Paternal microbiome perturbations impact offspring fitness.

Argaw-Denboba A, Schmidt TSB, Di Giacomo M, Ranjan B, Devendran S, Mastrorilli E, Lloyd CT, Pugliese D, Paribeni V, Dabin J, Pisaniello A, Espinola S, Crevenna A, Ghosh S, Humphreys N, Boruc O, Sarkies P, Zimmermann M, Bork P, Hackett JA

Nature, 2024

doi:10.1038/s41586-024-07336-w.

Overexpression of IκB⍺ modulates NF-κB activation of inflammatory target gene expression.

Downton P, Bagnall JS, England H, Spiller DG, Humphreys NE, Jackson DA, Paszek P, White MRH, Adamson AD

Frontiers in molecular biosciences, 2023

doi:10.3389/fmolb.2023.1187187.

Independent endothelial functions of PIEZO1 and TRPV4 in hepatic portal vein and predominance of PIEZO1 in mechanical and osmotic stress.

Endesh N, Chuntharpursat-Bon E, Revill C, Yuldasheva NY, Futers TS, Parsonage G, Humphreys N, Adamson A, Morley LC, Cubbon RM, Prasad KR, Foster R, Lichtenstein L, Beech DJ

Liver international, 2023

doi:10.1111/liv.15646.

PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing.

Chuntharpursat-Bon E, Povstyan OV, Ludlow MJ, Carrier DJ, Debant M, Shi J, Gaunt HJ, Bauer CC, Curd A, Simon Futers T, Baxter PD, Peckham M, Muench SP, Adamson A, Humphreys N, Tumova S, Bon RS, Cubbon R, Lichtenstein L, Beech DJ

Communications biology, 2023

doi:10.1038/s42003-023-04706-4.

A rare human variant that disrupts GPR10 signalling causes weight gain in mice.

Talbot F, Feetham CH, Mokrosiński J, Lawler K, Keogh JM, Henning E, Mendes de Oliveira E, Ayinampudi V, Saeed S, Bonnefond A, Arslan M, Yeo GSH, Froguel P, Bechtold DA, Adamson A, Humphreys N, Barroso I, Luckman SM, Farooqi IS

Nature communications, 2023

doi:10.1038/s41467-023-36966-3.

RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells.

Chen F, Gurler SB, Novo D, Selli C, Alferez DG, Eroglu S, Pavlou K, Zhang J, Sims AH, Humphreys NE, Adamson A, Campbell A, Sansom OJ, Tournier C, Clarke RB, Brennan K, Streuli CH, Ucar A

Oncogene, 2023

doi:10.1038/s41388-022-02574-6.

A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling.

Stables J, Green EK, Sehgal A, Patkar OL, Keshvari S, Taylor I, Ashcroft ME, Grabert K, Wollscheid-Lengeling E, Szymkowiak S, McColl BW, Adamson A, Humphreys NE, Mueller W, Starobova H, Vetter I, Shabestari SK, Blurton-Jones MM, Summers KM, Irvine KM, Pridans C, Hume DA

Development (Cambridge, England), 2022

doi:10.1242/dev.200237.

Loss of PKCα increases arterial medial calcification in a uremic mouse model of chronic kidney disease.

Borland SJ, Facchi C, Behnsen J, Adamson A, Humphreys NE, Withers PJ, Sherratt MJ, Francis SE, Brennan K, Ashton N, Canfield AE

bioRxiv, 2020

doi:10.1101/2020.05.20.097642.

Response to correspondence on "Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation".

