Superparamagnetic iron oxide nanoparticles reprogram the tumor microenvironment and reduce lung cancer regrowth after crizotinib treatment.

Horvat NK, Chocarro S, Marques O, Bauer TA, Qiu R, Diaz-Jimenez A, Helm B, Chen Y, Sawall S, Sparla R, Su L, Klingmüller U, Barz M, Hentze MW, Sotillo R, Muckenthaler MU

ACS nano, 2024

doi:10.1021/acsnano.3c08335.

Alterations of iron homeostasis as a potential druggable driver of long COVID.

Marques O, Muckenthaler MU

Nature immunology, 2024

doi:10.1038/s41590-024-01759-3.

Author Correction: Consensus Statement on the definition and classification of metabolic hyperferritinaemia.

Valenti L, Corradini E, Adams LA, Aigner E, Alqahtani S, Arrese M, Bardou-Jacquet E, Bugianesi E, Fernandez-Real JM, Girelli D, Hagström H, Henninger B, Kowdley K, Ligabue G, McClain D, Lainé F, Miyanishi K, Muckenthaler MU, Pagani A, Pedrotti P, Pietrangelo A, Prati D, Ryan JD, Silvestri L, Spearman CW, Stål P, Tsochatzis EA, Vinchi F, Zheng MH, Zoller H

Nature reviews. Endocrinology, 2023

doi:10.1038/s41574-023-00940-2.

Iron momeostasis in mice: does liver lobe matter?

Colucci S, Oliveira TC, Muckenthaler MU, Marques O

American journal of physiology. Gastrointestinal and liver physiology, 2023

doi:10.1152/ajpgi.00085.2023.

Consensus Statement on the definition and classification of metabolic hyperferritinaemia.

Valenti L, Corradini E, Adams LA, Aigner E, Alqahtani S, Arrese M, Bardou-Jacquet E, Bugianesi E, Fernandez-Real JM, Girelli D, Hagström H, Henninger B, Kowdley K, Ligabue G, McClain D, Lainé F, Miyanishi K, Muckenthaler MU, Pagani A, Pedrotti P, Pietrangelo A, Prati D, Ryan JD, Silvestri L, Spearman CW, Stål P, Tsochatzis EA, Vinchi F, Zheng MH, Zoller H

Nature reviews. Endocrinology, 2023

doi:10.1038/s41574-023-00807-6.

T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles.

Turco V, Pfleiderer K, Hunger J, Horvat NK, Karimian-Jazi K, Schregel K, Fischer M, Brugnara G, Jähne K, Sturm V, Streibel Y, Nguyen D, Altamura S, Agardy DA, Soni SS, Alsasa A, Bunse T, Schlesner M, Muckenthaler MU, Weissleder R, Wick W, Heiland S, Vollmuth P, Bendszus M, Rodell CB, Breckwoldt MO, Platten M

Nature communications, 2023

doi:10.1038/s41467-023-36321-6.

The role of iron in chronic inflammatory diseases: from mechanisms to treatment options in anemia of inflammation.

Marques O, Weiss G, Muckenthaler MU

Blood, 2022

doi:10.1182/blood.2021013472.

Pediatric T-ALL type-1 and type-2 relapses develop along distinct pathways of clonal evolution.

Richter-Pechańska P, Kunz JB, Rausch T, Erarslan-Uysal B, Bornhauser B, Frismantas V, Assenov Y, Zimmermann M, Happich M, von Knebel-Doeberitz C, von Neuhoff N, Köhler R, Stanulla M, Schrappe M, Cario G, Escherich G, Kirschner-Schwabe R, Eckert C, Avigad S, Pfister SM, Muckenthaler MU, Bourquin JP, Korbel JO, Kulozik AE

Leukemia, 2022

doi:10.1038/s41375-022-01587-0.

Hemochromatosis classification: update and recommendations by the BIOIRON Society.

