{"id":28501,"date":"2015-10-05T13:47:08","date_gmt":"2015-10-05T11:47:08","guid":{"rendered":"https:\/\/www.embl.org\/ells\/teachingbase\/opsins-bioinformatics\/part-4-topological-and-structural-analysis-of-proteins\/"},"modified":"2021-06-16T14:33:15","modified_gmt":"2021-06-16T14:33:15","slug":"part-4-topological-and-structural-analysis-of-proteins","status":"publish","type":"teachingbase","link":"https:\/\/www.embl.org\/ells\/teachingbase\/opsins-bioinformatics\/part-4-topological-and-structural-analysis-of-proteins\/?lang=el","title":{"rendered":"\u039c\u03ad\u03c1\u03bf\u03c2 4\u03bf: \u03a4\u03bf\u03c0\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b4\u03bf\u03bc\u03b9\u03ba\u03ae \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd"},"content":{"rendered":"\n<div class=\"vf-tabs\"><ul class=\"vf-tabs__list\" data-vf-js-tabs=\"true\"><li class=\"vf-tabs__item\"><a class=\"vf-tabs__link\" href=\"#vf-tabs__section-feeb5d9b-3c8d-4306-b0e3-a7aaf182833d\">Overview<\/a><\/li><li class=\"vf-tabs__item\"><a class=\"vf-tabs__link\" href=\"#vf-tabs__section-a825691f-52a3-4fdb-ad2b-e746a1da8a8c\">\u0397 \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 \u03c3\u03bf\u03c5<\/a><\/li><li class=\"vf-tabs__item\"><a class=\"vf-tabs__link\" href=\"#vf-tabs__section-a06ebf8a-83a2-4f49-a96a-4f17cb2ab058\">Uniprot \u03ba\u03b1\u03b9 PDBe<\/a><\/li><li class=\"vf-tabs__item\"><a class=\"vf-tabs__link\" href=\"#vf-tabs__section-a68c550e-908c-4c46-8c0b-6e40d1090e49\">\u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/a><\/li><li class=\"vf-tabs__item\"><a class=\"vf-tabs__link\" href=\"#vf-tabs__section-ff1dedb3-2691-46d2-9e4d-5d2ff1cc3fba\">Activity navigation<\/a><\/li><\/ul><div class=\"vf-tabs-content\" data-vf-js-tabs-content=\"true\">\n<section class=\"vf-tabs__section\" id=\"vf-tabs__section-feeb5d9b-3c8d-4306-b0e3-a7aaf182833d\"><h2>Overview<\/h2>\n<p>\u0395\u03ba\u03c4\u03cc\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03bd\u03b1 \u03b1\u03bd\u03b1\u03bb\u03cd\u03c3\u03bf\u03c5\u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03bf\u03c4\u03b1\u03b3\u03ae \u03b4\u03bf\u03bc\u03ae \u03c4\u03c9\u03bd \u03bf\u03c8\u03b9\u03bd\u03ce\u03bd, \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bc\u03b5 \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03bf\u03c5\u03bc\u03b5 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b5\u03c2 \u03b1\u03c0\u03cc \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 \u03b2\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03bc\u03ac\u03b8\u03bf\u03c5\u03bc\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03b4\u03bf\u03bc\u03ae \u03c4\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd. \u03a3\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1, \u03b8\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03bf\u03c5\u03bc\u03b5 \u03c4\u03b7 \u03b2\u03cc\u03b5\u03b9\u03b1 \u03c1\u03bf\u03b4\u03bf\u03c8\u03af\u03bd\u03b7 \u03c4\u03b7\u03bd \u03bf\u03c0\u03bf\u03af\u03b1 \u03c4\u03b1\u03c5\u03c4\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b1\u03bc\u03b5 \u03c3\u03c4\u03bf 1\u03bf \u03bc\u03ad\u03c1\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c9\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03bf\u03c5\u03bc\u03b5 \u03b1\u03bd\u03b1\u03b6\u03ae\u03c4\u03b7\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03b2\u03ac\u03c3\u03b7 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd Uniprot \u03b3\u03b9\u03b1 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b5\u03c2 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7 \u03b4\u03b5\u03c5\u03c4\u03b5\u03c1\u03bf\u03c4\u03b1\u03b3\u03ae \u03b4\u03bf\u03bc\u03ae \u03c4\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b8\u03ad\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7 (\u03bb.