{"id":15,"date":"2020-09-24T14:42:43","date_gmt":"2020-09-24T14:42:43","guid":{"rendered":"https:\/\/www.embl.org\/groups\/sharpe\/home\/"},"modified":"2024-08-30T14:25:52","modified_gmt":"2024-08-30T14:25:52","slug":"home","status":"publish","type":"page","link":"https:\/\/www.embl.org\/groups\/sharpe\/","title":{"rendered":"Home"},"content":{"rendered":"
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The Sharpe group brings together an interdisciplinary team of biologists, physicists and computer scientists to build multi-scale computer simulations of a paradigm of organogenesis \u2013 mammalian limb development.<\/p>\r\n\n Edit<\/a>\n <\/div>\n <\/div>\n <\/div>\n
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\n James Sharpe<\/a>\n <\/h3>\n \n

\n Head of EMBL Barcelona\n <\/p>\n \n \n \n \n \n \n

\n ORCID:<\/span>\n \n 0000-0002-1434-9743\n <\/a>\n <\/p>\n \n Edit\n <\/a>\n <\/article>\n <\/div>\n\n <\/div>\n<\/div>\n\n\n\n

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Previous and current research<\/h3>\n\n\n\n

How do networks of genes control populations of cells to build organised tissues and organs? Organ development is a multi-scale process, in which molecular and cellular events control large-scale tissue movements, but these \u2018macroscopic\u2019 dynamics are equally important in feeding-back to regulate molecular events. A full understanding of how genes control organogenesis will thus require multi-scale computer modelling, and we have chosen vertebrate limb development as a model system to explore this problem.<\/p>\n\n\n\n

Such a model should be based on quantitative data about dynamic tissue shapes and spatial distributions of gene activities. Traditional high-throughput and \u2018omics\u2019 technologies do not preserve spatial information, and we have therefore been developing and pioneering various 3D mesoscopic imaging technologies to generate geometric and spatial data for the model.<\/p>\n\n\n\n

Our research thus falls primarily into two main areas:<\/p>\n\n\n\n