{"id":28066,"date":"2014-11-27T11:00:44","date_gmt":"2014-11-27T10:00:44","guid":{"rendered":"https:\/\/www.embl.org\/ells\/teachingbase\/focus-on-insulin\/"},"modified":"2021-06-23T09:05:35","modified_gmt":"2021-06-23T09:05:35","slug":"focus-on-insulin","status":"publish","type":"teachingbase","link":"https:\/\/www.embl.org\/ells\/teachingbase\/focus-on-insulin\/?lang=fr","title":{"rendered":"Objet d&#8217;\u00e9tude : l&#8217;insuline"},"content":{"rendered":"\n<div class=\"vf-tabs\"><ul class=\"vf-tabs__list\" data-vf-js-tabs=\"true\"><li class=\"vf-tabs__item\"><a class=\"vf-tabs__link\" href=\"#vf-tabs__section-f96cf143-c40c-46ab-ba8b-84e41fde014c\">Aper\u00e7u<\/a><\/li><li class=\"vf-tabs__item\"><a class=\"vf-tabs__link\" href=\"#vf-tabs__section-8904878a-b65e-4ce4-80e6-51568c615b3a\">Info<\/a><\/li><li class=\"vf-tabs__item\"><a class=\"vf-tabs__link\" href=\"#vf-tabs__section-c3b73c14-0132-4d16-b4da-be8bca52a12e\">Primary<\/a><\/li><li class=\"vf-tabs__item\"><a class=\"vf-tabs__link\" href=\"#vf-tabs__section-1af92796-b70d-4daf-a861-c3b6928d7edf\">Sec.<\/a><\/li><li class=\"vf-tabs__item\"><a class=\"vf-tabs__link\" href=\"#vf-tabs__section-d94535f8-81b4-4691-bebb-b1ef4621058f\">Tert.<\/a><\/li><li class=\"vf-tabs__item\"><a class=\"vf-tabs__link\" href=\"#vf-tabs__section-99c60f7b-cee6-48f4-9464-32e6960784a7\">Quat.<\/a><\/li><li class=\"vf-tabs__item\"><a class=\"vf-tabs__link\" href=\"#vf-tabs__section-8c71fecb-a9e2-40c1-a1b0-aac7db2aad51\">Fiche de travail<\/a><\/li><li class=\"vf-tabs__item\"><a class=\"vf-tabs__link\" href=\"#vf-tabs__section-87d90ccb-95de-4a4a-9c85-ff6acc137f8d\">Associ\u00e9es<\/a><\/li><li class=\"vf-tabs__item\"><a class=\"vf-tabs__link\" href=\"#vf-tabs__section-54bdb726-5329-4976-a0be-12538c5ad04f\">Mat\u00e9riels suppl\u00e9mentaires<\/a><\/li><\/ul><div class=\"vf-tabs-content\" data-vf-js-tabs-content=\"true\">\n<section class=\"vf-tabs__section\" id=\"vf-tabs__section-f96cf143-c40c-46ab-ba8b-84e41fde014c\"><h2>Aper\u00e7u<\/h2>\n<p>Cette ressource p\u00e9dagogique vous guidera dans diff\u00e9rentes \u00e9tapes d&#8217;apprentissage pour l&#8217;exploration de la structure biologique de la mol\u00e9cule de l&#8217;insuline \u2013 de sa structure primaire jusqu&#8217;\u00e0 sa structure quaternaire.<\/p>\n\n\n\n<p>Voici comment d\u00e9buter :<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Choisissez le niveau de structure prot\u00e9inique que vous voulez \u00e9tudier en s\u00e9lectionnant l&#8217;un des onglets suivants.<\/li><li>\u00c9tudiez les d\u00e9tails structurels de l&#8217;insuline et effectuez les exercices propos\u00e9s.<\/li><li>Essayez par la suite de r\u00e9pondre aux questions du <strong>Test de connaissances sur l&#8217;Insuline<\/strong>.<\/li><li>La <strong>Fiche de travail sur l&#8217;Insuline<\/strong> peut \u00eatre imprim\u00e9e et utilis\u00e9e pour tester vos connaissances sur la biologie structurelle de l&#8217;insuline. Colorez les structures afin de les explorer en 3D!