{"id":22,"date":"2020-06-08T10:44:26","date_gmt":"2020-06-08T10:44:26","guid":{"rendered":"https:\/\/www.embl.org\/groups\/chemical-biology\/about\/"},"modified":"2022-10-20T17:08:42","modified_gmt":"2022-10-20T17:08:42","slug":"about","status":"publish","type":"page","link":"https:\/\/www.embl.org\/groups\/chemical-biology\/about\/","title":{"rendered":"About"},"content":{"rendered":"\n<div class=\"vf-grid | vf-grid__col-3\"><div class=\"vf-grid__col--span-2\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<p>The Chemical Biology Core Facility (CBCF) offers the infrastructure and expertise for assay development, small-molecule screening and use of medicinal chemistry to optimise compounds against novel targets for &#8216;biotool&#8217; or early drug development.<\/p>\n\n\n\n<p>The facility is set up as a collaboration between EMBL and <a rel=\"noreferrer noopener\" href=\"http:\/\/www.dkfz.de\/en\/index.html\" target=\"_blank\">German Cancer Research Center (DKFZ)<\/a> to provide the infrastructure and expertise to open up small molecule development to research groups at these institutions.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Our aim is to enable research groups to:<\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li>Explore the biology-chemistry interface by complementing excellence in biology with innovative chemistry<\/li><li>Identify novel low molecular weight compounds for use as \u2018biotools\u2019 to probe biological function<\/li><li>Generate added value on in-house targets for basic research and for Intellectual Property<\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Our key services<\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li>Application of high-throughput screening approaches to identify biotools or hit compounds<\/li><li>Computational screening using ligand-based and structure-based design strategies<\/li><li>Medicinal chemistry optimisation of hits to generate high-quality tool compounds<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th><\/th><th>Major achievements and accomplishments<\/th><\/tr><\/thead><tbody><tr><td>2004<\/td><td>Facility established in 2004 as a collaboration between EMBL and&nbsp;<a rel=\"noreferrer noopener\" href=\"http:\/\/www.dkfz.de\/en\/drugs\/index.php\" target=\"_blank\">German Cancer Research Center (DKFZ)<\/a>.<\/td><\/tr><tr><td>2006<\/td><td>Spin-off of Elara Pharmaceuticals GmbH out of the facility to develop dual inhibitors targeting tumors.<\/td><\/tr><tr><td>2009<\/td><td>Computational chemistry established. Spin-off of Savira GmbH to develop and commercialise screening derived hits targeting influenza virus.<\/td><\/tr><tr><td>2013<\/td><td>Upgrade of the P3 Evolution pipetting system to an automation platform linking the&nbsp; Janus robot, liquid handler, Cytomat cell incubator and Envision reader<\/td><\/tr><tr><td>2014<\/td><td>Medicinal Chemistry lab opened<\/td><\/tr><tr><td>2015<\/td><td>Execution of 1536 HTS screen with patient derived cells on automation platform<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Steering Committee<\/h3>\n\n\n\n<p>The overall direction of the facility is overseen by a steering committee which has senior members of staff from the EMBL and DKFZ. The projects are considered on a case-by-case basis, following preliminary evaluation for suitability and amenability to screening. The committee further reviews and assesses technical difficulties and determines priorities for new projects.<\/p>\n\n\n\n<p>Please contact&nbsp;us&nbsp;to submit a project proposal.<\/p>\n\n<\/div>\n<\/div>\n\n\n<div class=\"\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<h3 class=\"wp-block-heading\">Contact:<\/h3>\n\n\n\n<p><strong>Chemical Biology Core Facility<\/strong><br>EMBL Heidelberg, Meyerhofstra\u00dfe 1, 69117 Heidelberg, Germany<\/p>\n\n\n\n<p><strong>Phone:<\/strong>\u00a0+49 6221 387-8303<br><strong>Fax:<\/strong>\u00a0+49 6221 387-8306<br><strong>Email:<\/strong>\u00a0<a href=\"https:\/\/www.embl.org\/groups\/chemical-biology\/contact\/\" data-type=\"page\" data-id=\"3962\">General enquiries<\/a><\/p>\n\n\n\n<hr class=\"vf-divider\">\n\n\n\n<h3 class=\"wp-block-heading\">Technology partners<\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li>Agilent, Certara<\/li><li>GE<\/li><li>IDBS<\/li><li>Perkin Elmer<\/li><li>ThermoFisher<\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Chemistry partners<\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li>ChemDiv<\/li><li>Chembridge<\/li><li>Enamine<\/li><li>Sigma-Aldrich<\/li><\/ul>\n\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-title-left-aligned.php","meta":{"_acf_changed":false,"footnotes":""},"embl_taxonomy":[],"class_list":["post-22","page","type-page","status-publish","hentry"],"acf":[],"embl_taxonomy_terms":[],"_links":{"self":[{"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/pages\/22","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/comments?post=22"}],"version-history":[{"count":19,"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/pages\/22\/revisions"}],"predecessor-version":[{"id":3990,"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/pages\/22\/revisions\/3990"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/media?parent=22"}],"wp:term":[{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/embl_taxonomy?post=22"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}