{"id":14,"date":"2020-06-08T10:46:26","date_gmt":"2020-06-08T10:46:26","guid":{"rendered":"https:\/\/www.embl.org\/groups\/genomics\/home\/"},"modified":"2026-03-26T13:52:23","modified_gmt":"2026-03-26T13:52:23","slug":"home","status":"publish","type":"page","link":"https:\/\/www.embl.org\/groups\/genomics\/","title":{"rendered":"Home"},"content":{"rendered":"<div class=\"vf-grid vf-grid__col-3 | vf-u-margin__bottom--800\">\n      <div class=\"vf-grid__col--span-2\">\n      <div class=\"vf-content-hub-html\">\n  <!-- Generated by: http:\/\/content.embl.org\/api\/v1\/pattern.html?filter-content-type=profiles&amp;filter-uuid=cb2598c2-41a0-4a75-945b-b058bc2a1e75&amp;pattern=node-teaser -->\n      <div data-embl-js-conditional-edit=\"28180\">\n              <h1 class=\"vf-lede\">GeneCore is the in-house genomics service centre at EMBL equipped with state-of-the-art technologies required for functional genomics analyses and operated by highly-qualified staff.\u00a0<\/p>\r\n\n            <a class=\"vf-text vf-text--body-r vf-link embl-conditional-edit\" rel=\"noopener noreferrer nofollow\" href=\"\/node\/28180\" target=\"_blank\">Edit<\/a>\n    <\/div>\n  <\/div>\n    <\/div>\n      <div >\n\n<!-- <style>\n  .vf-content-hub-html {\n    --vf-stack-margin--custom: unset !important;\n  }\n<\/style> -->\n\n    <div class=\"vf-content-hub-html vf-stack vf-stack--600\" data-cache=\"54d5ae88\">\n      <!-- Generated by: http:\/\/content.embl.org\/api\/v1\/pattern.html?filter-content-type=person&amp;filter-field-value%5Bfield_person_positions.entity.field_position_membership%5D=leader&amp;filter-field-value%5Bfield_person_positions.entity.field_position_team.entity.field_foreignid%5D=164&amp;filter-ref-entity%5Bfield_person_positions%5D%5Btitle%5D=&amp;filter-ref-entity%5Bfield_person_positions%5D%5Bfield_position_primary%5D=1&amp;hide%5Bteam%2Cmobile%2Cphones%5D=1&amp;limit=5&amp;pattern=vf-profile-inline&amp;sort-field-value%5Bchanged%5D=DESC -->\n                \n                            <article class=\"vf-profile vf-profile--very-easy vf-profile--medium vf-profile--inline\" data-embl-js-conditional-edit=\"77730\">\n              <img decoding=\"async\" class=\"vf-profile__image\" src=\"https:\/\/content.embl.org\/\/sites\/default\/files\/styles\/medium\/public\/persons\/CP-60003318.jpg?itok=xiaqoqHv\" alt=\"image of Vladimir Benes\" \/>\n      \n              <h3 class=\"vf-profile__title\">\n                      <a href=\"https:\/\/www.embl.org\/people\/person\/benes\" class=\"vf-profile__link\">Vladimir Benes<\/a>\n                  <\/h3>\n      \n              <p class=\"vf-profile__job-title\">\n          Head of Genomics Core Facility and Scientific Ombudsperson\n        <\/p>\n      \n      \n      \n      \n      \n      \n              <p class=\"vf-profile__uuid\">\n          <span>ORCID:<\/span>\n          <a class=\"vf-profile__link vf-profile__link--secondary\" href=\"https:\/\/europepmc.org\/authors\/0000-0002-0352-2547\">\n            0000-0002-0352-2547\n          <\/a>\n        <\/p>\n            <a class=\"vf-text vf-text--body-r vf-link embl-conditional-edit\" rel=\"noopener noreferrer nofollow\" href=\"\/node\/77730\/77730\" target=\"_blank\">\n        Edit\n      <\/a>\n    <\/article>\n  <\/div>\n\n  <\/div>\n<\/div>\n\n\n\n<div class=\"embl-grid embl-grid--has-centered-content\"><div><!