Knock-out of dipeptidase CN2 in human proximal tubular cells disrupts dipeptide and amino acid homeostasis and para- and transcellular solute transport.

Pfeffer T, Krug SM, Kracke T, Schürfeld R, Colbatzky F, Kirschner P, Medert R, Freichel M, Schumacher D, Bartosova M, Zarogiannis SG, Muckenthaler MU, Altamura S, Pezer S, Volk N, Schwab C, Duensing S, Fleming T, Heidenreich E, Zschocke J, Hell R, Poschet G, Schmitt CP, Peters V

Acta physiologica (Oxford, England), 2024

doi:10.1111/apha.14126.

T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles.

Turco V, Pfleiderer K, Hunger J, Horvat NK, Karimian-Jazi K, Schregel K, Fischer M, Brugnara G, Jähne K, Sturm V, Streibel Y, Nguyen D, Altamura S, Agardy DA, Soni SS, Alsasa A, Bunse T, Schlesner M, Muckenthaler MU, Weissleder R, Wick W, Heiland S, Vollmuth P, Bendszus M, Rodell CB, Breckwoldt MO, Platten M

Nature communications, 2023

doi:10.1038/s41467-023-36321-6.

Hfe Is highly expressed in liver sinusoidal endothelial cells but is not needed to maintain systemic iron homeostasis in vivo.

Colucci S, Müdder K, Muckenthaler MU, Altamura S

HemaSphere, 2021

doi:10.1097/HS9.0000000000000667.

Constitutional PIGA mutations cause a novel subtype of hemochromatosis in patients with neurologic dysfunction.

Muckenthaler L, Marques O, Colucci S, Kunz JB, Fabrowski P, Bast T, Altamura S, Höchsmann B, Schrezenmeier H, Langlotz M, Richter-Pechanska P, Rausch T, Hofmeister-Mielke N, Gunkel N, Hentze MW, Kulozik AE, Muckenthaler MU

Blood, 2021

doi:10.1182/blood.2021013519.

Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload.

Altamura S, Müdder K, Schlotterer A, Fleming T, Heidenreich E, Qiu R, Hammes HP, Nawroth P, Muckenthaler MU

Molecular metabolism, 2021

doi:10.1016/j.molmet.2021.101235.

20 years of Hepcidin: how far we have come.

Colucci S, Marques O, Altamura S

Seminars in hematology, 2021

doi:10.1053/j.seminhematol.2021.05.001.

Mouse multipotent progenitor 5 cells are located at the interphase between hematopoietic stem and progenitor cells.

Sommerkamp P, Romero-Mulero MC, Narr A, Ladel L, Hustin L, Schönberger K, Renders S, Altamura S, Zeisberger P, Jäcklein K, Klimmeck D, Rodriguez-Fraticelli A, Camargo FD, Perié L, Trumpp A, Cabezas-Wallscheid N

Blood, 2022

doi:10.1182/blood.2020007876.

Liver sinusoidal endothelial cells suppress BMP2 production in response to TGFβ pathway activation.

Colucci S, Altamura S, Marques O, Dropmann A, Horvat NK, Müdder K, Hammad S, Dooley S, Muckenthaler MU

Hepatology (Baltimore, Md.), 2021

doi:10.1002/hep.31900.

Mild attenuation of the pulmonary inflammatory response in a mouse model of hereditary hemochromatosis type 4.

Marques O, Neves J, Horvat NK, Altamura S, Muckenthaler MU

Frontiers in physiology, 2020

doi:10.3389/fphys.2020.589351.

Hypoferremia is associated with increased hospitalization and oxygen demand in COVID-19 patients.

Hippchen T, Altamura S, Muckenthaler MU, Merle U

HemaSphere, 2020

doi:10.1097/HS9.0000000000000492.

Iron regulation in elderly Asian elephants ( Elephas maximus) chronically infected with Mycobacterium tuberculosis.

