{"id":13559,"date":"2023-12-23T11:52:30","date_gmt":"2023-12-23T11:52:30","guid":{"rendered":"https:\/\/www.embl.org\/groups\/galej\/?p=13559"},"modified":"2023-12-23T11:52:31","modified_gmt":"2023-12-23T11:52:31","slug":"molecular-dynamics-simulations-provide-new-insights-into-pre-mrna-splicing-mechanism","status":"publish","type":"post","link":"https:\/\/www.embl.org\/groups\/galej\/blog\/2023\/12\/molecular-dynamics-simulations-provide-new-insights-into-pre-mrna-splicing-mechanism\/","title":{"rendered":"Molecular dynamics simulations provide new insights into pre-mRNA splicing mechanism"},"content":{"rendered":"\n<p>We are happy to share a new collaborative work lead by Jana Aupic and Alessandra Magistrato from the National Research Council of Italy (CNR) in Triest.  Molecular dynamics simulations of the complete yeast catalytic spliceosome revealed detailed trajectories of the reagents during the first step of splicing catalysis and shed new light on the role of monovalent potassium ion in stabilising the substrate and promoting productive reaction. <\/p>\n\n\n\n<p>Congratulations to everyone involved!<\/p>\n\n\n\n<p> <\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image size-large\"><a href=\"https:\/\/www.nature.com\/articles\/s41467-023-44174-2\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"470\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/groups\/galej\/wp-content\/uploads\/2023\/12\/image-1024x470.png\" alt=\"\" class=\"wp-image-13561\" srcset=\"https:\/\/www.embl.org\/groups\/galej\/wp-content\/uploads\/2023\/12\/image-1024x470.png 1024w, https:\/\/www.embl.org\/groups\/galej\/wp-content\/uploads\/2023\/12\/image-300x138.png 300w, https:\/\/www.embl.org\/groups\/galej\/wp-content\/uploads\/2023\/12\/image-768x353.png 768w, https:\/\/www.embl.org\/groups\/galej\/wp-content\/uploads\/2023\/12\/image.png 1324w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>We are happy to share a new collaborative work lead by Jana Aupic and Alessandra Magistrato from the National Research Council of Italy (CNR) in Triest. Molecular dynamics simulations of the complete yeast catalytic spliceosome revealed detailed trajectories of the reagents during the first step of&hellip;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2029],"tags":[],"embl_taxonomy":[],"class_list":["post-13559","post","type-post","status-publish","format-standard","hentry","category-science"],"acf":[],"embl_taxonomy_terms":[],"featured_image_src":"https:\/\/www.embl.org\/groups\/galej\/wp-includes\/images\/media\/default.svg","_links":{"self":[{"href":"https:\/\/www.embl.org\/groups\/galej\/wp-json\/wp\/v2\/posts\/13559","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/groups\/galej\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.embl.org\/groups\/galej\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/groups\/galej\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/groups\/galej\/wp-json\/wp\/v2\/comments?post=13559"}],"version-history":[{"count":1,"href":"https:\/\/www.embl.org\/groups\/galej\/wp-json\/wp\/v2\/posts\/13559\/revisions"}],"predecessor-version":[{"id":13563,"href":"https:\/\/www.embl.org\/groups\/galej\/wp-json\/wp\/v2\/posts\/13559\/revisions\/13563"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/groups\/galej\/wp-json\/wp\/v2\/media?parent=13559"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.embl.org\/groups\/galej\/wp-json\/wp\/v2\/categories?post=13559"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.embl.org\/groups\/galej\/wp-json\/wp\/v2\/tags?post=13559"},{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/groups\/galej\/wp-json\/wp\/v2\/embl_taxonomy?post=13559"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}