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26 November 2024

Complex Portal expands Human Complexome with ML-predicted human protein complexes

The Complex Portal – an encyclopaedic resource of macromolecular complexes from key model organisms – has expanded its coverage of the Human Complexome. This includes: To find out more, read the new paper entitled Complex Portal 2025: Predicted human complexes and enhanced visualisation tools…

2024

uncategorizedupdates-from-data-resources

25 November 2024

Sparking a data revolution

Science & Technology The introduction of computational methods in biology opened up an entirely new world of insights and breakthroughs. Over the last several decades, EMBL has been at the forefront of discoveries and innovations that have not only propelled the field forward but also opened up access to bioinformatics…

2024

science-technology

25 October 2024

DECIPHER v11.28 Released

The v11.28 DECIPHER release is out now. Find out about the new features and improvements.

2024

updates-from-data-resources

23 October 2024

BioChemGraph: Unifying structural and bioactivity data to accelerate drug discovery

In the era of data-driven biology, integrating information from different resources is essential yet often challenging. The BioChemGraph project addresses this challenge by creating infrastructure that consolidates structural, functional, and biochemical annotations for small molecules and their…

2024

updates-from-data-resources

21 October 2024 InterPro logo

InterPro 102.0 released

InterPro version 102.0 and InterProScan 5.70-102.0 are now available. 

2024

updates-from-data-resources

8 October 2024

Machine learning discoveries honoured with 2024 Nobel Prize for Physics

Science & Technology The prize was awarded to John J. Hopfield, Princeton University, USA, and Geoffrey Hinton, University of Toronto, Canada, for their seminal contributions to the foundational methods that enabled the development of machine learning.

2024

science-technology

8 October 2024

New MGnify Proteins web resources launched

EMBL-EBI’s microbiome data resource MGnify produces a valuable trove of protein sequence data through its ongoing analysis of microbiome derived data. Two new MGnify Proteins web resources make this dataset easily accessible and searchable, both for large queries across the entire database…

2024

updates-from-data-resources

24 September 2024 Single Cell Expression Atlas logo on green background

Single Cell Expression Atlas 21 released

New datasets The release has 381 single-cell RNA-Seq experiments, consisting of more than 13.5 million cells from 21 different species to explore in the Single Cell Expression Atlas (SCEA). The resource now includes an entirely new class of data – externally analysed data, marked with an…

2024

updates-from-data-resources

4 September 2024

Alvis Brazma: What I’ve learned

People & Perspectives EMBL-EBI alumnus Alvis Brazma reflects on how mathematics and mountaineering have shaped his life and why keeping things simple in bioinformatics is key.

2024

people-perspectivesperspectives

23 August 2024

Welcome: David Ocaña

People & Perspectives EMBL-EBI’s new Head of Applications will use his expertise in cloud infrastructure and security to support the institute’s open data resources.

2024

people-perspectivesperspectives

1 August 2024 Open Targets logo

Why clinical trials stop: the role of genetics

Science & Technology Using machine learning to analyse the genetic factors behind early clinical trial termination, researchers find a link between genetic evidence and trial outcome.

2024

research-highlightsscience-technology

25 July 2024

DECIPHER v11.27 release

The v11.27 DECIPHER release is out now. Find out about the new features and improvements.

2024

updates-from-data-resources

21 June 2024

Welcome: Mallory Freeberg

People & Perspectives The new Team Leader for Human Genomics at EMBL-EBI shares how curiosity and maths shaped her career and what it takes to be a community builder.

2024

people-perspectivesperspectives

28 May 2024 DECIPHER logo

DECIPHER v11.26 release

The latest DECIPHER release includes AlphaMissense scores, links to the Open Targets Platform and more.

2024

updates-from-data-resources

17 May 2024 Expression Atlas logo

Expression Atlas 40 released

The latest Expression Atlas 40 release is now live, containing new RNA-seq datasets, including a featured experiment resulting from a collaboration with Genotype Tissue Expression (GTEx) project as well as new proteomics data derived from our collaboration with PRIDE. In total, this release…

2024

updates-from-data-resources

16 May 2024

Welcome: Julio Saez-Rodriguez

People & Perspectives EMBL-EBI's new Head of Research shares his plans and priorities.