<\/li><\/ul>\n<\/section>\n\n\n\n<section class=\"vf-tabs__section\" id=\"vf-tabs__section-8904878a-b65e-4ce4-80e6-51568c615b3a\"><h2>Info<\/h2>\n<p>L&#8217;insuline est synth\u00e9tis\u00e9e au d\u00e9part sous la forme de <strong>pr\u00e9proinsuline<\/strong>, une cha\u00eene polypeptidique \u00e0 110 acides amin\u00e9s qui contient des s\u00e9quences additionnelles :<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Une &#8220;pr\u00e9&#8221; s\u00e9quence N-terminale (un peptide signal form\u00e9 de 24 acides amin\u00e9s), qui permet la production de la prot\u00e9ine.<\/li><li>Une s\u00e9quence &#8220;pro&#8221; centrale (le peptide C form\u00e9 de 35 acides amin\u00e9s), qui d\u00e9termine le repliement ad\u00e9quat de la prot\u00e9ine.<\/li><\/ul>\n\n\n\n<p>Apr\u00e8s la traduction de la pr\u00e9proprot\u00e9ine dans le r\u00e9ticulum endoplasmique, une enzyme coupe les 24 acides amin\u00e9s de la section N-Terminale, qui vont se dissocier de la proinsuline, laquelle se repliera et permettra la formation de liaisons disulfures entre les r\u00e9sidus de cyst\u00e9ine.<br>\u00c0 cette \u00e9tape du processus, la prot\u00e9ine passe par l&#8217;appareil de Golgi, o\u00f9 le peptide C sera retir\u00e9, pour ainsi former la version d\u00e9finitive de l&#8217;insuline qui sera stock\u00e9e dans les v\u00e9sicules de l&#8217;appareil de Golgi.<\/p>\n\n\n\n<p>La prot\u00e9ine de l&#8217;<strong>insuline mature<\/strong> est compos\u00e9e de deux cha\u00eenes polypeptidiques (cha\u00eenes A et B) La cha\u00eene A est form\u00e9e de 21 acides amin\u00e9s et la cha\u00eene B comprend 30 acides amin\u00e9s.<\/p>\n<\/section>\n\n\n\n<section class=\"vf-tabs__section\" id=\"vf-tabs__section-c3b73c14-0132-4d16-b4da-be8bca52a12e\"><h2>Primary<\/h2>\n<p>La prot\u00e9ine de l&#8217;insuline mature consiste en deux cha\u00eenes de polypeptides (cha\u00eenes A et B). La cha\u00eene A est compos\u00e9e de 21 acides amin\u00e9s alors que la cha\u00eene B est form\u00e9e de 30 acides amin\u00e9s (vous pourrez trouver leurs s\u00e9quences ci-dessous).<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>T\u00e2che <\/strong><\/h3>\n\n\n\n<p>Dans les activit\u00e9s suivantes, comparez les cha\u00eenes A (et les cha\u00eenes B) des insulines humaines et porcines en alignant leurs s\u00e9quences d&#8217;acides amin\u00e9s. Y a-t-il des diff\u00e9rences dans leur s\u00e9quence d&#8217;acides amin\u00e9s respective ?<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Copiez les deux s\u00e9quences d&#8217;acides amin\u00e9s ci-dessous, soit celle de l&#8217;insuline humaine et celle de l&#8217;insuline porcine. S\u00e9lectionnez et copiez le bloc complet des s\u00e9quences d\u00e9butant par <em>&gt;sp<\/em> pour les cha\u00eenes A (\u00e9tape 1) puis pour les cha\u00eenes B (\u00e9tape 2).<\/li><li>Collez les s\u00e9quences dans la zone de recherche MUSCLE (raccourci-clavier Ctrl. + V).<\/li><li>Dans la section &#8220;\u00c9TAPE 2&#8221;, assurez-vous que le &#8220;<strong>Format de sortie<\/strong>&#8221; correspond \u00e0 <strong>\u201cClustalW\u201d<\/strong>.<\/li><li>Cliquez sur le gros bouton &#8220;<strong>Envoyer<\/strong>&#8221; et votre alignement sera trait\u00e9.<\/li><li>Vous pourrez voir le r\u00e9sultat en quelques secondes. Observez l&#8217;alignement et r\u00e9pondez aux questions du test.<\/li><\/ol>\n\n\n\n<p>Note : pour arriver \u00e0 envoyer le deuxi\u00e8me ensemble de s\u00e9quences, vous devrez peut-\u00eatre actualiser votre page ce qui permettra de vider la zone de recherche MUSCLE.