Ruetten M, Steinmetz HW, Thiersch M, Kik M, Vaughan L, Altamura S, Muckenthaler MU, Gassmann M

Frontiers in veterinary science, 2020

doi:10.3389/fvets.2020.596379.

Regulation of iron homeostasis: lessons from mouse models.

Altamura S, Marques O, Colucci S, Mertens C, Alikhanyan K, Muckenthaler MU

Molecular aspects of medicine, 2020

doi:10.1016/j.mam.2020.100872.

Hemochromatosis proteins are dispensable for the acute hepcidin response to BMP2.

Pagani A, Pettinato M, Colucci S, Dulja A, Rauner M, Nai A, Camaschella C, Altamura S, Muckenthaler MU, Silvestri L

Haematologica, 2020

doi:10.3324/haematol.2019.241984.

Disruption of the hepcidin/ferroportin regulatory circuitry causes low axial bone mass in mice.

Ledesma-Colunga MG, Baschant U, Fiedler IAK, Busse B, Hofbauer LC, Muckenthaler MU, Altamura S, Rauner M

Bone, 2020

doi:10.1016/j.bone.2020.115400.

Differential alternative polyadenylation landscapes mediate hematopoietic stem cell activation and regulate glutamine metabolism.

Sommerkamp P, Altamura S, Renders S, Narr A, Ladel L, Zeisberger P, Eiben PL, Fawaz M, Rieger MA, Cabezas-Wallscheid N, Trumpp A

Cell stem cell, 2020

doi:10.1016/j.stem.2020.03.003.

SLN124, a GalNAc-siRNA conjugate targeting TMPRSS6, efficiently prevents iron overload in hereditary haemochromatosis type 1.

Altamura S, Schaeper U, Dames S, Löffler K, Eisermann M, Frauendorf C, Müdder K, Neves J, Muckenthaler MU

HemaSphere, 2019

doi:10.1097/HS9.0000000000000301.

Radical sensing keeps noxious iron at bay.

Altamura S, Galy B

Nature metabolism, 2019

doi:10.1038/s42255-019-0070-7.

Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis.

Altamura S, Vegi NM, Hoppe PS, Schroeder T, Aichler M, Walch A, Okreglicka K, Hültner L, Schneider M, Ladinig C, Kuklik-Roos C, Mysliwietz J, Janik D, Neff F, Rathkolb B, Buske C, Hrabé de Angelis M, Muedder K, da Silva AR, Ganz T, Conrad M, Muckenthaler MU, Kopf M, Bornkamm GW

Haematologica, 2019

doi:10.3324/haematol.2018.212977.

Air-blood barrier thickening and alterations of alveolar epithelial type 2 cells in mouse lungs with disrupted hepcidin/ferroportin regulatory system.

Mühlfeld C, Neves J, Brandenberger C, Hegermann J, Wrede C, Altamura S, Muckenthaler MU

Histochemistry and cell biology, 2019

doi:10.1007/s00418-018-1737-y.

Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction.

Vinchi F, Porto G, Simmelbauer A, Altamura S, Passos ST, Garbowski M, Silva AMN, Spaich S, Seide SE, Sparla R, Hentze MW, Muckenthaler MU

European heart journal, 2019

doi:10.1093/eurheartj/ehz112.

Transferrin receptor 2 controls bone mass and pathological bone formation via BMP and Wnt signaling.

Rauner M, Baschant U, Roetto A, Pellegrino RM, Rother S, Salbach-Hirsch J, Weidner H, Hintze V, Campbell G, Petzold A, Lemaitre R, Henry I, Bellido T, Theurl I, Altamura S, Muckenthaler MU, Colucci S, Komla Ebri D, Schett G, Williams GR, Bassett JHD, Hofbauer LC, Platzbecker U

Nature metabolism, 2019

doi:10.1038/s42255-018-0005-8.

Transferrin receptor 2 is a potential novel therapeutic target for β-thalassemia: evidence from a murine model.

