The 2023 Report on the Proteome from the HUPO Human Proteome Project.

Omenn GS, Lane L, Overall CM, Lindskog C, Pineau C, Packer NH, Cristea IM, Weintraub ST, Orchard S, Roehrl MHA, Nice E, Guo T, Van Eyk JE, Liu S, Bandeira N, Aebersold R, Moritz RL, Deutsch EW.

J Proteome Res, 2024

doi:10.1021/acs.jproteome.3c00591.

The landscape of microRNA interaction annotation: analysis of three rare disorders as a case study.

Simona P, Panneerselvam K, Porras P, Duesbury M, Perfetto L, Licata L, Hermjakob H, Orchard S.

Database (Oxford), 2023

doi:10.1093/database/baad066.

Minimum information guidelines for experiments structurally characterizing intrinsically disordered protein regions.

Mészáros B, Hatos A, Palopoli N, Quaglia F, Salladini E, Van Roey K, Arthanari H, Dosztányi Z, Felli IC, Fischer PD, Hoch JC, Jeffries CM, Longhi S, Maiani E, Orchard S, Pancsa R, Papaleo E, Pierattelli R, Piovesan D, Pritisanac I, Tenorio L, Viennet T, Tompa P, Vranken W, Tosatto SCE, Davey NE.

Nat Methods, 2023

doi:10.1038/s41592-023-01915-x.

The landscape of microRNA interactions annotation: analysis of three rare disorders as case study

Simona P, Panneerselvam K, Porras P, Duesbury M, Perfetto L, Licata L, Hermjakob H, Orchard S.

2023

doi:10.1101/2023.06.20.545695.

UniProt and Mass Spectrometry-Based Proteomics-A 2-Way Working Relationship.

Bowler-Barnett EH, Fan J, Luo J, Magrane M, Martin MJ, Orchard S, UniProt Consortium.

Mol Cell Proteomics, 2023

doi:10.1016/j.mcpro.2023.100591.

UniProt Tools: BLAST, Align, Peptide Search, and ID Mapping.

Zaru R, Orchard S, UniProt Consortium.

Curr Protoc, 2023

doi:10.1002/cpz1.697.

Searching and Navigating UniProt Databases.

Lussi YC, Magrane M, Martin MJ, Orchard S, UniProt Consortium.

Curr Protoc, 2023

doi:10.1002/cpz1.700.

The Gene Ontology knowledgebase in 2023.

Gene Ontology Consortium, Aleksander SA, Balhoff J, Carbon S, Cherry JM, Drabkin HJ, Ebert D, Feuermann M, Gaudet P, Harris NL, Hill DP, Lee R, Mi H, Moxon S, Mungall CJ, Muruganugan A, Mushayahama T, Sternberg PW, Thomas PD, Van Auken K, Ramsey J, Siegele DA, Chisholm RL, Fey P, Aspromonte MC, Nugnes MV, Quaglia F, Tosatto S, Giglio M, Nadendla S, Antonazzo G, Attrill H, Dos Santos G, Marygold S, Strelets V, Tabone CJ, Thurmond J, Zhou P, Ahmed SH, Asanitthong P, Luna Buitrago D, Erdol MN, Gage MC, Ali Kadhum M, Li KYC, Long M, Michalak A, Pesala A, Pritazahra A, Saverimuttu SCC, Su R, Thurlow KE, Lovering RC, Logie C, Oliferenko S, Blake J, Christie K, Corbani L, Dolan ME, Drabkin HJ, Hill DP, Ni L, Sitnikov D, Smith C, Cuzick A, Seager J, Cooper L, Elser J, Jaiswal P, Gupta P, Jaiswal P, Naithani S, Lera-Ramirez M, Rutherford K, Wood V, De Pons JL, Dwinell MR, Hayman GT, Kaldunski ML, Kwitek AE, Laulederkind SJF, Tutaj MA, Vedi M, Wang SJ, D'Eustachio P, Aimo L, Axelsen K, Bridge A, Hyka-Nouspikel N, Morgat A, Aleksander SA, Cherry JM, Engel SR, Karra K, Miyasato SR, Nash RS, Skrzypek MS, Weng S, Wong ED, Bakker E, Berardini TZ, Reiser L, Auchincloss A, Axelsen K, Argoud-Puy G, Blatter MC, Boutet E, Breuza L, Bridge A, Casals-Casas C, Coudert E, Estreicher A, Livia Famiglietti M, Feuermann M, Gos A, Gruaz-Gumowski N, Hulo C, Hyka-Nouspikel N, Jungo F, Le Mercier P, Lieberherr D, Masson P, Morgat A, Pedruzzi I, Pourcel L, Poux S, Rivoire C, Sundaram S, Bateman A, Bowler-Barnett E, Bye-A-Jee H, Denny P, Ignatchenko A, Ishtiaq R, Lock A, Lussi Y, Magrane M, Martin MJ, Orchard S, Raposo P, Speretta E, Tyagi N, Warner K, Zaru R, Diehl AD, Lee R, Chan J, Diamantakis S, Raciti D, Zarowiecki M, Fisher M, James-Zorn C, Ponferrada V, Zorn A, Ramachandran S, Ruzicka L, Westerfield M.

