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EMBL Rome

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22 November 2024

Celebrating 25 years of EMBL Rome

Lab Matters EMBL Rome celebrates its 25th anniversary this year – some impressions of the symposium and party organised for staff and alumni to mark this special occasion.

2024

lab-matters

16 October 2024

All eyes on science!

Lab Matters EMBL Rome volunteers participated in the European Researchers’ Night organised by the CNR in Montelibretti, attended by over 1,500 visitors. They prepared activities and games reflecting the wide variety of projects conducted at the site and across EMBL.

2024

lab-matters

8 October 2024

Machine learning discoveries honoured with 2024 Nobel Prize for Physics

Science & Technology The prize was awarded to John J. Hopfield, Princeton University, USA, and Geoffrey Hinton, University of Toronto, Canada, for their seminal contributions to the foundational methods that enabled the development of machine learning.

2024

science-technology

10 July 2024

Leveraging expertise across EMBL services

Connections A scientific workshop on flow cytometry was organised at EMBL Rome, taking advantage of the presence of the Advanced Mobile Laboratory, the biggest unit of EMBL’s mobile lab fleet.

2024

connections

9 May 2024

An epigenome editing toolkit to dissect the mechanisms of gene regulation

Science & Technology A study from the Hackett group at EMBL Rome led to the development of an epigenetic editing system that allows to precisely program chromatin modifications at any specific position in the genome, to understand their causal role in transcription regulation.

2024

science-technology

1 May 2024 Alt Text: An artistic representation of gut microbes and sperm cells

Father’s gut microbes affect the next generation

Science & Technology Scientists from EMBL Rome and EMBL Heidelberg found that disrupting the gut microbiome of male mice increases the risk of disease in their offspring. Their findings suggest that a father’s pre-conception environment can have lifelong effects on offspring.

2024

science-technology

16 November 2023

New evidence on retinal function

Science & Technology A new study from the Asari group at EMBL Rome shows a different retinal function in awake mice compared to isolated retinal samples. These new insights could help to develop prosthetic devices that can act as a retina in the future.

2023

sciencescience-technology

9 October 2023

A night to share the wonders of science 

Lab Matters EMBL Rome celebrated the European Researchers’ Night by participating in an event organised at the CNR Campus in Montelibretti.

2023

lab-matters

26 July 2023 Participants listen to the trainer in front of a screen displaying a microscopy image

Imaging-based spatial-omics: EMBO Practical Course at EMBL Rome 

Lab MattersScience & Technology The first EMBO Practical Course on imaging-based spatial-omics was organised at EMBL Rome to explore the latest techniques to visualise RNA transcripts and proteins in their native tissues.

2023

lab-mattersscience-technology

28 June 2023 Female scientist in white lab coat enjoying camaraderie of colleagues.

After EMBL: Urtė Neniškytė

People & Perspectives EMBL Rome alumna Urtė Neniškytė returned to her native Lithuania, helping establish the Vilnius University-EMBL Partnership Institute and advance genome-editing technologies there.

2023

alumnipeople-perspectives

30 March 2023 Profile picture of Cornelius Gross, interim head of EMBL Rome

ERC Advanced Grant awarded to EMBL Rome researcher

EMBL AnnouncementsLab Matters Interim head of EMBL Rome Cornelius Gross has been awarded an Advanced grant from the European Research Council (ERC) for his project TERRITORY, aimed at investigating the neural basis of territorial aggression and fear.

2023

embl-announcementslab-matters

31 January 2023

ERC Consolidator Grant success at EMBL

EMBL AnnouncementsLab Matters EMBL Rome group leader Jamie Hackett receives EUR 2 million for the ModLogic project, aimed at understanding how chromatin modifications impact gene activity.

2023

embl-announcementslab-matters

1 June 2022

EMBL in Italy event held at GSK Vaccines in Siena

Connections The GSK Vaccines site in Siena hosted the annual EMBL in Italy event. The hybrid meeting brought together industry leaders, representatives from biotech start-ups, data scientists, and researchers from academia.

