Higher plasma creatinine is associated with an increased risk of death in patients with non-metastatic rectal but not colon cancer: Results from an international cohort consortium.

Ose J, Gigic B, Brezina S, Lin T, Peoples AR, Schobert PP, Baierl A, van Roekel E, Robinot N, Gicquiau A, Achaintre D, Scalbert A, van Duijnhoven FJB, Holowatyj AN, Gumpenberger T, Schrotz-King P, Ulrich AB, Ulvik A, Ueland PM, Weijenberg MP, Habermann N, Keski-Rahkonen P, Gsur A, Kok DE, Ulrich CM

Cancers, 2023

doi:10.3390/cancers15133391.

Cohort profile: biomarkers related to folate-dependent one-carbon metabolism in colorectal cancer recurrence and survival - the FOCUS Consortium.

Gigic B, van Roekel E, Holowatyj AN, Brezina S, Geijsen AJMR, Ulvik A, Ose J, Koole JL, Damerell V, Kiblawi R, Gumpenberger T, Lin T, Kvalheim G, Koelsch T, Kok DE, van Duijnhoven FJ, Bours MJ, Baierl A, Li CI, Grady W, Vickers K, Habermann N, Schneider M, Kampman E, Ueland PM, Ulrich A, Weijenberg M, Gsur A, Ulrich C, FOCUS Consortium

BMJ open, 2022

doi:10.1136/bmjopen-2022-062930.

Higher vitamin B6 status is associated with improved survival among patients with stage I-III colorectal cancer.

Holowatyj AN, Ose J, Gigic B, Lin T, Ulvik A, Geijsen AJMR, Brezina S, Kiblawi R, van Roekel EH, Baierl A, Böhm J, Bours MJL, Brenner H, Breukink SO, Chang-Claude J, de Wilt JHW, Grady WM, Grünberger T, Gumpenberger T, Herpel E, Hoffmeister M, Keulen ETP, Kok DE, Koole JL, Kosma K, Kouwenhoven EA, Kvalheim G, Li CI, Schirmacher P, Schrotz-King P, Singer MC, van Duijnhoven FJB, van Halteren HK, Vickers K, Vogelaar FJ, Warby CA, Wesselink E, Ueland PM, Ulrich AB, Schneider M, Habermann N, Kampman E, Weijenberg MP, Gsur A, Ulrich CM

The American journal of clinical nutrition, 2022

doi:10.1093/ajcn/nqac090.

Circulating tryptophan metabolites and risk of colon cancer: results from case-control and prospective cohort studies.

Papadimitriou N, Gunter MJ, Murphy N, Gicquiau A, Achaintre D, Brezina S, Gumpenberger T, Baierl A, Ose J, Geijsen AJ, van Roekel EH, Gsur A, Gigic B, Habermann N, Ulrich CM, Kampman E, Weijenberg MP, Ueland PM, Kaaks R, Katzke V, Krogh V, Bueno-de-Mesquita B, Ardanaz E, Travis RC, Schulze MB, Sánchez MJ, Colorado-Yohar SM, Weiderpass E, Scalbert A, Keski-Rahkonen P

International journal of cancer, 2021

doi:10.1002/ijc.33725.

Circulating B-vitamin biomarkers and B-vitamin supplement use in relation to quality of life in patients with colorectal cancer: results from the FOCUS consortium.

Koole JL, Bours MJL, Geijsen AJMR, Gigic B, Ulvik A, Kok DE, Brezina S, Ose J, Baierl A, Böhm J, Brenner H, Breukink SO, Chang-Claude J, van Duijnhoven FJB, van Duijvendijk P, Gumpenberger T, Habermann N, van Halteren HK, Hoffmeister M, Holowatyj AN, Janssen-Heijnen MLG, Keulen ETP, Kiblawi R, Kruyt FM, Li CI, Lin T, Midttun Ø, Peoples AR, van Roekel EH, Schneider MA, Schrotz-King P, Ulrich AB, Vickers K, Wesselink E, de Wilt JHW, Gsur A, Ueland PM, Ulrich CM, Kampman E, Weijenberg MP

The American journal of clinical nutrition, 2021

doi:10.1093/ajcn/nqaa422.

Targeted plasma metabolic profiles and risk of recurrence in stage II and III colorectal cancer patients: results from an international cohort consortium.