Gurumurthy CB, O'Brien AR, Quadros RM, Adams J, Alcaide P, Ayabe S, Ballard J, Batra SK, Beauchamp MC, Becker KA, Bernas G, Brough D, Carrillo-Salinas F, Chan W, Chen H, Dawson R, DeMambro V, D'Hont J, Dibb K, Eudy JD, Gan L, Gao J, Gonzales A, Guntur A, Guo H, Harms DW, Harrington A, Hentges KE, Humphreys N, Imai S, Ishii H, Iwama M, Jonasch E, Karolak M, Keavney B, Khin NC, Konno M, Kotani Y, Kunihiro Y, Lakshmanan I, Larochelle C, Lawrence CB, Li L, Lindner V, Liu XD, Lopez-Castejon G, Loudon A, Lowe J, Jerome-Majeweska L, Matsusaka T, Miura H, Miyasaka Y, Morpurgo B, Motyl K, Nabeshima YI, Nakade K, Nakashiba T, Nakashima K, Obata Y, Ogiwara S, Ouellet M, Oxburgh L, Piltz S, Pinz I, Ponnusamy MP, Ray D, Redder RJ, Rosen CJ, Ross N, Ruhe MT, Ryzhova L, Salvador AM, Alam SS, Sedlacek R, Sharma K, Smith C, Staes K, Starrs L, Sugiyama F, Takahashi S, Tanaka T, Trafford A, Uno Y, Vanhoutte L, Vanrockeghem F, Willis BJ, Wright CS, Yamauchi Y, Yi X, Yoshimi K, Zhang X, Zhang Y, Ohtsuka M, Das S, Garry DJ, Hochepied T, Thomas P, Parker-Thornburg J, Adamson AD, Yoshiki A, Schmouth JF, Golovko A, Thompson WR, Lloyd KCK, Wood JA, Cowan M, Mashimo T, Mizuno S, Zhu H, Kasparek P, Liaw L, Miano JM, Burgio G

Genome biology, 2021

doi:10.1186/s13059-021-02320-3.

LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation.

Green JP, Swanton T, Morris LV, El-Sharkawy LY, Cook J, Yu S, Beswick J, Adamson AD, Humphreys NE, Bryce R, Freeman S, Lawrence C, Brough D

eLife, 2020

doi:10.7554/eLife.59704.

A Transgenic line that reports CSF1R protein expression provides a definitive marker for the mouse mononuclear phagocyte system.

Grabert K, Sehgal A, Irvine KM, Wollscheid-Lengeling E, Ozdemir DD, Stables J, Luke GA, Ryan MD, Adamson A, Humphreys NE, Sandrock CJ, Rojo R, Verkasalo VA, Mueller W, Hohenstein P, Pettit AR, Pridans C, Hume DA

Journal of immunology, 2020

doi:10.4049/jimmunol.2000835.

Nuclear receptor REVERBα is a state-dependent regulator of liver energy metabolism.

Hunter AL, Pelekanou CE, Adamson A, Downton P, Barron NJ, Cornfield T, Poolman TM, Humphreys N, Cunningham PS, Hodson L, Loudon ASI, Iqbal M, Bechtold DA, Ray DW

Proceedings of the National Academy of Sciences of the United States of America, 2020

doi:10.1073/pnas.2005330117.

Cell-specific conditional deletion of interleukin-1 (IL-1) ligands and its receptors: a new toolbox to study the role of IL-1 in health and disease.

Pinteaux E, Abdulaal WH, Mufazalov IA, Humphreys NE, Simonsen-Jackson M, Francis S, Müller W, Waisman A

Journal of molecular medicine (Berlin, Germany), 2020

doi:10.1007/s00109-020-01928-5.

Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator.

Yang N, Smyllie NJ, Morris H, Gonçalves CF, Dudek M, Pathiranage DRJ, Chesham JE, Adamson A, Spiller DG, Zindy E, Bagnall J, Humphreys N, Hoyland J, Loudon ASI, Hastings MH, Meng QJ

PLoS genetics, 2020

doi:10.1371/journal.pgen.1008729.

RBCs prevent rapid PIEZO1 inactivation and expose slow deactivation as a mechanism of dehydrated hereditary stomatocytosis.

Evans EL, Povstyan OV, De Vecchis D, Macrae FL, Lichtenstein L, Futers TS, Parsonage G, Humphreys NE, Adamson A, Kalli AC, Ludlow MJ, Beech DJ

Blood, 2020

doi:10.1182/blood.2019004174.

Cardiac mitochondrial function depends on BUD23 mediated ribosome programming.

