes that her undergraduate degree in biochemistry set her up for the rest of her career. \u201cIt was a really good basis for everything we understand about modern molecular biology now,\u201d she said.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Her PhD took her to the now-defunct National Institute for Medical Research in Mill Hill, London, where she specialised in virology and immunology. There she first encountered the role of T cells in recognising virus infection.&nbsp;<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cI was working within two labs, one led by an immunologist, and the other led by a virologist, using influenza virus genetics to study how the T cells interact with viruses. It's been interesting helping my friends and colleagues understand pandemics because we had a lot of conversations in my lab about pandemics and how you track them,\u201d Courtneidge recalled.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Courtneidge would have likely have continued down that path if not for one of her PhD advisors, the virologist Sir John Skehel, intervening.&nbsp; \u201cJohn said, you shouldn't do the same thing for your postdoc that you did for your PhD,\u201d she recounted. \u201cThis is a time to broaden your horizons.\u201d<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Courtneidge began spending more time in the library, consciously following new, different trails of curiosity. She and Skehel discussed various scientific ideas at the lab bench all day long. That\u2019s how she settled upon cancer virus research.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>With Skehel\u2019s endorsement, Courtneidge became interested in the recently discovered novel retroviruses, and he helped her decide to pursue this in one of the labs on the US West Coast. Having never flown before and having only been abroad once, she found herself on a plane bound for University of California, San Francisco to work with the respected microbiologist J. Michael Bishop.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Bishop was later awarded the 1989 Nobel Prize in Physiology or Medicine with Harold Varmus, with whom he discovered the first human oncogene, c-<em>src<\/em> , which they were using to study cancer. Meanwhile, colleagues in the lab had just determined the protein that this particular oncogene made, c-Src. It had also just been discovered in another lab that the Src protein was a kinase \u2013 an enzyme that adds phosphate groups onto other proteins.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Courtneidge found she was one of the few scientists in the lab familiar with biochemistry and how to handle proteins. \u201cPeople were saying, \u2018Gosh, I wish there was a way we could find out where this protein is in the cell and what it does.\u2019 And I said \u2018this is something I know how to do\u2019,\u201d she said.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cIt was an amazing time to work on oncogenes,\u201d Courtneidge said. \u201cNow we had this single protein that could turn a normal cell into a cancer cell. There was this push to work out how it does that. That\u2019s when I started working on Src in the lab.\u201d<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:image {\"align\":\"left\",\"id\":53966,\"sizeSlug\":\"full\",\"linkDestination\":\"none\"} -->\n<figure class=\"wp-block-image alignleft size-full\"><img src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/PastedGraphic-1_retouched.jpg\" alt=\"\" class=\"wp-image-53966\"\/><figcaption>Sara Courtneidge in 1985. Credit: Sara A. Courtneidge<\/figcaption><\/figure>\n<!-- \/wp:image -->\n\n<!-- wp:paragraph -->\n<p>After her PhD, Courtneidge returned to the National Institute for Medical Research. It had recently been discovered by scientists at the Salk Institute that a DNA tumour virus oncogene called middle T had some kinase activity associated with it \u2013 but they couldn't show that it was a kinase itself. Once again, she possessed the skills and knowledge in the right place at the right time: \u201cI had all the tools from working on Src and Alan Smith\u2019s lab at NIMR had all the tools for working on polyomavirus and the middle T oncogene.\u201d<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Courtneidge collaborated with Smith and discovered that the Src protein binds to middle T protein produced by DNA tumour viruses when they infect the cell. That switches on Src activity that causes cancer. This major finding united two different research fields and paved the way for further developments.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cGenerally, most DNA viruses just take the brake away [from cell cycle regulation). But the polyomavirus both takes the brakes away and expresses a very potent tumour virus oncogene which activates the accelerator. It was pretty clear at the outset that that was a fundamental reuniting of the tumour virus fields, which were split for a while, and it started a lot of other research,\u201d said Courtneidge.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading -->\n<h2><strong>Becoming EMBL\u2019s first female senior scientist<\/strong><\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n<p>In 1985, Courtneidge brought this research to EMBL, where she was, for a long period, the only female group leader. She later became EMBL\u2019s first female senior scientist.&nbsp;<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cIt's an intolerable burden on women to be the one example of a woman in a room because then, if you give a bad talk, it is generalised into \u2018women give bad talks\u2019,\u201d she said.&nbsp; \u201cIf your paper isn't well received, it\u2019s \u2018women's papers are inferior\u2019.\u201d Courtneidge has been a passionate and active spokesperson for gender equality in science throughout her career, believing better representation is key.&nbsp;<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Courtneidge credits EMBL\u2019s multicultural environment for her insights into the many ways to approach research questions. She also recalls a \u201ccollaborative spirit and an open mindedness\u201d that fostered trust between colleagues and prioritised idea sharing above competition.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>&nbsp;\u201cI have never had more than 10 people in my lab since EMBL,\u201d she said of the impacts EMBL has had on her approach. \u201cHaving a smaller lab helps collaboration; it's not just about how many papers you produce and doing your own thing.