Artuso I, Lidonnici MR, Altamura S, Mandelli G, Pettinato M, Muckenthaler MU, Silvestri L, Ferrari G, Camaschella C, Nai A

Blood, 2018

doi:10.1182/blood-2018-05-852277.

Dietary stearic acid regulates mitochondria in vivo in humans.

Senyilmaz-Tiebe D, Pfaff DH, Virtue S, Schwarz KV, Fleming T, Altamura S, Muckenthaler MU, Okun JG, Vidal-Puig A, Nawroth P, Teleman AA

Nature communications, 2018

doi:10.1038/s41467-018-05614-6.

Modulation of glutathione peroxidase activity by age-dependent carbonylation in glomeruli of diabetic mice.

Wiedenmann T, Dietrich N, Fleming T, Altamura S, Deelman LE, Henning RH, Muckenthaler MU, Nawroth PP, Hammes HP, Wagner AH, Hecker M

Journal of Diabetes and its Complications, 2018

doi:10.1016/j.jdiacomp.2017.11.007.

Uncoupled iron homeostasis in type 2 diabetes mellitus.

Altamura S, Kopf S, Schmidt J, Müdder K, da Silva AR, Nawroth P, Muckenthaler MU

Journal of molecular medicine (Berlin, Germany), 2017

doi:10.1007/s00109-017-1596-3.

Vitamin A-retinoic acid signaling regulates hematopoietic stem cell dormancy.

Cabezas-Wallscheid N, Buettner F, Sommerkamp P, Klimmeck D, Ladel L, Thalheimer FB, Pastor-Flores D, Roma LP, Renders S, Zeisberger P, Przybylla A, Schönberger K, Scognamiglio R, Altamura S, Florian CM, Fawaz M, Vonficht D, Tesio M, Collier P, Pavlinic D, Geiger H, Schroeder T, Benes V, Dick TP, Rieger MA, Stegle O, Trumpp A

Cell, 2017

doi:10.1016/j.cell.2017.04.018.

Disruption of the Hepcidin/Ferroportin Regulatory System Causes Pulmonary Iron Overload and Restrictive Lung Disease.

Neves J, Leitz D, Kraut S, Brandenberger C, Agrawal R, Weissmann N, Mühlfeld C, Mall MA, Altamura S, Muckenthaler MU

EBioMedicine, 2017

doi:10.1016/j.ebiom.2017.04.036.

Cdk6 contributes to cytoskeletal stability in erythroid cells.

Uras IZ, Scheicher RM, Kollmann K, Glösmann M, Prchal-Murphy M, Tigan AS, Fux DA, Altamura S, Neves J, Muckenthaler M, Bennett KL, Kubicek S, Hinds PW, von Lindern M, Sexl V

Haematologica, 2017

doi:10.3324/haematol.2016.159947.

Transforming Growth Factor β1 (TGF-β1) Activates Hepcidin mRNA Expression in Hepatocytes.

Chen S, Feng T, Vujić Spasić M, Altamura S, Breitkopf-Heinlein K, Altenöder J, Weiss TS, Dooley S, Muckenthaler MU

The Journal of biological chemistry, 2016

doi:10.1074/jbc.M115.691543.

Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause.

Scognamiglio R, Cabezas-Wallscheid N, Thier MC, Altamura S, Reyes A, Prendergast ÁM, Baumgärtner D, Carnevalli LS, Atzberger A, Haas S, von Paleske L, Boroviak T, Wörsdörfer P, Essers MA, Kloz U, Eisenman RN, Edenhofer F, Bertone P, Huber W, van der Hoeven F, Smith A, Trumpp A

Cell, 2016

doi:10.1016/j.cell.2015.12.033.

Mice with hepcidin-resistant ferroportin accumulate iron in the retina.

Theurl M, Song D, Clark E, Sterling J, Grieco S, Altamura S, Galy B, Hentze M, Muckenthaler MU, Dunaief JL

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015

doi:10.1096/fj.15-276758.

Elevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin C and E.

