Network integration of thermal proteome profiling with multi-omics data decodes PARP inhibition.

Burtscher ML, Gade S, Garrido-Rodriguez M, Rutkowska A, Werner T, Eberl HC, Petretich M, Knopf N, Zirngibl K, Grandi P, Bergamini G, Bantscheff M, Fälth-Savitski M, Saez-Rodriguez J

Molecular systems biology, 2024

doi:10.1038/s44320-024-00025-w.

Comparison of methods and resources for cell-cell communication inference from single-cell RNA-Seq data.

Dimitrov D, Turei D, Garrido-Rodriguez M, Burmedi PL, Nagai JS, Boys C, Flores ROR, Kim H, Szalai B, Costa IG, Valdeolivas A, Dugourd A, Saez-Rodriguez J

Nat Commun, 2022

doi:10.1038/s41467-022-30755-0.

EHP-101 alleviates angiotensin II-induced fibrosis and inflammation in mice.

Garcia-Martin A, Navarrete C, Garrido-Rodriguez M, Prados ME, Caprioglio D, Appendino G, Munoz E

BIOMEDICINE & PHARMACOTHERAPY, 2021

doi:10.1016/j.biopha.2021.112007.

A novel CDC25A/DYRK2 regulatory switch modulates cell cycle and survival.

Lara-Chica M, Correa-Sáez A, Jiménez-Izquierdo R, Garrido-Rodríguez M, Ponce FJ, Moreno R, Morrison K, Di Vona C, Arató K, Jiménez-Jiménez C, Morrugares R, Schmitz ML, de la Luna S, de la Vega L, Calzado MA

Cell death and differentiation, 2021

doi:10.1038/s41418-021-00845-5.

Betulinic Acid Hydroxamate is Neuroprotective and Induces Protein Phosphatase 2A-Dependent HIF-1 alpha Stabilization and Post-transcriptional Dephosphorylation of Prolyl Hydrolase 2.

Prados ME, Correa-Saez A, Unciti-Broceta JD, Garrido-Rodriguez M, Jimenez-Jimenez C, Mazzone M, Minassi A, Appendino G, Calzado MA, Munoz E

Neurotherapeutics, 2021

doi:10.1007/s13311-021-01089-4.

Implementation of CRISPR/Cas9 genome editing to generate murine lung cancer models that depict the mutational landscape of human disease.

Hartmann O, Reissland M, Maier CR, Fischer T, Prieto-Garcia C, Baluapuri A, Schwarz J, Schmitz W, Garrido-Rodriguez M, Pahor N, Davies CC, Bassermann F, Orian A, Wolf E, Schulze A, Calzado MA, Rosenfeldt MT, Diefenbacher ME

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021

doi:10.3389/fcell.2021.641618.

A versatile workflow to integrate RNA-seq genomic and transcriptomic data into mechanistic models of signaling pathways.

Garrido-Rodriguez M, Lopez-Lopez D, Ortuno FM, Pena-Chilet M, Munoz E, Calzado MA, Dopazo J

PLoS Comput Biol, 2021

doi:10.1371/journal.pcbi.1008748.

Effects of EHP-101 on inflammation and remyelination in murine models of Multiple sclerosis.

Navarrete C, Garcia-Martin A, Garrido-Rodriguez M, Mestre L, Feliu A, Guaza C, Calzado MA, Munoz E

NEUROBIOLOGY OF DISEASE, 2020

doi:10.1016/j.nbd.2020.104994.

Delta(9)-Tetrahydrocannabinolic acid alleviates collagen-induced arthritis: Role of PPAR gamma and CB(1)receptors.

Palomares B, Garrido-Rodriguez M, Gonzalo-Consuegra C, Gomez-Canas M, Saen-oon S, Soliva R, Collado JA, Fernandez-Ruiz J, Morello G, Calzado MA, Appendino G, Munoz E

British journal of pharmacology, 2020

doi:10.1111/bph.15155.

Updating dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2): molecular basis, functions and role in diseases.

Correa-Saez A, Jimenez-Izquierdo R, Garrido-Rodriguez M, Morrugares R, Munoz E, Calzado MA

CELLULAR AND MOLECULAR LIFE SCIENCES, 2020

doi:10.1007/s00018-020-03556-1.

Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1.

Casares L, Garcia V, Garrido-Rodriguez M, Millan E, Collado JA, Garcia-Martin A, Penarando J, Calzado MA, de la Vega L, Munoz E

Redox Biol , 2020

doi:10.1016/j.redox.2019.101321.

Tetrahydrocannabinolic acid A (THCA-A) reduces adiposity and prevents metabolic disease caused by diet-induced obesity.

Palomares B, Ruiz-Pino F, Garrido-Rodriguez M, Prados ME, Sanchez-Garrido MA, Velasco I, Vazquez MJ, Nadal X, Ferreiro-Vera C, Morrugares R, Appendino G, Calzado MA, Tena-Sempere M, Munoz E

BIOCHEMICAL PHARMACOLOGY, 2020

doi:10.1016/j.bcp.2019.113693.

Phosphorylation-dependent regulation of the NOTCH1 intracellular domain by dual-specificity tyrosine-regulated kinase 2.

Morrugares R, Correa-Saez A, Moreno R, Garrido-Rodriguez M, Munoz E, de la Vega L, Calzado MA

CELLULAR AND MOLECULAR LIFE SCIENCES, 2020

doi:10.1007/s00018-019-03309-9.

Cannabinoid derivatives acting as dual PPAR gamma/CB2 agonists as therapeutic agents for systemic sclerosis.

Garcia-Martin A, Garrido-Rodriguez M, Navarrete C, Caprioglio D, Palomares B, DeMesa J, Rollland A, Appendino G, Munoz E

Biochem Pharmacol , 2019

doi:10.1016/j.bcp.2019.02.029.

SWATH proteomic profiling of prostate cancer cells identifies NUSAP1 as a potential molecular target for Galiellalactone.

Garrido-Rodriguez M, Ortea I, Calzado MA, Munoz E, Garcia V

JOURNAL OF PROTEOMICS, 2019

doi:10.1016/j.jprot.2018.10.012.

EHP-101, an oral formulation of the cannabidiol aminoquinone VCE-004.8, alleviates bleomycin-induced skin and lung fibrosis.

Garcia-Martin A, Garrido-Rodriguez M, Navarrete C, del Rio C, Bellido ML, Appendino G, Calzado MA, Munoz E

BIOCHEMICAL PHARMACOLOGY, 2018

doi:10.1016/j.bcp.2018.07.047.

Metabolomic profiling of human lung tumor tissues - nucleotide metabolism as a candidate for therapeutic interventions and biomarkers.

Moreno P, Jimenez-Jimenez C, Garrido-Rodriguez M, Calderon-Santiago M, Molina S, Lara-Chica M, Priego-Capote F, Salvatierra A, Munoz E, Calzado MA

MOLECULAR ONCOLOGY, 2018

doi:10.1002/1878-0261.12369.