{"id":22,"date":"2020-06-22T11:30:00","date_gmt":"2020-06-22T11:30:00","guid":{"rendered":"https:\/\/www.embl.org\/groups\/hennig\/publications\/"},"modified":"2020-12-04T10:50:42","modified_gmt":"2020-12-04T10:50:42","slug":"publications","status":"publish","type":"page","link":"https:\/\/www.embl.org\/groups\/hennig\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"
\n \n
\n

\n \n The bis-salphen Zn(II) unit: a versatile building block for self-assembled heteroleptic coordination cages.\n <\/a>\n <\/h3>\n

\n Donaggio L, Schweimer K, Heinemann FW, Hennig J, Kurz H\n <\/p>\n

\n Nanoscale, \n\n 2026<\/span>\n <\/p>\n\n

\n doi:10.1039\/d5nr04564a.\n <\/p>\n <\/article>\n

\n

\n \n TRIM2 E3 ligase substrate discovery reveals zinc-mediated regulation of TMEM106B in the endolysosomal pathway.\n <\/a>\n <\/h3>\n

\n Perez-Borrajero C, Stein F, Schweimer K, Rettel M, Schwarz JJ, Haberkant P, Lapouge K, Gayk J, Hoffmann T, Bhogaraju S, Noh KM, Savitski M, Mahamid J, Hennig J\n <\/p>\n

\n EMBO reports, \n\n 2026<\/span>\n <\/p>\n\n

\n doi:10.1038\/s44319-025-00667-3.\n <\/p>\n <\/article>\n

\n

\n \n Mechanistic insights into recruitment and regulation of the RNA helicase UPF1 in replication-dependent histone mRNA decay.\n <\/a>\n <\/h3>\n

\n Machado de Amorim A, Xue G, He W, Dittmers T, Lewandowski S, Perez-Borrajero C, Bethmann J, Mateva N, Krage C, Nandana V, Loll B, Hilal T, Hennig J, Urlaub H, Marzluff WF, Chakrabarti S\n <\/p>\n

\n Nature communications, \n\n 2026<\/span>\n <\/p>\n\n

\n doi:10.1038\/s41467-025-67991-z.\n <\/p>\n <\/article>\n

\n

\n \n Real-time tracking of mRNP complex assembly reveals various mechanisms that synergistically enhance translation repression.\n <\/a>\n <\/h3>\n

\n Payr M, Meyer J, Geissen EM, Hennig J, Duss O\n <\/p>\n

\n Cell reports, \n\n 2025<\/span>\n <\/p>\n\n

\n doi:10.1016\/j.celrep.2025.116492.\n <\/p>\n <\/article>\n

\n

\n \n Structural polymorphism of \u03b1-synuclein fibrils alters the pathway of Hsc70-mediated disaggregation.\n <\/a>\n <\/h3>\n

\n J\u00e4ger S, Tittelmeier J, Dang TL, Bellande T, Redeker V, Buell AK, Hennig J, Melki R, Nussbaum-Krammer C, Bukau B, Wentink AS\n <\/p>\n

\n The EMBO journal, \n\n 2025<\/span>\n <\/p>\n\n

\n doi:10.1038\/s44318-025-00573-3.\n <\/p>\n <\/article>\n

\n

\n \n The 76th Mosbacher Colloquium: AI-driven (r)evolution in structural biology and protein design.\n <\/a>\n <\/h3>\n

\n H\u00f6cker B, Koch I, Hennig J\n <\/p>\n

\n Biological chemistry, \n\n 2025<\/span>\n <\/p>\n\n

\n doi:10.1515\/hsz-2025-0184.\n <\/p>\n <\/article>\n

\n

\n \n Molecular basis of ParA ATPase activation by the CTPase ParB during bacterial chromosome segregation.\n <\/a>\n <\/h3>\n

\n Schnabel L, Osorio-Valeriano M, Perez-Borrajero C, Steinchen W, Mais CN, Simon B, Han\u00dfmann J, Thamm M, Hennig J, Bange G, Thanbichler M\n <\/p>\n

\n Nature communications, \n\n 2025<\/span>\n <\/p>\n\n

\n doi:10.1038\/s41467-025-63976-0.\n <\/p>\n <\/article>\n

\n

\n \n A direct interaction between the RNA-binding proteins Staufen and Tm1-I\/C in the oskar mRNA transport complex.\n <\/a>\n <\/h3>\n

\n Gaber T, Monecke T, Grabowski J, Simon B, Williams T, Roman V, Chao J, Hennig J, Ephrussi A, Niessing D, Heber S\n <\/p>\n

\n Cell reports, \n\n 2025<\/span>\n <\/p>\n\n

\n doi:10.1016\/j.celrep.2025.115906.\n <\/p>\n <\/article>\n

\n

\n \n AlphaDesign: a de novo protein design framework based on AlphaFold.\n <\/a>\n <\/h3>\n

\n Jendrusch MA, Yang ALJ, Cacace E, Bobonis J, Voogdt CGP, Kaspar S, Schweimer K, Perez-Borrajero C, Lapouge K, Scheurich J, Remans K, Hennig J, Typas A, Korbel JO, Sadiq SK\n <\/p>\n

\n Molecular systems biology, \n\n 2025<\/span>\n <\/p>\n\n

\n doi:10.1038\/s44320-025-00119-z.\n <\/p>\n <\/article>\n

\n

\n \n Structural biology of RNA and protein-RNA complexes after AlphaFold3.\n <\/a>\n <\/h3>\n

\n Hennig J\n <\/p>\n

\n Chembiochem : a European journal of chemical biology, \n\n 2025<\/span>\n <\/p>\n\n