2024

people-perspectivesperspectives

13 May 2024 Ensembl logo in white circle on blue and green background

Ensembl 112 has been released

Ensembl 112 and the corresponding release of Ensembl Genomes 59 has released. This includes exciting new fish species, many more drosophila species and new VEP updates.

2024

updates-from-data-resources

30 April 2024 Open Targets logo

MSD joins the Open Targets consortium

EMBL Announcements MSD joins as the latest partner in the Open Targets consortium, enhancing the initiative’s collaborative efforts in drug discovery.

2024

announcementsembl-announcements

2 April 2024

DECIPHER v11.25 released

The latest DECIPHER update, version 11.25, introduces new key features including the integration of functional data from multiplexed assays of variant effect (MAVEs) and much more.

2024

updates-from-data-resources

27 March 2024

Using Data Hubs to analyse SARS-CoV-2 and other pathogen sequences

The SARS-CoV-2 Data Hubs are a set of tools coupled with infrastructure that support four components: the submission, analysis, presentation and visualisation of SARS-CoV-2 raw read data, and its resulting analyses. What makes Data Hubs attractive is a unique set of features: A new publication in…

2024

updates-from-data-resources

8 March 2024 MGnify logo with text underneath which reads release

MGnify Genomes mouse gut catalogue v1.0 released

The MGnify data resource for microbiome data has launched the latest MGnify Genomes catalogue comprising 112,951 genomes derived from mouse gut datasets, represented by 2,847 species-level cluster representative genomes. This catalogue was generated as part of our work with the MRC funded…

2024

updates-from-data-resources

28 February 2024 DECIPHER logo

DECIPHER v11.24 Released

Version 11.24 of DECIPHER introduces a new ACMG/AMP pathogenicity interface for sequence variant predictions, displays ClinGen Variant Curation Expert Panel recommendations on gene pages, and updates ACMG secondary finding information to v3.2.

2024

updates-from-data-resources

29 January 2024 Man leaning against a wall

Welcome: Kyle Morris

Lab MattersPeople & Perspectives Kyle Morris joins EMBL-EBI as Electron Microscopy Data Bank (EMDB) Team Leader.

2024

lab-matterspeople-perspectives

12 January 2024 Ensembl logo in white circle on blue and green background

Ensembl 111 has been released

The Ensembl 111 features a range of new Ensembl VEP plugins and updated agricultural, fish, plant and metazoa species.

2024

updates-from-data-resources

14 November 2023 InterPro logo

InterPro 97.0 released

InterPro version 97.0 and InterProScan 5.64-97.0 are now available. InterPro now features hundreds of new methods integrated from partner databases, and InterProScan draws on over 40000 entries.

2023

updates-from-data-resources

28 September 2023 Visual of AlphaFold Protein prediction, embedded into a visual of scientific data

EMBL receives German AI prize

EMBL Announcements EMBL receives the German AI prize awarded for outstanding services to the research and development as well as application and commercialisation of artificial intelligence (AI) in life science research.

2023

embl-announcementsscience

26 September 2023 InterPro logo

InterPro 96.0 released

InterPro version 96.0 and InterProScan 5.64-96.0 are now available.

2023

updates-from-data-resources

21 September 2023

Understanding the mechanisms of enzyme catalysis

Science & Technology Enzymes constitute a large fraction of genomes – 20% in humans – which makes them a very important part of life. Despite decades of studies and a rich literature dedicated to understanding the reaction mechanisms of enzymes, the rules of enzyme catalysis are still not fully clear. A new…

2023

science-technologytechnology-and-innovation

21 September 2023 Man standing outside

Welcome: David Hulcoop

Lab MattersPeople & Perspectives David Hulcoop discusses how his experience bridging organisational cultures will help address critical challenges in drug discovery and target selection at Open Targets.

2023

announcementslab-matterspeople-perspectives

14 August 2023 Man standing in front of a building

Open data to power up the blue economy

People & Perspectives EMBL-EBI Senior Scientist Rob Finn explains why data coordination and sharing are fundamental for a sustainable blue economy.

