Research highlights
From stem cells to neurons
Scientists at EMBL Heidelberg have investigated stem cells and how they differentiate to become neurons. Their approach included an assessment of the complex interplay of molecules during the differentiation process and generated fundamental new insights into the role of a protein called Sox2 in…
Unravelling epigenetic reprogramming
A study conducted by the Hackett group at EMBL Rome has identified key factors controlling the complex system of gene regulation during early embryo development, shedding new light on the mechanisms behind these events and on their evolutionary implications. Their findings are published in Nature…
New insights into epigenetic modifications
Scientists at EMBL Rome unveil the mechanism behind the most studied epigenetic modification.…
Genetic cut and paste at atomic resolution
Researchers in the Marcia group at EMBL Grenoble and the De Vivo lab at the Italian Institute of Technology in Genoa have obtained some of the most detailed ever snapshots of the splicing process in systems known as group II self-splicing introns. The new insights will help scientists to develop…
Re-trafficking proteins to fight Salmonella infections
Scientists including members of EMBL’s Typas group have investigated how immune cells called macrophages respond to infection by the intracellular pathogen Salmonella enterica. They discovered that Salmonella causes newly produced cathepsins to accumulate in the nuclei of infected cells to…
Enabling functional genomics studies in individual cells
Scientists at EMBL Heidelberg have developed a new method, called Targeted Perturb-seq (TAP-seq), which increases the scale and precision of functional genomics CRISPR–Cas9 screens by orders of magnitude. Their method overcomes limitations in previous applications of single-cell RNA sequencing,…
New insights into gene regulation
EMBL researchers investigate the role of a histone protein in regulating gene expression…
Finding your way around Platynereis dumerilii
EMBL researchers combine multiple datasets to develop expandable atlas of an entire animal…
How transcription factors work together
EMBL researchers have developed a method to observe interactions between transcription factors…
A classification tool for transcription factors
The software diffTF quantifies activity of transcription factors and predicts their mode of action…