Ose J, Gigic B, Brezina S, Lin T, Baierl A, Geijsen AJMR, van Roekel E, Robinot N, Gicquiau A, Achaintre D, Keski-Rahkonen P, Duijnhoven FJBV, Gumpenberger T, Holowatyj AN, Kok DE, Koole A, Schrotz-King P, Ulrich AB, Schneider M, Ulvik A, Ueland PM, Weijenberg MP, Habermann N, Scalbert A, Gsur A, M Ulrich C

Metabolites, 2021

doi:10.3390/metabo11030129.

Untargeted metabolomics reveals major differences in the plasma metabolome between colorectal cancer and colorectal adenomas.

Gumpenberger T, Brezina S, Keski-Rahkonen P, Baierl A, Robinot N, Leeb G, Habermann N, Kok DEG, Scalbert A, Ueland PM, Ulrich CM, Gsur A

Metabolites, 2021

doi:10.3390/metabo11020119.

The ELIXIR Human Copy Number Variations Community: building bioinformatics infrastructure for research.

Salgado D, Armean IM, Baudis M, Beltran S, Capella-Gutierrez S, Carvalho-Silva D, Dominguez Del Angel V, Dopazo J, Furlong LI, Gao B, Garcia L, Gerloff D, Gut I, Gyenesei A, Habermann N, Hancock JM, Hanauer M, Hovig E, Johansson LF, Keane T, Korbel J, Lauer KB, Laurie S, Leskošek B, Lloyd D, Marques-Bonet T, Mei H, Monostory K, Piñero J, Poterlowicz K, Rath A, Samarakoon P, Sanz F, Saunders G, Sie D, Swertz MA, Tsukanov K, Valencia A, Vidak M, Yenyxe González C, Ylstra B, Béroud C

F1000Research, 2020

doi:10.12688/f1000research.24887.1.

Circulating folate and folic acid concentrations: associations with colorectal cancer recurrence and survival.

Geijsen AJMR, Ulvik A, Gigic B, Kok DE, van Duijnhoven FJB, Holowatyj AN, Brezina S, van Roekel EH, Baierl A, Bergmann MM, Böhm J, Bours MJL, Brenner H, Breukink SO, Bronner MP, Chang-Claude J, de Wilt JHW, Grady WM, Grünberger T, Gumpenberger T, Herpel E, Hoffmeister M, Huang LC, Jedrzkiewicz JD, Keulen ETP, Kiblawi R, Kölsch T, Koole JL, Kosma K, Kouwenhoven EA, Kruyt FM, Kvalheim G, Li CI, Lin T, Ose J, Pickron TB, Scaife CL, Schirmacher P, Schneider MA, Schrotz-King P, Singer MC, Swanson ER, van Duijvendijk P, van Halteren HK, van Zutphen M, Vickers K, Vogelaar FJ, Wesselink E, Habermann N, Ulrich AB, Ueland PM, Weijenberg MP, Gsur A, Ulrich CM, Kampman E

JNCI cancer spectrum, 2020

doi:10.1093/jncics/pkaa051.

Polymorphisms in the angiogenesis-related genes EFNB2, MMP2 and JAG1 are associated with survival of colorectal cancer patients.

Scherer D, Deutelmoser H, Balavarca Y, Toth R, Habermann N, Buck K, Kap EJ, Botma A, Seibold P, Jansen L, Lorenzo Bermejo J, Weigl K, Benner A, Hoffmeister M, Ulrich A, Burwinkel B, Brenner H, Ulrich CM, Chang-Claude J

International journal of molecular sciences, 2020

doi:10.3390/ijms21155395.

Multi-omics analysis reveals adipose-tumor crosstalk in colorectal cancer patients.

Holowatyj AN, Haffa M, Lin T, Scherer D, Gigic B, Ose J, Warby CA, Himbert C, Abbenhardt-Martin C, Achaintre D, Boehm J, Boucher KM, Gicquiau A, Gsur A, Habermann N, Kauczor HU, Herpel E, Kloor M, Keski-Rahkonen P, Kok DE, von Knebel Doeberitz M, Schirmacher P, Nattenmüller J, Schrotz-King P, Schneider M, Ueland PM, Simon T, Weijenberg MP, Viskochil R, Ulrich A, Scalbert A, Ulrich CM, Bowers LW, Hursting SD

Cancer Prevention Research, 2020

doi:10.1158/1940-6207.CAPR-19-0538.

Impact of pre-blood collection factors on plasma metabolomic profiles.