2022

alumniconnections

12 April 2022

EMBL consolidates ties with Sapienza University

ConnectionsLab Matters EMBL and the Sapienza University of Rome confirm their reciprocal interest in intensifying collaborations and launch new opportunities for exchange of expertise

2022

connectionslab-matters

8 April 2022 a metaphor for the process of epigenetic inheritance

A metaphor for epigenetic inheritance

Science & Technology Recent studies from the Hackett group at EMBL Rome have revealed new insights on the mechanism regulating transmission of non-genetic information during embryonic development, and inspired a scientific illustration

2022

sciencescience-technology

22 October 2021 Oblong shape with two holes and coloured dots inside, representing phytoplankton cells and nitrogen-fixing bacteria

Analysis and sorting with flow cytometry

Lab MattersScience & Technology A technology around since the ‘60s, flow cytometry has increasing applications. New leadership at EMBL’s flow cytometry facilities is looking to ease use, expand training, and encourage more collaboration.

2021

lab-mattersscience-technology

17 September 2021 Artistic representation of the complex cell circuit forming the retina

Vision unveiled: new roles for the retina in visual processing

Science & Technology EMBL scientists have found evidence of an unexpected role for retinal cells in pre-processing visual information; their results provide potential opportunity for future prosthetic visual aids.

2021

research-highlightssciencescience-technology

8 June 2021 Purple, blue and yellow dots on a black background.

Dream team

Science & Technology At EMBL, we have many dream teams – groups of individuals who support each other, innovate, and work together. One of those dream teams bridges two core facilities at EMBL Rome.

2021

picture-of-the-weekscience-technology

28 April 2021 Artistic representation of brain and DNA

Uniting strengths to expand research

ConnectionsLab Matters The European Molecular Biology Laboratory and the Italian Institute of Technology have signed an agreement to expand the scope of their collaboration to include areas of mutual interest and in the context of EMBL’s 2022-2026 Programme “Molecules to Ecosystems”.

2021

connectionslab-matters

30 March 2021 Ana Boskovic sitting in her office

Welcome: Ana Boskovic

Lab MattersPeople & Perspectives The new group leader at EMBL Rome will study how embryos can inherit non-genetic information from their parents that causes stable and heritable effects

2021

lab-matterspeople-perspectives

16 March 2021 Pink blooming tree in front of functional building.

Italian Spring

Lab Matters EMBL’s site in Monterotondo has recently been blessed with blue skies and sunshine, leading to trees blooming early on campus.

2021

lab-matterspicture-of-the-week

29 January 2021 Flags of EMBL, Italy and CNR

Strengthening collaborations in Italy

ConnectionsLab Matters EMBL and CNR have signed a memorandum of understanding to strengthen scientific cooperation. The agreement will foster collaborative projects and integrate them within the European and global scientific landscape.

2021

connectionslab-matters

28 October 2020 A brain hovers over a chess board, lines flow from the hypothalamus to the pieces, symbolising control over reactions to an aggressor and territory.

Should I run, or should I not? The neural basis of aggression and flight

Science & Technology Researchers in the Gross group at EMBL Rome have investigated the mechanism behind defensive behaviour in mice. They have identified a specific area of the brain that encodes both spatial and threat cues to drive location-specific defensive responses.

2020

sciencescience-technology

8 October 2020 Alvaro Crevenna, heads EMBL Rome’s Microscopy Facility. Credit: EMBL

Beyond the lens – microscopy at EMBL Rome

Lab MattersScience & Technology Research facilities play a crucial role in the advancement of science by supporting scientists with specialised expertise and state-of-the-art equipment. The Microscopy Facility at EMBL Rome exemplifies this role by making a wide variety of light microscopy technologies available to its researchers…

2020

lab-mattersscience-technology

7 August 2020 Black and white photo of Phil Avner sitting in his office and looking at his smartphone. a large stack of papers on his desk

Arrivederci Phil!

Lab MattersPeople & Perspectives As he enters retirement, Head of EMBL Rome Phil Avner reflects on his scientific career and memories from his time as Head of EMBL’s site in Italy

2020

lab-matterspeople-perspectives

2 July 2020 epigenetic reprogramming, epigenetic memory, Hackett group

Unravelling epigenetic reprogramming

Science & Technology A study conducted by the Hackett group at EMBL Rome has identified key factors controlling the complex system of gene regulation during early embryo development, shedding new light on the mechanisms behind these events and on their evolutionary implications. Their findings are published in Nature…

2020

sciencescience-technology

29 June 2020 Gene Editing and Embryology Facility at EMBL Rome

Editing the mouse genome to study SARS-CoV-2 infection

Science & Technology To study how SARS-CoV-2 infects cells, the Gene Editing and Embryology Facility (GEEF) at EMBL Rome will generate mice that express a human version of a protein called ACE2. The mouse line will be shared with preclinical research collaborators carrying out vaccine and antibody trials, and with the…

2020

sciencescience-technology

9 June 2020 Mouse embryonic fibroblasts and their cell skeletons

Glow-in-the-dark cell skeletons

Science & Technology This image shows mouse embryonic fibroblasts (MEFs), their cell skeletons (green) and nuclei (blue) under a confocal microscope, photographed by Julia Hansen in the lab of Matthieu Boulard at EMBL Rome.

