20 March 2023 Team leader Gergely Papp.

Welcome: Gergely Papp

Lab Matters Together with his team, Gergely Papp pushes the frontiers of technology development in the field of structural biology.



3 June 2022 he internal structure of a mitotic chromosome is shown with colourful threads representing DNA, one of which is shown being packaged into loops by the condensin protein complex. The background shows mitotic chromosomes in the cellular space

Shaping up the genome for cell division

Science Researchers have discovered the mechanism by which a family of DNA motor proteins packages loosely arranged strands of DNA into compact individual chromosomes during cell division.



20 December 2021 A detailed structure map shows two proteins interacting in the foreground, each shown in a different colour. The background shows small green dots marking bacteria

Solving molecular puzzles to find the perfect fit

Science Using cryo-EM and structural biology techniques, EMBL researchers have shown how two proteins of Legionella pneumophila interact. This finding sheds light on a mechanism critical to the infection process and could lead to the development of new drugs to treat pneumonia.



9 December 2021 Colourful interwoven coils are displayed against a grid of small black and white photographic images.

A gallery of human RNA polymerases

Science New structural biology research provides fundamental information critical to understanding enzyme mutations connected to rare diseases and cancers.



28 October 2021 female scientist sits in front of building

Welcome: Svetlana Dodonova

Lab Matters Svetlana Dodonova is one of EMBL's newest group leaders, leading a team of researchers who will study how genetic material is organised inside cells using structural biology approaches.



18 January 2021 man wearing sweater and glasses stands in front of snow and glassy building

Welcome: Timo Zimmermann

Lab Matters The EMBL Imaging Centre is scheduled to open in 2021 with Timo Zimmermann as Team Leader for advanced light microscopy technology development and service provision.



7 December 2020 Female scientist stands in front of electron microscope that is taller than she is

Seeing deeper inside cells

Science While cryo-electron tomography (cryo-ET) was first envisioned in 1968, the advances the Mahamid group are bringing to this 3D method for studying molecules directly inside cells are new, and are likely to greatly expand its use.



24 August 2020 Simone Mattei, the new team leader in electron microscopy service and technology development

Welcome: Simone Mattei

Lab Matters The new team leader offering services in electron microscopy discusses his hopes and plans for the forthcoming EMBL Imaging Centre



17 June 2020 Crystal selection for X-ray diffraction experiments.

Investigating the structure and mechanisms of coronavirus biomolecules

Science While global research on coronaviruses has shed light on the function of many SARS-CoV-2 proteins, the role of some crucial components remains unknown. Researchers at EMBL Grenoble will use a range of structural biology methods to try to solve some of the puzzles of the molecular mechanics of…



29 April 2020 The Influenza virus

Understanding the influenza virus

Science The infectious disease commonly known as flu is caused by the influenza virus. It spreads around the world in seasonal outbreaks, causing millions of infections and hundreds of thousands of deaths each year. Stephen Cusack, Head of EMBL Grenoble, has been studying different aspects of the influenza…



11 July 2019 Structure of the Elongator complex

A tRNA modifier at work

Science Using cryo-EM, scientists have determined the structure of a large protein complex called Elongator.



12 December 2010 This cryo-electron microscopy image shows the 3D structure of the ribosome (yellow/blue) bound to the signal recognition particle (SRP) and the SRP receptor (both in red). Below it is an atomic model of SRP (green-yellow/orange) and its receptor (pink). Image credits: EMBL/Schaffitzel.

How cells export and embed proteins in the membrane

Science Like an overprotective parent on the first day of school, a targeting factor sometimes needs a little push to let go of its cargo. Scientists at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have visualised one such hand-over. They were the first to determine the structure…



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