Hardikar S, Albrechtsen RD, Achaintre D, Lin T, Pauleck S, Playdon M, Holowatyj AN, Gigic B, Schrotz-King P, Boehm J, Habermann N, Brezina S, Gsur A, van Roekel EH, Weijenberg MP, Scalbert A, Keski-Rahkonen P, Ulrich CM, Ose J

Metabolites, 2020

doi:10.3390/metabo10050213.

Metabolomics profiling of visceral and abdominal subcutaneous adipose tissue in colorectal cancer patients: results from the ColoCare study.

Ose J, Holowatyj AN, Nattenmüller J, Gigic B, Lin T, Himbert C, Habermann N, Achaintre D, Scalbert A, Keski-Rahkonen P, Böhm J, Schrotz-King P, Schneider M, Ulrich A, Kampman E, Gsur A, Weijenberg M, Kauczor HU, Ueland PM, Ulrich CM

Cancer causes & control : CCC, 2020

doi:10.1007/s10552-020-01312-1.

One-carbon metabolites, B-vitamins and associations with systemic inflammation and angiogenesis biomarkers among colorectal cancer patients: results from the ColoCare Study.

Kiblawi R, Holowatyj AN, Gigic B, Brezina S, Geijsen AJMR, Ose J, Lin T, Hardikar S, Himbert C, Warby CA, Böhm J, Bours MJL, van Duijnhoven FJB, Gumpenberger T, Kok DE, van Roekel EH, Koole JL, Ulvik A, Schrotz-King P, Habermann N, Gsur A, Ueland PM, Weijenberg MP, Ulrich A, Schneider M, Playdon M, Ulrich CM

The British journal of nutrition, 2020

doi:10.1017/S0007114520000422.

Expression patterns of xenobiotic metabolizing enzymes in tumor and adjacent normal mucosa tissues among patients with colorectal cancer: the ColoCare study.

Beyerle J, Holowatyj AN, Haffa M, Frei E, Gigic B, Schrotz-King P, Böhm J, Habermann N, Stiborova M, Scherer D, Koelsch T, Skender S, Becker N, Herpel E, Schneider M, Schirmacher P, Ulrich A, Brenner H, Chang-Claude J, Haug U, Hoffmeister M, Ulrich CM, Owen RW

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2019

doi:10.1158/1055-9965.EPI-19-0449.

Transcriptome profiling of adipose tissue reveals depot-specific metabolic alterations among patients with colorectal cancer.

Haffa M, Holowatyj AN, Kratz M, Toth R, Benner A, Gigic B, Habermann N, Schrotz-King P, Böhm J, Brenner H, Schneider M, Ulrich A, Herpel E, Schirmacher P, Straub BK, Kauczor HU, Nattenmüller J, Ball CR, Lin T, Glimm H, Ulrich CM, Scherer D

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2019

doi:10.1210/jc.2019-00461.

Plasma metabolites associated with colorectal cancer stage: findings from an international consortium.

Geijsen AJMR, van Roekel EH, van Duijnhoven FJB, Achaintre D, Bachleitner-Hofmann T, Baierl A, Bergmann MM, Boehm J, Bours MJL, Brenner H, Breukink SO, Brezina S, Chang-Claude J, Herpel E, de Wilt JHW, Gigic B, Gicquiau A, Hansson BME, Gumpenberger T, Holowatyj AN, Hoffmeister M, Keski-Rahkonen P, Karner-Hanusch J, Koole JL, Keulen ETP, Ose J, Leeb G, Schneider MA, Schirmacher P, Stift A, Schrotz-King P, Wesselink E, van Zutphen M, Ulvik A, Vogelaar FJ, Kampman E, Scalbert A, Gsur A, Habermann N, Ulrich CM, Weijenberg MP, Ueland PM, Ulrich AB, Kok DE

International journal of cancer, 2019

doi:10.1002/ijc.32666.

Multiplatform urinary metabolomics profiling to discriminate cachectic from non-cachectic colorectal cancer patients: pilot results from the ColoCare Study.

Ose J, Gigic B, Lin T, Liesenfeld DB, Böhm J, Nattenmüller J, Scherer D, Zielske L, Schrotz-King P, Habermann N, Ochs-Balcom HM, Peoples AR, Hardikar S, Li CI, Shibata D, Toriola AT, Figueiredo J, Schmit S, Siegel EM, Ulrich A, Schneider M, Ulrich CM, Kauczor HU

Metabolites, 2019

doi:10.3390/metabo9090178.

Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer.

Wirbel J, Pyl PT, Kartal E, Zych K, Kashani A, Milanese A, Fleck JS, Voigt AY, Palleja A, Ponnudurai R, Sunagawa S, Coelho LP, Schrotz-King P, Vogtmann E, Habermann N, Niméus E, Thomas AM, Manghi P, Gandini S, Serrano D, Mizutani S, Shiroma H, Shiba S, Shibata T, Yachida S, Yamada T, Waldron L, Naccarati A, Segata N, Sinha R, Ulrich CM, Brenner H, Arumugam M, Bork P, Zeller G

Nature medicine, 2019

doi:10.1038/s41591-019-0406-6.

Plasma metabolites associated with colorectal cancer: a discovery-replication strategy.

Geijsen AJMR, Brezina S, Keski-Rahkonen P, Baierl A, Bachleitner-Hofmann T, Bergmann MM, Boehm J, Brenner H, Chang-Claude J, van Duijnhoven FJB, Gigic B, Gumpenberger T, Hofer P, Hoffmeister M, Holowatyj AN, Kok DE, Karner-Hanusch J, Ulvik A, Leeb G, Ose J, Robinot N, Schrotz-King P, Stift A, Ueland PM, Ulrich AB, Scalbert A, Kampman E, Gsur A, Habermann N, Ulrich CM

International journal of cancer, 2019

doi:10.1002/ijc.32146.

L-Thyroxine intake as a potential risk factor for the development of fatigue in breast cancer patients undergoing chemotherapy.

Schmidt ME, Wiskemann J, Johnson T, Habermann N, Schneeweiss A, Steindorf K

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2018

doi:10.1007/s00520-018-4095-3.

Pathway analysis of genetic variants in folate-mediated one-carbon metabolism-related genes and survival in a prospectively followed cohort of colorectal cancer patients.

Ose J, Botma A, Balavarca Y, Buck K, Scherer D, Habermann N, Beyerle J, Pfütze K, Seibold P, Kap EJ, Benner A, Jansen L, Butterbach K, Hoffmeister M, Brenner H, Schneider M, Ulrich A, Burwinkel B, Chang-Claude J, Ulrich CM

Cancer medicine, 2018

doi:10.1002/cam4.1407.

Effects of physical exercise on markers of inflammation in breast cancer patients during adjuvant chemotherapy.

van Vulpen JK, Schmidt ME, Velthuis MJ, Wiskemann J, Schneeweiss A, Vermeulen RCH, Habermann N, Ulrich CM, Peeters PHM, van der Wall E, May AM, Steindorf K

Breast cancer research and treatment, 2017

doi:10.1007/s10549-017-4608-7.

Associations of branched-chain amino acids with parameters of energy balance and survival in colorectal cancer patients: Results from the ColoCare Study.

Delphan M, Lin T, Liesenfeld DB, Nattenmüller J, Böhm JT, Gigic B, Habermann N, Zielske L, Schrotz-King P, Schneider M, Ulrich A, Kauczor HU, Ulrich CM, Ose J

Metabolomics : Official journal of the Metabolomic Society, 2018

doi:10.1007/s11306-017-1314-8.

Associations Between Dietary Patterns and Longitudinal Quality of Life Changes in Colorectal Cancer Patients: The ColoCare Study.

Gigic B, Boeing H, Toth R, Böhm J, Habermann N, Scherer D, Schrotz-King P, Abbenhardt-Martin C, Skender S, Brenner H, Chang-Claude J, Hoffmeister M, Syrjala K, Jacobsen PB, Schneider M, Ulrich A, Ulrich CM

Nutrition and cancer, 2017

doi:10.1080/01635581.2018.1397707.

Discovery of novel plasma proteins as biomarkers for the development of incisional hernias after midline incision in patients with colorectal cancer: The ColoCare study.

Böhm J, Pianka F, Stüttgen N, Rho J, Gigic B, Zhang Y, Habermann N, Schrotz-King P, Abbenhardt-Martin C, Zielske L, Lampe PD, Ulrich A, Diener MK, Ulrich CM

Surgery, 2016

doi:10.1016/j.surg.2016.08.025.

Using large-scale genome variation cohorts to decipher the molecular mechanism of cancer.

Habermann N, Mardin BR, Yakneen S, Korbel JO

Comptes rendus biologies, 2016

doi:10.1016/j.crvi.2016.05.008.