\n doi:10.1002\/cbic.202401047.\n <\/p>\n <\/article>\n

\n

\n \n 4D structural biology-The 9th Murnau Conference on structural biology:\n <\/a>\n <\/h3>\n

\n Hennig J, Paulino C\n <\/p>\n

\n Structure (London, England : 1993), \n\n 2025<\/span>\n <\/p>\n\n

\n doi:10.1016\/j.str.2024.11.012.\n <\/p>\n <\/article>\n

\n

\n \n The Drosophila RNA binding protein Hrp48 binds a specific RNA sequence of the msl-2 mRNA 3′ UTR to regulate translation.\n <\/a>\n <\/h3>\n

\n Lomoschitz A, Meyer J, Guitart T, Krepl M, Lapouge K, Hayn C, Schweimer K, Simon B, \u0160poner J, Gebauer F, Hennig J\n <\/p>\n

\n Biophysical chemistry, \n\n 2025<\/span>\n <\/p>\n\n

\n doi:10.1016\/j.bpc.2024.107346.\n <\/p>\n <\/article>\n

\n

\n \n Exploring the dynamics of messenger ribonucleoprotein-mediated translation repression.\n <\/a>\n <\/h3>\n

\n Meyer J, Payr M, Duss O, Hennig J\n <\/p>\n

\n Biochemical Society transactions, \n\n 2024<\/span>\n <\/p>\n\n

\n doi:10.1042\/BST20231240.\n <\/p>\n <\/article>\n

\n

\n \n Intrinsically disordered RNA-binding motifs cooperate to catalyze RNA folding and drive phase separation.\n <\/a>\n <\/h3>\n

\n Niedner-Boblenz A, Monecke T, Hennig J, Klostermann M, Hofweber M, Davydova E, Gerber AP, Anosova I, Mayer W, M\u00fcller M, Heym RG, Janowski R, Paillart JC, Dormann D, Zarnack K, Sattler M, Niessing D\n <\/p>\n

\n Nucleic acids research, \n\n 2024<\/span>\n <\/p>\n\n

\n doi:10.1093\/nar\/gkae1107.\n <\/p>\n <\/article>\n

\n

\n \n The molecular dissection of TRIM25’s RNA-binding mechanism provides key insights into its antiviral activity.\n <\/a>\n <\/h3>\n

\n \u00c1lvarez L, Haubrich K, Iselin L, Gillioz L, Ruscica V, Lapouge K, Augsten S, Huppertz I, Choudhury NR, Simon B, Masiewicz P, Lethier M, Cusack S, Rittinger K, Gabel F, Leitner A, Michlewski G, Hentze MW, Allain FHT, Castello A, Hennig J\n <\/p>\n

\n Nature communications, \n\n 2024<\/span>\n <\/p>\n\n

\n doi:10.1038\/s41467-024-52918-x.\n <\/p>\n <\/article>\n

\n

\n \n Exploring the expanding universe of host-virus interactions mediated by viral RNA.\n <\/a>\n <\/h3>\n

\n Castello A, \u00c1lvarez L, Kamel W, Iselin L, Hennig J\n <\/p>\n

\n Molecular cell, \n\n 2024<\/span>\n <\/p>\n\n

\n doi:10.1016\/j.molcel.2024.08.027.\n <\/p>\n <\/article>\n

\n

\n \n Response to Forker et al.\n <\/a>\n <\/h3>\n

\n Griffith-Jones S, \u00c1lvarez L, Mukhopadhyay U, Gharbi S, Rettel M, Adams M, Hennig J, Bhogaraju S\n <\/p>\n

\n The EMBO journal, \n\n 2024<\/span>\n <\/p>\n\n

\n doi:10.1038\/s44318-024-00141-1.\n <\/p>\n <\/article>\n

\n

\n \n The Listeria monocytogenes persistence factor ClpL is a potent stand-alone disaggregase.\n <\/a>\n <\/h3>\n

\n Bohl V, Hollmann NM, Melzer T, Katikaridis P, Meins L, Simon B, Flemming D, Sinning I, Hennig J, Mogk A\n <\/p>\n

\n eLife, \n\n 2024<\/span>\n <\/p>\n\n

\n doi:10.7554\/eLife.92746.\n <\/p>\n <\/article>\n

\n

\n \n Structural basis for RAD18 regulation by MAGEA4 and its implications for RING ubiquitin ligase binding by MAGE family proteins.\n <\/a>\n <\/h3>\n

\n Griffith-Jones S, \u00c1lvarez L, Mukhopadhyay U, Gharbi S, Rettel M, Adams M, Hennig J, Bhogaraju S\n <\/p>\n

\n The EMBO journal, \n\n 2024<\/span>\n <\/p>\n\n

\n doi:10.1038\/s44318-024-00058-9.\n <\/p>\n <\/article>\n

\n

\n \n Tropomyosin 1-I\/C coordinates kinesin-1 and dynein motors during oskar mRNA transport.\n <\/a>\n <\/h3>\n

\n Heber S, McClintock MA, Simon B, Mehtab E, Lapouge K, Hennig J, Bullock SL, Ephrussi A\n <\/p>\n

\n Nature structural & molecular biology, \n\n 2024<\/span>\n <\/p>\n\n

\n doi:10.1038\/s41594-024-01212-x.\n <\/p>\n <\/article>\n

\n

\n \n Regulation and mechanisms of action of RNA helicases.\n <\/a>\n <\/h3>\n

\n Lang N, Jagtap PKA, Hennig J\n <\/p>\n

\n RNA biology, \n\n 2024<\/span>\n <\/p>\n\n

\n doi:10.1080\/15476286.2024.2415801.\n <\/p>\n <\/article>\n

\n

\n \n Structural basis of RNA-induced autoregulation of the DExH-type RNA helicase maleless.\n <\/a>\n <\/h3>\n