<\/p>\n\n\n\n<p><strong>\u00c9tape 1 \u2013 Comparez les cha\u00eenes A :<\/strong><br>&gt;sp|P01308|90-110, cha\u00eene A Insuline, Humaine<br>GIVEQCCTSICSLYQLENYCN<br>&gt;sp|P01315|88-108, cha\u00eene A Insuline, Porcine<br>GIVEQCCTSICSLYQLENYCN<\/p>\n\n\n\n<p><strong>\u00c9tape 2 \u2013 Comparez les cha\u00eenes B :<\/strong><br>&gt;sp|P01308|25-54, Cha\u00eene B Insuline, Humaine<br>FVNQHLCGSHLVEALYLVCGERGFFYTPKT<br>&gt;sp|P01315|25-54, cha\u00eene B Insuline, Porcine<br>FVNQHLCGSHLVEALYLVCGERGFFYTPKA<\/p>\n\n\n<div\n  class=\"vf-embed vf-embed--custom-ratio\"\n\n  style=\"--vf-embed-max-width: 100%;\n    --vf-embed-custom-ratio-x: 640;\n    --vf-embed-custom-ratio-y: 320;\"\n><iframe loading=\"lazy\" width=\"640\" height=\"320\" src=\"https:\/\/www.ebi.ac.uk\/Tools\/msa\/muscle\/\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe><\/div>\n<\/section>\n\n\n\n<section class=\"vf-tabs__section\" id=\"vf-tabs__section-1af92796-b70d-4daf-a861-c3b6928d7edf\"><h2>Sec.<\/h2>\n<div class=\"vf-grid | vf-grid__col-2\"><div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<div class=\"wp-block-image\"><figure class=\"vf-figure  | vf-figure--align vf-figure--align-inline-start   size-large\"><a href=\"http:\/\/emblog.embl.de\/ells\/wp-content\/uploads\/2014\/11\/fig10-secB-color-label.png\"><img loading=\"lazy\" decoding=\"async\" width=\"406\" height=\"404\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/ells\/wp-content\/uploads\/2021\/05\/fig10-secB-color-label-e1623765862853.png\" alt=\"\" class=\"wp-image-1425\" srcset=\"https:\/\/www.embl.org\/ells\/wp-content\/uploads\/2021\/05\/fig10-secB-color-label-e1623765862853.png 406w, https:\/\/www.embl.org\/ells\/wp-content\/uploads\/2021\/05\/fig10-secB-color-label-e1623765862853-300x300.png 300w, https:\/\/www.embl.org\/ells\/wp-content\/uploads\/2021\/05\/fig10-secB-color-label-e1623765862853-150x150.png 150w\" sizes=\"auto, (max-width: 406px) 100vw, 406px\" \/><\/a><figcaption class=\"vf-figure__caption\">Insulin A-chain<\/figcaption><\/figure><\/div>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<p>La structure secondaire est d\u00e9termin\u00e9e par deux h\u00e9lices-a dans la cha\u00eene A.<\/p>\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"vf-grid | vf-grid__col-2\"><div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<div class=\"wp-block-image wp-image-6863\"><figure class=\"vf-figure  | vf-figure--align vf-figure--align-inline-start   size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"509\" height=\"530\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/ells\/wp-content\/uploads\/2021\/05\/fig9-A-color-e1623765958763.png\" alt=\"\" class=\"wp-image-1423\" srcset=\"https:\/\/www.embl.org\/ells\/wp-content\/uploads\/2021\/05\/fig9-A-color-e1623765958763.png 509w, https:\/\/www.embl.org\/ells\/wp-content\/uploads\/2021\/05\/fig9-A-color-e1623765958763-288x300.png 288w\" sizes=\"auto, (max-width: 509px) 100vw, 509px\" \/><figcaption class=\"vf-figure__caption\">Insulin B-chain<\/figcaption><\/figure><\/div>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<p>La cha\u00eene B poss\u00e8de une section majeure d&#8217;h\u00e9lice-a et une r\u00e9gion avec un feuillet b\u00eata. Celui-ci se replie avec pr\u00e9cision autour de la cha\u00eene A (voir la structure tertiaire).