--[vf\/content]-->\n<div class=\"vf-content\">\n<div class=\"vf-section-header | vf-u-margin__bottom--400\">\n  <h2 class=\"vf-section-header__heading\" \n    >\n  What we do  <\/h2>\n  <\/div>\n\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<p>The Genomics Core Facility (GeneCore) provides its services to a broad range of users ranging from small research groups to international consortia. <\/p>\n\n\n\n<p>Our massively parallel sequencing (MPS) suite boasts Illumina sequencers &#8211; NextSeq500, NextSeq2000, and MiSeq as well as PacBio Sequel IIe. We also work in close collaboration with the University of Heidelberg and the German Cancer Research Center (DKFZ) to further enhance the capabilities of these sequencing technologies. <\/p>\n\n\n\n<p>Preparation of MPS libraries for various applications is supported by a robust instrumentation infrastructure (e.g. Covaris, Bioanalyzer, Agilent Fragment Analyzer, Agilent Femto Pulse, Qubit, and more). <\/p>\n\n\n\n<p>To support processing of large quantities of samples we have employed a suite of liquid handling robots such as the Beckman Coulter i7, FXp, Echo acoustic liquid handler, and Dispendix iDot.<\/p>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"vf-divider\">\n\n\n\n<div class=\"embl-grid embl-grid--has-centered-content\"><div><!--[vf\/content]-->\n<div class=\"vf-content\">\n<div class=\"vf-section-header | vf-u-margin__bottom--400\">\n  <h2 class=\"vf-section-header__heading\" \n    >\n  News  <\/h2>\n  <\/div>\n\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<hr class=\"vf-divider\">\n\n\n\n<article class=\"vf-card vf-card--brand vf-card--striped vf-u-margin__bottom--800\" default>\n  <div class=\"vf-card__content | vf-stack vf-stack--400\">\n      <h3 class=\"vf-card__heading\">\n      GeneCore registration website [External Users]    <\/h3>\n                <p class=\"vf-card__text\">We are pleased to inform you that our new sample registration form is now available for external users.\r\n\r\n<p style=\"color: white;\">Click on the following link to access it: <a class=\"vf-card_link\" href=\"https:\/\/gc-registration.embl.org\/\"><strong>GeneCore Sample Registration<\/strong><\/a>\r\nPlease complete the form and send us the registration file along with any additional sample traces by <strong>email<\/strong>.<\/p>\r\n\r\n<p style=\"color: white;\">For EMBL users, this new form is not yet available. Please continue to use the existing internal GeneCore form available <strong><a class=\"vf-card_link\" href=\"https:\/\/www.genecore.embl.de\/\">here<\/a><\/strong>.<\/p><\/p>\n      <\/div>\n<\/article>\n\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"vf-divider\">\n\n\n\n<div class=\"embl-grid embl-grid--has-centered-content\"><div><!--[vf\/content]-->\n<div class=\"vf-content\">\n<div class=\"vf-section-header | vf-u-margin__bottom--400\">\n  <h2 class=\"vf-section-header__heading\" \n  id=\"projects-accomplishments\"  >\n  Major projects and accomplishments  <\/h2>\n  <\/div>\n\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<p>GeneCore provides the following analyses in a single-end or a pair-end sequencing mode, including multiplexing:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Genome-wide location analysis of nucleic acid-protein interactions \u2013 ChIP-Seq, CLIP-Seq.<\/li>\n\n\n\n<li>Transcriptome sequencing: RNA-Seq.<\/li>\n\n\n\n<li>Discovery of small non-coding RNAs: ncRNA-Seq.<\/li>\n\n\n\n<li>Genome-wide DNA methylation analysis: Methyl\/BS-Seq.<\/li>\n\n\n\n<li><em>De novo<\/em>&nbsp;sequencing &amp; re-sequencing of genomic DNA.<\/li>\n\n\n\n<li>Targeted enrichment (sequence capture) in solution coupled with MPS.<\/li>\n\n\n\n<li>Single-cell genomic applications (scRNA-Seq, scDNA-Seq).<\/li>\n\n\n\n<li>And much more.<\/li>\n<\/ul>\n\n\n\n<p>GeneCore continues to establish new protocols enabling the processing of challenging samples such as low input or metagenomics samples. <\/p>\n\n\n\n<p>For analysis of MPS data, we work intensively with EMBL\u2019s bioinformatics community on the development of in-house, freely accessible tools. <\/p>\n\n\n\n<p>To date, GeneCore has generated more than 100 terabases of MPS sequence data for its users. GeneCore staff also train individual researchers and organize practical courses on corresponding subjects.