\n Jagtap PKA, M\u00fcller M, Kiss AE, Thomae AW, Lapouge K, Beck M, Becker PB, Hennig J\n <\/p>\n

\n Molecular cell, \n\n 2023<\/span>\n <\/p>\n\n

\n doi:10.1016\/j.molcel.2023.10.026.\n <\/p>\n <\/article>\n

\n

\n \n Structural basis of aggregate binding by the AAA+ disaggregase ClpG.\n <\/a>\n <\/h3>\n

\n Katikaridis P, Simon B, Jenne T, Moon S, Lee C, Hennig J, Mogk A\n <\/p>\n

\n The Journal of biological chemistry, \n\n 2023<\/span>\n <\/p>\n\n

\n doi:10.1016\/j.jbc.2023.105336.\n <\/p>\n <\/article>\n

\n

\n \n Upstream of N-Ras C-terminal cold shock domains mediate poly(A) specificity in a novel RNA recognition mode and bind poly(A) binding protein.\n <\/a>\n <\/h3>\n

\n Hollmann NM, Jagtap PKA, Linse JB, Ullmann P, Payr M, Murciano B, Simon B, Hub JS, Hennig J\n <\/p>\n

\n Nucleic acids research, \n\n 2023<\/span>\n <\/p>\n\n

\n doi:10.1093\/nar\/gkac1277.\n <\/p>\n <\/article>\n

\n

\n \n A KLK6 activity-based probe reveals a role for KLK6 activity in pancreatic cancer cell invasion.\n <\/a>\n <\/h3>\n

\n Zhang L, Lovell S, De Vita E, Jagtap PKA, Lucy D, Goya Grocin A, Kj\u00e6r S, Borg A, Hennig J, Miller AK, Tate EW\n <\/p>\n

\n Journal of the American Chemical Society, \n\n 2022<\/span>\n <\/p>\n\n

\n doi:10.1021\/jacs.2c07378.\n <\/p>\n <\/article>\n

\n

\n \n Structure and dynamics of the von Willebrand Factor C6 domain.\n <\/a>\n <\/h3>\n

\n Chen PC, Kutzki F, Mojzisch A, Simon B, Xu ER, Aponte-Santamar\u00eda C, Horny K, Jeffries C, Schneppenheim R, Wilmanns M, Brehm MA, Gr\u00e4ter F, Hennig J\n <\/p>\n

\n Journal of structural biology, \n\n 2022<\/span>\n <\/p>\n\n

\n doi:10.1016\/j.jsb.2022.107923.\n <\/p>\n <\/article>\n

\n

\n \n Scalable synthesis and structural characterization of reversible KLK6 inhibitors.\n <\/a>\n <\/h3>\n

\n Baumann A, Isak D, Lohbeck J, Jagtap PKA, Janosch H, Miller AK\n <\/p>\n

\n RSC Advances, \n\n 2022<\/span>\n <\/p>\n\n

\n doi:10.1039\/d2ra04670a.\n <\/p>\n <\/article>\n

\n

\n \n Riboregulation of Enolase 1 activity controls glycolysis and embryonic stem cell differentiation.\n <\/a>\n <\/h3>\n

\n Huppertz I, Perez-Perri JI, Mantas P, Sekaran T, Schwarzl T, Russo F, Ferring-Appel D, Koskova Z, Dimitrova-Paternoga L, Kafkia E, Hennig J, Neveu PA, Patil K, Hentze MW\n <\/p>\n

\n Molecular cell, \n\n 2022<\/span>\n <\/p>\n\n

\n doi:10.1016\/j.molcel.2022.05.019.\n <\/p>\n <\/article>\n

\n

\n \n Vault RNA1-1 riboregulates the autophagic function of p62 by binding to K7\/R21 that are critical for p62 oligomerisation.\n <\/a>\n <\/h3>\n

\n B\u00fcscher M, Horos R, Huppertz I, Haubrich K, Dobrev N, Baudin F, Hennig J, Hentze MW\n <\/p>\n

\n RNA (New York, N.Y.), \n\n 2022<\/span>\n <\/p>\n\n

\n doi:10.1261\/rna.079129.122.\n <\/p>\n <\/article>\n

\n

\n \n Bioaccumulation of therapeutic drugs by human gut bacteria.\n <\/a>\n <\/h3>\n

\n Kl\u00fcnemann M, Andrejev S, Blasche S, Mateus A, Phapale P, Devendran S, Vappiani J, Simon B, Scott TA, Kafkia E, Konstantinidis D, Zirngibl K, Mastrorilli E, Banzhaf M, Mackmull MT, H\u00f6velmann F, Nesme L, Brochado AR, Maier L, Bock T, Periwal V, Kumar M, Kim Y, Tramontano M, Schultz C, Beck M, Hennig J, Zimmermann M, S\u00e9vin DC, Cabreiro F, Savitski MM, Bork P, Typas A, Patil KR\n <\/p>\n

\n Nature, \n\n 2021<\/span>\n <\/p>\n\n

\n doi:10.1038\/s41586-021-03891-8.\n <\/p>\n <\/article>\n

\n

\n \n Structural basis of PETISCO complex assembly during piRNA biogenesis in C. elegans.\n <\/a>\n <\/h3>\n

\n Perez-Borrajero C, Podvalnaya N, Holleis K, Lichtenberger R, Karaulanov E, Simon B, Basquin J, Hennig J, Ketting RF, Falk S\n <\/p>\n