Baxter M, Voronkov M, Poolman T, Galli G, Pinali C, Goosey L, Knight A, Krakowiak K, Maidstone R, Iqbal M, Zi M, Prehar S, Cartwright EJ, Gibbs J, Matthews LC, Adamson AD, Humphreys NE, Rebelo-Guiomar P, Minczuk M, Bechtold DA, Loudon A, Ray D

eLife, 2020

doi:10.7554/eLife.50705.

Complex deletion and proximal reinsertion of a 150bp regulatory sequence in the mouse Csf1r promoter mediated by CRISPR-Cas9.

Summers KM, Pridans C, Wollscheid-Lengeling E, Grabert H, Adamson A, Humphreys NE, Irvine KM, Hume DA

bioRxiv, 2019

doi:10.1101/872200.

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation.

Gurumurthy CB, O'Brien AR, Quadros RM, Adams J, Alcaide P, Ayabe S, Ballard J, Batra SK, Beauchamp MC, Becker KA, Bernas G, Brough D, Carrillo-Salinas F, Chan W, Chen H, Dawson R, DeMambro V, D'Hont J, Dibb KM, Eudy JD, Gan L, Gao J, Gonzales A, Guntur AR, Guo H, Harms DW, Harrington A, Hentges KE, Humphreys N, Imai S, Ishii H, Iwama M, Jonasch E, Karolak M, Keavney B, Khin NC, Konno M, Kotani Y, Kunihiro Y, Lakshmanan I, Larochelle C, Lawrence CB, Li L, Lindner V, Liu XD, Lopez-Castejon G, Loudon A, Lowe J, Jerome-Majewska LA, Matsusaka T, Miura H, Miyasaka Y, Morpurgo B, Motyl K, Nabeshima YI, Nakade K, Nakashiba T, Nakashima K, Obata Y, Ogiwara S, Ouellet M, Oxburgh L, Piltz S, Pinz I, Ponnusamy MP, Ray D, Redder RJ, Rosen CJ, Ross N, Ruhe MT, Ryzhova L, Salvador AM, Alam SS, Sedlacek R, Sharma K, Smith C, Staes K, Starrs L, Sugiyama F, Takahashi S, Tanaka T, Trafford AW, Uno Y, Vanhoutte L, Vanrockeghem F, Willis BJ, Wright CS, Yamauchi Y, Yi X, Yoshimi K, Zhang X, Zhang Y, Ohtsuka M, Das S, Garry DJ, Hochepied T, Thomas P, Parker-Thornburg J, Adamson AD, Yoshiki A, Schmouth JF, Golovko A, Thompson WR, Lloyd KCK, Wood JA, Cowan M, Mashimo T, Mizuno S, Zhu H, Kasparek P, Liaw L, Miano JM, Burgio G

Genome biology, 2019

doi:10.1186/s13059-019-1776-2.

Fibroblast-specific deletion of interleukin-1 receptor-1 reduces adverse cardiac remodeling following myocardial infarction.

Bageghni SA, Hemmings KE, Yuldasheva NY, Maqbool A, Gamboa-Esteves FO, Humphreys NE, Jackson MS, Denton CP, Francis S, Porter KE, Ainscough JF, Pinteaux E, Drinkhill MJ, Turner NA

JCI insight, 2019

doi:10.1172/jci.insight.125074.

Metabolic abnormalities of chronic high-dose glucocorticoids are not mediated by hypothalamic AgRP in male mice.

Sefton C, Davies A, Allen TJ, Wray JR, Shoop R, Adamson A, Humphreys N, Coll AP, White A, Harno E

Endocrinology, 2019

doi:10.1210/en.2019-00018.

Human TNF-Luc reporter mouse: a new model to quantify inflammatory responses.

Minshawi F, White MRH, Muller W, Humphreys N, Jackson D, Campbell BJ, Adamson A, Papoutsopoulou S

Scientific reports, 2019

doi:10.1038/s41598-018-36969-x.

Pak2 as a novel therapeutic target for cardioprotective endoplasmic reticulum stress response.

