The SAXS team at EMBL has been continuously developing advanced methods for the analysis of the SAXS\/SANS data on biological macromolecules in solutions. Together with ATSAS software suite, a number of web-services and software solutions exists.<\/p>\n\n\n\n
ATSAS<\/a> is a comprehensive program suite for small-angle scattering data analysis of biological macromolecules. Developed over decades at EMBL Hamburg, it supports workflows ranging from experimental data processing and primary analysis to ab initio<\/em> reconstruction, rigid body modeling, flexibility analysis and the comparison and refinement of atomic models against SAXS data.<\/p>\n\n\n\n EMBL Hamburg continues to distribute the ATSAS 3.2 series and to operate ATSAS online<\/a>, which provides access to computationally demanding applications such as CORAL, SASREF, EOM, SREFLEX, DAMMIN\/DAMMIF. Since version 4, the development and distribution of ATSAS<\/a> have been carried out by BioSAXS GmbH.<\/p>\n\n\n\n The Blanchet team continues to develop SAXS data-analysis methods and provides P12 users with support for data processing, structural analysis and interpretation.<\/p>\n\n\n\n The team also maintains pyATSAS<\/a>, a Python package providing lightweight interfaces to locally installed ATSAS command-line programs and utilities for preparing their input files. It enables ATSAS applications to be incorporated into scripts, automated analysis, and custom Python workflows.<\/p>\n\n\n\n SASBDB<\/a>, the Small Angle Scattering Biological DataBank, is an open, curated repository of freely accessible SAXS and SANS experimental data, associated models and fits. It contains several thousand datasets and structural models. SAXS users and structural biologists are encouraged to deposit their data and models to SASBDB to allow convenient access during manuscript review and post-publishing stages.<\/p>\n\n\n\n DARA<\/a>, a DAtabase fo RApid search of structural neighbours using SAXS data operates as a web server at EMBL Hamburg. It compares an uploaded scattering profile with a large database of over 150 thousand pre-computed SAXS curves from PDB structures. The user can submit an experimental SAXS curve (.dat file), a GNOM output file (.out file, recommended), or an atomic model (.pdb file). DARA returns a ranked list of structural neighbours and the associated information.<\/p>\n\n\n\nSASBDB databank<\/h3>\n\n\n\n
DARA and GNNOM web-server<\/h3>\n\n\n\n