{"id":14,"date":"2020-06-08T10:42:29","date_gmt":"2020-06-08T10:42:29","guid":{"rendered":"https:\/\/www.embl.org\/groups\/chemical-biology\/home\/"},"modified":"2024-11-20T08:39:06","modified_gmt":"2024-11-20T08:39:06","slug":"home","status":"publish","type":"page","link":"https:\/\/www.embl.org\/groups\/chemical-biology\/","title":{"rendered":"Home"},"content":{"rendered":"\n<div class=\"vf-grid | vf-grid__col-3\"><div class=\"vf-grid__col--span-2\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<p class=\"vf-lede\">The Chemical Biology Core Facility (CBCF) offers the infrastructure and expertise for assay development, small-molecule screening and computational chemistry approaches to design compounds against novel targets for \u2018biotool\u2019 or early drug development.<\/p>\n<!--\/vf-lede-->\n\n\n\n\n<p><\/p>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"embl-grid embl-grid--has-centered-content\"><div><!--[vf\/content]-->\n<div class=\"vf-content\">\n<div class=\"vf-section-header | vf-u-margin__bottom--400\">\n  <h2 class=\"vf-section-header__heading\" \n    >\n  Services provided  <\/h2>\n  <\/div>\n\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<p>The facility is set up as a collaboration between EMBL and <a rel=\"noreferrer noopener\" href=\"http:\/\/www.dkfz.de\/en\/index.html\" target=\"_blank\">German Cancer Research Center (DKFZ)<\/a> to provide the infrastructure and expertise to open up small molecule development to research groups at these institutions.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"\/groups\/chemical-biology\/screening\">Assay development and high-throughput screening<\/a><\/li>\n\n\n\n<li>Binding affinity studies for small molecules and antibodies using the&nbsp;<a href=\"https:\/\/www.embl.org\/groups\/chemical-biology\/screening\/#facilities\" data-type=\"page\">Biacore<\/a>&nbsp;surface plasmon resonance technology (SPR)<\/li>\n\n\n\n<li><a href=\"\/groups\/chemical-biology\/computational-chemistry\/\">Computational screening<\/a>&nbsp;using ligand-based and structure-based design strategies<\/li>\n\n\n\n<li>With the help of EMBL&#8217;s <a href=\"\/groups\/chemical-synthesis-core-facility\/\">Chemical Synthesis Core Facility<\/a>&nbsp; hit compounds can be optimised towards high quality tool compounds<\/li>\n\n\n\n<li>Managing compound acquisition through our chemistry partners<\/li>\n\n\n\n<li>Support in generating structure-activity relationships <\/li>\n\n\n\n<li>Support in optimisation of tool compounds towards therapeutic use<\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<figure class=\"vf-figure wp-block-image size-large\"><a href=\"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-content\/uploads\/2021\/04\/CBCF-9-m.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"667\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-content\/uploads\/2021\/04\/CBCF-9-m.jpg\" alt=\"\" class=\"wp-image-983\" srcset=\"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-content\/uploads\/2021\/04\/CBCF-9-m.jpg 1000w, https:\/\/www.embl.org\/groups\/chemical-biology\/wp-content\/uploads\/2021\/04\/CBCF-9-m-300x200.jpg 300w, https:\/\/www.embl.org\/groups\/chemical-biology\/wp-content\/uploads\/2021\/04\/CBCF-9-m-768x512.jpg 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/a><\/figure>\n\n\n\n<p><\/p>\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"vf-divider\">\n\n\n\n<div class=\"embl-grid embl-grid--has-centered-content\"><div><!--[vf\/content]-->\n<div class=\"vf-content\">\n<div class=\"vf-section-header | vf-u-margin__bottom--400\">\n  <h2 class=\"vf-section-header__heading\" \n    >\n        <a class=\"vf-section-header__heading vf-section-header__heading--is-link\"\n            href=\"\/groups\/chemical-biology\/screening\/\">Screening<svg aria-hidden=\"true\" class=\"vf-section-header__icon | vf-icon vf-icon-arrow--inline-end\" width=\"24\" height=\"24\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M0 12c0 6.627 5.373 12 12 12s12-5.373 12-12S18.627 0 12 0C5.376.008.008 5.376 0 12zm13.707-5.209l4.5 4.5a1 1 0 010 1.414l-4.5 4.5a1 1 0 01-1.414-1.414l2.366-2.367a.25.25 0 00-.177-.424H6a1 1 0 010-2h8.482a.25.25 0 00.177-.427l-2.366-2.368a1 1 0 011.414-1.414z\" fill=\"\" fill-rule=\"nonzero\"><\/path><\/svg><\/a>\n      <\/h2>\n  <\/div>\n\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<p>High Throughput Screening (HTS) allows a researcher to quickly conduct thousands of tests against a biological target through the use of automation (robotics,&nbsp;liquid handling devices,&nbsp;sensitive detectors), data processing and control software.&nbsp;<\/p>\n\n\n\n<p><\/p>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"vf-divider\">\n\n\n\n<div class=\"embl-grid embl-grid--has-centered-content\"><div><!--[vf\/content]-->\n<div class=\"vf-content\">\n<div class=\"vf-section-header | vf-u-margin__bottom--400\">\n  <h2 class=\"vf-section-header__heading\" \n    >\n        <a class=\"vf-section-header__heading vf-section-header__heading--is-link\"\n            href=\"\/groups\/chemical-biology\/computational-chemistry\/\">Computational Chemistry<svg aria-hidden=\"true\" class=\"vf-section-header__icon | vf-icon vf-icon-arrow--inline-end\" width=\"24\" height=\"24\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M0 12c0 6.627 5.373 12 12 12s12-5.373 12-12S18.627 0 12 0C5.376.008.008 5.376 0 12zm13.707-5.209l4.5 4.5a1 1 0 010 1.414l-4.5 4.5a1 1 0 01-1.414-1.414l2.366-2.367a.25.25 0 00-.177-.424H6a1 1 0 010-2h8.482a.25.25 0 00.177-.427l-2.366-2.368a1 1 0 011.414-1.414z\" fill=\"\" fill-rule=\"nonzero\"><\/path><\/svg><\/a>\n      <\/h2>\n  <\/div>\n\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<p>Computational chemistry methods are integral to the process of active molecule identification and optimisation. These include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Chemoinformatics approaches<\/li>\n\n\n\n<li>Molecular modelling<\/li>\n\n\n\n<li>Computational screening using ligand-based and structure-based design strategies<\/li>\n\n\n\n<li>Managing compound acquisition through our chemistry partners<\/li>\n\n\n\n<li>Commercial software available: SYBYL-X including SurflexDock and SurflexSim, LeadIT including FlexX and FlexS, Muse, Spartan<\/li>\n\n\n\n<li>Access to the HPC compute cluster at EMBL which provides access to more than 5800 CPUs for scientific computing at EMBL<\/li>\n<\/ul>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"vf_template_with-nav-bar.php","meta":{"_acf_changed":false,"footnotes":""},"embl_taxonomy":[],"class_list":["post-14","page","type-page","status-publish","hentry"],"acf":[],"embl_taxonomy_terms":[],"_links":{"self":[{"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/pages\/14","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/comments?post=14"}],"version-history":[{"count":178,"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/pages\/14\/revisions"}],"predecessor-version":[{"id":17319,"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/pages\/14\/revisions\/17319"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/media?parent=14"}],"wp:term":[{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/groups\/chemical-biology\/wp-json\/wp\/v2\/embl_taxonomy?post=14"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}