Binder P, Wang S, Radu M, Zi M, Collins L, Khan S, Li Y, Sekeres K, Humphreys NE, Swanton E, Reid A, Pu F, Oceandy D, Guan K, Hille S, Müller OJ, Frey N, Chernoff J, Cartwright EJ, Wang X, Liu W

Circulation research, 2019

doi:10.1161/CIRCRESAHA.118.312829.

ADAMTS10-mediated tissue disruption in Weill-Marchesani syndrome.

Mularczyk EJ, Singh M, Godwin ARF, Galli F, Humphreys N, Adamson AD, Mironov A, Cain SA, Sengle G, Boot-Handford RP, Cossu G, Kielty CM, Baldock C

Human molecular genetics, 2018

doi:10.1093/hmg/ddy276.

Distinct cellular mechanisms underlie smooth muscle turnover in vascular development and repair.

Roostalu U, Aldeiri B, Albertini A, Humphreys N, Simonsen-Jackson M, Wong JKF, Cossu G

Circulation research, 2018

doi:10.1161/CIRCRESAHA.117.312111.

CRISPR/Cas9 mediated mutation of mouse IL-1α nuclear localisation sequence abolishes expression.

Daniels MJD, Adamson AD, Humphreys N, Brough D

Scientific reports, 2017

doi:10.1038/s41598-017-17387-x.

Generation of induced pluripotent stem cells from virus-free in vivo reprogramming of BALB/c mouse liver cells.

de Lázaro I, Bussy C, Yilmazer A, Jackson MS, Humphreys NE, Kostarelos K

Biomaterials, 2014

doi:10.1016/j.biomaterials.2014.05.086.

Immunity to gastrointestinal nematodes: mechanisms and myths.

Grencis RK, Humphreys NE, Bancroft AJ

Immunological reviews, 2014

doi:10.1111/imr.12188.

Aging aggravates ischemic stroke-induced brain damage in mice with chronic peripheral infection.

Dhungana H, Malm T, Denes A, Valonen P, Wojciechowski S, Magga J, Savchenko E, Humphreys N, Grencis R, Rothwell N, Koistinaho J

Aging cell, 2013

doi:10.1111/acel.12106.

Experimental stroke-induced changes in the bone marrow reveal complex regulation of leukocyte responses.

Denes A, McColl BW, Leow-Dyke SF, Chapman KZ, Humphreys NE, Grencis RK, Allan SM, Rothwell NJ

Journal of cerebral blood flow and metabolism, 2011

doi:10.1038/jcbfm.2010.198.

Chronic systemic infection exacerbates ischemic brain damage via a CCL5 (regulated on activation, normal T-cell expressed and secreted)-mediated proinflammatory response in mice.

Dénes A, Humphreys N, Lane TE, Grencis R, Rothwell N

The Journal of neuroscience, 2010

doi:10.1523/JNEUROSCI.1227-10.2010.

Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function.

Massacand JC, Stettler RC, Meier R, Humphreys NE, Grencis RK, Marsland BJ, Harris NL

Proceedings of the National Academy of Sciences of the United States of America, 2009

doi:10.1073/pnas.0906367106.

IL-1-dependent, IL-1R1-independent resistance to gastrointestinal nematodes.

Humphreys NE, Grencis RK

European journal of immunology, 2009

doi:10.1002/eji.200838938.

IL-33, a potent inducer of adaptive immunity to intestinal nematodes.

Humphreys NE, Xu D, Hepworth MR, Liew FY, Grencis RK

Journal of immunology, 2008

doi:10.4049/jimmunol.180.4.2443.

Intraepithelial NK cell-derived IL-13 induces intestinal pathology associated with nematode infection.

McDermott JR, Humphreys NE, Forman SP, Donaldson DD, Grencis RK

Journal of immunology (Baltimore, Md. : 1950), 2005

doi:10.4049/jimmunol.175.5.3207.

Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion.

Cliffe LJ, Humphreys NE, Lane TE, Potten CS, Booth C, Grencis RK

Science (New York, N.Y.), 2005

doi:10.1126/science.1108661.