Genetics, 2023

doi:10.1093/genetics/iyad031.

Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Barrio-Hernandez I, Schwartzentruber J, Shrivastava A, Del-Toro N, Gonzalez A, Zhang Q, Mountjoy E, Suveges D, Ochoa D, Ghoussaini M, Bradley G, Hermjakob H, Orchard S, Dunham I, Anderson CA, Porras P, Beltrao P.

Nat Genet, 2023

doi:10.1038/s41588-023-01327-9.

Proteomics Standards Initiative at Twenty Years: Current Activities and Future Work.

Deutsch EW, Vizcaíno JA, Jones AR, Binz PA, Lam H, Klein J, Bittremieux W, Perez-Riverol Y, Tabb DL, Walzer M, Ricard-Blum S, Hermjakob H, Neumann S, Mak TD, Kawano S, Mendoza L, Van Den Bossche T, Gabriels R, Bandeira N, Carver J, Pullman B, Sun Z, Hoffmann N, Shofstahl J, Zhu Y, Licata L, Quaglia F, Tosatto SCE, Orchard SE.

J Proteome Res, 2023

doi:10.1021/acs.jproteome.2c00637.

Annotation of biologically relevant ligands in UniProtKB using ChEBI.

Coudert E, Gehant S, de Castro E, Pozzato M, Baratin D, Neto T, Sigrist CJA, Redaschi N, Bridge A, UniProt Consortium.

Bioinformatics, 2023

doi:10.1093/bioinformatics/btac793.

EMBL's European Bioinformatics Institute (EMBL-EBI) in 2022.

Thakur M, Bateman A, Brooksbank C, Freeberg M, Harrison M, Hartley M, Keane T, Kleywegt G, Leach A, Levchenko M, Morgan S, McDonagh EM, Orchard S, Papatheodorou I, Velankar S, Vizcaino JA, Witham R, Zdrazil B, McEntyre J.

Nucleic Acids Res, 2023

doi:10.1093/nar/gkac1098.

UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium.

Nucleic Acids Res, 2023

doi:10.1093/nar/gkac1052.

The 2022 Report on the Human Proteome from the HUPO Human Proteome Project.

Omenn GS, Lane L, Overall CM, Pineau C, Packer NH, Cristea IM, Lindskog C, Weintraub ST, Orchard S, Roehrl MHA, Nice E, Liu S, Bandeira N, Chen YJ, Guo T, Aebersold R, Moritz RL, Deutsch EW.

J Proteome Res, 2023

doi:10.1021/acs.jproteome.2c00498.

MIADE metadata guidelines: Minimum Information About a Disorder Experiment

Mészáros B, Hatos A, Palopoli N, Quaglia F, Salladini E, Van Roey K, Arthanari H, Dosztányi Z, Felli IC, Fischer PD, Hoch JC, Jeffries CM, Longhi S, Maiani E, Orchard S, Pancsa R, Papaleo E, Pierattelli R, Piovesan D, Pritisanac I, Viennet T, Tompa P, Vranken W, Tosatto SC, Davey NE.

2022

doi:10.1101/2022.07.12.495092.

IMEx Databases: Displaying Molecular Interactions into a Single, Standards-Compliant Dataset.

Porras P, Orchard S, Licata L.

Methods Mol Biol, 2022

doi:10.1007/978-1-0716-2095-3_2.

The IntAct database: efficient access to fine-grained molecular interaction data.

Del Toro N, Shrivastava A, Ragueneau E, Meldal B, Combe C, Barrera E, Perfetto L, How K, Ratan P, Shirodkar G, Lu O, Mészáros B, Watkins X, Pundir S, Licata L, Iannuccelli M, Pellegrini M, Martin MJ, Panni S, Duesbury M, Vallet SD, Rappsilber J, Ricard-Blum S, Cesareni G, Salwinski L, Orchard S, Porras P, Panneerselvam K, Hermjakob H.

Nucleic Acids Res, 2022

doi:10.1093/nar/gkab1006.