\n Genes & development, \n\n 2021<\/span>\n <\/p>\n\n

\n doi:10.1101\/gad.348648.121.\n <\/p>\n <\/article>\n

\n

\n \n Validation and classification of RNA binding proteins identified by mRNA interactome capture.\n <\/a>\n <\/h3>\n

\n Vaishali, Dimitrova-Paternoga L, Haubrich K, Sun M, Ephrussi A, Hennig J\n <\/p>\n

\n RNA, \n\n 2021<\/span>\n <\/p>\n\n

\n doi:10.1261\/rna.078700.121.\n <\/p>\n <\/article>\n

\n

\n \n Structure and dynamics of the quaternary hunchback mRNA translation repression complex.\n <\/a>\n <\/h3>\n

\n Maco\u0161ek J, Simon B, Linse JB, Jagtap PKA, Winter SL, Foot J, Lapouge K, Perez K, Rettel M, Ivanovi\u0107 MT, Masiewicz P, Murciano B, Savitski MM, Loedige I, Hub JS, Gabel F, Hennig J\n <\/p>\n

\n Nucleic acids research, \n\n 2021<\/span>\n <\/p>\n\n

\n doi:10.1093\/nar\/gkab635.\n <\/p>\n <\/article>\n

\n

\n \n Molecular basis of mRNA transport by a kinesin-1-atypical tropomyosin complex.\n <\/a>\n <\/h3>\n

\n Dimitrova-Paternoga L, Jagtap PKA, Cyrklaff A, Vaishali, Lapouge K, Sehr P, Perez K, Heber S, L\u00f6w C, Hennig J, Ephrussi A\n <\/p>\n

\n Genes & development, \n\n 2021<\/span>\n <\/p>\n\n

\n doi:10.1101\/gad.348443.121.\n <\/p>\n <\/article>\n

\n

\n \n Divergent evolution toward sex chromosome-specific gene regulation in Drosophila.\n <\/a>\n <\/h3>\n

\n Villa R, Jagtap PKA, Thomae AW, Campos Sparr A, Forn\u00e9 I, Hennig J, Straub T, Becker PB\n <\/p>\n

\n Genes & development, \n\n 2021<\/span>\n <\/p>\n\n

\n doi:10.1101\/gad.348411.121.\n <\/p>\n <\/article>\n

\n

\n \n Mechanism of riboregulation of p62 proteinoligomerisation by vault RNA1-1 inselective autophagy.\n <\/a>\n <\/h3>\n

\n B\u00fcscher M, Horos R, Haubrich K, Dobrev N, Baudin F, Hennig J, Hentze MW\n <\/p>\n

\n \n\n 2021<\/span>\n <\/p>\n\n

\n doi:10.1101\/2021.04.12.439413.\n <\/p>\n <\/article>\n

\n

\n \n Gain-of-function variant p.Pro2555Arg of von Willebrand factor increases aggregate size through altering stem dynamics.\n <\/a>\n <\/h3>\n

\n Huck V, Chen PC, Xu ER, Tischer A, Klemm U, Aponte-Santamar\u00eda C, Mess C, Obser T, Kutzki F, K\u00f6nig G, Denis C, Gr\u00e4ter F, Wilmanns M, Auton M, Schneider SW, Schneppenheim R, Hennig J, Brehm MA\n <\/p>\n

\n Thrombosis and haemostasis, \n\n 2020<\/span>\n <\/p>\n\n

\n doi:10.1055\/a-1344-4405.\n <\/p>\n <\/article>\n

\n

\n \n Molecular dissection of amyloid disaggregation by human HSP70.\n <\/a>\n <\/h3>\n

\n Wentink AS, Nillegoda NB, Feufel J, Ubartait\u0117 G, Schneider CP, De Los Rios P, Hennig J, Barducci A, Bukau B\n <\/p>\n

\n Nature, \n\n 2020<\/span>\n <\/p>\n\n

\n doi:10.1038\/s41586-020-2904-6.\n <\/p>\n <\/article>\n

\n

\n \n Transcriptional regulation of the N \u03b5 -fructoselysine metabolism in Escherichia coli by global and substrate-specific cues.\n <\/a>\n <\/h3>\n

\n von Armansperg BG, Koller F, Gericke N, Hellwig M, Jagtap PKA, Heermann R, Hennig J, Henle T, Lassak J\n <\/p>\n

\n Molecular microbiology, \n\n 2020<\/span>\n <\/p>\n\n

\n doi:10.1111\/mmi.14608.\n <\/p>\n <\/article>\n

\n

\n \n Pseudo-RNA-binding domains mediate RNA structure specificity in Upstream of N-Ras.\n <\/a>\n <\/h3>\n

\n Hollmann NM, Jagtap PKA, Masiewicz P, Guitart T, Simon B, Provaznik J, Stein F, Haberkant P, Sweetapple LJ, Villacorta L, Moojiman D, Benes V, Savitski MM, Gebauer F, Hennig J\n <\/p>\n

\n \n\n 2020<\/span>\n <\/p>\n\n

\n doi:10.1016\/j.celrep.2020.107930.\n <\/p>\n <\/article>\n

\n

\n \n Structure-based screening of binding affinities via small-angle X-ray scattering.\n <\/a>\n <\/h3>\n

\n Chen PC, Masiewicz P, Perez K, Hennig J\n <\/p>\n

\n \n\n 2020<\/span>\n <\/p>\n\n

\n doi:10.1107\/S2052252520004169.\n <\/p>\n <\/article>\n

\n

\n \n Macrocyclic peptides uncover a novel binding mode for reversible inhibitors of LSD1.\n <\/a>\n <\/h3>\n

