{"id":287,"date":"2020-06-09T10:11:34","date_gmt":"2020-06-09T10:11:34","guid":{"rendered":"https:\/\/www.embl.org\/groups\/chemical-biology\/?page_id=287"},"modified":"2021-04-27T07:27:31","modified_gmt":"2021-04-27T07:27:31","slug":"medicinal-chemistry","status":"publish","type":"page","link":"https:\/\/www.embl.org\/groups\/chemical-biology\/medicinal-chemistry\/","title":{"rendered":"Medicinal Chemistry"},"content":{"rendered":"\n<div class=\"vf-grid | vf-grid__col-3\"><div class=\"vf-grid__col--span-2\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<ul class=\"wp-block-list\"><li>Headed by a Medicinal Chemist with 20 years of Big Pharma experience<\/li><li>Staffed by experienced postdoctoral Chemists<\/li><li>Expertise in small molecule synthesis as well as in peptide, bioconjugate and exotic molecule synthesis<\/li><li>Consultation provided on all chemistry questions<\/li><li>Training provided to visitors<\/li><\/ul>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"vf-grid | vf-grid__col-3\"><div class=\"vf-grid__col--span-2\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<h2 class=\"wp-block-heading\">Facilities and services<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">A state-of-the-art Medicinal Chemistry Lab equipped to Industry standards:<\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li>10 fumes hoods<\/li><li>Analytical UPLC-MS-ELSD system<\/li><li>Preparative HPLC-MS<\/li><li>Preparative HPLC<\/li><li>Flash Chromatography system<\/li><li>Microwave Reactor<\/li><li>H-Cube Flow Hydrogenator<\/li><li>NMR (autosampler, multinucleus)<\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Focus on productivity and efficiency:<\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li>Parallel synthesis and work-up equipment<\/li><li>Use of automated systems to save time<\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Provides consultancy and support in developing Chemistry strategies for projects:<\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li>Most Principal Investigators are not chemists and require chemistry advice and planning support to get the most out of their projects<\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Cost estimation for Chemistry projects as well as outsourcing advice is provided<\/h3>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<figure class=\"vf-figure wp-block-image size-large\"><a href=\"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-content\/uploads\/2020\/06\/main-lab.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"820\" height=\"547\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-content\/uploads\/2020\/06\/main-lab.jpg\" alt=\"The main lab\" class=\"wp-image-306\" srcset=\"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-content\/uploads\/2020\/06\/main-lab.jpg 820w, https:\/\/www.embl.org\/groups\/chemical-biology\/wp-content\/uploads\/2020\/06\/main-lab-300x200.jpg 300w, https:\/\/www.embl.org\/groups\/chemical-biology\/wp-content\/uploads\/2020\/06\/main-lab-768x512.jpg 768w\" sizes=\"auto, (max-width: 820px) 100vw, 820px\" \/><\/a><figcaption class=\"vf-figure__caption\">The main lab<\/figcaption><\/figure>\n\n\n\n<figure class=\"vf-figure wp-block-image size-large\"><a href=\"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-content\/uploads\/2020\/06\/instrument-room.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"820\" height=\"547\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-content\/uploads\/2020\/06\/instrument-room.jpg\" alt=\"Chemical Biology Core Facility Instrument room\" class=\"wp-image-307\" srcset=\"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-content\/uploads\/2020\/06\/instrument-room.jpg 820w, https:\/\/www.embl.org\/groups\/chemical-biology\/wp-content\/uploads\/2020\/06\/instrument-room-300x200.jpg 300w, https:\/\/www.embl.org\/groups\/chemical-biology\/wp-content\/uploads\/2020\/06\/instrument-room-768x512.jpg 768w\" sizes=\"auto, (max-width: 820px) 100vw, 820px\" \/><\/a><figcaption class=\"vf-figure__caption\">The Instrument room<\/figcaption><\/figure>\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"vf-divider\">\n\n\n\n<div class=\"vf-grid | vf-grid__col-3\"><div class=\"vf-grid__col--span-2\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<h2 class=\"wp-block-heading\">Projects<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Optimising screening hits to generate more potent and selective tool compounds for research<\/li><li>Hit-to-Lead programs for screening hits<\/li><li>Chemistry support for target identification for phenotypic screening hits<\/li><li>Compound design and optimisation based on structural biology results<\/li><li>Small-molecule and peptide synthesis<\/li><li><em>De novo<\/em>&nbsp;design of bioactive molecules<\/li><li>Hit-to-Preclinical Development using CROs<\/li><\/ul>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<figure class=\"vf-figure wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"820\" height=\"508\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-content\/uploads\/2020\/06\/projects02.jpg\" alt=\"A typical fume hood for one scientist\" class=\"wp-image-315\" srcset=\"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-content\/uploads\/2020\/06\/projects02.jpg 820w, https:\/\/www.embl.org\/groups\/chemical-biology\/wp-content\/uploads\/2020\/06\/projects02-300x186.jpg 300w, https:\/\/www.embl.org\/groups\/chemical-biology\/wp-content\/uploads\/2020\/06\/projects02-768x476.jpg 768w\" sizes=\"auto, (max-width: 820px) 100vw, 820px\" \/><figcaption class=\"vf-figure__caption\">A typical fume hood for one scientist<\/figcaption><\/figure>\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"vf-divider\">\n\n\n\n<div class=\"vf-grid | vf-grid__col-3\"><div class=\"vf-grid__col--span-2\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<h2 class=\"wp-block-heading\">Visitors<\/h2>\n\n\n\n<p>We have visitor hoods available for researchers who carry out the chemistry part of interdisciplinary projects at EMBL and the rest in their home labs. Full training of visitors is provided. Supervision and advice is provided by the staff chemists of the MedChem lab. Visitors have access to all lab infrastructure.<\/p>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-title-left-aligned.php","meta":{"_acf_changed":false,"footnotes":""},"embl_taxonomy":[],"class_list":["post-287","page","type-page","status-publish","hentry"],"acf":[],"embl_taxonomy_terms":[],"_links":{"self":[{"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/pages\/287","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/comments?post=287"}],"version-history":[{"count":79,"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/pages\/287\/revisions"}],"predecessor-version":[{"id":997,"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/pages\/287\/revisions\/997"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/media?parent=287"}],"wp:term":[{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/embl_taxonomy?post=287"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}