The gene regulation knowledge commons: the action area of GREEKC.

Kuiper M, Bonello J, Fernández-Breis JT, Bucher P, Futschik ME, Gaudet P, Kulakovskiy IV, Licata L, Logie C, Lovering RC, Makeev VJ, Orchard S, Panni S, Perfetto L, Sant D, Schulz S, Vercruysse S, Zerbino DR, Lægreid A, GRECO Consortium.

Biochim Biophys Acta Gene Regul Mech, 2022

doi:10.1016/j.bbagrm.2021.194768.

Complex Portal 2022: new curation frontiers.

Meldal BHM, Perfetto L, Combe C, Lubiana T, Ferreira Cavalcante JV, Bye-A-Jee H, Waagmeester A, Del-Toro N, Shrivastava A, Barrera E, Wong E, Mlecnik B, Bindea G, Panneerselvam K, Willighagen E, Rappsilber J, Porras P, Hermjakob H, Orchard S.

Nucleic Acids Res, 2022

doi:10.1093/nar/gkab991.

The Enzyme Portal: an integrative tool for enzyme information and analysis.

Zaru R, Onwubiko J, Ribeiro AJM, Cochrane K, Tyzack JD, Muthukrishnan V, Pravda L, Thornton JM, O'Donovan C, Velanker S, Orchard S, Leach A, Martin MJ.

FEBS J, 2022

doi:10.1111/febs.16168.

Open access: Let's talk about open access, open data and open software

Avles R, Burdett T, Levchenko M, Orchard S, Swan A.

2021

doi:10.6019/tol.openaccessdiscussion-w.2021.00001.1.

Gene Ontology curation of the blood-brain barrier to improve the analysis of Alzheimer's and other neurological diseases.

Saverimuttu SCC, Kramarz B, Rodríguez-López M, Garmiri P, Attrill H, Thurlow KE, Makris M, de Miranda Pinheiro S, Orchard S, Lovering RC.

Database (Oxford), 2021

doi:10.1093/database/baab067.

Integration of transcription coregulator complexes with sequence-specific DNA-binding factor interactomes.

Velthuijs N, Meldal B, Geessinck Q, Porras P, Medvedeva Y, Zubritskiy A, Orchard S, Logie C.

Biochim Biophys Acta Gene Regul Mech, 2021

doi:10.1016/j.bbagrm.2021.194749.

Network expansion of genetic associations defines a pleiotropy map of human cell biology

Barrio-Hernandez I, Schwartzentruber J, Shrivastava A, del-Toro N, Zhang Q, Bradley G, Hermjakob H, Orchard S, Dunham I, Anderson CA, Porras P, Beltrao P.

2021

doi:10.1101/2021.07.19.452924.

UniRule: a unified rule resource for automatic annotation in the UniProt Knowledgebase.

MacDougall A, Volynkin V, Saidi R, Poggioli D, Zellner H, Hatton-Ellis E, Joshi V, O'Donovan C, Orchard S, Auchincloss AH, Baratin D, Bolleman J, Coudert E, de Castro E, Hulo C, Masson P, Pedruzzi I, Rivoire C, Arighi C, Wang Q, Chen C, Huang H, Garavelli J, Vinayaka CR, Yeh LS, Natale DA, Laiho K, Martin MJ, Renaux A, Pichler K, The UniProt Consortium.

Bioinformatics, 2021

doi:10.1093/bioinformatics/btaa663.

Analysing the yeast complexome-the Complex Portal rising to the challenge.

Meldal BHM, Pons C, Perfetto L, Del-Toro N, Wong E, Aloy P, Hermjakob H, Orchard S, Porras P.

Nucleic Acids Res, 2021

doi:10.1093/nar/gkab077.

The Gene Ontology resource: enriching a GOld mine.

Gene Ontology Consortium.

Nucleic Acids Res, 2021

doi:10.1093/nar/gkaa1113.

UniProt: the universal protein knowledgebase in 2021.

UniProt Consortium.

Nucleic Acids Res, 2021

doi:10.1093/nar/gkaa1100.

The Minimum Information about a Molecular Interaction CAusal STatement (MI2CAST).

Touré V, Vercruysse S, Acencio ML, Lovering RC, Orchard S, Bradley G, Casals-Casas C, Chaouiya C, Del-Toro N, Flobak Å, Gaudet P, Hermjakob H, Hoyt CT, Licata L, Lægreid A, Mungall CJ, Niknejad A, Panni S, Perfetto L, Porras P, Pratt D, Saez-Rodriguez J, Thieffry D, Thomas PD, Türei D, Kuiper M.