\u03c7., \u03c0\u03c9\u03c2 \u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b9\u03ba\u03ae \u03b4\u03bf\u03bc\u03ae \u03c4\u03bf\u03c0\u03bf\u03b8\u03b5\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7). \u0398\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03bf\u03c5\u03bc\u03b5 \u03c4\u03b7\u03bd \u0395\u03c5\u03c1\u03c9\u03c0\u03b1\u03ca\u03ba\u03ae \u03b2\u03ac\u03c3\u03b7 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd (PDBe), \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03bf\u03c0\u03c4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03bf\u03c5\u03bc\u03b5 \u03c4\u03b9\u03c2 \u03c4\u03c1\u03b9\u03c3\u03b4\u03b9\u03ac\u03c3\u03c4\u03b1\u03c4\u03b5\u03c2 \u03b4\u03bf\u03bc\u03ad\u03c2 \u03c4\u03c9\u03bd \u03b2\u03cc\u03b5\u03b9\u03c9\u03bd \u03c1\u03bf\u03b4\u03bf\u03c8\u03b9\u03bd\u03ce\u03bd.<\/p>\n<\/section>\n\n\n\n<section class=\"vf-tabs__section\" id=\"vf-tabs__section-a825691f-52a3-4fdb-ad2b-e746a1da8a8c\"><h2>\u0397 \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 \u03c3\u03bf\u03c5<\/h2>\n<p><strong>\u03a0\u03c1\u03bf\u03c7\u03ce\u03c1\u03b7\u03c3\u03b5 \u03cc\u03c0\u03c9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03ba\u03ac\u03c4\u03c9:<\/strong><\/p>\n\n\n\n<p><strong>1.<\/strong> \u0391\u03bd\u03b1\u03b6\u03ae\u03c4\u03b7\u03c3\u03b5 \u03c4\u03b7 \u03b2\u03cc\u03b5\u03b9\u03b1 \u03c1\u03bf\u03b4\u03bf\u03c8\u03af\u03bd\u03b7 \u03c3\u03c4\u03b7 \u03b2\u03ac\u03c3\u03b7 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd Uniprot \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c0\u03ac\u03c1\u03b5\u03b9\u03c2 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b5\u03c5\u03c4\u03b5\u03c1\u03bf\u03c4\u03b1\u03b3\u03ae \u03b4\u03bf\u03bc\u03ae \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c4\u03bf\u03c0\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03b7\u03c2.<br><strong>2.<\/strong> \u0391\u03bd\u03b1\u03ba\u03ac\u03bb\u03c5\u03c8\u03b5 \u03c4\u03b7\u03bd \u03c4\u03c1\u03b9\u03c3\u03b4\u03b9\u03ac\u03c3\u03c4\u03b1\u03c4\u03b7 \u03b4\u03bf\u03bc\u03ae \u03c4\u03b7\u03c2 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd PDBe.<br><strong>3.<\/strong> \u03a0\u03c1\u03bf\u03c3\u03c0\u03ac\u03b8\u03b7\u03c3\u03b5 \u03bd\u03b1 \u03b1\u03c0\u03b1\u03bd\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b9\u03c2 \u03b5\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2.<\/p>\n<\/section>\n\n\n\n<section class=\"vf-tabs__section\" id=\"vf-tabs__section-a06ebf8a-83a2-4f49-a96a-4f17cb2ab058\"><h2>Uniprot \u03ba\u03b1\u03b9 PDBe<\/h2>\n<p id=\"tw-target-text\"><strong>1.<\/strong> \u0386\u03bd\u03bf\u03b9\u03b3\u03bc\u03b1 \u03c3\u03c5\u03bd\u03b4\u03ad\u03c3\u03bc\u03bf\u03c5 \u03c3\u03b5 \u03bd\u03ad\u03bf \u03c0\u03b1\u03c1\u03ac\u03b8\u03c5\u03c1\u03bf \u03c0\u03c1\u03bf\u03b3\u03c1\u03ac\u03bc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c0\u03b5\u03c1\u03b9\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2: <a href=\"https:\/\/www.uniprot.