Girelli D, Busti F, Brissot P, Cabantchik I, Muckenthaler MU, Porto G

Blood, 2022

doi:10.1182/blood.2021011338.

Hfe Is highly expressed in liver sinusoidal endothelial cells but is not needed to maintain systemic iron homeostasis in vivo.

Colucci S, Müdder K, Muckenthaler MU, Altamura S

HemaSphere, 2021

doi:10.1097/HS9.0000000000000667.

Maternal early-pregnancy ferritin and offspring neurodevelopment: A prospective cohort study from gestation to school age.

Sammallahti S, Tiemeier H, Reiss IKM, Muckenthaler MU, El Marroun H, Vermeulen M

Paediatric and perinatal epidemiology, 2021

doi:10.1111/ppe.12854.

Iron Deficiency Caused by Intestinal Iron Loss-Novel Candidate Genes for Severe Anemia.

Huettmann C, Stelljes M, Sivalingam S, Fobker M, Vrachimis A, Exler A, Wenning C, Wempe C, Penke M, Buness A, Ludwig KU, Muckenthaler MU, Steinbicker AU

Genes, 2021

doi:10.3390/genes12121869.

Investigation of Iron Deficiency and Iron Overload.

Gattermann N, Muckenthaler MU, Kulozik AE, Metzgeroth G, Hastka J

Deutsches Arzteblatt international, 2021

doi:10.3238/arztebl.m2021.0290.

Core cross-linked polymeric micelles for specific iron delivery: inducing sterile inflammation in macrophages.

Bauer TA, Horvat NK, Marques O, Chocarro S, Mertens C, Colucci S, Schmitt S, Carrella LM, Morsbach S, Koynov K, Fenaroli F, Blümler P, Jung M, Sotillo R, Hentze MW, Muckenthaler MU, Barz M

Advanced healthcare materials, 2021

doi:10.1002/adhm.202100385.

Liver sinusoidal endothelial cells suppress BMP2 production in response to TGFβ pathway activation.

Colucci S, Altamura S, Marques O, Dropmann A, Horvat NK, Müdder K, Hammad S, Dooley S, Muckenthaler MU

Hepatology (Baltimore, Md.), 2021

doi:10.1002/hep.31900.

Vasculo-toxic and pro-inflammatory action of unbound haemoglobin, haem and iron in transfusion-dependent patients with haemolytic anaemias.

Vinchi F, Sparla R, Passos ST, Sharma R, Vance SZ, Zreid HS, Juaidi H, Manwani D, Yazdanbakhsh K, Nandi V, Silva AMN, Agarvas AR, Fibach E, Belcher JD, Vercellotti GM, Ghoti H, Muckenthaler MU

British journal of haematology, 2021

doi:10.1111/bjh.17361.

Mild attenuation of the pulmonary inflammatory response in a mouse model of hereditary hemochromatosis type 4.

Marques O, Neves J, Horvat NK, Altamura S, Muckenthaler MU

Frontiers in physiology, 2020

doi:10.3389/fphys.2020.589351.

Hypoferremia is associated with increased hospitalization and oxygen demand in COVID-19 patients.

Hippchen T, Altamura S, Muckenthaler MU, Merle U

HemaSphere, 2020

doi:10.1097/HS9.0000000000000492.

Iron regulation in elderly Asian elephants ( Elephas maximus) chronically infected with Mycobacterium tuberculosis.

Ruetten M, Steinmetz HW, Thiersch M, Kik M, Vaughan L, Altamura S, Muckenthaler MU, Gassmann M

Frontiers in veterinary science, 2020

doi:10.3389/fvets.2020.596379.

Iron deficiency.

Pasricha SR, Tye-Din J, Muckenthaler MU, Swinkels DW

Lancet (London, England), 2020

doi:10.1016/S0140-6736(20)32594-0.

Regulation of iron homeostasis: lessons from mouse models.

