Publications

PMRT1, a Plasmodium-specific parasite plasma membrane transporter, is essential for asexual and sexual blood stage development.

Wichers JS, Mesén-Ramírez P, Fuchs G, Yu-Strzelczyk J, Stäcker J, von Thien H, Alder A, Henshall I, Liffner B, Nagel G, Löw C, Wilson D, Spielmann T, Gao S, Gilberger TW, Bachmann A, Strauss J

mBio 2022

35404116. doi:10.1128/mbio.00623-22.

Impact of distant peptide substrate residues on enzymatic activity of SlyD.

Pazicky S, Werle AA, Lei J, Löw C, Weininger U

Cellular and molecular life sciences : CMLS 2022

35184231. doi:10.1007/s00018-022-04179-4.

N-terminal phosphorylation regulates the activity of Glycogen Synthase Kinase 3 from Plasmodium falciparum.

Pazicky S, Alder A, Mertens H, Svergun DI, Gilberger T, Löw C

The Biochemical journal 2022

35023554. doi:10.1042/BCJ20210829.

Completing the family of human EH domains: solution structure of the internal EH domain of γ-synergin.

Kovermann M, Weininger U, Löw C

Protein science : a publication of the Protein Society 2021

34967068. doi:10.1002/pro.4269.

Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes.

Killer M, Wald J, Pieprzyk J, Marlovits TC, Löw C

Science advances 2021

34730990. doi:10.1126/sciadv.abk3259.

Deamidation drives molecular aging of the SARS-CoV-2 spike protein receptor-binding motif.

Lorenzo R, Defelipe LA, Aliperti L, Niebling S, Custódio TF, Löw C, Schwarz JJ, Remans K, Craig PO, Otero LH, Klinke S, García-Alai M, Sánchez IE, Alonso LG

The Journal of biological chemistry 2021

34499924. doi:10.1016/j.jbc.2021.101175.

Molecular basis of mRNA transport by a kinesin-1-atypical tropomyosin complex.

Dimitrova-Paternoga L, Jagtap PKA, Cyrklaff A, Vaishali, Lapouge K, Sehr P, Perez K, Heber S, Löw C, Hennig J, Ephrussi A

Genes & development 2021

34140355. doi:10.1101/gad.348443.121.

Single-molecule FRET of membrane transport proteins.

Bartels K, Lasitza-Male T, Hofmann H, Löw C

Chembiochem : a European journal of chemical biology 2021

33945656. doi:10.1002/cbic.202100106.

Identification of novel inner membrane complex and apical annuli proteins of the malaria parasite Plasmodium falciparum.

Wichers JS, Wunderlich J, Heincke D, Pazicky S, Strauss J, Schmitt M, Kimmel J, Wilcke L, Scharf S, von Thien H, Burda PC, Spielmann T, Löw C, Filarsky M, Bachmann A, Gilberger TW

Cellular microbiology 2021

33830607. doi:10.1111/cmi.13341.

Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2.

Custódio TF, Das H, Sheward DJ, Hanke L, Pazicky S, Pieprzyk J, Sorgenfrei M, Schroer MA, Gruzinov AY, Jeffries CM, Graewert MA, Svergun DI, Dobrev N, Remans K, Seeger MA, McInerney GM, Murrell B, Hällberg BM, Löw C

Nature communications 2020

33149112. doi:10.1038/s41467-020-19204-y.

In-depth interrogation of protein thermal unfolding data with MoltenProt.

Kotov V, Mlynek G, Vesper O, Pletzer M, Wald J, Teixeira-Duarte CM, Celia H, Garcia-Alai M, Nussberger S, Buchanan SK, Morais-Cabral JH, Loew C, Djinovic-Carugo K, Marlovits TC

Protein science : a publication of the Protein Society 2020

33140490. doi:10.1002/pro.3986.

Structural role of essential light chains in the apicomplexan glideosome.

Pazicky S, Dhamotharan K, Kaszuba K, Mertens HDT, Gilberger T, Svergun D, Kosinski J, Weininger U, Löw C

Communications biology 2020

33051581. doi:10.1038/s42003-020-01283-8.

Characterization of the complex of the lysosomal membrane transporter MFSD1 and its accessory subunit GLMP.