Allergen-induced cytokine phenotypes in mice: role of CD4 and CD8 T cell populations.

Dearman RJ, Humphreys N, Skinner RA, Kimber I

Clinical & Experimental Allergy, 2005

doi:10.1111/j.1365-2222.2005.02209.x.

Exposure of mice to the nitroso metabolite of sulfamethoxazole stimulates interleukin 5 production by CD4+ T-cells.

Hopkins JE, Naisbitt DJ, Humphreys N, Dearman RJ, Kimber I, Park BK

Toxicology, 2005

doi:10.1016/j.tox.2004.08.010.

WSX-1: a key role in induction of chronic intestinal nematode infection.

Bancroft AJ, Humphreys NE, Worthington JJ, Yoshida H, Grencis RK

Journal of immunology (Baltimore, Md. : 1950), 2004

doi:10.4049/jimmunol.172.12.7635.

The role of CD8+ cells in the establishment and maintenance of a Trichuris muris infection.

Humphreys NE, Worthington JJ, Little MC, Rice EJ, Grencis RK

Parasite Immunology, 2004

doi:10.1111/j.0141-9838.2004.00702.x.

Methods for the identification of chemical respiratory allergens in rodents: comparisons of cytokine profiling with induced changes in serum IgE.

Dearman RJ, Skinner RA, Humphreys NE, Kimber I

Journal of Applied Toxicology, 2003

doi:10.1002/jat.907.

Modulation of intestinal muscle contraction by interleukin-9 (IL-9) or IL-9 neutralization: correlation with worm expulsion in murine nematode infections.

Khan WI, Richard M, Akiho H, Blennerhasset PA, Humphreys NE, Grencis RK, Van Snick J, Collins SM

Infection and immunity, 2003

doi:10.1128/IAI.71.5.2430-2438.2003.

Assessment of cumulative allergen-activated lymph node cell proliferation using flow cytometry.

Humphreys NE, Dearman RJ, Kimber I

Toxicological sciences, 2003

doi:10.1093/toxsci/kfg056.

Chemical allergy: considerations for the practical application of cytokine profiling.

Dearman RJ, Betts CJ, Humphreys N, Flanagan BF, Gilmour NJ, Basketter DA, Kimber I

Toxicological sciences, 2003

doi:10.1093/toxsci/71.2.137.

Effects of ageing on the immunoregulation of parasitic infection.

Humphreys NE, Grencis RK

Infection and immunity, 2002

doi:10.1128/IAI.70.9.5148-5157.2002.

The effect of challenge and trickle Trichuris muris infections on the polarisation of the immune response.

Bancroft AJ, Else KJ, Humphreys NE, Grencis RK

International journal for parasitology, 2001

doi:10.1016/s0020-7519(01)00281-8.

Beta7 integrin-deficient mice: delayed leukocyte recruitment and attenuated protective immunity in the small intestine during enteric helminth infection.

Artis D, Humphreys NE, Potten CS, Wagner N, Müller W, McDermott JR, Grencis RK, Else KJ

European journal of immunology, 2000

doi:10.1002/1521-4141(200006)30:6<1656::AID-IMMU1656>3.0.CO;2-Z.

Anti-IL-9 vaccination prevents worm expulsion and blood eosinophilia in Trichuris muris-infected mice.

Richard M, Grencis RK, Humphreys NE, Renauld JC, Van Snick J

Proceedings of the National Academy of Sciences of the United States of America, 2000

doi:10.1073/pnas.97.2.767.

Tumor necrosis factor alpha is a critical component of interleukin 13-mediated protective T helper cell type 2 responses during helminth infection.

Artis D, Humphreys NE, Bancroft AJ, Rothwell NJ, Potten CS, Grencis RK

The Journal of experimental medicine, 1999

doi:10.1084/jem.190.7.953.

Interleukin-9 is involved in host protective immunity to intestinal nematode infection.

Faulkner H, Humphreys N, Renauld JC, Van Snick J, Grencis R

European journal of immunology, 1997

doi:10.1002/eji.1830271011.