Altamura S, Marques O, Colucci S, Mertens C, Alikhanyan K, Muckenthaler MU

Molecular aspects of medicine, 2020

doi:10.1016/j.mam.2020.100872.

Geographical ancestry affects normal hemoglobin values in high-altitude residents.

Mairbäurl H, Gassmann M, Muckenthaler MU

Journal of applied physiology (Bethesda, Md. : 1985), 2020

doi:10.1152/japplphysiol.00025.2020.

Cell-specific expression of Hfe determines the outcome of Salmonella enterica serovar Typhimurium infection in mice.

Nairz M, Metzendorf C, Vujic-Spasic M, Mitterstiller AM, Schroll A, Haschka D, Hoffmann A, Von Raffay L, Sparla R, Huck CW, Talasz H, Moser PL, Muckenthaler MU, Weiss G

Haematologica, 2020

doi:10.3324/haematol.2019.241745.

HFE and ALK3 act in the same signaling pathway.

Traeger L, Schnittker J, Dogan DY, Oguama D, Kuhlmann T, Muckenthaler MU, Krijt J, Urzica EI, Steinbicker AU

Free radical biology & medicine, 2020

doi:10.1016/j.freeradbiomed.2020.08.023.

Chromatin accessibility landscape of pediatric T-lymphoblastic leukemia and human T-cell precursors.

Erarslan-Uysal B, Kunz JB, Rausch T, Richter-Pechańska P, van Belzen IA, Frismantas V, Bornhauser B, Ordoñez-Rueada D, Paulsen M, Benes V, Stanulla M, Schrappe M, Cario G, Escherich G, Bakharevich K, Kirschner-Schwabe R, Eckert C, Loukanov T, Gorenflo M, Waszak SM, Bourquin JP, Muckenthaler MU, Korbel JO, Kulozik AE

EMBO molecular medicine, 2020

doi:10.15252/emmm.202012104.

Hemoglobin concentration of young men at residential altitudes between 200 and 2000 m mirrors Switzerland's topography.

Staub K, Haeusler M, Bender N, Morozova I, Eppenberger P, Panczak R, Zwahlen M, Schaer DJ, Maggiorini M, Ulrich S, Gassmann NN, Muckenthaler MU, Rühli F, Gassmann M

Blood, 2020

doi:10.1182/blood.2019004135.

Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma.

Thielmann CM, Costa da Silva M, Muley T, Meister M, Herpel E, Muckenthaler MU

Scientific reports, 2019

doi:10.1038/s41598-019-47833-x.

Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction.

Vinchi F, Porto G, Simmelbauer A, Altamura S, Passos ST, Garbowski M, Silva AMN, Spaich S, Seide SE, Sparla R, Hentze MW, Muckenthaler MU

European heart journal, 2019

doi:10.1093/eurheartj/ehz112.

PDX models recapitulate the genetic and epigenetic landscape of pediatric T-cell leukemia.

Richter-Pechańska P, Kunz JB, Bornhauser B, von Knebel Doeberitz C, Rausch T, Erarslan-Uysal B, Assenov Y, Frismantas V, Marovca B, Waszak SM, Zimmermann M, Seemann J, Happich M, Stanulla M, Schrappe M, Escherich G, Cario G, Kirschner-Schwabe R, Bakharevich K, Muckenthaler MU, Eckert C, Bourquin JP, Korbel JO, Kulozik AE

EMBO molecular medicine, 2018

doi:10.15252/emmm.201809443.

Uncoupled iron homeostasis in type 2 diabetes mellitus.

Altamura S, Kopf S, Schmidt J, Müdder K, da Silva AR, Nawroth P, Muckenthaler MU

Journal of molecular medicine (Berlin, Germany), 2017

doi:10.1007/s00109-017-1596-3.

Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages.