López DM, Kählau L, Jungnickel KEJ, Löw C, Damme M

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020

32959924. doi:10.1096/fj.202000912RR.

Membrane chemistry tunes the structure of a peptide transporter.

Lasitza-Male T, Bartels K, Jungwirth J, Wiggers F, Rosenblum G, Hofmann H, Löw C

Angewandte Chemie (International ed. in English) 2020

32744783. doi:10.1002/anie.202008226.

Structural insights into PfARO and characterization of its interaction with PfAIP.

Geiger M, Brown C, Wichers JS, Strauss J, Lill A, Thuenauer R, Liffner B, Wilcke L, Lemcke S, Heincke D, Pazicky S, Bachmann A, Löw C, Wilson D, Filarsky M, Zhang K, Burda PC, Gilberger TW, Junop M

Journal of molecular biology 2019

31877322. doi:10.1016/j.jmb.2019.12.024.

Dissecting the gene expression, localization, membrane topology, and function of the Plasmodium falciparum STEVOR protein family.

Wichers JS, Scholz JAM, Strauss J, Witt S, Lill A, Ehnold LI, Neupert N, Liffner B, Lühken R, Petter M, Lorenzen S, Wilson DW, Löw C, Lavazec C, Bruchhaus I, Gilberger TW, Tannich E, Bachmann A

mBio 2019

31363031. doi:10.1128/mBio.01500-19.

High-throughput stability screening for detergent-solubilized membrane proteins.

Kotov V, Bartels K, Veith K, Josts I, Subhramanyam UKT, Günther C, Labahn J, Marlovits TC, Moraes I, Tidow H, Löw C, Garcia-Alai MM

Scientific reports 2019

31316088. doi:10.1038/s41598-019-46686-8.

Structure of prototypic peptide transporter DtpA from E. coli in complex with valganciclovir provides insights into drug binding of human PepT1.

Ural-Blimke Y, Flayhan A, Strauss J, Rantos V, Bartels K, Nielsen R, Pardon E, Steyaert J, Kosinski J, Quistgaard EM, Low C

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2019

30644743. doi:10.1021/jacs.8b11343.

Probing the architecture of a multi-PDZ domain protein: structure of PDZK1 in solution.

Hajizadeh N, Pieprzyk J, Skopintsev P, Flayhan A, Svergun DI, Loew C

2018

30220543. doi:10.1016/j.str.2018.07.016.

Tripeptide binding in a Proton-Dependent Oligopeptide Transporter.

Martinez Molledo M, Quistgaard EM, Löw C

FEBS letters 2018

30194725. doi:10.1002/1873-3468.13246.

Transient Expression of Recombinant Membrane-eGFP Fusion Proteins in HEK293 Cells.

Pieprzyk J, Pazicky S, Löw C

Methods in molecular biology (Clifton, N.J.) 2018

30242677. doi:10.1007/978-1-4939-8730-6_2.

Multispecific Substrate Recognition in a Proton-Dependent Oligopeptide Transporter

Martinez Molledo M, Quistgaard EM, Flayhan A, Pieprzyk J, Löw C

2018

29429879. doi:10.1016/j.str.2018.01.005.

Saposin Lipid Nanoparticles: A Highly Versatile and Modular Tool for Membrane Protein Research.

Flayhan A, Mertens HDT, Ural-Blimke Y, Martinez Molledo M, Svergun DI, Löw C

Structure (London, England : 1993) 2018

29413323. doi:10.1016/j.str.2018.01.007.

Lipid-like Peptides can Stabilize Integral Membrane Proteins for Biophysical and Structural Studies.

Veith K, Martinez Molledo M, Almeida Hernandez Y, Josts I, Nitsche J, Löw C, Tidow H

Chembiochem : a European journal of chemical biology 2017

28603929. doi:10.1002/cbic.201700235.

Structure determination of a major facilitator peptide transporter: Inward facing PepTSt from Streptococcus thermophilus crystallized in space group P3121.

Quistgaard EM, Martinez Molledo M, Löw C

PloS one 2017

28264013. doi:10.1371/journal.pone.0173126.

Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD

Quistgaard EM, Weininger U, Ural-Blimke Y, Modig K, Nordlund P, Akke M, Low C

BMC BIOLOGY 2016

27664121. doi:10.1186/s12915-016-0300-3.