\n Yang J, Talibov VO, Peintner S, Rhee C, Poongavanam V, Geitmann M, Sebastiano MR, Simon B, Hennig J, Dobritzsch D, Danielson UH, Kihlberg J\n <\/p>\n

\n ACS omega, \n\n 2020<\/span>\n <\/p>\n\n

\n doi:10.1021\/acsomega.9b03493.\n <\/p>\n <\/article>\n

\n

\n \n Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions.\n <\/a>\n <\/h3>\n

\n Ibarra IL, Hollmann NM, Klaus B, Augsten S, Velten B, Hennig J, Zaugg JB\n <\/p>\n

\n Nature communications, \n\n 2020<\/span>\n <\/p>\n\n

\n doi:10.1038\/s41467-019-13888-7.\n <\/p>\n <\/article>\n

\n

\n \n Integrative structural biology of protein-RNA complexes.\n <\/a>\n <\/h3>\n

\n Dimitrova-Paternoga L, Jagtap PKA, Chen PC, Hennig J\n <\/p>\n

\n Structure (London, England : 1993), \n\n 2020<\/span>\n <\/p>\n\n

\n doi:10.1016\/j.str.2019.11.017.\n <\/p>\n <\/article>\n

\n

\n \n Highlight: young research groups in Germany – continued.\n <\/a>\n <\/h3>\n

\n Hennig J, Feige MJ\n <\/p>\n

\n Biological chemistry, \n\n 2019<\/span>\n <\/p>\n\n

\n doi:10.1515\/hsz-2019-0361.\n <\/p>\n <\/article>\n

\n

\n \n Combined small-angle X-ray and neutron scattering restraints in molecular dynamics simulations.\n <\/a>\n <\/h3>\n

\n Chen PC, Shevchuk R, Strnad FM, Lorenz C, Karge L, Gilles R, Stadler AM, Hennig J, Hub JS\n <\/p>\n

\n Journal of chemical theory and computation, \n\n 2019<\/span>\n <\/p>\n\n

\n doi:10.1021\/acs.jctc.9b00292.\n <\/p>\n <\/article>\n

\n

\n \n Structural basis of an asymmetric condensin ATPase cycle.\n <\/a>\n <\/h3>\n

\n Hassler M, Shaltiel IA, Kschonsak M, Simon B, Merkel F, Th\u00e4richen L, Bailey HJ, Maco\u0161ek J, Bravo S, Metz J, Hennig J, Haering CH\n <\/p>\n

\n Molecular cell, \n\n 2019<\/span>\n <\/p>\n\n

\n doi:10.1016\/j.molcel.2019.03.037.\n <\/p>\n <\/article>\n

\n

\n \n Switching the post-translational modification of translation elongation factor EF-P.\n <\/a>\n <\/h3>\n

\n Volkwein W, Krafczyk R, Jagtap PKA, Parr M, Mankina E, Macosek J, Guo Z, F\u00fcrst M, Pfab M, Frishman D, Hennig J, Jung K, Lassak J\n <\/p>\n

\n \n\n 2019<\/span>\n <\/p>\n\n

\n doi:10.3389\/fmicb.2019.01148.\n <\/p>\n <\/article>\n

\n

\n \n Emerging RNA-binding roles in the TRIM family of ubiquitin ligases.\n <\/a>\n <\/h3>\n

\n Williams FP, Haubrich K, Perez-Borrajero C, Hennig J\n <\/p>\n

\n Biological chemistry, \n\n 2019<\/span>\n <\/p>\n\n

\n doi:10.1515\/hsz-2019-0158.\n <\/p>\n <\/article>\n

\n

\n \n Highlight: young research groups in Germany.\n <\/a>\n <\/h3>\n

\n GBM Young Investigators, Hennig J, Feige MJ\n <\/p>\n

\n Biological chemistry, \n\n 2019<\/span>\n <\/p>\n\n

\n doi:10.1515\/hsz-2019-0246.\n <\/p>\n <\/article>\n

\n

\n \n Structure, dynamics and roX2-lncRNA binding of tandem double-stranded RNA binding domains dsRBD1,2 of Drosophila helicase Maleless.\n <\/a>\n <\/h3>\n

\n Pravin Kumar Ankush Jagtap, Marisa M\u00fcller, Pawel Masiewicz, S\u00f6ren von B\u00fclow, Nele Merret Hollmann, Po-Chia Chen, Bernd Simon, Andreas W Thomae, Peter B Becker, Janosch Hennig\n <\/p>\n

\n \n\n 2019<\/span>\n <\/p>\n\n

\n doi:10.1093\/nar\/gkz125.\n <\/p>\n <\/article>\n

\n

\n \n Structure and dynamics of the platelet integrin-binding C4 domain of von Willebrand factor.\n <\/a>\n <\/h3>\n

\n Xu ER, von B\u00fclow S, Chen PC, Lenting PJ, Kol\u0161ek K, Aponte-Santamar\u00eda C, Simon B, Foot J, Obser T, Schneppenheim R, Gr\u00e4ter F, Denis CV, Wilmanns M, Hennig J\n <\/p>\n

\n Blood, \n\n 2019<\/span>\n <\/p>\n\n

\n doi:10.1182\/blood-2018-04-843615.\n <\/p>\n <\/article>\n

\n

\n \n The role of small-angle scattering in structure-based screening applications.\n <\/a>\n <\/h3>\n