Díaz V, Peinado AB, Barba-Moreno L, Altamura S, Butragueño J, González-Gross M, Alteheld B, Stehle P, Zapico AG, Muckenthaler MU, Gassmann M

Physiological reports, 2015

doi:10.14814/phy2.12475.

A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia.

Guida C, Altamura S, Klein FA, Galy B, Boutros M, Ulmer AJ, Hentze MW, Muckenthaler MU

Blood, 2015

doi:10.1182/blood-2014-08-595256.

Increased hepcidin levels in high-altitude pulmonary edema.

Altamura S, Bärtsch P, Dehnert C, Maggiorini M, Weiss G, Theurl I, Muckenthaler MU, Mairbäurl H

Journal of applied physiology (Bethesda, Md. : 1985), 2015

doi:10.1152/japplphysiol.00940.2014.

Resistance of Ferroportin to Hepcidin Binding causes Exocrine Pancreatic Failure and Fatal Iron Overload

Altamura S, Kessler R, Gröne HJ, Gretz N, Hentze MW, Galy B, Muckenthaler MU

Cell metabolism, 2014

doi:10.1016/j.cmet.2014.07.007.

Human L-ferritin deficiency is characterized by idiopathic generalized seizures and atypical restless leg syndrome.

Cozzi A, Santambrogio P, Privitera D, Broccoli V, Rotundo LI, Garavaglia B, Benz R, Altamura S, Goede JS, Muckenthaler MU, Levi S

The Journal of experimental medicine, 2013

doi:10.1084/jem.20130315.

Administration of recombinant erythropoietin alone does not improve the phenotype in iron refractory iron deficiency anemia patients.

Lehmberg K, Grosse R, Muckenthaler MU, Altamura S, Nielsen P, Schmid H, Graubner U, Oyen F, Zeller W, Schneppenheim R, Janka GE

Annals of hematology, 2013

doi:10.1007/s00277-012-1618-8.

Pegylated interferon-α induced hypoferremia is associated with the immediate response to treatment in hepatitis C.

Ryan JD, Altamura S, Devitt E, Mullins S, Lawless MW, Muckenthaler MU, Crowe J

Hepatology (Baltimore, Md.), 2012

doi:10.1002/hep.25666.

Growth differentiation factor 15 in patients with congenital dyserythropoietic anaemia (CDA) type II

Casanovas G, Swinkels DW, Altamura S, Schwarz K, Laarakkers CM, Gross HJ, Wiesneth M, Heimpel H, Muckenthaler MU

Journal of molecular medicine (Berlin, Germany), 2011

doi:10.1007/s00109-011-0751-5.

The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice

Castoldi M, Vujic Spasic M, Altamura S, Elmén J, Lindow M, Kiss J, Stolte J, Sparla R, D'Alessandro LA, Klingmüller U, Fleming RE, Longerich T, Gröne HJ, Benes V, Kauppinen S, Hentze MW, Muckenthaler MU

The Journal of clinical investigation, 2011

doi:10.1172/jci44883.

A novel TMPRSS6 mutation that prevents protease auto-activation causes IRIDA

Altamura S, D'Alessio F, Selle B, Muckenthaler MU

The Biochemical journal, 2010

doi:10.1042/bj20100668.

SELDI-TOF MS detection of urinary hepcidin.

Altamura S, Kiss J, Blattmann C, Gilles W, Muckenthaler MU

Biochimie, 2009

doi:10.1016/j.biochi.2009.04.010.

Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD

Casanovas G, Mleczko-Sanecka K, Altamura S, Hentze MW, Muckenthaler MU

Journal of molecular medicine (Berlin, Germany), 2009

doi:10.1007/s00109-009-0447-2.

Iron toxicity in diseases of aging: Alzheimer's disease, Parkinson's disease and atherosclerosis.

Altamura S, Muckenthaler MU

Journal of Alzheimer's disease : JAD, 2009

doi:10.3233/jad-2009-1010.