{"id":58,"date":"2019-11-05T14:51:09","date_gmt":"2019-11-05T14:51:09","guid":{"rendered":"https:\/\/www.embl.org\/groups\/steinmetz\/?page_id=58"},"modified":"2022-05-13T10:56:23","modified_gmt":"2022-05-13T10:56:23","slug":"research-highlights","status":"publish","type":"page","link":"https:\/\/www.embl.org\/groups\/steinmetz\/research-highlights\/","title":{"rendered":"Research highlights"},"content":{"rendered":"\n
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Select Publications:<\/strong><\/p>\n\n\n\n

Article:<\/td>Transcriptional neighborhoods regulate transcript isoform lengths and expression levels. Brooks A*, Hughes A*, Clauder-Muenster S, Mitchell L, Boeke J, Steinmetz LM<\/span>#<\/sup>. Science<\/em><\/strong> <\/em>(2022).
DOI<\/a> | Free-access Link<\/a><\/td><\/tr>
Article:<\/td>High-speed fluorescence image-enabled cell sorting. Schraivogel D, Kuhn TM, Rauscher B, Rodr\u00edguez-Mart\u00ednez M, Paulsen M, Owsley K, Middlebrook A, Tischer C, Ramasz B, Ordo\u00f1ez-Rueda D, Dees M, Cuylen-Haering S#<\/sup>, Diebold E#<\/sup>, Steinmetz LM<\/span>#<\/sup>. Science<\/em><\/strong> (2022).
DOI<\/a> | Free-access Link<\/a><\/td><\/tr>
Article: <\/td>Single-molecule, full-length transcript isoform sequencing reveals disease-associated RNA isoforms in cardiomyocytes. Zhu C*, Wu J*, Sun H, Briganti F, Meder B, Wei W, Steinmetz LM<\/span>. Nature Communications<\/em><\/strong> (2021).
DOI<\/a> <\/td><\/tr>
Article:<\/td>Targeted Perturb-seq enables genome-scale genetic screens in single cells.
Schraivogel D*, Gschwind AR*, Milbank JH, Leonce DR, Jakob P, Mathur L, Korbel JO, Merten CA, Velten L, Steinmetz LM<\/span>. Nature methods<\/strong><\/em> (2020).
DOI<\/a> | PubMed<\/a><\/td><\/tr>
Article: <\/td>Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization. Baccin C*, Al-Sabah J*, Velten L*, Helbling PM, Gr\u00fcnschl\u00e4ger F, Hern\u00e1ndez-Malmierca P, Nombela-Arrieta C, Steinmetz LM,<\/span> Trumpp A, Haas S. Nature cell biology<\/em><\/strong> (2019).
DOI<\/a> | PubMed<\/a><\/td><\/tr>
Article:


<\/td>		Zuo E*, Sun Y*, Wei W*, Yuan T*, Ying W, Sun H, Yuan L, Steinmetz LM<\/span>, Li Y, Yang H. Cytosine base editor generates substantial off-target single nucleotide variants in mouse embryos. Science. <\/em><\/strong>(2019).
DOI <\/a>| PubMed<\/a><\/td><\/tr>
Article: <\/td>Roy KR*, Smith JD*, Vonesch SC*, Lin G, Tu CS, Lederer AR, Chu A, Suresh S, Nguyen M, Horecka J, Tripathi A, Burnett WT, Morgan MA, Schulz J, Orsley KM, Wei W, Aiyar RS, Davis RW, Bankaitis VA, Haber JE, Salit ML, St Onge RP, Steinmetz LM<\/span>. Multiplexed precision genome editing with trackable genomic barcodes in yeast. Nature Biotechnology<\/em><\/strong> (2018).
DOI<\/a> | PubMed<\/a><\/td><\/tr>
Article:<\/td>Velten L*, Haas SF*, Raffel S*, Blaszkiewicz S, Islam S, Hennig BP, Hirche C, Lutz C, Buss EC, Nowak D, Boch T, Hofmann WK, Ho AD, Huber W, Trumpp A, Essers MAG, Steinmetz LM<\/span>. Human haematopoietic stem cell lineage commitment is a continuous process. Nat Cell Biol.<\/em><\/strong> (2017).
<\/a>DOI<\/a> | PubMed<\/a> <\/td><\/tr>
Article:<\/td>Pelechano V*, Wei W*, Steinmetz LM<\/span>. Widespread co-translational RNA decay reveals ribosome dynamics. Cell. <\/em><\/strong>(2015).
DOI<\/a> <\/a>| PubMed<\/a><\/td><\/tr>
Article: <\/td>Pelechano V*, Wei W*, Steinmetz LM<\/span>. Extensive transcriptional heterogeneity revealed by isoform profiling. Nature.<\/em><\/strong> (2013).
DOI<\/a> | PubMed<\/a> <\/td><\/tr>
Article:<\/td>Xu Z*, Wei W*, Gagneur J, Perocchi F, Clauder-M\u00fcnster S, Camblong J, Guffanti E, Stutz F, Huber W, Steinmetz LM. Bidirectional promoters generate pervasive transcription in yeast. Nature.<\/em><\/strong> (2009).
DOI<\/a> | PubMed<\/a> <\/td><\/tr>
Article:<\/td>Steinmetz LM*<\/span>, Scharfe C*, Deutschbauer AM, Mokranjac D, Herman ZS, Jones T, Chu AM, Giaever G, Prokisch H, Oefner PJ, Davis RW. Systematic screen for human disease genes in yeast. Nature Genet.<\/em><\/strong> (2002).
DOI<\/a> | PubMed<\/a><\/td><\/tr>
Article: <\/td>Steinmetz LM<\/span>*, Sinha H, Richards DR, Spiegelman JI, Oefner PJ, McCusker JH, Davis RW. Dissecting the architecture of a quantitative trait locus in yeast. Nature.<\/em><\/strong> (2002).
DOI<\/a> | PubMed<\/a> <\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
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Features on Steinmetz Lab Research:<\/h4>\n\n\n\n

See here<\/a> for the full collection of EMBL news articles on our work<\/p>\n\n\n\n

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\"Cover<\/a>
Image Credit: illustratoren.de\/TobiasWuestefeld<\/figcaption><\/figure>\n\n<\/div>\n<\/div>\n\n\n
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Image credit: illustratoren.de\/TobiasWuestefeld. Cover design: Erin Dewalt.<\/figcaption><\/figure>\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n
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\"Nature<\/a>
Image: illustratoren.de\/TobiasWuestefeld.
Cover Design: Lauren Heslop.<\/figcaption><\/figure>\n\n<\/div>\n<\/div>\n\n\n
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\"Nature<\/a>
Image credit: illustratoren.de\/TobiasWuestefeld<\/figcaption><\/figure>\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n
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\"G3<\/a>
Image: Aleksandra Krolik (EMBL)<\/figcaption><\/figure>\n\n<\/div>\n<\/div>\n\n\n
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\"Genome<\/a>
Image: Sophia Genetics<\/figcaption><\/figure>\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n
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\"G3<\/a>
Image: Petra Riedinger, Paul Theodor Pyl & Jonathan Landry<\/figcaption><\/figure>\n\n<\/div>\n<\/div>\n\n\n
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\"\"<\/a>
Image: Hubert Becker<\/figcaption><\/figure>\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n
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Image: Petra Riedinger & Stefan Wilkening<\/figcaption><\/figure>\n\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n
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