\n Chen PC, Hennig J\n <\/p>\n

\n Biophysical reviews, \n\n 2018<\/span>\n <\/p>\n\n

\n doi:10.1007\/s12551-018-0464-x.\n <\/p>\n <\/article>\n

\n

\n \n Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.\n <\/a>\n <\/h3>\n

\n Koliopoulos MG, Lethier M, van der Veen AG, Haubrich K, Hennig J, Kowalinski E, Stevens RV, Martin SR, Reis E Sousa C, Cusack S, Rittinger K\n <\/p>\n

\n Nature communications, \n\n 2018<\/span>\n <\/p>\n\n

\n doi:10.1038\/s41467-018-04214-8.\n <\/p>\n <\/article>\n

\n

\n \n A general small-angle X-ray scattering-based screening protocol validated for protein-RNA interactions.\n <\/a>\n <\/h3>\n

\n Chen PC, Masiewicz P, Rybin V, Svergun D, Hennig J\n <\/p>\n

\n ACS combinatorial science, \n\n 2018<\/span>\n <\/p>\n\n

\n doi:10.1021\/acscombsci.8b00007.\n <\/p>\n <\/article>\n

\n

\n \n Ab Initio prediction of NMR spin relaxation parameters from molecular dynamics simulations.\n <\/a>\n <\/h3>\n

\n Chen PC, Hologne M, Walker O, Hennig J\n <\/p>\n

\n Journal of chemical theory and computation, \n\n 2018<\/span>\n <\/p>\n\n

\n doi:10.1021\/acs.jctc.7b00750.\n <\/p>\n <\/article>\n

\n

\n \n Structural basis for EarP-mediated arginine glycosylation of translation elongation factor EF-P.\n <\/a>\n <\/h3>\n

\n Krafczyk R, Maco\u0161ek J, Jagtap PKA, Gast D, Wunder S, Mitra P, Jha AK, Rohr J, Hoffmann-R\u00f6der A, Jung K, Hennig J, Lassak J\n <\/p>\n

\n mBio, \n\n 2017<\/span>\n <\/p>\n\n

\n doi:10.1128\/mBio.01412-17.\n <\/p>\n <\/article>\n

\n

\n \n Segmental, domain-selective perdeuteration and small-angle neutron scattering for structural analysis of multi-domain proteins.\n <\/a>\n <\/h3>\n

\n Sonntag M, Jagtap PKA, Simon B, Appavou MS, Geerlof A, Stehle R, Gabel F, Hennig J, Sattler M\n <\/p>\n

\n Angewandte Chemie (International ed. in English), \n\n 2017<\/span>\n <\/p>\n\n

\n doi:10.1002\/anie.201702904.\n <\/p>\n <\/article>\n

\n

\n \n Resolving the \u03b1-glycosidic linkage of arginine-rhamnosylated translation elongation factor P triggers generation of the first ArgRha specific antibody.\n <\/a>\n <\/h3>\n

\n Li X, Krafczyk R, Maco\u0161ek J, Li Y-L, Zou Y, Simon B, Pan X, Wu Q-Y, Yan F, Li S, Hennig J, Jung K, Lassak J, Hu H-G\n <\/p>\n

\n Chemical science, \n\n 2016<\/span>\n <\/p>\n\n

\n doi:10.1039\/c6sc02889f.\n <\/p>\n <\/article>\n

\n

\n \n Improved accuracy from joint X-ray and NMR refinement of a protein-RNA complex structure.\n <\/a>\n <\/h3>\n

\n Carlon A, Ravera E, Hennig J, Parigi G, Sattler M, Luchinat C\n <\/p>\n

\n Journal of the American Chemical Society, \n\n 2016<\/span>\n <\/p>\n\n

\n doi:10.1021\/jacs.5b11598.\n <\/p>\n <\/article>\n

\n

\n \n Structural basis for cpSRP43 chromodomain selectivity and dynamics in Alb3 insertase interaction.\n <\/a>\n <\/h3>\n

\n Horn A, Hennig J, Ahmed YL, Stier G, Wild K, Sattler M, Sinning I\n <\/p>\n

\n Nature communications, \n\n 2015<\/span>\n <\/p>\n\n

\n doi:10.1038\/ncomms9875.\n <\/p>\n <\/article>\n

\n

\n \n The crystal structure of the NHL domain in complex with RNA reveals the molecular basis of Drosophila brain-tumor-mediated gene regulation.\n <\/a>\n <\/h3>\n

\n Loedige I, Jakob L, Treiber T, Ray D, Stotz M, Treiber N, Hennig J, Cook KB, Morris Q, Hughes TR, Engelmann JC, Krahn MP, Meister G\n <\/p>\n

\n Cell reports, \n\n 2015<\/span>\n <\/p>\n\n

\n doi:10.1016\/j.celrep.2015.09.068.\n <\/p>\n <\/article>\n

\n

\n \n Efficient segmental isotope labeling of multi-domain proteins using Sortase A.\n <\/a>\n <\/h3>\n

\n Freiburger L, Sonntag M, Hennig J, Li J, Zou P, Sattler M\n <\/p>\n

\n Journal of biomolecular NMR, \n\n 2015<\/span>\n <\/p>\n\n

\n doi:10.1007\/s10858-015-9981-0.\n <\/p>\n <\/article>\n

\n

\n \n Deciphering the protein-RNA recognition code: Combining large-scale quantitative methods with structural biology.\n <\/a>\n <\/h3>\n

\n Hennig J, Sattler M\n <\/p>\n

\n BioEssays : news and reviews in molecular, cellular and developmental biology, \n\n 2015<\/span>\n <\/p>\n\n

\n doi:10.1002\/bies.201500033.\n <\/p>\n <\/article>\n

\n

\n \n Structural analysis of protein-RNA complexes in solution using NMR paramagnetic relaxation enhancements.\n <\/a>\n <\/h3>\n