Bioinformatics, 2021

doi:10.1093/bioinformatics/btaa622.

Towards a unified open access dataset of molecular interactions.

Porras P, Barrera E, Bridge A, Del-Toro N, Cesareni G, Duesbury M, Hermjakob H, Iannuccelli M, Jurisica I, Kotlyar M, Licata L, Lovering RC, Lynn DJ, Meldal B, Nanduri B, Paneerselvam K, Panni S, Pastrello C, Pellegrini M, Perfetto L, Rahimzadeh N, Ratan P, Ricard-Blum S, Salwinski L, Shirodkar G, Shrivastava A, Orchard S.

Nat Commun, 2020

doi:10.1038/s41467-020-19942-z.

The IMEx coronavirus interactome: an evolving map of Coronaviridae-host molecular interactions.

Perfetto L, Pastrello C, Del-Toro N, Duesbury M, Iannuccelli M, Kotlyar M, Licata L, Meldal B, Panneerselvam K, Panni S, Rahimzadeh N, Ricard-Blum S, Salwinski L, Shrivastava A, Cesareni G, Pellegrini M, Orchard S, Jurisica I, Hermjakob H, Porras P.

Database (Oxford), 2020

doi:10.1093/database/baaa096.

Analysing the Yeast Complexome - The Complex Portal rising to the challenge

Meldal BHM, Pons C, Perfetto L, Del-Toro N, Wong E, Aloy P, Hermjakob H, Orchard S, Porras P.

2020

doi:10.1101/2020.11.03.367086.

A Coordinated Approach by Public Domain Bioinformatics Resources to Aid the Fight Against Alzheimer's Disease Through Expert Curation of Key Protein Targets.

Breuza L, Arighi CN, Argoud-Puy G, Casals-Casas C, Estreicher A, Famiglietti ML, Georghiou G, Gos A, Gruaz-Gumowski N, Hinz U, Hyka-Nouspikel N, Kramarz B, Lovering RC, Lussi Y, Magrane M, Masson P, Perfetto L, Poux S, Rodriguez-Lopez M, Stoeckert C, Sundaram S, Wang LS, Wu E, Orchard S, IMEx Consortium, UniProt Consortium.

J Alzheimers Dis, 2020

doi:10.3233/jad-200206.

The IMEx Coronavirus interactome: an evolving map of Coronaviridae-Host molecular interactions

Perfetto L, Pastrello C, Del-Toro N, Duesbury M, Iannuccelli M, Kotlyar M, Licata L, Meldal B, Panneerselvam K, Panni S, Rahimzadeh N, Ricard-Blum S, Salwinski L, Shrivastava A, Cesareni G, Pellegrini M, Orchard S, Jurisica I, Hermjakob H, Porras P.

2020

doi:10.1101/2020.06.16.153817.

Gene Ontology Curation of Neuroinflammation Biology Improves the Interpretation of Alzheimer's Disease Gene Expression Data.

Kramarz B, Huntley RP, Rodríguez-López M, Roncaglia P, Saverimuttu SCC, Parkinson H, Bandopadhyay R, Martin MJ, Orchard S, Hooper NM, Brough D, Lovering RC.

J Alzheimers Dis, 2020

doi:10.3233/jad-200207.

UniRule: a unified rule resource for automatic annotation in the UniProt Knowledgebase.

MacDougall A, Volynkin V, Saidi R, Poggioli D, Zellner H, Hatton-Ellis E, Joshi V, O'Donovan C, Orchard S, Auchincloss AH, Baratin D, Bolleman J, Coudert E, de Castro E, Hulo C, Masson P, Pedruzzi I, Rivoire C, Arighi C, Wang Q, Chen C, Huang H, Garavelli J, Vinayaka CR, Yeh LS, Natale DA, Laiho K, Martin MJ, Renaux A, Pichler K, UniProt Consortium.

Bioinformatics, 2020

doi:10.1093/bioinformatics/btaa485.

The Minimum Information about a Molecular Interaction Causal Statement (MI2CAST)

Touré V, Vercruysse S, Acencio ML, Lovering R, Orchard S, Bradley G, Casals-Casas C, Chaouiya C, del-Toro N, Flobak Å, Gaudet P, Hermjakob H, Licata L, Lægreid A, Mungall C, Niknejad A, Panni S, Perfetto L, Porras P, Pratt D, Thieffry D, Thomas P, Türei D, Saez-Rodriguez J, Kuiper M.

2020

doi:10.20944/preprints202004.0480.v1.

The ELIXIR Core Data Resources: fundamental infrastructure for the life sciences.

