{"id":4308,"date":"2022-12-08T16:01:20","date_gmt":"2022-12-08T16:01:20","guid":{"rendered":"https:\/\/www.embl.org\/groups\/hentze\/?page_id=4308"},"modified":"2022-12-09T05:44:39","modified_gmt":"2022-12-09T05:44:39","slug":"about-us","status":"publish","type":"page","link":"https:\/\/www.embl.org\/groups\/hentze\/about-us\/","title":{"rendered":"About Us"},"content":{"rendered":"\n<figure class=\"vf-figure wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"564\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/groups\/hentze\/wp-content\/uploads\/2022\/12\/HentzeGroup_2021_small.jpg\" alt=\"Hentze Lab 2021\" class=\"wp-image-4296\" srcset=\"https:\/\/www.embl.org\/groups\/hentze\/wp-content\/uploads\/2022\/12\/HentzeGroup_2021_small.jpg 1024w, https:\/\/www.embl.org\/groups\/hentze\/wp-content\/uploads\/2022\/12\/HentzeGroup_2021_small-300x165.jpg 300w, https:\/\/www.embl.org\/groups\/hentze\/wp-content\/uploads\/2022\/12\/HentzeGroup_2021_small-768x423.jpg 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p>Our group joined the EMBL in 1989. At the time, cytoplasmic gene regulation by RNA-binding proteins was quite a peripheral entity in gene regulation. This has now changed profoundly. Our major focus is on unraveling the roles of RNA-binding proteins, especially RNA-binding enzymes and their importance in connecting gene regulation and metabolism. This explores novel mechanisms of <strong>riboregulation<\/strong>, where the enzymatic activity is regulated through binding of RNA to the protein.<\/p>\n\n\n\n<p>The model systems that we examine range from yeast and mammalian cell lines to transgenic and knockout mice. We combine systems level approaches with detailed mechanistic and biochemical analyses.<\/p>\n\n\n\n<p>\u201cMolecular Medicine\u201d represents the other central interest of our work. Our primary orientation is to elucidate disease mechanisms as a starting point for insight-based clinical interventions. Specifically, we are interested in diseases of iron metabolism. Furthermore, we work on nonsense-mediated decay (NMD), which is important in many genetic diseases and serves to degrade mRNAs with mutations leading to premature translation termination codons. We closely cooperate with the \u201c<a href=\"http:\/\/www.embl.de\/research\/partnerships\/mmpu\/index.html\">Molecular Medicine Partnership Unit<\/a>&nbsp;(MMPU)\u201d, an innovative and interdisciplinary unit that is jointly run by the University of Heidelberg and the EMBL. The MMPU is co-directed by Andreas Kulozik (Heidelberg University) and Matthias Hentze (EMBL).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our group joined the EMBL in 1989. At the time, cytoplasmic gene regulation by RNA-binding proteins was quite a peripheral entity in gene regulation. This has now changed profoundly. Our major focus is on unraveling the roles of RNA-binding proteins, especially RNA-binding enzymes and their&hellip;<\/p>\n","protected":false},"author":5,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"embl_taxonomy":[],"class_list":["post-4308","page","type-page","status-publish","hentry"],"acf":[],"embl_taxonomy_terms":[],"_links":{"self":[{"href":"https:\/\/www.embl.org\/groups\/hentze\/wp-json\/wp\/v2\/pages\/4308","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/groups\/hentze\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.embl.org\/groups\/hentze\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/groups\/hentze\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/groups\/hentze\/wp-json\/wp\/v2\/comments?post=4308"}],"version-history":[{"count":3,"href":"https:\/\/www.embl.org\/groups\/hentze\/wp-json\/wp\/v2\/pages\/4308\/revisions"}],"predecessor-version":[{"id":4330,"href":"https:\/\/www.embl.org\/groups\/hentze\/wp-json\/wp\/v2\/pages\/4308\/revisions\/4330"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/groups\/hentze\/wp-json\/wp\/v2\/media?parent=4308"}],"wp:term":[{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/groups\/hentze\/wp-json\/wp\/v2\/embl_taxonomy?post=4308"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}