Costa da Silva M, Breckwoldt MO, Vinchi F, Correia MP, Stojanovic A, Thielmann CM, Meister M, Muley T, Warth A, Platten M, Hentze MW, Cerwenka A, Muckenthaler MU

Frontiers in immunology, 2017

doi:10.3389/fimmu.2017.01479.

Methylglyoxal and advanced glycation end products in patients with diabetes - What we know so far and the missing links.

Groener JB, Oikonomou D, Cheko R, Kender Z, Zemva J, Kihm L, Muckenthaler M, Peters V, Fleming T, Kopf S, Nawroth PP

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2019

doi:10.1055/s-0043-106443.

Identification of a genetically defined ultra-high-risk group in relapsed pediatric T-lymphoblastic leukemia.

Richter-Pechańska P, Kunz JB, Hof J, Zimmermann M, Rausch T, Bandapalli OR, Orlova E, Scapinello G, Sagi JC, Stanulla M, Schrappe M, Cario G, Kirschner-Schwabe R, Eckert C, Benes V, Korbel JO, Muckenthaler MU, Kulozik AE

Blood Cancer Journal, 2017

doi:10.1038/bcj.2017.3.

A Red Carpet for Iron Metabolism.

Muckenthaler MU, Rivella S, Hentze MW, Galy B

Cell, 2017

doi:10.1016/j.cell.2016.12.034.

CRLF2 over-expression is a poor prognostic marker in children with high risk T-cell acute lymphoblastic leukemia.

Palmi C, Savino AM, Silvestri D, Bronzini I, Cario G, Paganin M, Buldini B, Galbiati M, Muckenthaler MU, Bugarin C, Mina PD, Nagel S, Barisone E, Casale F, Locatelli F, Nigro LL, Micalizzi C, Parasole R, Pession A, Putti MC, Santoro N, Testi AM, Ziino O, Kulozik AE, Zimmermann M, Schrappe M, Villa A, Gaipa G, Basso G, Biondi A, Valsecchi MG, Stanulla M, Conter V, Kronnie GT, Cazzaniga G

Oncotarget, 2016

doi:10.18632/oncotarget.10610.

The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse

Bandapalli OR, Schuessele S, Kunz JB, Rausch T, Stütz AM, Tal N, Geron I, Gershman N, Izraeli S, Eilers J, Vaezipour N, Kirschner-Schwabe R, Hof J, von Stackelberg A, Schrappe M, Stanulla M, Zimmermann M, Koehler R, Avigad S, Handgretinger R, Frismantas V, Bourquin JP, Bornhauser B, Korbel JO, Muckenthaler MU, Kulozik AE

Haematologica, 2014

doi:10.3324/haematol.2014.104992.

A multi-scale model of hepcidin promoter regulation reveals factors controlling systemic iron homeostasis

Casanovas G, Banerji A, d'Alessio F, Muckenthaler MU, Legewie S

PLoS computational biology, 2014

doi:10.1371/journal.pcbi.1003421.

MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma

Lodrini M, Oehme I, Schroeder C, Milde T, Schier MC, Kopp-Schneider A, Schulte JH, Fischer M, De Preter K, Pattyn F, Castoldi M, Muckenthaler MU, Kulozik AE, Westermann F, Witt O, Deubzer HE

Nucleic acids research, 2013

doi:10.1093/nar/gkt346.

Novel mutations in the ferritin-L iron-responsive element that only mildly impair IRP binding cause hereditary hyperferritinaemia cataract syndrome

Luscieti S, Tolle G, Aranda J, Campos CB, Risse F, Morán É, Muckenthaler MU, Sánchez M

Orphanet journal of rare diseases, 2013

doi:10.1186/1750-1172-8-30.

Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins

Sanchez M, Galy B, Schwanhaeusser B, Blake J, Bähr-Ivacevic T, Benes V, Selbach M, Muckenthaler MU, Hentze MW

Blood, 2011

doi:10.1182/blood-2011-04-343541.