Drysdale R, Cook CE, Petryszak R, Baillie-Gerritsen V, Barlow M, Gasteiger E, Gruhl F, Haas J, Lanfear J, Lopez R, Redaschi N, Stockinger H, Teixeira D, Venkatesan A, Elixir Core Data Resource Forum, Blomberg N, Durinx C, McEntyre J.

Bioinformatics, 2020

doi:10.1093/bioinformatics/btz959.

Caenorhabditis elegans phosphatase complexes in UniProtKB and Complex Portal.

Bye-A-Jee H, Zaru R, Magrane M, Orchard S, UniProt Consortium.

FEBS J, 2020

doi:10.1111/febs.15213.

Challenges in the annotation of pseudoenzymes in databases: the UniProtKB approach.

Zaru R, Magrane M, Orchard S, UniProt Consortium.

FEBS J, 2020

doi:10.1111/febs.15100.

Non-coding RNA regulatory networks.

Panni S, Lovering RC, Porras P, Orchard S.

Biochim Biophys Acta Gene Regul Mech, 2020

doi:10.1016/j.bbagrm.2019.194417.

An intrinsically disordered proteins community for ELIXIR.

Davey NE, Babu MM, Blackledge M, Bridge A, Capella-Gutierrez S, Dosztanyi Z, Drysdale R, Edwards RJ, Elofsson A, Felli IC, Gibson TJ, Gutmanas A, Hancock JM, Harrow J, Higgins D, Jeffries CM, Le Mercier P, Mészáros B, Necci M, Notredame C, Orchard S, Ouzounis CA, Pancsa R, Papaleo E, Pierattelli R, Piovesan D, Promponas VJ, Ruch P, Rustici G, Romero P, Sarntivijai S, Saunders G, Schuler B, Sharan M, Shields DC, Sussman JL, Tedds JA, Tompa P, Turewicz M, Vondrasek J, Vranken WF, Wallace BA, Wichapong K, Tosatto SCE.

F1000Res, 2019

doi:10.12688/f1000research.20136.1.

An intrinsically disordered proteins community for ELIXIR

Davey NE, Babu MM, Blackledge M, Bridge A, Capella-Gutierrez S, Dosztanyi Z, Drysdale R, Edwards RJ, Elofsson A, Felli IC, Gibson TJ, Gutmanas A, Hancock JM, Harrow J, Higgins D, Jeffries CM, Le Mercier P, Mészáros B, Necci M, Notredame C, Orchard S, Ouzounis CA, Pancsa R, Papaleo E, Pierattelli R, Piovesan D, Promponas VJ, Ruch P, Rustici G, Romero P, Sarntivijai S, Saunders G, Schuler B, Sharan M, Shields DC, Sussman JL, Tedds JA, Tompa P, Turewicz M, Vondrasek J, Vranken WF, Wallace BA, Wichapong K, Tosatto SCE.

2019

doi:10.12688/f1000research.20136.1.

Human Proteome Project Mass Spectrometry Data Interpretation Guidelines 3.0.

Deutsch EW, Lane L, Overall CM, Bandeira N, Baker MS, Pineau C, Moritz RL, Corrales F, Orchard S, Van Eyk JE, Paik YK, Weintraub ST, Vandenbrouck Y, Omenn GS.

J Proteome Res, 2019

doi:10.1021/acs.jproteome.9b00542.

FAIR adoption, assessment and challenges at UniProt.

Garcia L, Bolleman J, Gehant S, Redaschi N, Martin M, UniProt Consortium.

Sci Data, 2019

doi:10.1038/s41597-019-0180-9.

Emerging concepts in pseudoenzyme classification, evolution, and signaling.

Ribeiro AJM, Das S, Dawson N, Zaru R, Orchard S, Thornton JM, Orengo C, Zeqiraj E, Murphy JM, Eyers PA.

Sci Signal, 2019

doi:10.1126/scisignal.aat9797.

Human Proteome Project Mass Spectrometry Data Interpretation Guidelines 3.0

Deutsch EW, Lane L, Overall CM, Bandeira N, Baker MS, Pineau C, Moritz RL, Corrales F, Orchard S, Van Eyk JE, Paik Y, Weintraub ST, Vandenbrouck Y, Omenn GS.

2019

doi:10.1101/733576.

Publisher Correction: Capturing variation impact on molecular interactions in the IMEx Consortium mutations data set.

IMEx Consortium contributing authors, Del-Toro N, Duesbury M, Koch M, Perfetto L, Shrivastava A, Ochoa D, Wagih O, Piñero J, Kotlyar M, Pastrello C, Beltrao P, Furlong LI, Jurisica I, Hermjakob H, Orchard S, Porras P.

