The Listeria monocytogenes persistence factor ClpL is a potent stand-alone disaggregase.

Bohl V, Hollmann NM, Melzer T, Katikaridis P, Meins L, Simon B, Flemming D, Sinning I, Hennig J, Mogk A

eLife, 2024

doi:10.7554/eLife.92746.

Tropomyosin 1-I/C coordinates kinesin-1 and dynein motors during oskar mRNA transport.

Heber S, McClintock MA, Simon B, Mehtab E, Lapouge K, Hennig J, Bullock SL, Ephrussi A

Nature structural & molecular biology, 2024

doi:10.1038/s41594-024-01212-x.

Structural basis of aggregate binding by the AAA+ disaggregase ClpG.

Katikaridis P, Simon B, Jenne T, Moon S, Lee C, Hennig J, Mogk A

The Journal of biological chemistry, 2023

doi:10.1016/j.jbc.2023.105336.

Structural basis for specific RNA recognition by the alternative splicing factor RBM5.

Soni K, Jagtap PKA, Martínez-Lumbreras S, Bonnal S, Geerlof A, Stehle R, Simon B, Valcárcel J, Sattler M

Nature communications, 2023

doi:10.1038/s41467-023-39961-w.

Mechanistic insights into RNA surveillance by the canonical poly(A) polymerase Pla1 of the MTREC complex.

Soni K, Sivadas A, Horvath A, Dobrev N, Hayashi R, Kiss L, Simon B, Wild K, Sinning I, Fischer T

Nature communications, 2023

doi:10.1038/s41467-023-36402-6.

Upstream of N-Ras C-terminal cold shock domains mediate poly(A) specificity in a novel RNA recognition mode and bind poly(A) binding protein.

Hollmann NM, Jagtap PKA, Linse JB, Ullmann P, Payr M, Murciano B, Simon B, Hub JS, Hennig J

Nucleic acids research, 2023

doi:10.1093/nar/gkac1277.

Structure and dynamics of the von Willebrand Factor C6 domain.

Chen PC, Kutzki F, Mojzisch A, Simon B, Xu ER, Aponte-Santamaría C, Horny K, Jeffries C, Schneppenheim R, Wilmanns M, Brehm MA, Gräter F, Hennig J

Journal of structural biology, 2022

doi:10.1016/j.jsb.2022.107923.

Tropomyosin 1-I/C co-ordinates kinesin-1 and dynein motors during oskar mRNA transport.

Heber S, McClintock MA, Simon B, Hennig J, Bullock SL, Ephrussi A

bioRxiv, 2022

doi:10.1101/2022.10.26.513919.

Bioaccumulation of therapeutic drugs by human gut bacteria.

Klünemann M, Andrejev S, Blasche S, Mateus A, Phapale P, Devendran S, Vappiani J, Simon B, Scott TA, Kafkia E, Konstantinidis D, Zirngibl K, Mastrorilli E, Banzhaf M, Mackmull MT, Hövelmann F, Nesme L, Brochado AR, Maier L, Bock T, Periwal V, Kumar M, Kim Y, Tramontano M, Schultz C, Beck M, Hennig J, Zimmermann M, Sévin DC, Cabreiro F, Savitski MM, Bork P, Typas A, Patil KR

Nature, 2021

doi:10.1038/s41586-021-03891-8.

Structural basis of PETISCO complex assembly during piRNA biogenesis in C. elegans.

Perez-Borrajero C, Podvalnaya N, Holleis K, Lichtenberger R, Karaulanov E, Simon B, Basquin J, Hennig J, Ketting RF, Falk S

Genes & development, 2021

doi:10.1101/gad.348648.121.

Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere.

Bogomolovas J, Fleming JR, Franke B, Manso B, Simon B, Gasch A, Markovic M, Brunner T, Knöll R, Chen J, Labeit S, Scheffner M, Peter C, Mayans O

EMBO reports, 2021

doi:10.15252/embr.201948018.

Structure and dynamics of the quaternary hunchback mRNA translation repression complex.

Macošek J, Simon B, Linse JB, Jagtap PKA, Winter SL, Foot J, Lapouge K, Perez K, Rettel M, Ivanović MT, Masiewicz P, Murciano B, Savitski MM, Loedige I, Hub JS, Gabel F, Hennig J

Nucleic acids research, 2021

doi:10.1093/nar/gkab635.