\n Hennig J, Warner LR, Simon B, Geerlof A, Mackereth CD, Sattler M\n <\/p>\n

\n Methods in enzymology, \n\n 2015<\/span>\n <\/p>\n\n

\n doi:10.1016\/bs.mie.2015.02.006.\n <\/p>\n <\/article>\n

\n

\n \n The EBNA-2 N-terminal transactivation domain folds into a dimeric structure required for target gene activation.\n <\/a>\n <\/h3>\n

\n Friberg A, Thumann S, Hennig J, Zou P, N\u00f6ssner E, Ling PD, Sattler M, Kempkes B\n <\/p>\n

\n PLoS pathogens, \n\n 2015<\/span>\n <\/p>\n\n

\n doi:10.1371\/journal.ppat.1004910.\n <\/p>\n <\/article>\n

\n

\n \n Local destabilization of the metal-binding region in human copper-zinc superoxide dismutase by remote mutations is a possible determinant for progression of ALS.\n <\/a>\n <\/h3>\n

\n Hennig J, Andr\u00e9sen C, Museth AK, Lundstr\u00f6m P, Tibell LA, Jonsson BH\n <\/p>\n

\n Biochemistry, \n\n 2015<\/span>\n <\/p>\n\n

\n doi:10.1021\/bi500606j.\n <\/p>\n <\/article>\n

\n

\n \n Structural basis for the assembly of the Sxl-Unr translation regulatory complex.\n <\/a>\n <\/h3>\n

\n Hennig J, Militti C, Popowicz GM, Wang I, Sonntag M, Geerlof A, Gabel F, Gebauer F, Sattler M\n <\/p>\n

\n Nature, \n\n 2014<\/span>\n <\/p>\n\n

\n doi:10.1038\/nature13693.\n <\/p>\n <\/article>\n

\n

\n \n The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins.\n <\/a>\n <\/h3>\n

\n Feige MJ, Gr\u00e4wert MA, Marcinowski M, Hennig J, Behnke J, Ausl\u00e4nder D, Herold EM, Peschek J, Castro CD, Flajnik M, Hendershot LM, Sattler M, Groll M, Buchner J\n <\/p>\n

\n Proceedings of the National Academy of Sciences of the United States of America, \n\n 2014<\/span>\n <\/p>\n\n

\n doi:10.1073\/pnas.1321502111.\n <\/p>\n <\/article>\n

\n

\n \n The dynamic duo: combining NMR and small angle scattering in structural biology.\n <\/a>\n <\/h3>\n

\n Hennig J, Sattler M\n <\/p>\n

\n Protein science : a publication of the Protein Society, \n\n 2014<\/span>\n <\/p>\n\n

\n doi:10.1002\/pro.2467.\n <\/p>\n <\/article>\n

\n

\n \n Breaking the protein-RNA recognition code.\n <\/a>\n <\/h3>\n

\n Hennig J, Gebauer F, Sattler M\n <\/p>\n

\n Cell cycle (Georgetown, Tex.), \n\n 2014<\/span>\n <\/p>\n\n

\n doi:10.4161\/15384101.2014.986625.\n <\/p>\n <\/article>\n

\n

\n \n Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1.\n <\/a>\n <\/h3>\n

\n Wang I, Hennig J, Jagtap PK, Sonntag M, Valc\u00e1rcel J, Sattler M\n <\/p>\n

\n Nucleic acids research, \n\n 2014<\/span>\n <\/p>\n\n

\n doi:10.1093\/nar\/gku193.\n <\/p>\n <\/article>\n

\n

\n \n The NHL domain of BRAT is an RNA-binding domain that directly contacts the hunchback mRNA for regulation.\n <\/a>\n <\/h3>\n

\n Loedige I, Stotz M, Qamar S, Kramer K, Hennig J, Schubert T, L\u00f6ffler P, L\u00e4ngst G, Merkl R, Urlaub H, Meister G\n <\/p>\n

\n Genes & development, \n\n 2014<\/span>\n <\/p>\n\n

\n doi:10.1101\/gad.236513.113.\n <\/p>\n <\/article>\n

\n

\n \n Structural features of Argonaute-GW182 protein interactions.\n <\/a>\n <\/h3>\n

\n Pfaff J, Hennig J, Herzog F, Aebersold R, Sattler M, Niessing D, Meister G\n <\/p>\n

\n Proceedings of the National Academy of Sciences of the United States of America, \n\n 2013<\/span>\n <\/p>\n\n

\n doi:10.1073\/pnas.1308510110.\n <\/p>\n <\/article>\n

\n

\n \n Protein conformational exchange measured by 1H R1\u03c1 relaxation dispersion of methyl groups.\n <\/a>\n <\/h3>\n

\n Weininger U, Blissing AT, Hennig J, Ahlner A, Liu Z, Vogel HJ, Akke M, Lundstr\u00f6m P\n <\/p>\n

\n Journal of biomolecular NMR, \n\n 2013<\/span>\n <\/p>\n\n

\n doi:10.1007\/s10858-013-9764-4.\n <\/p>\n <\/article>\n

\n

\n \n Combining NMR and small angle X-ray and neutron scattering in the structural analysis of a ternary protein-RNA complex.\n <\/a>\n <\/h3>\n

\n Hennig J, Wang I, Sonntag M, Gabel F, Sattler M\n <\/p>\n

\n Journal of biomolecular NMR, \n\n 2013<\/span>\n <\/p>\n\n

\n doi:10.1007\/s10858-013-9719-9.\n <\/p>\n <\/article>\n

\n

\n \n Structural characteristics determine the cause of the low enzyme activity of two thiopurine S-methyltransferase allelic variants: a biophysical characterization of TPMT*2 and TPMT*5.\n <\/a>\n <\/h3>\n