Nat Commun, 2019

doi:10.1038/s41467-019-08814-w.

CausalTAB: the PSI-MITAB 2.8 updated format for signalling data representation and dissemination.

Perfetto L, Acencio ML, Bradley G, Cesareni G, Del Toro N, Fazekas D, Hermjakob H, Korcsmaros T, Kuiper M, Lægreid A, Lo Surdo P, Lovering RC, Orchard S, Porras P, Thomas PD, Touré V, Zobolas J, Licata L.

Bioinformatics, 2019

doi:10.1093/bioinformatics/btz132.

Integration of macromolecular complex data into the Saccharomyces Genome Database.

Wong ED, Skrzypek MS, Weng S, Binkley G, Meldal BHM, Perfetto L, Orchard SE, Engel SR, Cherry JM, SGD Project.

Database (Oxford), 2019

doi:10.1093/database/baz008.

Capturing variation impact on molecular interactions in the IMEx Consortium mutations data set.

IMEx Consortium Curators, Del-Toro N, Duesbury M, Koch M, Koch M, Perfetto L, Shrivastava A, Ochoa D, Wagih O, Piñero J, Kotlyar M, Pastrello C, Beltrao P, Furlong LI, Jurisica I, Hermjakob H, Hermjakob H, Orchard S, Porras P.

Nat Commun, 2019

doi:10.1038/s41467-018-07709-6.

The Gene Ontology Resource: 20 years and still GOing strong.

The Gene Ontology Consortium.

Nucleic Acids Res, 2019

doi:10.1093/nar/gky1055.

UniProt: a worldwide hub of protein knowledge.

UniProt Consortium.

Nucleic Acids Res, 2019

doi:10.1093/nar/gky1049.

Complex Portal 2018: extended content and enhanced visualization tools for macromolecular complexes.

Meldal BHM, Bye-A-Jee H, Gajdoš L, Hammerová Z, Horácková A, Melicher F, Perfetto L, Pokorný D, Lopez MR, Türková A, Wong ED, Xie Z, Casanova EB, Del-Toro N, Koch M, Porras P, Hermjakob H, Orchard S.

Nucleic Acids Res, 2019

doi:10.1093/nar/gky1001.

Improving the Gene Ontology Resource to Facilitate More Informative Analysis and Interpretation of Alzheimer's Disease Data.

Kramarz B, Roncaglia P, Meldal BHM, Huntley RP, Martin MJ, Orchard S, Parkinson H, Brough D, Bandopadhyay R, Hooper NM, Lovering RC.

Genes (Basel), 2018

doi:10.3390/genes9120593.

CausalTab: PSI-MITAB 2.8 updated format for signaling data representation and dissemination

Perfetto L, Acencio M, Bradley G, Cesareni G, Toro N, Fazekas D, Hermjakob H, Korcsmaros T, Kuiper M, Lægreid A, Surdo PL, Lovering R, Orchard S, Porras P, Thomas P, Touré V, Zobolas J, Licata L.

2018

doi:10.1101/385773.

Best practice data life cycle approaches for the life sciences

Griffin PC, Khadake J, LeMay KS, Lewis SE, Orchard S, Pask A, Pope B, Roessner U, Russell K, Seemann T, Treloar A, Tyagi S, Christiansen JH, Dayalan S, Gladman S, Hangartner SB, Hayden HL, Ho WW, Keeble-Gagnère G, Korhonen PK, Neish P, Prestes PR, Richardson MF, Watson-Haigh NS, Wyres KL, Young ND, Schneider MV.

2018

doi:10.12688/f1000research.12344.2.

FAIRsharing, a cohesive community approach to the growth in standards, repositories and policies

Sansone S, McQuilton P, Rocca-Serra P, Gonzalez-Beltran A, Izzo M, Lister AL, Thurston M, And the FAIRsharing community (https://fairsharing.org/communities):.

2018

doi:10.1101/245183.

Capturing variation impact on molecular interactions: the IMEx Consortium mutations data set

The IMEx Consortium Curators, del Toro N, Duesbury M, Koch M, Perfetto L, Shrivastava A, Ochoa D, Wagih O, Piñero J, Kotlyar M, Pastrello C, Beltrao P, Furlong L, Jurisica I, Hermjakob H, Orchard S, Porras P.

2018

doi:10.1101/346833.

Biocuration: Distilling data into knowledge.

International Society for Biocuration.

PLoS Biol, 2018

doi:10.1371/journal.pbio.2002846.

JAMI: a Java library for molecular interactions and data interoperability.

