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Research highlights

stem cells neurons differentiation

From stem cells to neurons

Scientists at EMBL Heidelberg have investigated stem cells and how they differentiate to become neurons. Their approach included an assessment of the complex interplay of molecules during the differentiation process and generated fundamental new insights into the role of a protein called Sox2 in…

By Fabian Oswald

Science

epigenetic reprogramming, epigenetic memory, Hackett group

Unravelling epigenetic reprogramming

A study conducted by the Hackett group at EMBL Rome has identified key factors controlling the complex system of gene regulation during early embryo development, shedding new light on the mechanisms behind these events and on their evolutionary implications. Their findings are published in Nature…

By Rossana De Lorenzi

Science

New insights into epigenetic modifications

Scientists at EMBL Rome unveil the mechanism behind the most studied epigenetic modification.…

By Rossana De Lorenzi

Science

This image shows the structure of a bacterial group II intron

Genetic cut and paste at atomic resolution

Researchers in the Marcia group at EMBL Grenoble and the De Vivo lab at the Italian Institute of Technology in Genoa have obtained some of the most detailed ever snapshots of the splicing process in systems known as group II self-splicing introns. The new insights will help scientists to develop…

By Marius Bruer

Science

Microscopic image showing a macrophage that has been infected with Salmonella (green), causing cellular cathepsins (red) to locate to the nucels (blue).

Re-trafficking proteins to fight Salmonella infections

Scientists including members of EMBL’s Typas group have investigated how immune cells called macrophages respond to infection by the intracellular pathogen Salmonella enterica. They discovered that Salmonella causes newly produced cathepsins to accumulate in the nuclei of infected cells to…

By Marius Bruer

Science

An illustration of single-cell RNA sequencing (scRNA-seq)

Enabling functional genomics studies in individual cells

Scientists at EMBL Heidelberg have developed a new method, called Targeted Perturb-seq (TAP-seq), which increases the scale and precision of functional genomics CRISPR–Cas9 screens by orders of magnitude. Their method overcomes limitations in previous applications of single-cell RNA sequencing,…

By Marius Bruer

Science

New insights into gene regulation

EMBL researchers investigate the role of a histone protein in regulating gene expression…

By Chloe Cross

Science

PlatyBrowser

Finding your way around Platynereis dumerilii

EMBL researchers combine multiple datasets to develop expandable atlas of an entire animal…

By Marius Bruer

Science

Forkhead-Ets cooperation

How transcription factors work together

EMBL researchers have developed a method to observe interactions between transcription factors…

By Fabian Oswald

Science

TF bound to DNA

A classification tool for transcription factors

The software diffTF quantifies activity of transcription factors and predicts their mode of action…

By Fabian Oswald

Science

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