{"id":23,"date":"2023-11-15T10:52:36","date_gmt":"2023-11-15T10:52:36","guid":{"rendered":"https:\/\/www.embl.org\/groups\/chemical-synthesis-core-facility\/home\/"},"modified":"2024-02-15T21:22:49","modified_gmt":"2024-02-15T21:22:49","slug":"home","status":"publish","type":"page","link":"https:\/\/www.embl.org\/groups\/chemical-synthesis-core-facility\/","title":{"rendered":"Home"},"content":{"rendered":"\n\n\n<div class=\"vf-grid | vf-grid__col-3\"><div class=\"vf-grid__col--span-2\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<p class=\"wp-block-paragraph\">The Chemical Synthesis Core Facility specializes in small-molecule synthesis. Our mission is to support projects from groups lacking chemical synthesis expertise or infrastructure, providing services ranging from consultation, design, synthesis and characterization of small-molecule tool compounds for a variety of biological applications.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Available infrastructure and instrumentation<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The Chemical Synthesis Core Facility is equipped with a state-of-the-art laboratory, fully equipped for efficient synthetic work. This includes:<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Synthesis infrastructure and instrumentation<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>10 fume hoods for chemical synthesis<\/li>\n\n\n\n<li>Preparative HPLC-MS<\/li>\n\n\n\n<li>Preparative HPLC<\/li>\n\n\n\n<li>Flash chromatography system<\/li>\n\n\n\n<li>Microwave reactor<\/li>\n\n\n\n<li>H-Cube flow hydrogenator<\/li>\n\n\n\n<li>Lyophilizer<\/li>\n\n\n\n<li>Centrifugal evaporator<\/li>\n\n\n\n<li>Parallel reaction stations<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Characterisation implementation<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Analytical UPLC-MS-ELSD system<\/li>\n\n\n\n<li>Analytical Chiral HPLC<\/li>\n\n\n\n<li>400MHz NMR equipped with autosampler and enabling multinuclei measurements<\/li>\n\n\n\n<li>Polarimeter<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">In addition, the large resources in other Core Facilities at EMBL also enable us to perform advanced characterisations including: UV-Vis, fluorescence spectroscopy, and HRMS.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><\/h2>\n\n<\/div>\n<\/div>\n\n\n<div class=\"\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"937\" height=\"624\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/groups\/chemical-synthesis-core-facility\/wp-content\/uploads\/2024\/01\/ChemLab1.jpg\" alt=\"\" class=\"wp-image-120\" srcset=\"https:\/\/www.embl.org\/groups\/chemical-synthesis-core-facility\/wp-content\/uploads\/2024\/01\/ChemLab1.jpg 937w, https:\/\/www.embl.org\/groups\/chemical-synthesis-core-facility\/wp-content\/uploads\/2024\/01\/ChemLab1-300x200.jpg 300w, https:\/\/www.embl.org\/groups\/chemical-synthesis-core-facility\/wp-content\/uploads\/2024\/01\/ChemLab1-768x511.jpg 768w\" sizes=\"auto, (max-width: 937px) 100vw, 937px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"937\" height=\"624\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/groups\/chemical-synthesis-core-facility\/wp-content\/uploads\/2024\/01\/ChemLab2.jpg\" alt=\"\" class=\"wp-image-122\" srcset=\"https:\/\/www.embl.org\/groups\/chemical-synthesis-core-facility\/wp-content\/uploads\/2024\/01\/ChemLab2.jpg 937w, https:\/\/www.embl.org\/groups\/chemical-synthesis-core-facility\/wp-content\/uploads\/2024\/01\/ChemLab2-300x200.jpg 300w, https:\/\/www.embl.org\/groups\/chemical-synthesis-core-facility\/wp-content\/uploads\/2024\/01\/ChemLab2-768x511.jpg 768w\" sizes=\"auto, (max-width: 937px) 100vw, 937px\" \/><\/figure>\n\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"vf_template_front_page.php","meta":{"_acf_changed":false,"footnotes":""},"embl_taxonomy":[],"class_list":["post-23","page","type-page","status-publish","hentry"],"acf":[],"embl_taxonomy_terms":[],"_links":{"self":[{"href":"https:\/\/www.embl.org\/groups\/chemical-synthesis-core-facility\/wp-json\/wp\/v2\/pages\/23","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/groups\/chemical-synthesis-core-facility\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.embl.org\/groups\/chemical-synthesis-core-facility\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/groups\/chemical-synthesis-core-facility\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/groups\/chemical-synthesis-core-facility\/wp-json\/wp\/v2\/comments?post=23"}],"version-history":[{"count":14,"href":"https:\/\/www.embl.org\/groups\/chemical-synthesis-core-facility\/wp-json\/wp\/v2\/pages\/23\/revisions"}],"predecessor-version":[{"id":187,"href":"https:\/\/www.embl.org\/groups\/chemical-synthesis-core-facility\/wp-json\/wp\/v2\/pages\/23\/revisions\/187"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/groups\/chemical-synthesis-core-facility\/wp-json\/wp\/v2\/media?parent=23"}],"wp:term":[{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/groups\/chemical-synthesis-core-facility\/wp-json\/wp\/v2\/embl_taxonomy?post=23"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}