Two to tango: regulation of Mammalian iron metabolism

Hentze MW, Muckenthaler MU, Galy B, Camaschella C

Cell, 2010

doi:10.1016/j.cell.2010.06.028.

The IronChip evaluation package: a package of perl modules for robust analysis of custom microarrays

Vainshtein Y, Sanchez M, Brazma A, Hentze MW, Dandekar T, Muckenthaler MU

BMC bioinformatics, 2010

doi:10.1186/1471-2105-11-112.

Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD

Casanovas G, Mleczko-Sanecka K, Altamura S, Hentze MW, Muckenthaler MU

Journal of molecular medicine (Berlin, Germany), 2009

doi:10.1007/s00109-009-0447-2.

miChip: a microarray platform for expression profiling of microRNAs based on locked nucleic acid (LNA) oligonucleotide capture probes

Castoldi M, Benes V, Hentze MW, Muckenthaler MU

Methods (San Diego, Calif.), 2007

doi:10.1016/j.ymeth.2007.04.009.

Expression of the subgenomic hepatitis C virus replicon alters iron homeostasis in Huh7 cells

Fillebeen C, Muckenthaler M, Andriopoulos B, Bisaillon M, Mounir Z, Hentze MW, Koromilas AE, Pantopoulos K

Journal of hepatology, 2007

doi:10.1016/j.jhep.2007.01.035.

Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency

Sanchez M, Galy B, Muckenthaler MU, Hentze MW

Nature structural & molecular biology, 2007

doi:10.1038/nsmb1222.

Physiologic systemic iron metabolism in mice deficient for duodenal Hfe

Vujic Spasic M, Kiss J, Herrmann T, Kessler R, Stolte J, Galy B, Rathkolb B, Wolf E, Stremmel W, Hentze MW, Muckenthaler MU

Blood, 2007

doi:10.1182/blood-2006-07-036186.

Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1

Ludwiczek S, Theurl I, Muckenthaler MU, Jakab M, Mair SM, Theurl M, Kiss J, Paulmichl M, Hentze MW, Ritter M, Weiss G

Nature medicine, 2007

doi:10.1038/nm1542.

Identification of target mRNAs of regulatory RNA-binding proteins using mRNP immunopurification and microarrays

Sanchez M, Galy B, Hentze MW, Muckenthaler MU

Nature protocols, 2007

doi:10.1038/nprot.2007.293.

STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation

Verga Falzacappa MV, Vujic Spasic M, Kessler R, Stolte J, Hentze MW, Muckenthaler MU

Blood, 2007

doi:10.1182/blood-2006-07-033969.

The molecular circuitry regulating the switch between iron deficiency and overload in mice

Mok H, Mlodnicka AE, Hentze MW, Muckenthaler M, Schumacher A

The Journal of biological chemistry, 2006

doi:10.1074/jbc.m509857200.

Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)

Galy B, Ferring D, Minana B, Bell O, Janser HG, Muckenthaler M, Schümann K, Hentze MW

Blood, 2005

doi:10.1182/blood-2005-04-1365.

Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus

Fillebeen C, Rivas-Estilla AM, Bisaillon M, Ponka P, Muckenthaler M, Hentze MW, Koromilas AE, Pantopoulos K

The Journal of biological chemistry, 2005

doi:10.1074/jbc.m412687200.

Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity

Wang J, Chen G, Muckenthaler M, Galy B, Hentze MW, Pantopoulos K

Molecular and cellular biology, 2004

doi:10.1128/mcb.24.3.954-965.2004.

Iron overload in adult Hfe-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1/ferroportin

Herrmann T, Muckenthaler M, van der Hoeven F, Brennan K, Gehrke SG, Hubert N, Sergi C, Gröne HJ, Kaiser I, Gosch I, Volkmann M, Riedel HD, Hentze MW, Stewart AF, Stremmel W

Journal of molecular medicine (Berlin, Germany), 2004

doi:10.1007/s00109-003-0508-x.