<\/p>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"vf-divider\">\n\n\n\n<div class=\"embl-grid embl-grid--has-centered-content\"><div><!--[vf\/content]-->\n<div class=\"vf-content\">\n<div class=\"vf-section-header | vf-u-margin__bottom--400\">\n  <h2 class=\"vf-section-header__heading\" \n  id=\"services\"  >\n  Services provided  <\/h2>\n  <\/div>\n\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<ul class=\"wp-block-list\">\n<li>MPS sequencing.<\/li>\n\n\n\n<li>miRNA qPCR profiling, Bioanalyzer, liquid handling robotics.<\/li>\n\n\n\n<li>Access to instruments and complete support: qPCR, NanoDrop, qbit, Agilent Bioanalyzer, and PCR cyclers.<\/li>\n\n\n\n<li>Consultation and experiment design advice.<\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n<div class=\"vf-links\">\n      <h3 class=\"vf-links__heading\">See also:<\/h3>\n    <ul class=\"vf-links__list vf-list\">\n    <li class=\"vf-list__item\">\n          <a class=\"vf-list__link\" href=\"https:\/\/www.embl.org\/internal-information\/scientific-services-fees\/#genecore\">\n        Service fees 2026      <\/a>\n      <\/li>\n  <\/ul>\n\n<\/div>\n\n\n\n<p><\/p>\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"vf-divider\">\n\n\n\n<div class=\"embl-grid embl-grid--has-centered-content\"><div><!--[vf\/content]-->\n<div class=\"vf-content\">\n<div class=\"vf-section-header | vf-u-margin__bottom--400\">\n  <h2 class=\"vf-section-header__heading\" \n  id=\"technology-partners\"  >\n  Technology Partners  <\/h2>\n  <\/div>\n\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<p>MPS continues to be a very dynamic and rapidly evolving technology. We collaborate with several companies involved in developing MPS-related products, for instance testing them in our workflows. GeneCore is a member of the early-access program of Illumina, Agilent, NEB, Dispendix, and Beckman Coulter. <\/p>\n\n\n\n<p>A detailed overview of the GeneCore activities can be found at&nbsp;<a href=\"https:\/\/www.genecore.embl.de\/\" target=\"_blank\" rel=\"noreferrer noopener\">www.genecore.embl.de<\/a>.<\/p>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"vf-divider\">\n\n\n\n<div class=\"embl-grid embl-grid--has-centered-content\"><div><!--[vf\/content]-->\n<div class=\"vf-content\">\n<div class=\"vf-section-header | vf-u-margin__bottom--400\">\n  <h2 class=\"vf-section-header__heading\" \n  id=\"publications\"  >\n        <a class=\"vf-section-header__heading vf-section-header__heading--is-link\"\n      id=\"publications\"      href=\"https:\/\/www.embl.org\/groups\/genomics\/publications\/\">Selected Publications<svg aria-hidden=\"true\" class=\"vf-section-header__icon | vf-icon vf-icon-arrow--inline-end\" width=\"24\" height=\"24\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M0 12c0 6.627 5.373 12 12 12s12-5.373 12-12S18.627 0 12 0C5.376.008.008 5.376 0 12zm13.707-5.209l4.5 4.5a1 1 0 010 1.414l-4.5 4.5a1 1 0 01-1.414-1.414l2.366-2.367a.25.25 0 00-.177-.424H6a1 1 0 010-2h8.482a.25.25 0 00.177-.427l-2.366-2.368a1 1 0 011.414-1.414z\" fill=\"\" fill-rule=\"nonzero\"><\/path><\/svg><\/a>\n      <\/h2>\n  <\/div>\n\n\n\n\n<p><\/p>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<article class=\"vf-summary vf-summary--publication\">\n    <h3 class=\"vf-summary__title\">\n        <a href=\"http:\/\/europepmc.org\/article\/MED\/32398640\" class=\"vf-summary__link\">\n        Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation.        <\/a>\n    <\/h3>\n    <p class=\"vf-summary__author\">\n      Vobo\u0159il M, Brabec T, Dobe\u0161 J, \u0160pl\u00edchalov\u00e1 I, B\u0159ezina J, \u010cepkov\u00e1 A, Dobe\u0161ov\u00e1 M, Aidarova A, Kubov\u010diak J, Tsyklauri O, \u0160t\u011bp\u00e1nek O, Bene\u0161 V, Sedl\u00e1\u010dek R, Klein L, Kol\u00e1\u0159 M, Filipp D.    <\/p>\n    <p class=\"vf-summary__source\">\n    Nat Commun        <span class=\"vf-summary__date\">2020<\/span>\n    <\/p>\n\n    <p class=\"vf-summary__text\">\n    doi:10.1038\/s41467-020-16081-3    <\/p>\n<\/article>\n\n\n\n<article class=\"vf-summary vf-summary--publication\">\n    <h3 class=\"vf-summary__title\">\n        <a href=\"http:\/\/europepmc.org\/article\/MED\/32315617\" class=\"vf-summary__link\">\n        MorphoSeq: full single-cell transcriptome dynamics up to gastrulation in a chordate.        <\/a>\n    <\/h3>\n    <p class=\"vf-summary__author\">\n      Sladitschek HL, Fiuza UM, Pavlinic D, Benes V, Hufnagel L, Neveu PA.    <\/p>\n    <p class=\"vf-summary__source\">\n    Cell        <span class=\"vf-summary__date\">2020<\/span>\n    <\/p>\n\n    <p class=\"vf-summary__text\">\n    doi:10.1016\/j.cell.2020.03.055    <\/p>\n<\/article>\n\n\n\n<article class=\"vf-summary vf-summary--publication\">\n    <h3 class=\"vf-summary__title\">\n        <a href=\"http:\/\/europepmc.org\/article\/MED\/32265286\" class=\"vf-summary__link\">\n        Loss of N-glycanase 1 alters transcriptional and translational regulation in K562 cell lines.        <\/a>\n    <\/h3>\n    <p class=\"vf-summary__author\">\n      Mueller WF, Jakob P, Sun H, Clauder-M\u00fcnster S, Ghidelli-Disse S, Ordonez D, Boesche M, Bantscheff M, Collier P, Haase B, Benes V, Paulsen M, Sehr P, Lewis J, Drewes G, Steinmetz LM.    <\/p>\n    <p class=\"vf-summary__source\">\n    G3: Genes, Genomes, Genetics        <span class=\"vf-summary__date\">2020<\/span>\n    <\/p>\n\n    <p class=\"vf-summary__text\">\n    doi:10.1534\/g3.119.401031    <\/p>\n<\/article>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"vf-divider\">\n\n\n\n<div class=\"embl-grid embl-grid--has-centered-content\"><div><!--[vf\/content]-->\n<div class=\"vf-content\">\n<div class=\"vf-section-header | vf-u-margin__bottom--400\">\n  <h2 class=\"vf-section-header__heading\" \n  id=\"contact\"  >\n  Contact  <\/h2>\n  <\/div>\n\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<p><strong>Genomics Core Facility<\/strong><br>EMBL Heidelberg, <br>Meyerhofstra\u00dfe 1, <br>69117 Heidelberg, <br>Germany<\/p>\n\n\n\n<p><br>Tel:+49 6221 387- 8486\/ -8492<br>E-mail: <a href=\"mailto:genecore@embl.de\">genecore@embl.de<\/a><\/p>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"vf_template_homepage.php","meta":{"_acf_changed":false,"footnotes":""},"embl_taxonomy":[],"class_list":["post-14","page","type-page","status-publish","hentry"],"acf":[],"embl_taxonomy_terms":[],"_links":{"self":[{"href":"https:\/\/www.embl.org\/groups\/genomics\/wp-json\/wp\/v2\/pages\/14","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/groups\/genomics\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.embl.org\/groups\/genomics\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/groups\/genomics\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/groups\/genomics\/wp-json\/wp\/v2\/comments?post=14"}],"version-history":[{"count":150,"href":"https:\/\/www.embl.org\/groups\/genomics\/wp-json\/wp\/v2\/pages\/14\/revisions"}],"predecessor-version":[{"id":24491,"href":"https:\/\/www.embl.org\/groups\/genomics\/wp-json\/wp\/v2\/pages\/14\/revisions\/24491"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/groups\/genomics\/wp-json\/wp\/v2\/media?parent=14"}],"wp:term":[{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/groups\/genomics\/wp-json\/wp\/v2\/embl_taxonomy?post=14"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}