2023

people-perspectivesperspectivesscience

25 July 2023 Ensembl logo in white circle on blue and green background

Ensembl Bacteria releases new annotation for all its genomes

Ensembl 110 and Ensembl Genomes 57 have introduced in-house prokaryotic gene annotation across genomes available in Ensembl Bacteria.  Since its inception, Ensembl Bacteria has imported user-submitted annotations from the International Nucleotide Sequence Database Collaboration (INSDC) for…

2023

updates-from-data-resources

17 July 2023 Ensembl logo in white circle on blue and green background

Ensembl 110 has been released

Ensembl 100 release brings exciting updates, such as the addition of regulation data to 5 animal genomes studied extensively in agriculture.

2023

updates-from-data-resources

7 July 2023 InterPro logo

InterPro 95.0 released

InterPro version 95.0 and InterProScan 5.63-95.0 are now available! InterPro now features hundreds of new methods integrated from partner databases, and InterProScan draws on over 39000 entries. InterPro version 95.0 – new features include: InterPro 95.0 covers 81.7% of UniProt Knowledgebase…

2023

updates-from-data-resources

5 July 2023 Man standing in corridor

David Hulcoop appointed as Open Targets Director

EMBL Announcements Coming from a pharmaceutical industry background, David Hulcoop is set to take over as Executive Director of the public-private partnership Open Targets.

2023

announcementsembl-announcements

16 May 2023

Managing a bioinformatics core facility

BioImage Archive Team Leader Matthew Hartley shares his experience and tips for people interested in managing a bioinformatics core facility.

2023

technology-and-innovation

10 May 2023 Globe with genome data from multiple people

A more diverse human reference genome

Science & Technology The human pangenome – one of the most complete collections of genome sequences released so far – captures rich human diversity.

2023

announcementssciencescience-technology

18 April 2023 Decorative image showing WormBase ParaSite logo

WormBase ParaSite 18 released

Science & Technology WormBase ParaSite release 18 adds largest number of new genomes and annotations since launch, as well as full integration with AlphaFold.

2023

science-technologyupdates-from-data-resources

11 April 2023 Phylogenetic tree with beams of light to represent data

MAPLE: a phylogenetic tool for pandemic-scale genome data

Science & Technology EMBL-EBI researchers have developed a new tool capable of performing state-of-the-art phylogenetic inference on larger datasets than previously thought possible.

2023

research-highlightssciencescience-technology

7 March 2023 InterPro logo

New releases: InterPro 93.0 and InterProScan 5.61-93.0

InterPro now features hundreds of new methods integrated from partner databases, and InterProScan draws on over 38,000 entries. InterPro version 93.0 InterPro 93.0 integrates 300 new methods from the CDD (261), PANTHER (12), PROSITE profiles (17), SMART (9), TIGRFAMs (1) databases, and covers 81.7%…

2023

updates-from-data-resources

23 February 2023 Decorative image

New Job Dispatcher website launched

EMBL-EBI’s Software Development and Operations team is delighted to announce the launch of a brand-new Job Dispatcher website, currently in development.  The updated website provides a landing page for the Job Dispatcher services, making it easier for users to find and navigate services…

2023

updates-from-data-resources

16 February 2023

New EU-funded Project: Fragment-Screen

Lab MattersScience & Technology EMBL is one of the partners of this project that aims to accelerate drug discovery and development, bringing in expertise from EMBL Grenoble and EMBL-EBI.

2023

lab-mattersscience-technology

8 February 2023 Ensembl logo in white circle on blue and green background

Ensembl 109 has been released

Latest Ensembl and Ensembl Genomes releases bring updates to donkey and horse assemblies, and lots of new plants and metazoa.

2023

updates-from-data-resources

4 January 2023 InterPro logo

New releases: InterPro 92.0 and InterProScan 5.60-92.0

InterPro version 92.0 and InterProScan 5.60-92.0 are now available. InterPro now features hundreds of new methods integrated from partner databases, and InterProScan draws on over 38000 entries.

