{"id":75,"date":"2026-05-26T15:17:53","date_gmt":"2026-05-26T15:17:53","guid":{"rendered":"https:\/\/www.embl.org\/groups\/osterman\/?page_id=75"},"modified":"2026-05-26T15:17:54","modified_gmt":"2026-05-26T15:17:54","slug":"publications","status":"publish","type":"page","link":"https:\/\/www.embl.org\/groups\/osterman\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n
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\n \n Phages reconstitute NAD+ to counter bacterial immunity <\/a>\n <\/h3>\n

Osterman I, Samra H, Rousset F, Loseva E, Itkin M, Malitsky S, Yirmiya E, Millman A, Sorek R.<\/p>\n

\n Nature 2024<\/span>\n <\/p>\n

doi:10.1038\/s41586-024-07986-w.<\/p>\n <\/article>\n\n\n

\n

\n \n Bacterial defense via RES-mediated NAD+ depletion is countered by phage phosphatases <\/a>\n <\/h3>\n

Osterman I, Hurieva B, Yirmiya E, Hochhauser D, Itkin M, Malitsky S, Sorek R<\/p>\n

\n bioRxiv 2026<\/span>\n <\/p>\n

doi:10.64898\/2026.01.28.702374.<\/p>\n <\/article>\n\n\n

\n

\n \n Bacteria sense virus-induced genome degradation via methylated mononucleotides <\/a>\n <\/h3>\n

Osterman I, Hurieve B, Moses S, Falkovich AH, Itkin M, Malitsky S, Yirmiya E, Sorek R.<\/p>\n

\n bioRxiv 2025<\/span>\n <\/p>\n

doi:10.1101\/2025.11.05.686725.<\/p>\n <\/article>\n\n\n

\n

\n \n Structural modeling reveals phage proteins that manipulate bacterial immune signaling <\/a>\n <\/h3>\n

Tal N, Hadary R, Chang RB, Osterman I, Jacobson R, Yirmiya E, Bechon N, Hochhauser D, L\u00f3pez Rivera M, Madhala B, Garb J, Goldsmith M, Wein T, Kranzusch PJ, Amitai G, Sorek R.<\/p>\n

\n Science 2026<\/span>\n <\/p>\n

doi:10.1126\/science.aea1761.<\/p>\n <\/article>\n\n\n

\n

\n \n TIR domains produce histidine-ADPR as an immune signal in bacteria <\/a>\n <\/h3>\n

Sabonis D, Avraham C, Chang RB, Lu A, Herbst E, Silanskas A, Vilutis D, Leavitt A, Yirmiya E, Toyoda HC, Ruksenaite A, Zaremba M, Osterman I, Amitai G, Kranzusch PJ, Sorek R, Tamulaitiene G.<\/p>\n

\n Nature 2025<\/span>\n <\/p>\n

doi:10.1038\/s41586-025-08930-2.<\/p>\n <\/article>\n\n\n

\n

\n \n TIR signaling activates caspase-like immunity in bacteria <\/a>\n <\/h3>\n

Rousset F, Osterman I, Scherf T, Falkovich AH, Leavitt A, Amitai G, Shir S, Malitsky S, Itkin M, Savidor A, Sorek R.<\/p>\n

\n Science 2025<\/span>\n <\/p>\n

doi:10.1126\/science.adu2262.<\/p>\n <\/article>\n\n\n

\n

\n \n Phage genome engineering with retrons <\/a>\n <\/h3>\n

Osterman I, Sorek R.<\/p>\n

\n Nat Biotechnol 2025<\/span>\n <\/p>\n

doi:10.1038\/s41587-024-02392-z.<\/p>\n <\/article>\n\n\n

\n

\n \n Tricking phages with a reverse move <\/a>\n <\/h3>\n

Osterman I, Sorek R.<\/p>\n

\n Science 2024<\/span>\n <\/p>\n

doi:10.1126\/science.ads3638.<\/p>\n <\/article>\n\n\n

\n

\n \n Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel <\/a>\n <\/h3>\n

Osterman IA, Wieland M, Maviza TP, Lashkevich KA, Lukianov DA, Komarova ES, Zakalyukina YV, Buschauer R, Shiriaev DI, Leyn SA, Zlamal JE, Biryukov MV, Skvortsov DA, Tashlitsky VN, Polshakov VI, Cheng J, Polikanov YS, Bogdanov AA, Osterman AL, Dmitriev SE, Beckmann R, Dontsova OA, Wilson DN, Sergiev PV.<\/p>\n

\n Nat Chem Biol 2020<\/span>\n <\/p>\n

doi:10.1038\/s41589-020-0578-x.<\/p>\n <\/article>\n\n\n

\n

\n \n Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel <\/a>\n <\/h3>\n

Metelev M, Osterman IA, Ghilarov D, Khabibullina NF, Yakimov A, Shabalin K, Utkina I, Travin DY, Komarova ES, Serebryakova M, Artamonova T, Khodorkovskii M, Konevega AL, Sergiev PV, Severinov K, Polikanov YS.<\/p>\n

\n Nat Chem Biol 2017<\/span>\n <\/p>\n

doi:10.1038\/nchembio.2462.<\/p>\n <\/article>\n\n\n

\n

\n \n Sorting Out Antibiotics' Mechanisms of Action: a Double Fluorescent Protein Reporter for High-Throughput Screening of Ribosome and DNA Biosynthesis Inhibitors <\/a>\n <\/h3>\n

Osterman IA, Komarova ES, Shiryaev DI, Korniltsev IA, Khven IM, Lukyanov DA, Tashlitsky VN, Serebryakova MV, Efremenkova OV, Ivanenkov YA, Bogdanov AA, Sergiev PV, Dontsova OA.<\/p>\n

\n Antimicrob Agents Chemother 2016<\/span>\n <\/p>\n

doi:10.1128\/aac.02117-16.<\/p>\n <\/article>\n\n\n

\n

\n \n Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome <\/a>\n <\/h3>\n

Polikanov YS, Osterman IA, Szal T, Tashlitsky VN, Serebryakova MV, Kusochek P, Bulkley D, Malanicheva IA, Efimenko TA, Efremenkova OV, Konevega AL, Shaw KJ, Bogdanov AA, Rodnina MV, Dontsova OA, Mankin AS, Steitz TA, Sergiev PV.<\/p>\n

\n Mol Cell 2014<\/span>\n <\/p>\n

doi:10.1016\/j.molcel.2014.09.020.<\/p>\n <\/article>\n\n<\/div>\n<\/div>\n\n\n

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