<\/p>\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n<\/section>\n\n\n\n<section class=\"vf-tabs__section\" id=\"vf-tabs__section-d94535f8-81b4-4691-bebb-b1ef4621058f\"><h2>Tert.<\/h2>\n<div class=\"vf-grid | vf-grid__col-2\"><div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<div class=\"wp-block-image\"><figure class=\"vf-figure  | vf-figure--align vf-figure--align-inline-start   size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"415\" height=\"566\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/ells\/wp-content\/uploads\/2021\/05\/Insulin_tertiary_numb-e1623766022844.png\" alt=\"\" class=\"wp-image-1542\" srcset=\"https:\/\/www.embl.org\/ells\/wp-content\/uploads\/2021\/05\/Insulin_tertiary_numb-e1623766022844.png 415w, https:\/\/www.embl.org\/ells\/wp-content\/uploads\/2021\/05\/Insulin_tertiary_numb-e1623766022844-220x300.png 220w\" sizes=\"auto, (max-width: 415px) 100vw, 415px\" \/><\/figure><\/div>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<p>La structure tertiaire est stabilis\u00e9e par des ponts disulfures (voir la fiche de travail sur l&#8217;insuline). La partie externe de la prot\u00e9ine est polaire, alors que sa partie interne est principalement hydrophobe.<\/p>\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"vf-grid | vf-grid__col-2\"><div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<div class=\"wp-block-image\"><figure class=\"vf-figure  | vf-figure--align vf-figure--align-inline-start   size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"456\" height=\"584\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/ells\/wp-content\/uploads\/2021\/05\/fig6-e1623766058988.png\" alt=\"\" class=\"wp-image-1422\" srcset=\"https:\/\/www.embl.org\/ells\/wp-content\/uploads\/2021\/05\/fig6-e1623766058988.png 456w, https:\/\/www.embl.org\/ells\/wp-content\/uploads\/2021\/05\/fig6-e1623766058988-234x300.png 234w\" sizes=\"auto, (max-width: 456px) 100vw, 456px\" \/><\/figure><\/div>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<p>L&#8217;insuline est compos\u00e9e de deux cha\u00eenes de polypeptides (cha\u00eenes A et B), qui sont unies l&#8217;une \u00e0 l&#8217;autre par deux ponts disulfures; un troisi\u00e8me pont disulfure est situ\u00e9 \u00e0 l&#8217;int\u00e9rieur de la cha\u00eene A.<\/p>\n\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n\n\n<section class=\"vf-tabs__section\" id=\"vf-tabs__section-99c60f7b-cee6-48f4-9464-32e6960784a7\"><h2>Quat.<\/h2>\n<figure class=\"vf-figure wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"500\" height=\"392\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/ells\/wp-content\/uploads\/2021\/05\/Insulin-quaternary-structure_1-e1623766858559.png\" alt=\"\" class=\"wp-image-1543\"\/><\/figure>\n\n\n\n<p>En ce qui concerne la structure quaternaire, l&#8217;insuline a tendance \u00e0 former des dim\u00e8res lorsqu&#8217;elle est plac\u00e9e en solution, ce qui permet la formation de liaisons hydrog\u00e8nes entre les extr\u00e9mit\u00e9s C-terminales de la cha\u00eene B.