Enhancer-promoter interactions become more instructive in the transition from cell-fate specification to tissue differentiation.

Pollex T, Rabinowitz A, Gambetta MC, Marco-Ferreres R, Viales RR, Jankowski A, Schaub C, Furlong EEM

Nature genetics, 2024

doi:10.1038/s41588-024-01678-x.

Chromatin gene-gene loops support the cross-regulation of genes with related function.

Pollex T, Marco-Ferreres R, Ciglar L, Ghavi-Helm Y, Rabinowitz A, Viales RR, Schaub C, Jankowski A, Girardot C, Furlong EEM

Molecular cell, 2023

doi:10.1016/j.molcel.2023.12.023.

CTCF, BEAF-32, and CP190 are not required for the establishment of TADs in early Drosophila embryos but have locus-specific roles.

Cavalheiro GR, Girardot C, Viales RR, Pollex T, Cao TBN, Lacour P, Feng S, Rabinowitz A, Furlong EEM

Science advances, 2023

doi:10.1126/sciadv.ade1085.

The hourglass model of evolutionary conservation during embryogenesis extends to developmental enhancers with signatures of positive selection.

Liu J, Viales RR, Khoueiry P, Reddington JP, Girardot C, Furlong E, Robinson-Rechavi M

Genome research, 2021

doi:10.1101/gr.275212.121.

Cis-acting variation is common across regulatory layers but is often buffered during embryonic development.

Floc'hlay S, Wong E, Zhao B, Viales RR, Thomas-Chollier M, Thieffry D, Garfield DA, Furlong EEM

Genome research, 2020

doi:10.1101/gr.266338.120.

Lineage-resolved enhancer and promoter usage during a time course of embryogenesis.

Reddington JP, Garfield DA, Sigalova OM, Karabacak Calviello A, Marco-Ferreres R, Girardot C, Viales RR, Degner JF, Ohler U, Furlong EEM

Developmental cell, 2020

doi:10.1016/j.devcel.2020.10.009.

Characterization of button loci that promote homologous chromosome pairing and cell-type-specific interchromosomal gene regulation.

Viets K, Sauria MEG, Chernoff C, Rodriguez Viales R, Echterling M, Anderson C, Tran S, Dove A, Goyal R, Voortman L, Gordus A, Furlong EEM, Taylor J, Johnston RJ

Developmental cell, 2019

doi:10.1016/j.devcel.2019.09.007.

Highly rearranged chromosomes reveal uncoupling between genome topology and gene expression.

Ghavi-Helm Y, Jankowski A, Meiers S, Viales RR, Korbel JO, Furlong EEM

Nature genetics, 2019

doi:10.1038/s41588-019-0462-3.

Non-coding RNA expression, function, and variation during Drosophila embryogenesis.

Schor IE, Bussotti G, Maleš M, Forneris M, Viales RR, Enright AJ, Furlong EEM

Current biology : CB, 2018

doi:10.1016/j.cub.2018.09.026.

The degree of enhancer or promoter activity is reflected by the levels and directionality of eRNA transcription.

Mikhaylichenko O, Bondarenko V, Harnett D, Schor IE, Males M, Viales RR, Furlong EEM

Genes & development, 2018

doi:10.1101/gad.308619.117.

First identification of Krüppel-like factor 2 mutation in heritable pulmonary arterial hypertension.

Eichstaedt CA, Song J, Viales RR, Pan Z, Benjamin N, Fischer C, Hoeper MM, Ulrich S, Hinderhofer K, Grünig E

Clinical science (London, England : 1979), 2017

doi:10.1042/cs20160930.

Genetic variants regulating expression levels and isoform diversity during embryogenesis.

Cannavò E, Koelling N, Harnett D, Garfield D, Casale FP, Ciglar L, Gustafson HE, Viales RR, Marco-Ferreres R, Degner JF, Zhao B, Stegle O, Birney E, Furlong EE

Nature, 2016

doi:10.1038/nature20802.

Identification of genetic defects in pulmonary arterial hypertension by a new gene panel diagnostic tool

Song J, Eichstaedt CA, Viales RR, Benjamin N, Harutyunova S, Fischer C, Grunig E, Hinderhofer K

CLINICAL SCIENCE, 2016

doi:10.1042/CS20160531.