{"id":234,"date":"2020-09-29T16:39:06","date_gmt":"2020-09-29T16:39:06","guid":{"rendered":"https:\/\/www.embl.org\/groups\/galej\/?p=234"},"modified":"2020-10-10T11:52:28","modified_gmt":"2020-10-10T11:52:28","slug":"a-new-spliceosome-assembly-intermediate","status":"publish","type":"post","link":"https:\/\/www.embl.org\/groups\/galej\/blog\/2020\/09\/a-new-spliceosome-assembly-intermediate\/","title":{"rendered":"A new spliceosome assembly intermediate identified"},"content":{"rendered":"\n<p>Check out our latest pre-print from the Nagai group identifying a new spliceosome assembly intermediate. The most complete and accurate depiction of the catalytic spliceosome to date; 9 datasets, 12 focused maps, 4 years in making. Fantastic effort by Max Wilkinson and Sebastian Fica.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2020.09.22.306647v1\">https:\/\/www.biorxiv.org\/content\/10.1101\/2020.09.22.306647v1<\/a><\/p>\n\n\n\n<p>More on tweeter:<\/p>\n\n\n\n<figure class=\"wp-block-embed-twitter wp-block-embed is-type-rich is-provider-twitter\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"twitter-tweet\" data-width=\"500\" data-dnt=\"true\"><p lang=\"en\" dir=\"ltr\">Super excited to finally share this! With <a href=\"https:\/\/twitter.com\/Seb_Fica?ref_src=twsrc%5Etfw\">@Seb_Fica<\/a> and <a href=\"https:\/\/twitter.com\/WojtekGalej?ref_src=twsrc%5Etfw\">@WojtekGalej<\/a> we found a new spliceosome intermediate that explains the equilibrium between the two steps of catalysis &#8211; branching and exon ligation. 1\/n for more movies and <a href=\"https:\/\/twitter.com\/hashtag\/cryoEM?src=hash&amp;ref_src=twsrc%5Etfw\">#cryoEM<\/a>!<a href=\"https:\/\/t.co\/wPmYWIEdik\">https:\/\/t.co\/wPmYWIEdik<\/a> <a href=\"https:\/\/t.co\/xDm1Ccg3o1\">pic.twitter.com\/xDm1Ccg3o1<\/a><\/p>&mdash; Max Wilkinson (@maxewilkinson) <a href=\"https:\/\/twitter.com\/maxewilkinson\/status\/1308789245029490694?ref_src=twsrc%5Etfw\">September 23, 2020<\/a><\/blockquote><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script>\n<\/div><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Check out our latest pre-print from the Nagai group identifying a new spliceosome assembly intermediate. The most complete and accurate depiction of the catalytic spliceosome to date; 9 datasets, 12 focused maps, 4 years in making. Fantastic effort by Max Wilkinson and Sebastian Fica.&hellip;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2029],"tags":[],"embl_taxonomy":[],"class_list":["post-234","post","type-post","status-publish","format-standard","hentry","category-science"],"acf":[],"embl_taxonomy_terms":[],"featured_image_src":"https:\/\/www.embl.org\/groups\/galej\/wp-includes\/images\/media\/default.svg","_links":{"self":[{"href":"https:\/\/www.embl.org\/groups\/galej\/wp-json\/wp\/v2\/posts\/234","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/groups\/galej\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.embl.org\/groups\/galej\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/groups\/galej\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/groups\/galej\/wp-json\/wp\/v2\/comments?post=234"}],"version-history":[{"count":3,"href":"https:\/\/www.embl.org\/groups\/galej\/wp-json\/wp\/v2\/posts\/234\/revisions"}],"predecessor-version":[{"id":237,"href":"https:\/\/www.embl.org\/groups\/galej\/wp-json\/wp\/v2\/posts\/234\/revisions\/237"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/groups\/galej\/wp-json\/wp\/v2\/media?parent=234"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.embl.org\/groups\/galej\/wp-json\/wp\/v2\/categories?post=234"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.embl.org\/groups\/galej\/wp-json\/wp\/v2\/tags?post=234"},{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/groups\/galej\/wp-json\/wp\/v2\/embl_taxonomy?post=234"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}