<\/p>\n<\/section>\n\n\n\n<section class=\"vf-tabs__section\" id=\"vf-tabs__section-8c71fecb-a9e2-40c1-a1b0-aac7db2aad51\"><h2>Fiche de travail<\/h2>\n<p>Commencez par t\u00e9l\u00e9charger la Fiche de travail sur l&#8217;insuline et imprimez-la.<\/p>\n\n\n\n<div class=\"wp-block-file\"><a  href=\"https:\/\/www.embl.org\/ells\/wp-content\/uploads\/2021\/05\/Insulin-worksheet-EMBLog.pdf\" class=\"wp-block-file__button vf-button vf-button--primary vf-button--pill vf-button--s\" download style=\"margin:0 0 0 .75em;\">Download<\/a><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">T\u00e2ches <\/h2>\n\n\n\n<ol class=\"wp-block-list\"><li>Utilisez vos lunettes st\u00e9r\u00e9o pour explorer la structure 3D de la prot\u00e9ine (en haut \u00e0 gauche).<\/li><li>Colorez la <strong>cha\u00eene A de l&#8217;insuline<\/strong> selon le sch\u00e9ma de couleur ci-dessous.<\/li><li>Colorez la <strong>cha\u00eene B de l&#8217;insuline<\/strong> selon le sch\u00e9ma de couleur ci-dessous.<\/li><li>Colorez les structures suivantes dans la prot\u00e9ine de l&#8217;insuline sur la droite :<ul><li>h\u00e9lices alpha<\/li><li>feuillets b\u00eata<\/li><li>liaisons disulfures<\/li><\/ul><\/li><\/ol>\n\n\n\n<h3 class=\"wp-block-heading\">Sch\u00e9ma de coloration:<\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li>h\u00e9lice alpha \u2013 <strong>rouge<\/strong><\/li><li>feuillet b\u00eata \u2013 <strong>jaune<\/strong><\/li><li>parties non structur\u00e9es de la prot\u00e9ine \u2013 <strong>vert<\/strong><\/li><li>Liaisons disulfures \u2013 <strong>orange<\/strong><\/li><li>L&#8217;extr\u00e9mit\u00e9 N-terminale de la prot\u00e9ine \u2013 <strong>bleu<\/strong><\/li><li>L&#8217;extr\u00e9mit\u00e9 C-terminale de la prot\u00e9ine \u2013 <strong>violet<\/strong><\/li><\/ul>\n<\/section>\n\n\n\n<section class=\"vf-tabs__section\" id=\"vf-tabs__section-87d90ccb-95de-4a4a-9c85-ff6acc137f8d\"><h2>Associ\u00e9es<\/h2>\n<p>Effectuez le <a href=\"https:\/\/play.kahoot.it\/v2\/lobby?quizId=2bf641ed-4c7a-41c6-8801-eab1d591787e\" data-type=\"URL\" data-id=\"https:\/\/play.kahoot.it\/v2\/lobby?quizId=2bf641ed-4c7a-41c6-8801-eab1d591787e\" target=\"_blank\" rel=\"noreferrer noopener\">TEST de connaissances<\/a> sur l&#8217;insuline pour v\u00e9rifier votre niveau de connaissances de cette mol\u00e9cule fascinante.<\/p>\n\n\n\n<div class=\"vf-grid | vf-grid__col-3\"><div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<figure class=\"vf-figure wp-block-image size-large\"><a href=\"https:\/\/play.kahoot.it\/v2\/lobby?quizId=2bf641ed-4c7a-41c6-8801-eab1d591787e\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"419\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/ells\/wp-content\/uploads\/2021\/05\/logo_kahoot_01-1024x419.png\" alt=\"\" class=\"wp-image-871\" srcset=\"https:\/\/www.embl.org\/ells\/wp-content\/uploads\/2021\/05\/logo_kahoot_01-1024x419.png 1024w, https:\/\/www.embl.org\/ells\/wp-content\/uploads\/2021\/05\/logo_kahoot_01-300x123.png 300w, https:\/\/www.embl.org\/ells\/wp-content\/uploads\/2021\/05\/logo_kahoot_01-768x314.png 768w, https:\/\/www.embl.org\/ells\/wp-content\/uploads\/2021\/05\/logo_kahoot_01-1536x628.png 1536w, https:\/\/www.embl.org\/ells\/wp-content\/uploads\/2021\/05\/logo_kahoot_01.png 