2023

updates-from-data-resources

20 December 2022

First linked dataset on Pathogens Portal

The first  cohort study linking data across categories was recently added on the Pathogens Portal Cohort Browser and is also accessible from the BioSamples browser. This pilot study comes from Erasmus Medical Centre through the ReCoDID project, one of the COVID-19 Data Platform supporting…

2022

updates-from-data-resources

11 November 2022 Photos of four panel discussion speakers

Open science for climate justice

Our experts discuss the importance of open science for food security and preserving global biodiversity.

2022

perspectivesscience

2 November 2022 Fluorescent microscopy image of skeletal muscle with biological data imagery

AI4LIFE: AI models for bioimaging

Researchers across EMBL are helping to make artificial intelligence (AI) models for bioimaging analysis interoperable and openly available to the scientific community.

2022

announcementsscience

21 October 2022 Ensembl logo in white circle on blue and green background

Ensembl 108 has been released

We are pleased to announce the release of Ensembl 108, and the corresponding release of Ensembl Genomes 55 featuring changes in the human default tracks, new genomes in Ensembl Plants and Ensembl Metazoa, and the addition of mitochondrial annotation for Tasmanian devil. Genome assemblies and…

2022

updates-from-data-resources

9 September 2022 Monochrome decorative image with the word "statement" on grey background.

In tribute to Her Majesty Queen Elizabeth II

The United Kingdom is a founding member of EMBL, and has hosted EMBL’s European Bioinformatics Institute since 1994. We recognise that the passing of Her Majesty Queen Elizabeth II will have a profound impact on the country, and we extend our deepest sympathies to the Royal Family at this…

2022

announcements

1 August 2022

Shining a light on how bacteria interact

Science & Technology Machine learning has helped researchers uncover new insights into how bacteria infect host cells.

2022

research-highlightssciencescience-technology

13 July 2022 Decorative image showing a double helix DNA road and with what look like road signs.

Uncharted territories in the human genome

Science & Technology Scientists identify previously unexplored gene segments to be added to human genome databases.

2022

research-highlightssciencescience-technology

7 July 2022 Single Cell Expression Atlas logo on green background

Interactive data visualisation for Single Cell Expression Atlas

Using powerful data visualisation and interactive search results across datasets allows users to explore hypotheses across a range of metadata, and discover new insights backed by expertly curated, consistently reanalysed single cell sequencing data. Searching for metadata, allows a powerful…

2022

updates-from-data-resources

9 June 2022 ArrayExpress logo; a red A and green E in a circle with the word ArrayExpress

ArrayExpress interface to close

On 30 September 2022 the ArrayExpress interface will close. All datasets have now been migrated from ArrayExpress into the BioStudies ArrayExpress collection

2022

updates-from-data-resources

5 May 2022 Microscopy image showing mouse cells in blue on a dark background. The mouse cells look like little blue blobs.

Interpreting bioimages with deep learning

Science & Technology Virginie Uhlmann shares her tips for using deep learning for bioimage analysis in the life sciences.

2022

perspectivessciencescience-technology

21 April 2022 Portrait of Guy Cochrane, Team Leader at EMBL-EBI's European Nucleotide Archive. Credit: Jeff Dowling/EMBL-EBI.

Guy Cochrane appointed Executive Director of Global Biodata Coalition

The GBC is a coalition of life sciences and biomedical research funders that aims to optimise the funding and management of biodata resources worldwide. The organisation has two priority aims: to better coordinate and share approaches for efficient management and growth of the biodata…

2022

announcements

24 February 2022 Expression Atlas database logo - A magnifying glass highlighting a yellow section on a blue background

New Expression Atlas release in collaboration with PRIDE

New Expression Atlas release features differential-proteomics and baseline-proteomics experiments in collaboration with the PRIDE team at EMBL-EBI. This also includes new baseline DIA proteomics experiments as well as new differential proteomics datasets.  To improve reproducibility,…

2022

updates-from-data-resources

28 January 2022 Collage with protein structure in the background and text in the foreground. Text says "17 organisms on the WHO’s neglected tropical diseases list and 10 organisms on its antimicrobial resistance list"

AlphaFold update – neglected tropical diseases

Latest AlphaFold database update adds 27 new organisms and almost 200,000 new protein structure predictions relevant to neglected tropical diseases and antimicrobial resistance

2022

updates-from-data-resources

14 January 2022 Woman standing next to a hedge

Welcome: Melissa Harrison

Lab MattersPeople & Perspectives Melissa Harrison joins EMBL-EBI as the new Team Leader of Literature Services. We found out more about her plans for open access publishing and Europe PMC.