2020

picture-of-the-weekscience-technology

12 September 2019 Tara stopover in Rome

EMBL and Tara: Rome

EMBL Announcements The next stop on Tara’s journey will be at the mouth of the Tiber

2019

embl-announcementsevents

31 May 2010 This microscopy image shows that, in a mouse embryo, MiR451 (dark purple) is produced only in the liver, where red blood cells are being formed at this developmental stage. Image credits: Kasper Rasmussen/EMBL

Making enough red blood cells

Science & Technology Red blood cells, the delivery men that take oxygen to cells all around the body, have short lives. To keep enough of them in circulation, the human body produces around 2 million of these cells every second – even more in response to challenges like severe blood loss. In a study published today…

2010

sciencescience-technology

10 December 2009 These microscopy images demonstrate the effects of Notch signalling on the hearts of newborn mice (top) and of adult mice after a heart attack (bottom). In a normal neonatal heart (top left), the two major heart chambers (ventricles) are clearly separated by tissue (septum). But when Notch signalling was inactivated in an embryo’s heart muscle cells, the septum between the ventricles of the newborn mouse’s heart was incomplete (asterisk). The same defect commonly occurs in humans with congenital heart disease, often leading to circulatory distress. In the images of adult hearts (bottom), healthy tissue is shown in red and damaged tissue in blue. Normally (bottom left), a heart attack causes extensive tissue damage to the left ventricle (right-hand cavity), but mice in which Notch was re-activated after the heart attack had reduced tissue damage (bottom right) and improved cardiac function. Image credit: EMBL

From fruit fly wings to heart failure. Why Not(ch)?

Science & Technology Almost a century after it was discovered in fruit flies with notches in their wings, the Notch signalling pathway may come to play an important role in the recovery from heart attacks. In a study published today in Circulation Research, scientists at the European Molecular Biology Laboratory (EMBL)…

2009

sciencescience-technology

21 September 2009 This microscopy image, taken ten days after injury, shows that the muscle fibres of normal mice (left) had re-grown, while in mice which couldn’t boost C/EBPβ production (right) there were still many fibres that had not regenerated (arrowheads), and the tissue had a number of scars (arrows).

To regenerate muscle, cellular garbage men must become builders

Science & Technology For scientists at the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy, what seemed like a disappointing result turned out to be an important discovery. Their findings, published online this week in the journal Proceedings of the National Academy of Sciences (PNAS), provide…

2009

sciencescience-technology

13 September 2009 In normal skin (left), the stem cells at the base, shown in green, differentiate into skin cells, shown in red. In mice whose skin has neither C/EBPα nor C/EBPβ (middle), this differentiation is blocked: green-labeled stem cells appear in upper layers of skin, and there are no differentiated skin cells (no red staining). This also happens at the initial stages of basal cell carcinomas. In skin where C/EBPα is present but has lost its capacity to interact with E2F, a molecule that regulates the cell cycle (right), skin cells start differentiating abnormally, before they have properly exited the stem cell ‘program’ (yellow/orange). This is similar to what is observed in the initial stages of squamous cell carcinomas, a more aggressive and invasive skin tumour.

How stem cells make skin

Science & Technology Stem cells have a unique ability: when they divide, they can either give rise to more stem cells, or to a variety of specialised cell types. In both mice and humans, a layer of cells at the base of the skin contains stem cells that can develop into the specialised cells in the layers above.…

2009

sciencescience-technology

22 June 2009 EMBL Rome

European centre of excellence for mouse biology celebrates its 10th anniversary

Lab Matters Mice are one of biology’s most important model organisms, because 98% of their genes and many of their traits and diseases are similar to ours. Researchers at the Mouse Biology Unit of the European Molecular Biology Laboratory (EMBL) take advantage of these similarities and use mice to study…

2009

lab-matters

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