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.uniprot.org\/<\/a><\/p>\n\n\n\n<p><strong>2. <\/strong>\u039a\u03ac\u03bd\u03b5 \u03b1\u03bd\u03b1\u03b6\u03ae\u03c4\u03b7\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03b2\u03ac\u03c3\u03b7 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u201cProtein Knowledgebase (UniProtKB)\u201d \u03bc\u03b5 \u03c4\u03bf \u03bd\u03b1 \u03b5\u03b9\u03c3\u03ac\u03b3\u03b5\u03b9\u03c2 \u03b5\u03af\u03c4\u03b5 \u03c4\u03bf\u03bd \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc \u03ba\u03c9\u03b4\u03b9\u03ba\u03cc, \u03b5\u03af\u03c4\u03b5 \u03c4\u03bf \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c4\u03b7\u03c2 \u03b2\u03cc\u03b5\u03b9\u03b1\u03c2 \u03c1\u03bf\u03b4\u03bf\u03c8\u03af\u03bd\u03b7\u03c2 \u03c3\u03c4\u03bf \u03c0\u03b5\u03b4\u03af\u03bf \u03b1\u03bd\u03b1\u03b6\u03ae\u03c4\u03b7\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c4\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf \u201csearch\u201d. <strong>Uniprot name: OPSD_BOVIN, accession number: P02699<\/strong><br>\u03a3\u03c4\u03b7 \u03c3\u03b5\u03bb\u03af\u03b4\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd, \u03b8\u03b1 \u03b2\u03c1\u03b5\u03b9\u03c2 \u03bc\u03b9\u03b1 \u03c0\u03b5\u03c1\u03af\u03bb\u03b7\u03c8\u03b7 \u03cc\u03bb\u03c9\u03bd \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ce\u03bd \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03b9\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03b1\u03c5\u03c4\u03ae. \u039c\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b9\u03c2 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b5\u03c2 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c0\u03c1\u03bf\u03c3\u03c0\u03ac\u03b8\u03b7\u03c3\u03b5 \u03bd\u03b1 \u03b1\u03c0\u03b1\u03bd\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b9\u03c2 \u03b5\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03bf\u03cd\u03bd.<\/p>\n\n\n\n<p><strong>3.<\/strong> \u0393\u03b9\u03b1 \u03bd\u03b1 \u03c0\u03bb\u03bf\u03b7\u03b3\u03b7\u03b8\u03b5\u03af\u03c2 \u03c3\u03c4\u03b7\u03bd PDBe (Protein Data Bank in Europe), \u03c0\u03ae\u03b3\u03b1\u03b9\u03bd\u03b5 \u03c3\u03c4\u03bf \u03c0\u03b5\u03b4\u03af\u03bf &#8220;\u0391\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03af\u03b5\u03c2&#8221; \u03ba\u03b1\u03b9 \u03ba\u03ac\u03bd\u03b5 \u03ba\u03bb\u03b9\u03ba \u03c3\u03c4\u03bf &#8220;UniParc&#8221; \u03b4\u03af\u03c0\u03bb\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc \u03ba\u03c9\u03b4\u03b9\u03ba\u03cc (accession number). \u039c\u03b5 \u03b1\u03c5\u03c4\u03cc\u03bd \u03c4\u03bf\u03bd \u03c4\u03c1\u03cc\u03c0\u03bf \u03b8\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b2\u03b5\u03af\u03c2 \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03b8\u03ae\u03ba\u03b7 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03b9\u03ce\u03bd \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 \u03c3\u03c5\u03bd\u03b4\u03ad\u03c3\u03bc\u03bf\u03c5\u03c2 \u03b3\u03b9\u03b1 \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c7\u03c9\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u03af\u03bd\u03b7. \u03a0\u03c1\u03bf\u03c3\u03c0\u03ac\u03b8\u03b7\u03c3\u03b5 \u03bd\u03b1 \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c5\u03bd\u03b4\u03ad\u03c3\u03bc\u03bf\u03c5\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd PDB (cf. &#8220;Database&#8221; column) \u03ba\u03b1\u03b9 \u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03c4\u03b1\u03c7\u03c9\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2, \u03ba\u03ac\u03bd\u03b5 \u03ba\u03bb\u03b9\u03ba \u03c3\u03c4\u03b7 \u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03ad\u03c2 (\u03b7 \u03ad\u03ba\u03c4\u03b7 \u03c3\u03c4\u03ae\u03bb\u03b7 \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c7\u03ce\u03c1\u03b7\u03c3\u03b7).