1590w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n\n\n<section class=\"vf-tabs__section\" id=\"vf-tabs__section-54bdb726-5329-4976-a0be-12538c5ad04f\"><h2>Mat\u00e9riels suppl\u00e9mentaires<\/h2>\n<h4 class=\"wp-block-heading\"><strong>Regardez la pr\u00e9sentation <strong><a href=\"https:\/\/www.embl.org\/ells\/insight-lecture\/embl-insight-lecture-2013\/\">EMBL Insight Lecture 2013<\/a> <em>\u201cFrom Code to Function <\/em><\/strong><em><strong><em>\u2013<\/em><\/strong> Observation de la synth\u00e8se des prot\u00e9ines au microscope \u00e9lectronique<\/em>&#8220;.<\/strong><\/h4>\n\n\n\n<div class=\"vf-grid | vf-grid__col-2\"><div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<figure class=\"vf-figure wp-block-image size-large\"><a href=\"https:\/\/www.embl.org\/ells\/insight-lecture\/embl-insight-lecture-2013\/\"><img loading=\"lazy\" decoding=\"async\" width=\"567\" height=\"402\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/ells\/wp-content\/uploads\/2021\/05\/protein-synthesis_web.png\" alt=\"\" class=\"wp-image-1367\" srcset=\"https:\/\/www.embl.org\/ells\/wp-content\/uploads\/2021\/05\/protein-synthesis_web.png 567w, https:\/\/www.embl.org\/ells\/wp-content\/uploads\/2021\/05\/protein-synthesis_web-300x213.png 300w\" sizes=\"auto, (max-width: 567px) 100vw, 567px\" \/><\/a><figcaption class=\"vf-figure__caption\">Protein synthesis in the cell. Watch the EMBL Insight Lecture 2013 \u201cFrom Code to Function \u2013 Observing Protein Synthesis Through the Electron Microscope\u201d<\/figcaption><\/figure>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<p>Christiane Schaffitzel and her team study the function and three-dimensional structure of ribosomes using a combination of molecular biology, biochemistry and cryo-electron microscopy. In her talk, Christiane gives an overview of the steps involved in protein synthesis and the role ribosomes play in the process. She then illustrates how her research group uses cryo-electron microscopy to study the structures of these fascinating molecules. Christiane\u2019s central research questions are: what we can learn from the make up of these fascinating molecules and how are synthesised proteins targeted to their destinations?<\/p>\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n<\/section>\n<\/div><\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Explore the biological structure of the insulin molecule \u2013 from primary to quaternary structure.<\/p>\n","protected":false},"featured_media":28067,"parent":0,"menu_order":9,"template":"","class_list":["post-28066","teachingbase","type-teachingbase","status-publish","has-post-thumbnail","hentry","age-group-16-19","topic-area-structural-computational-biology"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.embl.org\/ells\/wp-json\/wp\/v2\/teachingbase\/28066","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/ells\/wp-json\/wp\/v2\/teachingbase"}],"about":[{"href":"https:\/\/www.embl.org\/ells\/wp-json\/wp\/v2\/types\/teachingbase"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.embl.org\/ells\/wp-json\/wp\/v2\/media\/28067"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/ells\/wp-json\/wp\/v2\/media?parent=28066"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}