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EMBL Taxonomy:

Molecular Systems Biology

Year
4 December 2024

From snapshots to motion: watching biology in action

Science & Technology With a novel approach, EMBL scientists discovered important interactions between molecular machines, potentially offering new opportunities for drug development.

2024

science-technology

24 September 2024 Illustration showing several drugs being broken down when reaching a community of gut bacteria. This community has different types of bacteria.

Better together: gut microbiome communities’ resilience to drugs

Science & Technology EMBL Heidelberg researchers compared the effect of drugs on isolated bacteria versus those growing in communities. This is the first study showing that bacteria are more resilient when in community due to cross-protection strategies. This could help researchers design more efficient therapies.

2024

science-technology

28 September 2023 Visual of AlphaFold Protein prediction, embedded into a visual of scientific data

EMBL receives German AI prize

EMBL Announcements EMBL receives the German AI prize awarded for outstanding services to the research and development as well as application and commercialisation of artificial intelligence (AI) in life science research.

2023

embl-announcementsscience

23 March 2022 Two Drosophila embryos stained with fluorescent dye on a purple background that indicates either solid or liquid state

From liquid to solid to drive development

Science & Technology Condensates are membraneless organelles that control specific functions within a cell. Scientists at EMBL Heidelberg have shown how the physical state of condensates can influence biological function.

2022

sciencescience-technology

8 September 2021 Illustration of two halves of a pill, which releases chemical molecules that are taken up by gut bacteria in the vicinity.

Common medications accumulate in gut bacteria

Science & Technology A new collaborative study led by EMBL group leaders Kiran Patil, Nassos Typas, and Peer Bork has found that common medications accumulate in human gut bacteria. This process reduces drug effectiveness and affects the metabolism of common gut microbes, thereby altering the gut microbiome.

2021

sciencescience-technology

20 April 2021 Black-and-white sphere with coronavirus spike protein structures and a two-layered ring of virus membrane superimposed.

Variations on a spike

Science & Technology What does coronavirus’s spike protein look like in 3D? EMBL scientists and colleagues used cryo-electron tomography and molecular dynamics simulations to find out.

2021

picture-of-the-weekscience-technology

17 February 2021 Illustration of a pink capsule passing through a grey pore in a yellow membrane.

A new piece of the HIV infection puzzle explored

Science & Technology Researchers from EMBL and Heidelberg University Hospital combine high-resolution imaging to observe the infection process in cell nuclei, opening the door for new therapeutics.

2021

sciencescience-technology

3 September 2020 Left: Slice of a cell in grey. Right: Two 3D reconstructions of parts of the slice, showing the internal structure.

Nuclear pores in their natural context

Science & Technology Scientists from the Beck group have studied the 3D structure of nuclear pores in budding yeast. They show how the architecture of the nuclear pore complex differs inside cells compared to its form observed in vitro studies.

2020

sciencescience-technology

31 July 2020 This visual representation shows the newly identified architecture (left) of the coupled molecular machines responsible for transcription (green; DNA in magenta) and translation (blue and yellow), accompanied by the protein interaction network from mass spectrometry (centre) and the cryo-electron tomography data (right) from Mycoplasma pneumoniae that was used to model the structure. Credit: Liang Xue and Julia Mahamid/EMBL

Visualising the cell’s molecular machinery in action

Science & Technology A new approach that allows researchers to see molecular machinery at work inside cells has offered a deeper understanding of how bacteria produce proteins and a unique glimpse into how they respond to antibiotics.

2020

sciencescience-technology

11 March 2011

Small code change, big effect

Science & Technology Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have developed a new method which enables researchers to label any protein of their choice with any of a wide variety of previously available compounds, in living cells, by introducing a single reactive…

2011

sciencescience-technology

30 September 2009 In the centre, a structural model determined by X-ray crystallography shows how the two tags (attached to a short section of the histone protein – all in cyan) fit neatly into the Brdt pocket (purple). In the background image, hypercompaction by Brdt causes relatively diffuse chromatin (stained blue inside the nuclei of two cells on the top left) to compact and clump together (two on the bottom right).

Putting the squeeze on sperm DNA

Science & Technology In the quest for speed, olympic swimmers shave themselves or squeeze into high-tech super-suits. In the body, sperm are the only cells that swim and, as speed is crucial to fertility, have developed their own ways to become exceptionally streamlined. Scientists at the European Molecular Biology…

2009

sciencescience-technology

23 June 2009 Lattice maps for immature HIV particles. The 3D computer reconstruction shows the immature Gag lattice of HIV that matures to form the protein shell of the infecious virus. Maps are shown in perspective such that hexamers on the rear surface of the particle appear smaller. The side of the particle toward the viewer lacks ordered Gag. IMAGE: John Briggs/EMBL

New electron microscopy images reveal the assembly of HIV

Science & Technology Scientists at the European Molecular Biology Laboratory (EMBL) and the University Clinic Heidelberg, Germany, have produced a three-dimensional reconstruction of HIV (Human Immunodeficiency Virus), which shows the structure of the immature form of the virus at unprecedented detail. Immature HIV is…

2009

sciencescience-technology

9 June 2009 Reflect applied to a pubmed webpage. Protein names found in the text are highlighted in blue, chemicals in orange. Pop-up windows provide extra information on the biomolecules.

New EMBL service makes web browsing efficient for biologists

Science & Technology The life sciences are scaling up and produce huge amounts of data and new literature at an amazing pace. The European Molecular Biology Laboratory (EMBL) now offers a new free service to help researchers, teachers and students keep up-to-date with scientific literature on the web, especially when…

2009

sciencescience-technology

23 April 2009

New study reveals the protein that makes phosphate chains in yeast

Science & Technology It can be found in all life forms, and serves a multitude of purposes, from energy storage to stress response to bone calcification. This molecular jack-of-all trades is polyphosphate, a long chain of phosphate molecules. Researchers at the European Molecular Biology Laboratory (EMBL) in…

2009

sciencescience-technology

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