\u201d<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:image {\"id\":53968,\"sizeSlug\":\"large\",\"linkDestination\":\"none\"} -->\n<figure class=\"wp-block-image size-large\"><img src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/PastedGraphic-2_retouched1-1024x736.jpg\" alt=\"\" class=\"wp-image-53968\"\/><figcaption>Courtneidge group members in the late 1980s. Top row, left to right: Stefano Fumagalli, Leonardo Brizuela, Manfred Koegl, Thorsten Erpen, Geraldine Twamleyl-Stein. Bottom row, left to right: Gema Alonso, Angelika Heber, Serge Roche, Margaret Jones. Credit: Sara A. Courtneidge<\/figcaption><\/figure>\n<!-- \/wp:image -->\n\n<!-- wp:heading -->\n<h2><strong>Translational research and industry beckon<\/strong><\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n<p>After nearly 10 years in Heidelberg, industry called.&nbsp;&nbsp;<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cAt EMBL, we were publishing great papers, left, right and centre with wonderful people in my lab,\u201d she said. \u201cBut I reached a point where I asked, \u2018Is there more\u2019?\u201d<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>An opportunity in San Francisco caught her attention.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cIf you want to develop treatments for people based on all the amazing scientific discoveries that were happening in the oncogene field, you had to apply that in some way. And I just thought: \u2018I need to put my money where my mouth is,\u2019\u201d she said.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Courtneidge joined SUGEN Inc. as Head of Research in 1994, where she guided novel kinase discovery and validation efforts in oncology, and developed the company\u2019s research operations. Her own research had to move to the backburner while she focused on the company\u2019s priorities, but Courtneidge has no regrets. She believes scientists should gain experience in both translational and fundamental research.&nbsp;<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cHow are you going to sell your research to a company if you haven\u2019t thought through what they\u2019d be interested in? What are the potential risks? What are the economics?\u201d she said.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Realising the day-to-day demands of business administration were leaving her little time for the scientific research she loved, Courtneidge ultimately returned to academia in 2001 to establish a lab at the Van Andel Research Institute in Grand Rapids, Michigan, focusing on applying fundamental research on how cancer cells move to identifying ways to interfere with metastasis.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>She has since served as a professor and Director of the Tumor Microenvironment and Metastasis Program, and Director of Academic Affairs, at the Sanford Burnham Medical Research Institute, before joining Oregon Health and Science University in 2014, where she worked as an Associate Director of Translational Sciences for the Knight Cancer Institute.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Courtneidge\u2019s work over a number of decades has significantly contributed to understanding oncogene transformation, regulation, substrate selection, and function.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>But Courtneidge is characteristically humble about her legacy. Instead of awards or accolades, she focuses on discoveries and new knowledge.&nbsp;<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cI want to leave a body of work and a toolbox for others to carry it forward,\u201d she reflected. \u201cI stood on the shoulders of giants, and I want everybody to keep climbing upwards towards better understanding\u201d.<\/p>\n<!-- \/wp:paragraph -->","post_title":"From academia to industry and back","post_excerpt":"Sara A. Courtneidge, recipient of the 2022 Lennart Philipson Award, reflects on the fundamental and translational research aspects of her career in cancer research","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"from-academia-to-industry-and-back","to_ping":"","pinged":"","post_modified":"2022-11-16 12:38:21","post_modified_gmt":"2022-11-16 11:38:21","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.embl.org\/news\/?post_type=embletc&#038;p=53304","menu_order":0,"post_type":"embletc","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Building bioinformatics capacity in Latin America | EMBL<\/title>\n<meta name=\"description\" content=\"The CABANA project was born out of a desire to strengthen bioinformatics capacity and accelerate data-driven biology in Latin America.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/embletc\/issue-99\/building-bioinformatics-capacity-in-latin-america\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Building bioinformatics capacity in Latin America | EMBL\" \/>\n<meta property=\"og:description\" content=\"The CABANA project was born out of a desire to strengthen bioinformatics capacity and accelerate data-driven biology in Latin America.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/embletc\/issue-99\/building-bioinformatics-capacity-in-latin-america\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:modified_time\" content=\"2023-01-25T13:40:52+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/CABANA-UniAndes-2018-38_1000X600.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"601\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"9 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.embl.org\/news\/embletc\/issue-99\/building-bioinformatics-capacity-in-latin-america\/\",\"url\":\"https:\/\/www.embl.org\/news\/embletc\/issue-99\/building-bioinformatics-capacity-in-latin-america\/\",\"name\":\"Building bioinformatics capacity in Latin America | EMBL\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/embletc\/issue-99\/building-bioinformatics-capacity-in-latin-america\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/embletc\/issue-99\/building-bioinformatics-capacity-in-latin-america\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/CABANA-UniAndes-2018-38_1000X600.jpg\",\"datePublished\":\"2022-11-16T11:00:00+00:00\",\"dateModified\":\"2023-01-25T13:40:52+00:00\",\"description\":\"The CABANA project was born out of a desire to strengthen bioinformatics capacity and accelerate data-driven biology in Latin America.\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.embl.org\/news\/embletc\/issue-99\/building-bioinformatics-capacity-in-latin-america\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.embl.org\/news\/embletc\/issue-99\/building-bioinformatics-capacity-in-latin-america\/#primaryimage\",\"url\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/CABANA-UniAndes-2018-38_1000X600.jpg\",\"contentUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/11\/CABANA-UniAndes-2018-38_1000X600.jpg\",\"width\":1000,\"height\":601,\"caption\":\"CABANA participants during a break at a train-the-trainer course at the Universidad de los Andes in Colombia. 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