Sivade Dumousseau M, Koch M, Shrivastava A, Alonso-López D, De Las Rivas J, Del-Toro N, Combe CW, Meldal BHM, Heimbach J, Rappsilber J, Sullivan J, Yehudi Y, Orchard S.

BMC Bioinformatics, 2018

doi:10.1186/s12859-018-2119-0.

Encompassing new use cases - level 3.0 of the HUPO-PSI format for molecular interactions.

Sivade Dumousseau M, Alonso-López D, Ammari M, Bradley G, Campbell NH, Ceol A, Cesareni G, Combe C, De Las Rivas J, Del-Toro N, Heimbach J, Hermjakob H, Jurisica I, Koch M, Licata L, Lovering RC, Lynn DJ, Meldal BHM, Micklem G, Panni S, Porras P, Ricard-Blum S, Roechert B, Salwinski L, Shrivastava A, Sullivan J, Thierry-Mieg N, Yehudi Y, Van Roey K, Orchard S.

BMC Bioinformatics, 2018

doi:10.1186/s12859-018-2118-1.

Searching and Extracting Data from the EMBL-EBI Complex Portal.

Meldal BHM, Orchard S.

Methods Mol Biol, 2018

doi:10.1007/978-1-4939-7759-8_24.

Best practice data life cycle approaches for the life sciences.

Griffin PC, Khadake J, LeMay KS, Lewis SE, Orchard S, Pask A, Pope B, Roessner U, Russell K, Seemann T, Treloar A, Tyagi S, Christiansen JH, Dayalan S, Gladman S, Hangartner SB, Hayden HL, Ho WWH, Keeble-Gagnère G, Korhonen PK, Neish P, Prestes PR, Richardson MF, Watson-Haigh NS, Wyres KL, Young ND, Schneider MV.

F1000Res, 2017

doi:10.12688/f1000research.12344.2.

ComplexViewer: visualization of curated macromolecular complexes.

Combe CW, Sivade MD, Hermjakob H, Heimbach J, Meldal BHM, Micklem G, Orchard S, Rappsilber J.

Bioinformatics, 2017

doi:10.1093/bioinformatics/btx497.

Proteomics Standards Initiative: Fifteen Years of Progress and Future Work.

Deutsch EW, Orchard S, Binz PA, Bittremieux W, Eisenacher M, Hermjakob H, Kawano S, Lam H, Mayer G, Menschaert G, Perez-Riverol Y, Salek RM, Tabb DL, Tenzer S, Vizcaíno JA, Walzer M, Jones AR.

J Proteome Res, 2017

doi:10.1021/acs.jproteome.7b00370.

10th Anniversary Treasure Hunt

Armstrong D, Burke M, Huerta L, Levchenko M, Mitchell A, Morgan S, Mugumbate G, Mutowo P, Orchard S, Perry E, Pundir S, Richardson L, Tang A.

2017

doi:10.6019/tol.treasure-t.2017.00001.1.

Best Practice Data Life Cycle Approaches for the Life Sciences

Griffin PC, Khadake J, LeMay KS, Lewis SE, Orchard S, Pask A, Pope B, Roessner U, Russell K, Seemann T, Treloar A, Tyagi S, Christiansen JH, Dayalan S, Gladman S, Hangartner SB, Hayden HL, Ho WWH, Keeble-Gagnère G, Korhonen PK, Neish P, Prestes PR, Richardson MF, Watson-Haigh NS, Wyres KL, Young ND, Schneider MV.

2017

doi:10.1101/167619.

The yeast noncoding RNA interaction network.

Panni S, Prakash A, Bateman A, Orchard S.

RNA, 2017

doi:10.1261/rna.060996.117.

Overview of the interactive task in BioCreative V.

Wang Q, S Abdul S, Almeida L, Ananiadou S, Balderas-Martínez YI, Batista-Navarro R, Campos D, Chilton L, Chou HJ, Contreras G, Cooper L, Dai HJ, Ferrell B, Fluck J, Gama-Castro S, George N, Gkoutos G, Irin AK, Jensen LJ, Jimenez S, Jue TR, Keseler I, Madan S, Matos S, McQuilton P, Milacic M, Mort M, Natarajan J, Pafilis E, Pereira E, Rao S, Rinaldi F, Rothfels K, Salgado D, Silva RM, Singh O, Stefancsik R, Su CH, Subramani S, Tadepally HD, Tsaprouni L, Vasilevsky N, Wang X, Chatr-Aryamontri A, Laulederkind SJ, Matis-Mitchell S, McEntyre J, Orchard S, Pundir S, Rodriguez-Esteban R, Van Auken K, Lu Z, Schaeffer M, Wu CH, Hirschman L, Arighi CN.