2022

lab-matterspeople-perspectives

24 November 2021 A man standing in front of hedges

Welcome: Tudor Groza

Lab MattersPeople & Perspectives Tudor Groza joins EMBL-EBI as our new Phenomics Team Lead. We found out from Tudor exactly what this new role will entail

2021

lab-matterspeople-perspectives

16 November 2021 Collage showing different species that play an essential part in global food security, including cattle, pollinators and plants

Can data help feed a hungry world?

Science & Technology How genomics, open data, and multidisciplinary science can improve food security.

2021

sciencescience-technology

10 November 2021 Logo showing an opened padlock and the words “Data Use Ontology” and biomedical samples in background.

DUO: streamlining access to biomedical datasets

Science & Technology The GA4GH Data Use Ontology (DUO) supports a data authorisation and access framework to streamline consent to use biomedical data

2021

sciencescience-technology

10 November 2021 Graphic representations of different types of bacteria.

Making sense of bacterial DNA data

Science & Technology A vast, curated collection of bacterial genomes is now organised, searchable and open to the community.

2021

sciencescience-technology

26 October 2021 Photo of researcher using MGnify database

Novel enzymes for a Green Economy

Science & Technology Using metagenomic data to find novel enzymes for plastic degradation and beyond

2021

sciencescience-technology

6 September 2021 Cells organised according to their transcript data changing to the seqFISH mouse embryo map.

The Spatial Mouse Atlas: new insights into cell fate

Science & Technology Researchers have combined spatial gene expression information with single-cell genomics data to create a high-resolution atlas of mouse organogenesis.

2021

sciencescience-technology

5 July 2021

Welcome: Sarah Dyer

Lab MattersPeople & Perspectives EMBL welcomes Sarah Dyer, the new Non-Vertebrate Genomics Team Leader at EMBL-EBI.

2021

lab-matterspeople-perspectives

9 June 2021 R2DT software for RNA structures

Visualising RNA structures using R2DT

Science & Technology New software enables scientists to visualise RNA secondary structures using the world’s largest RNA structure dataset.

2021

sciencescience-technology

31 May 2021 Collage showing injection needle, coronavirus and vaccine vials

Genomic surveillance of SARS-CoV-2 in England

Science & Technology The largest in-depth analysis of genomic surveillance data mapping out the dynamics of 62 lineages of the SARS-CoV-2 virus.

2021

sciencescience-technology

8 April 2021 Genetics of ageing

Linking genetics and age-related diseases

Science & Technology Researchers have used human medical and genetic data from UK Biobank to investigate the genetics of age-related diseases

2021

sciencescience-technology

7 April 2021 Man standing next to painting

Welcome: Matthew Hartley

Lab MattersPeople & Perspectives The challenges and opportunities when setting up a global archive for bioimages

2021

lab-matterspeople-perspectives

18 February 2021 Phages invading gut bacteria.

The thousands of viruses living in your gut

Science & Technology Scientists identify more than 140 000 virus species in the human gut; more than half have never been seen before

2021

sciencescience-technology

22 December 2020 Eulalia clavigera. Photo credit: Marine Biological Association

Darwin Tree of Life: looking back on 2020

Science & Technology Despite restrictions, 2020 has been a busy year for the Darwin Tree of Life Project. We take a look at some of this year’s achievements and highlights.

2020

sciencescience-technology

4 December 2020 Haemoglobin protein structure shown over a matrix symbolising artificial intelligence

Solving the protein structure puzzle

Science & Technology How artificial intelligence can help us solve the mysteries of the protein universe

2020

sciencescience-technology

23 October 2020 Futuristic image of deep learning schema superimposed on computer code

Bringing AI out of the black box

Lab MattersScience & Technology Why should researchers make artificial intelligence more transparent and how can they do it?