Structural analysis of the SRP Alu domain from Plasmodium falciparum reveals a non-canonical open conformation.

Soni K, Kempf G, Manalastas-Cantos K, Hendricks A, Flemming D, Guizetti J, Simon B, Frischknecht F, Svergun DI, Wild K, Sinning I

Communications biology, 2021

doi:10.1038/s42003-021-02132-y.

Pseudo-RNA-binding domains mediate RNA structure specificity in Upstream of N-Ras.

Hollmann NM, Jagtap PKA, Masiewicz P, Guitart T, Simon B, Provaznik J, Stein F, Haberkant P, Sweetapple LJ, Villacorta L, Moojiman D, Benes V, Savitski MM, Gebauer F, Hennig J

2020

doi:10.1016/j.celrep.2020.107930.

Macrocyclic peptides uncover a novel binding mode for reversible inhibitors of LSD1.

Yang J, Talibov VO, Peintner S, Rhee C, Poongavanam V, Geitmann M, Sebastiano MR, Simon B, Hennig J, Dobritzsch D, Danielson UH, Kihlberg J

ACS omega, 2020

doi:10.1021/acsomega.9b03493.

Structural basis of an asymmetric condensin ATPase cycle.

Hassler M, Shaltiel IA, Kschonsak M, Simon B, Merkel F, Thärichen L, Bailey HJ, Macošek J, Bravo S, Metz J, Hennig J, Haering CH

Molecular cell, 2019

doi:10.1016/j.molcel.2019.03.037.

Improving the sensitivity of FT-NMR spectroscopy by apodization weighted sampling.

Simon B, Köstler H

Journal of biomolecular NMR, 2019

doi:10.1007/s10858-019-00243-7.

Structure, dynamics and roX2-lncRNA binding of tandem double-stranded RNA binding domains dsRBD1,2 of Drosophila helicase Maleless.

Pravin Kumar Ankush Jagtap, Marisa Müller, Pawel Masiewicz, Sören von Bülow, Nele Merret Hollmann, Po-Chia Chen, Bernd Simon, Andreas W Thomae, Peter B Becker, Janosch Hennig

2019

doi:10.1093/nar/gkz125.

Structure and dynamics of the platelet integrin-binding C4 domain of von Willebrand factor.

Xu ER, von Bülow S, Chen PC, Lenting PJ, Kolšek K, Aponte-Santamaría C, Simon B, Foot J, Obser T, Schneppenheim R, Gräter F, Denis CV, Wilmanns M, Hennig J

Blood, 2018

doi:10.1182/blood-2018-04-843615.

Structural basis for terminal loop recognition and stimulation of pri-miRNA-18a processing by hnRNP A1.

Kooshapur H, Choudhury NR, Simon B, Mühlbauer M, Jussupow A, Fernandez N, Jones AN, Dallmann A, Gabel F, Camilloni C, Michlewski G, Caceres JF, Sattler M

Nature communications, 2018

doi:10.1038/s41467-018-04871-9.

DENR-MCTS1 heterodimerization and tRNA recruitment are required for translation reinitiation.

Ahmed YL, Schleich S, Bohlen J, Mandel N, Simon B, Sinning I, Teleman AA

PLoS biology, 2018

doi:10.1371/journal.pbio.2005160.

Segmental, domain-selective perdeuteration and small-angle neutron scattering for structural analysis of multi-domain proteins.

Sonntag M, Jagtap PKA, Simon B, Appavou MS, Geerlof A, Stehle R, Gabel F, Hennig J, Sattler M

Angewandte Chemie (International ed. in English), 2017

doi:10.1002/anie.201702904.

A bromodomain-DNA interaction facilitates acetylation-dependent bivalent nucleosome recognition by the BET protein BRDT

Miller TC, Simon B, Rybin V, Grötsch H, Curtet S, Khochbin S, Carlomagno T, Müller CW

NATURE COMMUNICATIONS, 2016

doi:10.1038/ncomms13855.

