{"id":2941,"date":"2013-09-25T13:05:35","date_gmt":"2013-09-25T11:05:35","guid":{"rendered":"http:\/\/emblog.embl.de\/ells\/?page_id=2941"},"modified":"2021-06-18T14:18:58","modified_gmt":"2021-06-18T14:18:58","slug":"how-can-you-fold-a-protein","status":"publish","type":"teachingbase","link":"https:\/\/www.embl.org\/ells\/teachingbase\/how-can-you-fold-a-protein\/","title":{"rendered":"How can you fold a protein?"},"content":{"rendered":"\n<div class=\"vf-tabs\"><ul class=\"vf-tabs__list\" data-vf-js-tabs=\"true\"><li class=\"vf-tabs__item\"><a class=\"vf-tabs__link\" href=\"#vf-tabs__section-ca1f7db6-6aef-48c3-be02-2f1146ec75df\">Introduction<\/a><\/li><li class=\"vf-tabs__item\"><a class=\"vf-tabs__link\" href=\"#vf-tabs__section-0bfd6d44-234e-4af3-b906-883c8c2a7fdf\">Materials<\/a><\/li><li class=\"vf-tabs__item\"><a class=\"vf-tabs__link\" href=\"#vf-tabs__section-8b0bea6d-082a-4948-93f8-b7029c442c47\">Folding tutorial<\/a><\/li><\/ul><div class=\"vf-tabs-content\" data-vf-js-tabs-content=\"true\">\n<section class=\"vf-tabs__section\" id=\"vf-tabs__section-ca1f7db6-6aef-48c3-be02-2f1146ec75df\"><h2>Introduction<\/h2>\n<h3 class=\"wp-block-heading\">Create your own protein model<\/h3>\n\n\n\n<p>Would you like to create your own three-dimensional model of a protein using an A4 paper template?<\/p>\n\n\n\n<p>You can do this by following the instructions to fold a triosephosphate isomerase (TIM) barrel. TIM barrels are some of the most common structural motifs found in proteins. In a TIM barrel eight \u03b1-helices and eight parallel \u03b2-strands form a solenoid that curves around to close on itself in a doughnut shape. Triosephosphate isomerase is a conserved metabolic enzyme that is involved in the production of chemical energy from sugar, a process called glycolysis.<\/p>\n<\/section>\n\n\n\n<section class=\"vf-tabs__section\" id=\"vf-tabs__section-0bfd6d44-234e-4af3-b906-883c8c2a7fdf\"><h2>Materials<\/h2>\n<p>Download the TIM barrel folding template here.<\/p>\n\n\n\n<div class=\"wp-block-file\"><a  href=\"https:\/\/www.embl.org\/ells\/wp-content\/uploads\/2021\/05\/timbarrel_guide.pdf\" class=\"wp-block-file__button vf-button vf-button--primary vf-button--pill vf-button--s\" download style=\"margin:0 0 0 .75em;\">Download<\/a><\/div>\n<\/section>\n\n\n\n<section class=\"vf-tabs__section\" id=\"vf-tabs__section-8b0bea6d-082a-4948-93f8-b7029c442c47\"><h2>Folding tutorial<\/h2>\n<h3 class=\"wp-block-heading\">Folding tutorial<\/h3>\n\n\n\n<ol class=\"wp-block-list\"><li>Cut out protein&nbsp;&nbsp;along dotted lines<\/li><li>Curl blue helix&nbsp;behind arrows&nbsp;matching the&nbsp;numbers and&nbsp;sticking down.<\/li><li>Bend tube with red arrows facing inwards to create the barrel. Stick last tab to finish.<\/li><\/ol>\n\n\n\n<p><\/p>\n\n\n\n<p>Some explanatory pictures accompanying the folding tutorial can be found on the&nbsp;TIM barrel folding template.<\/p>\n<\/section>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>3D paper model of a TIM barrel-shaped protein<\/p>\n","protected":false},"featured_media":26086,"parent":0,"menu_order":8,"template":"","class_list":["post-2941","teachingbase","type-teachingbase","status-publish","has-post-thumbnail","hentry","age-group-05-10","age-group-10-12","age-group-12-14","age-group-14-16","topic-area-structural-computational-biology"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.embl.org\/ells\/wp-json\/wp\/v2\/teachingbase\/2941","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/ells\/wp-json\/wp\/v2\/teachingbase"}],"about":[{"href":"https:\/\/www.embl.org\/ells\/wp-json\/wp\/v2\/types\/teachingbase"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.embl.org\/ells\/wp-json\/wp\/v2\/media\/26086"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/ells\/wp-json\/wp\/v2\/media?parent=2941"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}