Postdoctoral Fellow - Bioinformatician/-statistician in cancer omics


Key information

  • Location: EMBL Heidelberg
  • Staff category: Postdoctoral Fellow - Science, research and training
  • Contract duration: 3 + 3 years. Funding is available for 6 years
  • Grading: NA
  • Closing date: 19 July 2020
  • Reference number: HD01760

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About this position

The research group of Wolfgang Huber (www.huber.embl.org) at EMBL works on biological data science and mathematical / computational method development. The interdisciplinary and international team uses statistical data analysis and modelling to discover and understand biological principles and biomedical applications and collaborates with researchers in basic biology and cancer research.

About the project SMART-CARE
The SMART-CARE consortium is a collaboration between EMBL, the German Cancer Research Centre, the University Hospital Heidelberg, Heidelberg University and Mannheim University of Applied Sciences. It aims to develop new systems medicine approaches to battle cancer recurrence, using the integration of proteome and metabolome mass spectrometry approaches with other ‘omics and clinical data. The consortium brings together clinical, mass spectrometry and computational expertise.
Cancer recurrence is the main determinant of cancer related death and a major global health problem. The surge of genomic technologies in clinical research has brought great benefits in disease stratification, yet genetic information alone is rarely sufficient to accurately identify the dynamic process of disease progression. Systematic analyses of proteins and metabolites using mass spectrometry in combination with statistical data analysis and mathematical modelling promise a new generation of disease stratifications and biomarkers that could be used to tailor precision cancer therapies. To this end, there is a need to develop and establish powerful and standardizable methods for proteome and metabolome analysis. The aim of the SMART-CARE project is to establish mass spectrometry-based systems medicine technologies and data analysis methods in the clinical setting.

Your role

You will be part of the Huber group at EMBL Heidelberg and participate in the SMART-CARE project. The primary goal of the position is to evaluate proteomic, metabolomic and other ‘omic data types in terms of their ability to explain patient and disease heterogeneity, and to predict tumor recurrence and treatment response. You will have the opportunity to shape your own research profile by pursuing research in method development and collaborative analysis of novel datasets. Your activities will comprise:
- Advanced statistical inference and biological model building; Use, adapt, or further develop methods for data integration (incl. Multi Omics Factor Analysis, MOFA) and statistical learning.
- Find and establish optimal approaches for data-type specific preprocessing and feature engineering.
- Perform and automate data quality control and visualization.
- Publish computational methods and biological discoveries in scientific articles, and publish scientific software as, e.g., R/Bioconductor packages.

You have

A PhD or equivalent qualification in quantitative sciences (mathematics, physics, quantitative biology and related fields).

You are interested in data science, statistics, scientific computing, and cancer. You are able to assess, adapt or further develop computational methods and wish to make or contribute to biological discoveries. You are interested in interdisciplinary science, enjoy collaborative work and like to communicate concepts and results to other scientists in different fields of research. You are excited by pushing science forward with your own ideas.

You might also have

Why join us

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits. EMBL is an international research organisation with a collegial and family friendly working environment. Its interdisciplinary and international workforce is bubbling with ideas. The remuneration package comprises a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits. You will be included in the well-established EMBL postdoctoral programme. A child care facility is available on campus.

What else you need to know

EMBL is Europe’s flagship research laboratory for the life sciences, performing research in molecular biology, physics, chemistry and computer science. Its 1753 employees, Postdoc and PhD fellows work from six sites: Barcelona, Cambridge, Hamburg, Heidelberg, Grenoble and Rome. EMBL’s mission includes offering vital services in training scientists, students and visitors at all levels; developing new instruments and methods in the life sciences; promoting technology transfer, and integrating European life science research.
Heidelberg is one of the hubs of life science research in Europe, with a major university hospital and of the largest cancer research centres in the world that are also part of the SMART-CARE consortium.

Please apply through www.embl.org/jobs
If you have any questions, please contact Wolfgang Huber (wolfgang.huber@embl.org).


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