<\/p>\n\n\n\n<p><strong>4.<\/strong> \u039c\u03b5 \u03b1\u03c5\u03c4\u03cc\u03bd \u03c4\u03bf\u03bd \u03c4\u03c1\u03cc\u03c0\u03bf \u03bc\u03b5\u03c4\u03b1\u03c6\u03ad\u03c1\u03b5\u03c3\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03c7\u03ce\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 PDBe \u03c0\u03bf\u03c5 \u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03b7 \u03b2\u03cc\u03b5\u03b9\u03b1 \u03c1\u03bf\u03b4\u03bf\u03c8\u03af\u03bd\u03b7.<\/p>\n\n\n\n<p><strong>5.<\/strong> \u039a\u03ac\u03bd\u03b5 \u03ba\u03bb\u03b9\u03ba \u03c3\u03c4\u03bf &#8220;View in 3D&#8221; \u03ba\u03b1\u03b9 \u03b5\u03c0\u03af\u03bb\u03b5\u03be\u03b5 &#8220;Astex Viewer&#8221;. \u03a3\u03b7\u03bc\u03b5\u03af\u03c9\u03c3\u03b5 \u03cc\u03c4\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b5\u03b9\u03b1\u03c3\u03c4\u03b5\u03af \u03bd\u03b1 \u03ac\u03b4\u03b5\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c4\u03c1\u03ad\u03be\u03b5\u03b9\u03c2 \u03c4\u03b7 Java \u03c3\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf.<\/p>\n\n\n\n<p><strong>6.<\/strong> \u03a4\u03ce\u03c1\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af\u03c2 \u03bd\u03b1 \u03b4\u03b5\u03b9\u03c2 \u03c4\u03b7\u03bd \u03c4\u03c1\u03b9\u03c3\u03b4\u03b9\u03ac\u03c3\u03c4\u03b1\u03c4\u03b7 \u03b1\u03c0\u03b5\u03b9\u03ba\u03cc\u03bd\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03bf\u03bc\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03b2\u03cc\u03b5\u03b9\u03b1\u03c2 \u03c1\u03bf\u03b4\u03bf\u03c8\u03af\u03bd\u03b7\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ae\u03c2 \u03ba\u03bf\u03c1\u03b4\u03ad\u03bb\u03b1\u03c2. \u039c\u03c0\u03bf\u03c1\u03b5\u03af\u03c2 \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03bd \u03ba\u03ad\u03c1\u03c3\u03bf\u03c1\u03b1 \u03c3\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c4\u03c1\u03ad\u03c8\u03b5\u03b9\u03c2 \u03c4\u03b7 \u03b4\u03bf\u03bc\u03ae. \u039c\u03b5\u03c1\u03b9\u03ba\u03ac \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03b1 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac (\u03cc\u03c0\u03c9\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c2 \u03b4\u03bf\u03bc\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03b1\u03c0\u03b1\u03c1\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 \u03ae \u03c7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03cc\u03c2) \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd \u03b5\u03af\u03c4\u03b5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf \u03bc\u03b5\u03bd\u03bf\u03cd \u03c3\u03c4\u03b1 \u03b1\u03c1\u03b9\u03c3\u03c4\u03b5\u03c1\u03ac, \u03b5\u03af\u03c4\u03b5 \u03c0\u03b1\u03c4\u03ce\u03bd\u03c4\u03b1\u03c2 \u03b4\u03b5\u03be\u03af \u03ba\u03bb\u03b9\u03ba \u03c3\u03c4\u03b7\u03bd \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1. \u03a0\u03c1\u03bf\u03c3\u03c0\u03ac\u03b8\u03b7\u03c3\u03b5 \u03bd\u03b1 \u03b1\u03c0\u03b1\u03bd\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b9\u03c2 \u03b5\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 \u03b2\u03b1\u03c3\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf\u03c2 \u03c3\u03c4\u03b7\u03bd \u03c4\u03c1\u03b9\u03c3\u03b4\u03b9\u03ac\u03c3\u03c4\u03b1\u03c4\u03b7 \u03b4\u03bf\u03bc\u03ae \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2.