\n Wennerstrand P, Dametto P, Hennig J, Klingstedt T, Skoglund K, Appell ML, M\u00e5rtensson LG\n <\/p>\n

\n Biochemistry, \n\n 2012<\/span>\n <\/p>\n\n

\n doi:10.1021\/bi300377d.\n <\/p>\n <\/article>\n

\n

\n \n MTMDAT-HADDOCK: high-throughput, protein complex structure modeling based on limited proteolysis and mass spectrometry.\n <\/a>\n <\/h3>\n

\n Hennig J, de Vries SJ, Hennig KD, Randles L, Walters KJ, Sunnerhagen M, Bonvin AM\n <\/p>\n

\n BMC structural biology, \n\n 2012<\/span>\n <\/p>\n\n

\n doi:10.1186\/1472-6807-12-29.\n <\/p>\n <\/article>\n

\n

\n \n Anti-Ro52 autoantibodies from patients with Sjogren’s syndrome inhibit the Ro52 E3 ligase activity by blocking the E3\/E2 interface.\n <\/a>\n <\/h3>\n

\n Espinosa A, Hennig J, Ambrosi A, Anandapadmanaban M, Abelius MS, Sheng Y, Nyberg F, Arrowsmith CH, Sunnerhagen M, Wahren-Herlenius M\n <\/p>\n

\n The Journal of biological chemistry, \n\n 2011<\/span>\n <\/p>\n\n

\n doi:10.1074\/jbc.m111.241786.\n <\/p>\n <\/article>\n

\n

\n \n MTMDAT: Automated analysis and visualization of mass spectrometry data for tertiary and quaternary structure probing of proteins.\n <\/a>\n <\/h3>\n

\n Hennig J, Hennig KD, Sunnerhagen M\n <\/p>\n

\n Bioinformatics (Oxford, England), \n\n 2008<\/span>\n <\/p>\n\n

\n doi:10.1093\/bioinformatics\/btn116.\n <\/p>\n <\/article>\n

\n

\n \n The fellowship of the RING: the RING-B-box linker region interacts with the RING in TRIM21\/Ro52, contains a native autoantigenic epitope in Sjogren syndrome, and is an integral and conserved region in TRIM proteins.\n <\/a>\n <\/h3>\n

\n Hennig J, Bresell A, Sandberg M, Hennig KD, Wahren-Herlenius M, Persson B, Sunnerhagen M\n <\/p>\n

\n Journal of molecular biology, \n\n 2008<\/span>\n <\/p>\n\n

\n doi:10.1016\/j.jmb.2008.01.005.\n <\/p>\n <\/article>\n

\n

\n \n Structural, functional and immunologic characterization of folded subdomains in the Ro52 protein targeted in Sjogren’s syndrome.\n <\/a>\n <\/h3>\n

\n Ottosson L, Hennig J, Espinosa A, Brauner S, Wahren-Herlenius M, Sunnerhagen M\n <\/p>\n

\n Molecular immunology, \n\n 2006<\/span>\n <\/p>\n\n

\n doi:10.1016\/j.molimm.2005.04.013.\n <\/p>\n <\/article>\n

\n

\n \n Structural organization and Zn2+-dependent subdomain interactions involving autoantigenic epitopes in the Ring-B-box-coiled-coil (RBCC) region of Ro52.\n <\/a>\n <\/h3>\n

\n Hennig J, Ottosson L, Andr\u00e9sen C, Horvath L, Kuchroo VK, Broo K, Wahren-Herlenius M, Sunnerhagen M\n <\/p>\n

\n The Journal of biological chemistry, \n\n 2005<\/span>\n <\/p>\n\n

\n doi:10.1074\/jbc.m503066200.\n <\/p>\n <\/article>\n

\n

\n \n Structurally derived mutations define congenital heart block-related epitopes within the 200-239 amino acid stretch of the Ro52 protein.\n <\/a>\n <\/h3>\n

\n Ottosson L, Salomonsson S, Hennig J, Sonesson SE, D\u00f6rner T, Raats J, Kuchroo VK, Sunnerhagen M, Wahren-Herlenius M\n <\/p>\n

\n Scandinavian journal of immunology, \n\n 2005<\/span>\n <\/p>\n\n

\n doi:10.1111\/j.0300-9475.2005.01542.x.\n <\/p>\n <\/article>\n <\/div>\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-publications.php","meta":{"_acf_changed":false,"footnotes":""},"embl_taxonomy":[],"class_list":["post-22","page","type-page","status-publish","hentry"],"acf":[],"embl_taxonomy_terms":[],"_links":{"self":[{"href":"https:\/\/www.embl.org\/groups\/hennig\/wp-json\/wp\/v2\/pages\/22","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/groups\/hennig\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.embl.org\/groups\/hennig\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/groups\/hennig\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/groups\/hennig\/wp-json\/wp\/v2\/comments?post=22"}],"version-history":[{"count":3,"href":"https:\/\/www.embl.org\/groups\/hennig\/wp-json\/wp\/v2\/pages\/22\/revisions"}],"predecessor-version":[{"id":147,"href":"https:\/\/www.embl.org\/groups\/hennig\/wp-json\/wp\/v2\/pages\/22\/revisions\/147"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/groups\/hennig\/wp-json\/wp\/v2\/media?parent=22"}],"wp:term":[{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/groups\/hennig\/wp-json\/wp\/v2\/embl_taxonomy?post=22"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}