A saposin-lipoprotein nanoparticle system for membrane proteins.

Frauenfeld J, Löving R, Armache JP, Sonnen AF, Guettou F, Moberg P, Zhu L, Jegerschöld C, Flayhan A, Briggs JA, Garoff H, Löw C, Cheng Y, Nordlund P

Nature methods 2016

26950744. doi:10.1038/nmeth.3801.

Understanding transport by the major facilitator superfamily (MFS): structures pave the way.

Quistgaard EM, Löw C, Guettou F, Nordlund P

Nature reviews. Molecular cell biology 2016

26758938. doi:10.1038/nrm.2015.25.

Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2.

Guettou F, Quistgaard EM, Raba M, Moberg P, Löw C, Nordlund P

Nature structural & molecular biology 2014

25064511. doi:10.1038/nsmb.2860.

Structural and Biochemical Characterization of Human PR70 in Isolation and in Complex with the Scaffolding Subunit of Protein Phosphatase 2A

Dovega R, Tsutakawa S, Quistgaard EM, Anandapadamanaban M, Löw C, Nordlund P

PloS one 2014

25007185. doi:10.1371/journal.pone.0101846.

Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A

Löw C, Quistgaard EM, Kovermann M, Anandapadamanaban M, Balbach J, Nordlund P

Biological chemistry 2014

25003389. doi:10.1515/hsz-2014-0106.

Metal-mediated crystallization of the xylose transporter XylE from Escherichia coli in three different crystal forms

Quistgaard EM, Löw C, Moberg P, Nordlund P

Journal of structural biology 2013

24060988. doi:10.1016/j.jsb.2013.09.009.

Structural insights into substrate recognition in proton-dependent oligopeptide transporters

Guettou F, Quistgaard EM, Trésaugues L, Moberg P, Jegerschöld C, Zhu L, Jong AJ, Nordlund P, Löw C

EMBO reports 2013

23867627. doi:10.1038/embor.2013.107.

Structural and biophysical characterization of the cytoplasmic domains of human BAP29 and BAP31

Quistgaard EM, Löw C, Moberg P, Guettou F, Maddi K, Nordlund P

PloS one 2013

23967155. doi:10.1371/journal.pone.0071111.

Slow aromatic ring flips detected despite near-degenerate NMR frequencies of the exchanging nuclei

Weininger U, Respondek M, Löw C, Akke M

The journal of physical chemistry. B 2013

23859599. doi:10.1021/jp4058065.

High-throughput analytical gel filtration screening of integral membrane proteins for structural studies

Löw C, Moberg P, Quistgaard EM, Hedrén M, Guettou F, Frauenfeld J, Haneskog L, Nordlund P

Biochimica et biophysica acta 2013

23403133. doi:10.1016/j.bbagen.2013.02.001.

Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters

Quistgaard EM, Löw C, Moberg P, Trésaugues L, Nordlund P

Nature structural & molecular biology 2013

23624861. doi:10.1038/nsmb.2569.

Rapid screening of integral membrane proteins – detergents suitable for structure determination

Guettou F, Löw C, Quistgard E, Hedrén M, Frauenfeld J, Nordlund P, Haneskog L, Moberg P

2013

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Nanobody mediated crystallization of an archeal mechanosensitive channel

Löw C, Yau YH, Pardon E, Jegerschöld C, Wåhlin L, Quistgaard EM, Moberg P, Geifman-Shochat S, Steyaert J, Nordlund P

PloS one 2013

24205053. doi:10.1371/journal.pone.0077984.

High-resolution insights into binding of unfolded polypeptides by the PPIase chaperone SlpA

Quistgaard EM, Nordlund P, Löw C

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012

22735173. doi:10.1096/fj.12-208397.

Metallochaperone SlyD

Löw C, Stubbs MT, Haupt C, Balbach J

2012

doi:10.1002/9781119951438.eibc2061.

Optimisation of over-expression in E. coli and biophysical characterisation of human membrane protein synaptogyrin 1

Löw C, Jegerschöld C, Kovermann M, Moberg P, Nordlund P

PloS one 2012

22675529. doi:10.1371/journal.pone.0038244.

Escherichia coli peptide binding protein OppA has a preference for positively charged peptides

Klepsch MM, Kovermann M, Löw C, Balbach J, Permentier HP, Fusetti F, de Gier JW, Slotboom DJ, Berntsson RP

Journal of molecular biology 2011

21983341. doi:10.1016/j.jmb.2011.09.043.

