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Mice

Fallingwater filled with mice

Nadia Rosenthal describes how she built EMBL Rome’s mouse…

By Guest author(s)

Alumni

From rodents to roadsters

Klaus Rajewsky recalls the pioneering spirit of EMBL Rome’s first…

By Josh Tapley

Alumni
Susumu Tonegawa

Exploring the principles of episodic memory

Nobel prize laureate Susumu Tonegawa describes his work in memory research over the past…

By Fabian Oswald

Events

Managing chronic pain with light

Scientists at EMBL Rome develop new method that uses light to manage neuropathic pain in…

By Iris Kruijen

Science

Making your brain social

In many people with autism and other neurodevelopmental disorders, different parts of the brain don’t talk to each other very well. Scientists have…

By Guest author(s)

Science

What are you scared of?

What do bullies and sex have in common? Based on work by scientists at the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy, it…

By Guest author(s)

Science

Freeze or run? Not that simple

Fear can make you run, it can make you fight, and it can glue you to the spot. Scientists at the European Molecular Biology Laboratory (EMBL) in…

By Guest author(s)

Science
These microscopy images demonstrate the effects of Notch signalling on the hearts of newborn mice (top) and of adult mice after a heart attack (bottom). In a normal neonatal heart (top left), the two major heart chambers (ventricles) are clearly separated by tissue (septum). But when Notch signalling was inactivated in an embryo’s heart muscle cells, the septum between the ventricles of the newborn mouse’s heart was incomplete (asterisk). The same defect commonly occurs in humans with congenital heart disease, often leading to circulatory distress. In the images of adult hearts (bottom), healthy tissue is shown in red and damaged tissue in blue. Normally (bottom left), a heart attack causes extensive tissue damage to the left ventricle (right-hand cavity), but mice in which Notch was re-activated after the heart attack had reduced tissue damage (bottom right) and improved cardiac function. Image credit: EMBL

From fruit fly wings to heart failure. Why Not(ch)?

Almost a century after it was discovered in fruit flies with notches in their wings, the Notch signalling pathway may come to play an important role…

By Guest author(s)

Science
This microscopy image, taken ten days after injury, shows that the muscle fibres of normal mice (left) had re-grown, while in mice which couldn’t boost C/EBPβ production (right) there were still many fibres that had not regenerated (arrowheads), and the tissue had a number of scars (arrows).

To regenerate muscle, cellular garbage men must become builders

For scientists at the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy, what seemed like a disappointing result turned out to be…

By Guest author(s)

Science
In normal skin (left), the stem cells at the base, shown in green, differentiate into skin cells, shown in red. In mice whose skin has neither C/EBPα nor C/EBPβ (middle), this differentiation is blocked: green-labeled stem cells appear in upper layers of skin, and there are no differentiated skin cells (no red staining). This also happens at the initial stages of basal cell carcinomas. In skin where C/EBPα is present but has lost its capacity to interact with E2F, a molecule that regulates the cell cycle (right), skin cells start differentiating abnormally, before they have properly exited the stem cell ‘program’ (yellow/orange). This is similar to what is observed in the initial stages of squamous cell carcinomas, a more aggressive and invasive skin tumour.

How stem cells make skin

Stem cells have a unique ability: when they divide, they can either give rise to more stem cells, or to a variety of specialised cell types. In both…

By Guest author(s)

Science

Pregnant mice block out unwelcome admirers to protect their pups

Mouse mothers-to-be have a remarkable way to protect their unborn pups. Because the smell of a strange male’s urine can cause miscarriage and…

By Guest author(s)

Science

Life savers in the gut

Researchers from the European Molecular Biology Laboratory (EMBL) have discovered that proteins that regulate the body’s iron household play a…

By Guest author(s)

Science

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