2020

lab-mattersscience-technology

22 October 2020 An artistic image of colorful wires connected to a could database.

EOSC: shaping Europe’s digital future

ConnectionsLab Matters EMBL’s Rupert Lück is engaged in developing the European Open Science Cloud (EOSC): the infrastructure that will support the future of data sharing and analysis in Europe.

2020

connectionslab-matters

15 October 2020 Four blue circular objects are surrounded with green structures, and the central blue circle with pink structures. The blue circles are human cell nuclei, and pink and green structures are proteins.

Repurposing drugs for a pan-coronavirus treatment

Science & Technology Scientists from the Beltrao Group at EMBL-EBI and collaborators identified drug targets common to SARS-CoV-2, SARS-CoV-1, and MERS-CoV, three pathogenic coronaviruses. They also found potential drugs that could be repurposed as COVID-19 treatments, and against emerging coronavirus strains in the…

2020

sciencescience-technology

8 September 2020 This image shows sections of the brain organoids that have been derived from pluripotent stem cells. The increasing use of organoids like this one be key to advancing personalised medicine.

Achieving personalised therapeutics

Lab MattersScience & Technology A decadal roadmap points the way to cell-based medicine for Europe

2020

lab-mattersscience-technology

7 September 2020 Human silhouette showing internal organs including oesophagus and stomach. Circle with DNA bases A,T, C and G superimposed.

Genome sequencing accelerates cancer detection

Science & Technology The Gerstung Group at EMBL-EBI and collaborators have developed a statistical model that analyses genomic data to predict whether a patient has a high or low risk of developing oesophageal cancer.

2020

sciencescience-technology

2 September 2020 Microscopy image of cerebral organoid cross section

An organoid cell atlas to enhance biomedical research

EMBL AnnouncementsLab Matters EMBL-EBI is one of the eight European institutes involved in the Humanoid Cell Atlas initiative, a new open-access platform that combines single-cell profiling and organoid technology

2020

embl-announcementslab-matters

20 August 2020 A portrait photo of Geetika Malhotra, new Head of Web Development at EMBL-EBI.

Welcome: Geetika Malhotra

Lab MattersPeople & Perspectives The Web Development team provides a central source of web design and development for EMBL’s European Bioinformatics Institute (EMBL-EBI). In July, Geetika Malhotra joined the team as their new Head.

2020

lab-matterspeople-perspectives

19 August 2020 A human heart sits at the centre of the illustration. The left ventricle is see-through, showing patterns of trabeculae. Around the heart are some notes from Leonardo da Vinci.

New clues to a 500-year old mystery about the human heart

Science & Technology An international team of scientists involving Ewan Birney's group has investigated the function of a complex mesh of muscle fibres that line the inner surface of the heart.

2020

sciencescience-technology

5 August 2020 The tuatara, an iguana-like reptile with a crest of spikes, sits on a forest floor.

The curious genome of the tuatara, an ancient reptile in peril

Science & Technology A global team of researchers including the Flicek Team at EMBL-EBI has partnered up with the Māori tribe Ngātiwai to sequence the genome of the tuatara, a rare reptile endemic to New Zealand.

2020

sciencescience-technology

3 August 2020 A woman with glasses holds a book. The book cover says "Gene naming rules". Thought bubbles float around her head and display gene symbols like BRCA1.

Bagpipe and Pokemon, or how not to name a human gene

Science & Technology The human genome harbours about 19 000 protein-coding genes, many of which still have no known function. As scientists unveil the secrets of our DNA, they come across novel genes that they need to refer to using a unique name. The Human Genome Organisation’s Gene Nomenclature Committee (HGNC) at…

2020

sciencescience-technology

27 July 2020 Mosaic of microscopy images of tumour, forming two broken DNA molecules

Artificial intelligence finds patterns of mutations and survival in tumour images

Science & Technology Researchers have developed an artificial intelligence algorithm that uses computer vision to analyse tissue samples from cancer patients. The algorithm can distinguish between healthy and cancerous tissues, and can also identify patterns DNA and RNA changes in tumours.