Resolving the α-glycosidic linkage of arginine-rhamnosylated translation elongation factor P triggers generation of the first ArgRha specific antibody.

Li X, Krafczyk R, Macošek J, Li Y-L, Zou Y, Simon B, Pan X, Wu Q-Y, Yan F, Li S, Hennig J, Jung K, Lassak J, Hu H-G

Chemical science, 2016

doi:10.1039/c6sc02889f.

Synthesis of Highly Selective Submicromolar Microcystin-Based Inhibitors of Protein Phosphatase (PP)2A over PP1.

Fontanillo M, Zemskov I, Häfner M, Uhrig U, Salvi F, Simon B, Wittmann V, Köhn M

Angewandte Chemie (International ed. in English), 2016

doi:10.1002/anie.201606449.

Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I.

Bogomolovas J, Fleming JR, Anderson BR, Williams R, Lange S, Simon B, Khan MM, Rudolf R, Franke B, Bullard B, Rigden DJ, Granzier H, Labeit S, Mayans O

Open biology, 2016

doi:10.1098/rsob.160114.

Automated structure modeling of large protein assemblies using crosslinks as distance restraints.

Ferber M, Kosinski J, Ori A, Rashid UJ, Moreno-Morcillo M, Simon B, Bouvier G, Batista PR, Müller CW, Beck M, Nilges M

Nature methods, 2016

doi:10.1038/nmeth.3838.

The structure of the SOLE element of oskar mRNA.

Simon B, Masiewicz P, Ephrussi A, Carlomagno T

RNA (New York, N.Y.), 2015

doi:10.1261/rna.049601.115.

Structural analysis of protein-RNA complexes in solution using NMR paramagnetic relaxation enhancements.

Hennig J, Warner LR, Simon B, Geerlof A, Mackereth CD, Sattler M

Methods in enzymology, 2015

doi:10.1016/bs.mie.2015.02.006.

RNA structure determination by solid-state NMR spectroscopy.

Marchanka A, Simon B, Althoff-Ospelt G, Carlomagno T

Nature communications, 2015

doi:10.1038/ncomms8024.

NMR approaches for structural analysis of multidomain proteins and complexes in solution.

Göbl C, Madl T, Simon B, Sattler M

Progress in Nuclear Magnetic Resonance Spectroscopy, 2014

doi:10.1016/j.pnmrs.2014.05.003.

A role for central carbon metabolism in mammalian embryonic development?

Snaebjornsson M, Prior N, Bulusu V, Simon B, Carlomagno T, Aulehla A

Cancer & metabolism, 2014

doi:10.1186/2049-3002-2-S1-P69.

¹H, ¹³C, and ¹⁵N chemical shift assignments of the phosphotyrosine binding domain 2 (PTB2) of human FE65

Dietl A, Wild K, Simon B

Biomolecular NMR assignments, 2013

doi:10.1007/s12104-013-9460-z.

The structure of the box C/D enzyme reveals regulation of RNA methylation

Lapinaite A, Simon B, Skjaerven L, Rakwalska-Bange M, Gabel F, Carlomagno T

Nature, 2013

doi:10.1038/nature12581.

Efficient detection of hydrogen bonds in dynamic regions of RNA by sensitivity-optimized NMR pulse sequences

Dallmann A, Simon B, Duszczyk MM, Kooshapur H, Pardi A, Bermel W, Sattler M

Angewandte Chemie (International ed. in English), 2013

doi:10.1002/anie.201304391.

A suite of solid-state NMR experiments for RNA intranucleotide resonance assignment in a 21 kDa protein-RNA complex

Marchanka A, Simon B, Carlomagno T

Angewandte Chemie (International ed. in English), 2013

doi:10.1002/anie.201304779.

Structural principles of RNA catalysis in a 2'-5' lariat-forming ribozyme

Carlomagno T, Amata I, Codutti L, Falb M, Fohrer J, Masiewicz P, Simon B

Journal of the American Chemical Society, 2013

doi:10.1021/ja311868t.

Functional role of the flexible N-terminal extension of FKBP38 in catalysis

Kang C, Ye H, Chia J, Choi BH, Dhe-Paganon S, Simon B, Schütz U, Sattler M, Yoon HS

Scientific reports, 2013

doi:10.1038/srep02985.

Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity

Ballaré C, Lange M, Lapinaite A, Martin GM, Morey L, Pascual G, Liefke R, Simon B, Shi Y, Gozani O, Carlomagno T, Benitah SA, Di Croce L

Nature structural & molecular biology, 2012

doi:10.1038/nsmb.2434.

Phosphorylation of LRP1 regulates the interaction with Fe65

Klug W, Dietl A, Simon B, Sinning I, Wild K

FEBS letters, 2011

doi:10.1016/j.febslet.2011.09.028.

Genetic variation in titin in arrhythmogenic right ventricular cardiomyopathy-overlap syndromes

Taylor M, Graw S, Sinagra G, Barnes C, Slavov D, Brun F, Pinamonti B, Salcedo EE, Sauer W, Pyxaras S, Anderson B, Simon B, Bogomolovas J, Labeit S, Granzier H, Mestroni L

Circulation, 2011

doi:10.1161/circulationaha.110.005405.

Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF

Mackereth CD, Madl T, Bonnal S, Simon B, Zanier K, Gasch A, Rybin V, Valcárcel J, Sattler M

Nature, 2011

doi:10.1038/nature10171.

Structure and VP16 binding of the Mediator Med25 activator interaction domain

Vojnic E, Mourão A, Seizl M, Simon B, Wenzeck L, Larivière L, Baumli S, Baumgart K, Meisterernst M, Sattler M, Cramer P

Nature structural & molecular biology, 2011

doi:10.1038/nsmb.1997.

Recognition of 2'-O-methylated 3'-end of piRNA by the PAZ domain of a Piwi protein

Simon B, Kirkpatrick JP, Eckhardt S, Reuter M, Rocha EA, Andrade-Navarro MA, Sehr P, Pillai RS, Carlomagno T

Structure (London, England : 1993), 2011

doi:10.1016/j.str.2010.11.015.

Structure of the K-turn U4 RNA: a combined NMR and SANS study

Falb M, Amata I, Gabel F, Simon B, Carlomagno T

Nucleic acids research, 2010

doi:10.1093/nar/gkq380.

Elucidation of the structure and intermolecular interactions of a reversible cyclic-peptide inhibitor of the proteasome by NMR spectroscopy and molecular modeling

Stauch B, Simon B, Basile T, Schneider G, Malek NP, Kalesse M, Carlomagno T

Angewandte Chemie (International ed. in English), 2010

doi:10.1002/anie.201000140.

An efficient protocol for NMR-spectroscopy-based structure determination of protein complexes in solution

Simon B, Madl T, Mackereth CD, Nilges M, Sattler M

Angewandte Chemie (International ed. in English), 2010

doi:10.1002/anie.200906147.

Screening of fusion partners for high yield expression and purification of bioactive viscotoxins

Bogomolovas J, Simon B, Sattler M, Stier G

Protein expression and purification, 2009

doi:10.1016/j.pep.2008.10.003.

Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19

Neufeld C, Filipp FV, Simon B, Neuhaus A, Schüller N, David C, Kooshapur H, Madl T, Erdmann R, Schliebs W, Wilmanns M, Sattler M

The EMBO journal, 2009

doi:10.1038/emboj.2009.7.

Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2

Radzimanowski J, Simon B, Sattler M, Beyreuther K, Sinning I, Wild K

EMBO reports, 2008

doi:10.1038/embor.2008.188.

A structure refinement protocol combining NMR residual dipolar couplings and small angle scattering restraints

Gabel F, Simon B, Nilges M, Petoukhov M, Svergun D, Sattler M

Journal of biomolecular NMR, 2008

doi:10.1007/s10858-008-9258-y.

1H, 13C, and 15N chemical shift assignments for the Eps15-EH2-stonin 2 complex

Rumpf J, Simon B, Groemping Y, Sattler M

Biomolecular NMR assignments, 2008

doi:10.1007/s12104-008-9083-y.

Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity

Rumpf J, Simon B, Jung N, Maritzen T, Haucke V, Sattler M, Groemping Y

The EMBO journal, 2008

doi:10.1038/sj.emboj.7601980.