<\/p>\n<\/section>\n\n\n\n<section class=\"vf-tabs__section\" id=\"vf-tabs__section-a68c550e-908c-4c46-8c0b-6e40d1090e49\"><h2>\u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<p><strong>1.<\/strong> \u039c\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b9\u03c2 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7 \u03b2\u03ac\u03c3\u03b7 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd Uniprot, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af\u03c2 \u03bd\u03b1 \u03b1\u03c0\u03b1\u03bd\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b9\u03c2 \u03c0\u03b1\u03c1\u03b1\u03ba\u03ac\u03c4\u03c9 \u03b5\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2;<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>\u03a0\u03cc\u03c3\u03b1 \u03b4\u03b9\u03b1\u03bc\u03b5\u03bc\u03b2\u03c1\u03b1\u03bd\u03b9\u03ba\u03ac \u03c4\u03bc\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c4\u03b5\u03b9 \u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03c4\u03b1\u03bd\u03b5\u03bc\u03b7\u03bc\u03ad\u03bd\u03b1 \u03c3\u03c4\u03b7 \u03b4\u03bf\u03bc\u03ae \u03c4\u03b7\u03c2;<\/li><li>\u03a0\u03bf\u03b9\u03b1 \u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03b9\u03ba\u03ac \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b9\u03c0\u03b1 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd \u03c4\u03bf \u03ba\u03ad\u03bd\u03c4\u03c1\u03bf \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c7\u03c1\u03c9\u03bc\u03bf\u03c6\u03cc\u03c1\u03bf\u03c5;<\/li><li>\u03a0\u03bf\u03b9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b4\u03b5\u03c5\u03c4\u03b5\u03c1\u03bf\u03c4\u03b1\u03b3\u03ae\u03c2 \u03b4\u03bf\u03bc\u03ae \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 (\u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1-\u03ad\u03bb\u03b9\u03ba\u03b5\u03c2 \u03ae \u03b2-\u03c0\u03c4\u03c5\u03c7\u03c9\u03c4\u03ad\u03c2 \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b5\u03c2;<\/li><\/ul>\n\n\n\n<p><strong>2. <\/strong>\u039c\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b7\u03bd \u03c4\u03c1\u03b9\u03c3\u03b4\u03b9\u03ac\u03c3\u03c4\u03b1\u03c4\u03b7 \u03b4\u03bf\u03bc\u03ae \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af\u03c2 \u03bd\u03b1 \u03b1\u03c0\u03b1\u03bd\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b9\u03c2 \u03c0\u03b1\u03c1\u03b1\u03ba\u03ac\u03c4\u03c9 \u03b5\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2;<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>\u03a0\u03bf\u03b9\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03c3\u03c7\u03ae\u03bc\u03b1 \u03c4\u03b7\u03c2 \u03b2\u03cc\u03b5\u03b9\u03b1\u03c2 \u03c1\u03bf\u03b4\u03bf\u03c8\u03af\u03bd\u03b7\u03c2;<\/li><li>\u039c\u03c0\u03bf\u03c1\u03b5\u03af\u03c2 \u03bd\u03b1 \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b1-\u03ad\u03bb\u03b9\u03ba\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b2-\u03c0\u03c4\u03c5\u03c7\u03c9\u03c4\u03ad\u03c2 \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b5\u03c2; \u0391\u03c5\u03c4\u03ae \u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03ba\u03c1\u03c5\u03c3\u03c4\u03b1\u03bb\u03bb\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03b4\u03b9\u03bc\u03b5\u03c1\u03ad\u03c2, \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b4\u03cd\u03bf \u03c0\u03bf\u03bb\u03c5\u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2. \u039c\u03c0\u03bf\u03c1\u03b5\u03af\u03c2 \u03bd\u03b1 \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b1 \u03b4\u03cd\u03bf \u03c3\u03b5\u03c4 \u03c4\u03c9\u03bd 7 \u03b4\u03b9\u03b1\u03bc\u03b5\u03bc\u03b2\u03c1\u03b1\u03bd\u03b9\u03ba\u03ce\u03bd \u03b5\u03bb\u03af\u03ba\u03c9\u03bd;<\/li><li>\u039c\u03c0\u03bf\u03c1\u03b5\u03af\u03c2 \u03bd\u03b1 \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b7 \u03b8\u03ad\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03ad\u03bd\u03c4\u03c1\u03bf \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c7\u03c1\u03c9\u03bc\u03bf\u03c6\u03cc\u03c1\u03bf\u03c5 \u03bc\u03ad\u03c3\u03b1 \u03c3\u03c4\u03b7 \u03b4\u03bf\u03bc\u03ae \u03c4\u03b7\u03c2 &#8220;\u03ba\u03bf\u03c1\u03b4\u03ad\u03bb\u03b1\u03c2&#8221;;<\/li><\/ul>\n<\/section>\n\n\n\n<section class=\"vf-tabs__section\" id=\"vf-tabs__section-ff1dedb3-2691-46d2-9e4d-5d2ff1cc3fba\"><h2>Activity navigation<\/h2>\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/www.embl.org\/ells\/teachingbase\/opsins-bioinformatics\/?lang=el\" data-type=\"teachingbase\" data-id=\"28422\">\u0391\u03bd\u03b1\u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03bf\u03c5\u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c4\u03c9\u03bd \u03c6\u03c9\u03c4\u03bf\u03b5\u03c5\u03b1\u03af\u03c3\u03b8\u03b7\u03c4\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd<\/a><\/li><li><a href=\"https:\/\/www.embl.org\/ells\/teachingbase\/opsins-bioinformatics\/part-1-search-for-protein-identity\/?lang=el\" data-type=\"teachingbase\" data-id=\"28444\">\u039c\u03ad\u03c1\u03bf\u03c2 1\u03bf: \u03a4\u03b1\u03c5\u03c4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2<\/a><\/li><li><a href=\"https:\/\/www.embl.org\/ells\/teachingbase\/opsins-bioinformatics\/part-2-multiple-sequence-alignment-of-protein-sequences\/?lang=el\" data-type=\"teachingbase\" data-id=\"28458\">\u039c\u03ad\u03c1\u03bf\u03c2 2\u03bf: \u03a0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ae \u03b5\u03c5\u03b8\u03c5\u03b3\u03c1\u03ac\u03bc\u03bc\u03b9\u03c3\u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b9\u03ba\u03ce\u03bd 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\u03b4\u03bf\u03bc\u03b9\u03ba\u03ae \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd<\/a><\/li><\/ul>\n<\/section>\n<\/div><\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":28502,"parent":28422,"menu_order":1,"template":"","class_list":["post-28501","teachingbase","type-teachingbase","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.embl.org\/ells\/wp-json\/wp\/v2\/teachingbase\/28501","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/ells\/wp-json\/wp\/v2\/teachingbase"}],"about":[{"href":"https:\/\/www.embl.org\/ells\/wp-json\/wp\/v2\/types\/teachingbase"}],"up":[{"embeddable":true,"href":"https:\/\/www.embl.org\/ells\/wp-json\/wp\/v2\/teachingbase\/28422"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.embl.org\/ells\/wp-json\/wp\/v2\/media\/28502"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/ells\/wp-json\/wp\/v2\/media?parent=28501"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}