Conformational plasticity and dynamics in the generic protein folding catalyst SlyD unraveled by single-molecule FRET

Kahra D, Kovermann M, Löw C, Hirschfeld V, Haupt C, Balbach J, Hübner CG

Journal of molecular biology 2011

21596048. doi:10.1016/j.jmb.2011.05.002.

NMR relaxation unravels interdomain crosstalk of the two domain prolyl isomerase and chaperone SlyD

Kovermann M, Zierold R, Haupt C, Löw C, Balbach J

Biochimica et biophysica acta 2011

21466862. doi:10.1016/j.bbapap.2011.03.016.

Stability of membrane proteins analyzed by gel filtration

Moberg P, Burstedt M, Nordlund P, Haneskog L, Löw C

2011

doi:.

Rapid buffer scouting and quality control of integral membrane proteins

Löw C, Hedrén M, Nordlund P, Haneskog L, Moberg P

2011

doi:.

Structural studies of the human tetraspan vesicle membrane proteins

Loew C, Nordlund P

FEBS JOURNAL 2010

doi:.

Crystal structure determination and functional characterization of the metallochaperone SlyD from Thermus thermophilus

Löw C, Neumann P, Tidow H, Weininger U, Haupt C, Friedrich-Epler B, Scholz C, Stubbs MT, Balbach J

Journal of molecular biology 2010

20230833. doi:10.1016/j.jmb.2010.03.014.

Energy Landscapes of Protein Folding: From Structure to Function

Löw C

2009

doi:.

Structure-based stability analysis of an extremely stable dimeric DNA binding protein from Sulfolobus islandicus

Weininger U, Zeeb M, Neumann P, Löw C, Stubbs MT, Lipps G, Balbach J

Biochemistry 2009

19788170. doi:10.1021/bi900760n.

The folding pathway of onconase is directed by a conserved intermediate

Schulenburg C, Löw C, Weininger U, Mrestani-Klaus C, Hofmann H, Balbach J, Ulbrich-Hofmann R, Arnold U

Biochemistry 2009

19655705. doi:10.1021/bi900596j.

Fast amide proton exchange reveals close relation between native-state dynamics and unfolding kinetics

Hofmann H, Weininger U, Löw C, Golbik RP, Balbach J, Ulbrich-Hofmann R

Journal of the American Chemical Society 2009

19061322. doi:10.1021/ja8048942.

Conformational switch upon phosphorylation: human CDK inhibitor p19INK4d between the native and partially folded state

Löw C, Homeyer N, Weininger U, Sticht H, Balbach J

ACS chemical biology 2009

19063602. doi:10.1021/cb800219m.

Structure and dynamics of helix-0 of the N-BAR domain in lipid micelles and bilayers

Löw C, Weininger U, Lee H, Schweimer K, Neundorf I, Beck-Sickinger AG, Pastor RW, Balbach J

Biophysical journal 2008

18658220. doi:10.1529/biophysj.108.134155.

Structural insights into an equilibrium folding intermediate of an archaeal ankyrin repeat protein

Löw C, Weininger U, Neumann P, Klepsch M, Lilie H, Stubbs MT, Balbach J

Proceedings of the National Academy of Sciences of the United States of America 2008

18305166. doi:10.1073/pnas.0710657105.

Identification of three phases in Onconase refolding

Schulenburg C, Martinez-Senac MM, Löw C, Golbik R, Ulbrich-Hofmann R, Arnold U

The FEBS journal 2007

17944937. doi:10.1111/j.1742-4658.2007.06106.x.

Folding mechanism of an ankyrin repeat protein: scaffold and active site formation of human CDK inhibitor p19(INK4d)

Löw C, Weininger U, Zeeb M, Zhang W, Laue ED, Schmid FX, Balbach J

Journal of molecular biology 2007

17804013. doi:10.1016/j.jmb.2007.07.063.

Recognition of T-rich single-stranded DNA by the cold shock protein Bs-CspB in solution

Zeeb M, Max KE, Weininger U, Löw C, Sticht H, Balbach J

Nucleic acids research 2006

16956971. doi:10.1093/nar/gkl376.