The Ig doublet Z1Z2: a model system for the hybrid analysis of conformational dynamics in Ig tandems from titin

Marino M, Zou P, Svergun D, Garcia P, Edlich C, Simon B, Wilmanns M, Muhle-Goll C, Mayans O

Structure (London, England : 1993), 2006

doi:10.1016/j.str.2006.07.009.

A target function for quaternary structural refinement from small angle scattering and NMR orientational restraints

Gabel F, Simon B, Sattler M

European biophysics journal : EBJ, 2006

doi:10.1007/s00249-005-0037-3.

New NMR assignment 1H, 13C, and 15N assignment of the second PH domain of human pleckstrin (234-350)

Edlich C, Simon B, Sattler M, Muhle-Goll C

Journal of biomolecular NMR, 2006

doi:10.1007/s10858-005-6053-x.

Backbone 1H, 13C, and 15N resonance assignments of the N-terminal domain of FKBP38 (FKBP38NTD)

Kang CB, Ye H, Vivekanandan S, Simon B, Sattler M, Yoon HS

Journal of biomolecular NMR, 2006

doi:10.1007/s10858-006-9001-5.

The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition

Lingel A, Simon B, Izaurralde E, Sattler M

EMBO reports, 2005

doi:10.1038/sj.embor.7400583.

NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) disease

Bottomley MJ, Stier G, Pennacchini D, Legube G, Simon B, Akhtar A, Sattler M, Musco G

The Journal of biological chemistry, 2005

doi:10.1074/jbc.m413959200.

NMR assignment of the Drosophila Argonaute2 PAZ domain

Lingel A, Simon B, Izaurralde E, Sattler M

Journal of biomolecular NMR, 2004

doi:10.1023/b:jnmr.0000032513.15693.04.

Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain

Lingel A, Simon B, Izaurralde E, Sattler M

Nature structural & molecular biology, 2004

doi:10.1038/nsmb777.

Fast identification of folded human protein domains expressed in E. coli suitable for structural analysis

Scheich C, Leitner D, Sievert V, Leidert M, Schlegel B, Simon B, Letunic I, Büssow K, Diehl A

BMC structural biology, 2004

doi:10.1186/1472-6807-4-4.

Speeding up biomolecular NMR spectroscopy

Simon B, Sattler M

Angewandte Chemie (International ed. in English), 2004

doi:10.1002/anie.200301680.

Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain

Lingel A, Simon B, Izaurralde E, Sattler M

Nature, 2003

doi:10.1038/nature02123.

Establishing the yeast Saccharomyces cerevisiae as a system for expression of human proteins on a proteome-scale

Holz C, Prinz B, Bolotina N, Sievert V, Büssow K, Simon B, Stahl U, Lang C

Journal of structural and functional genomics, 2003

doi:10.1023/a:1026226429429.

De novo structure determination from residual dipolar couplings by NMR spectroscopy

Simon B, Sattler M

Angewandte Chemie (International ed. in English), 2002

doi:10.1002/1521-3773(20020201)41:3<437::aid-anie437>3.0.co;2-3.

A TROSY relayed HCCH-COSY experiment for correlating adenine H2/H8 resonances in uniformly 13C-labeled RNA molecules

Simon B, Zanier K, Sattler M

Journal of biomolecular NMR, 2001

doi:10.1023/a:1011214914452.

Heteronuclear relaxation study of the PH domain of beta-spectrin: restriction of loop motions upon binding inositol trisphosphate

Gryk MR, Abseher R, Simon B, Nilges M, Oschkinat H

Journal of molecular biology, 1998

doi:10.1006/jmbi.1998.1731.

Rotating-frame-imaging technique for spatially resolved diffusion and flow studies in the fringe field of RF probe coils

Simon B, Kimmich R, Kostler H

JOURNAL OF MAGNETIC RESONANCE SERIES A, 1996

doi:10.1006/jmra.1996.0011.

MAGNETIZATION-GRID ROTATING-FRAME IMAGING TECHNIQUE FOR DIFFUSION AND FLOW MEASUREMENTS

KIMMICH R, SIMON B, KOSTLER H

JOURNAL OF MAGNETIC RESONANCE SERIES A, 1995

doi:10.1006/jmra.1995.1002.