2020

sciencescience-technology

20 July 2020 A magnifying glass hovers over the human gut, revealing its biodiversity.

Unparalleled inventory of the human gut ecosystem

Science & Technology An international team of scientists has collated all known bacterial genomes from the human gut microbiome into a single large database. Their work will allow researchers to explore the links between bacterial genes and proteins, and their effects on human health.

2020

sciencescience-technology

8 July 2020 Alexander Aulehla on the left and Paul Flicek on the Right

Two EMBL scientists become EMBO Members

EMBL AnnouncementsLab Matters This year, EMBO elected 63 new members, including Alexander Aulehla, Group Leader and Senior Scientist at EMBL Heidelberg, and Paul Flicek, Associate Director of EMBL-EBI Services, Senior Scientist, Group and Team Leader at EMBL-EBI.

2020

embl-announcementslab-matters

1 July 2020 New Informatics Science Director at Open Targets, Ellie McDonagh

Welcome: Ellie McDonagh

Lab MattersPeople & Perspectives Open Targets welcomes new Informatics Science Director

2020

lab-matterspeople-perspectives

24 June 2020 Artist's impression of DNA lesions. Credit: Petra Korlevic

Unpicking the complexity of DNA mutations

Science & Technology DNA damage caused by chemical mutagens is not repaired immediately and can create more genetic diversity in tumours.

2020

sciencescience-technology

26 May 2020 Bioinformatic analysis of over 4700 SARS-CoV-2 genomes revealed that many of the most interesting changes in the SARS-CoV-2 genome that have been reported so far are likely to be technical artefacts, rather than biological mutations.

Distinguishing coronavirus genome mutations from inadvertent errors

Science & Technology EMBL scientists have performed a large-scale analysis of over 4700 SARS-CoV-2 genome sequences. They found that many of the most interesting changes in the SARS-CoV-2 genome that have been reported so far are likely to be technical artefacts, rather than biological mutations.

2020

sciencescience-technology

14 September 2011

Five countries and EMBL sign Memorandum of Understanding to make ELIXIR a reality

Lab Matters Today marks an important step for ELIXIR, Europe’s emerging research infrastructure for life-science information, as five countries plus the European Molecular Biology Laboratory (EMBL) have signed a Memorandum of Understanding to catalyse the implementation and construction of ELIXIR. The…

2011

lab-matters

31 May 2010 This microscopy image shows that, in a mouse embryo, MiR451 (dark purple) is produced only in the liver, where red blood cells are being formed at this developmental stage. Image credits: Kasper Rasmussen/EMBL

Making enough red blood cells

Science & Technology Red blood cells, the delivery men that take oxygen to cells all around the body, have short lives. To keep enough of them in circulation, the human body produces around 2 million of these cells every second – even more in response to challenges like severe blood loss. In a study published today…

2010

sciencescience-technology

8 April 2010 This image shows the 5,372 samples as dots colour-coded for the six major clusters identified by comparing gene expression profiles. The left and right panels of the figure are projections of the same three-dimensional shape viewed from two different perspectives. Image credit: Brazma / EMBL.

Variations on the genetic theme

Science & Technology Just like members of an orchestra are active at different times although playing the same piece of music, every cell in our body contains the same genetic sequence but expresses this differently to give rise to cells and tissues with specialised properties. By integrating gene expression data from…

2010

sciencescience-technology

18 January 2010

Open access drug discovery database launches with half a million compounds

Science & Technology ChEMBLdb, a vast online database of information on the properties and activities of drugs and drug-like small molecules and their targets, launches today with information on over half a million compounds. The data lie at the heart of translating information from the human genome into successful new…

2010

sciencescience-technology

25 January 2009

Re-write the textbooks: transcription is bidirectional

Science & Technology Genes that contain instructions for making proteins make up less than 2% of the human genome. Yet, for unknown reasons, most of our genome is transcribed into RNA. The same is true for many other organisms that are easier to study than humans. Researchers in the groups of Lars Steinmetz at the…

2009

sciencescience-technology

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