Database (Oxford), 2016

doi:10.1093/database/baw119.

Gene regulation knowledge commons: community action takes care of DNA binding transcription factors.

Tripathi S, Vercruysse S, Chawla K, Christie KR, Blake JA, Huntley RP, Orchard S, Hermjakob H, Thommesen L, Lægreid A, Kuiper M.

Database (Oxford), 2016

doi:10.1093/database/baw088.

The MIntAct Project and Molecular Interaction Databases.

Licata L, Orchard S.

Methods Mol Biol, 2016

doi:10.1007/978-1-4939-3572-7_3.

The cardiovascular gene annotation initiative: Impact on data analysis

Lovering RC, Rodriguez-Lopez M, Campbell NH, Huntley RP, Sawford T, O’Donovan C, Orchard S, Hermjakob H, Martin M, Mayr M, Humphries SE, Talmud PJ.

Atherosclerosis, 2015

doi:10.1016/j.atherosclerosis.2015.04.135.

The Confidence Information Ontology: a step towards a standard for asserting confidence in annotations.

Bastian FB, Chibucos MC, Gaudet P, Giglio M, Holliday GL, Huang H, Lewis SE, Niknejad A, Orchard S, Poux S, Skunca N, Robinson-Rechavi M.

Database (Oxford), 2015

doi:10.1093/database/bav043.

Shared resources, shared costs--leveraging biocuration resources.

Orchard S, Hermjakob H.

Database (Oxford), 2015

doi:10.1093/database/bav009.

Development of data representation standards by the human proteome organization proteomics standards initiative.

Deutsch EW, Albar JP, Binz PA, Eisenacher M, Jones AR, Mayer G, Omenn GS, Orchard S, Vizcaíno JA, Hermjakob H.

J Am Med Inform Assoc, 2015

doi:10.1093/jamia/ocv001.

A visual review of the interactome of LRRK2: Using deep-curated molecular interaction data to represent biology.

Porras P, Duesbury M, Fabregat A, Ueffing M, Orchard S, Gloeckner CJ, Hermjakob H.

Proteomics, 2015

doi:10.1002/pmic.201400390.

Merging and scoring molecular interactions utilising existing community standards: tools, use-cases and a case study.

Villaveces JM, Jiménez RC, Porras P, Del-Toro N, Duesbury M, Dumousseau M, Orchard S, Choi H, Ping P, Zong NC, Askenazi M, Habermann BH, Hermjakob H.

Database (Oxford), 2015

doi:10.1093/database/bau131.

UniProt: a hub for protein information.

UniProt Consortium.

Nucleic Acids Res, 2015

doi:10.1093/nar/gku989.

The complex portal--an encyclopaedia of macromolecular complexes.

Meldal BH, Forner-Martinez O, Costanzo MC, Dana J, Demeter J, Dumousseau M, Dwight SS, Gaulton A, Licata L, Melidoni AN, Ricard-Blum S, Roechert B, Skyzypek MS, Tiwari M, Velankar S, Wong ED, Hermjakob H, Orchard S.

Nucleic Acids Res, 2015

doi:10.1093/nar/gku975.

Meeting new challenges: The 2014 HUPO-PSI/COSMOS Workshop: 13-15 April 2014, Frankfurt, Germany.

Orchard S, Albar JP, Binz PA, Kettner C, Jones AR, Salek RM, Vizcaino JA, Deutsch EW, Hermjakob H.

Proteomics, 2014

doi:10.1002/pmic.201470164.

Expert curation in UniProtKB: a case study on dealing with conflicting and erroneous data.

Poux S, Magrane M, Arighi CN, Bridge A, O'Donovan C, Laiho K, UniProt Consortium.

Database (Oxford), 2014

doi:10.1093/database/bau016.

Activities at the Universal Protein Resource (UniProt).

UniProt Consortium.

Nucleic Acids Res, 2014

doi:10.1093/nar/gkt1140.

The MIntAct project--IntAct as a common curation platform for 11 molecular interaction databases.

Orchard S, Ammari M, Aranda B, Breuza L, Briganti L, Broackes-Carter F, Campbell NH, Chavali G, Chen C, del-Toro N, Duesbury M, Dumousseau M, Galeota E, Hinz U, Iannuccelli M, Jagannathan S, Jimenez R, Khadake J, Lagreid A, Licata L, Lovering RC, Meldal B, Melidoni AN, Milagros M, Peluso D, Perfetto L, Porras P, Raghunath A, Ricard-Blum S, Roechert B, Stutz A, Tognolli M, van Roey K, Cesareni G, Hermjakob H.

Nucleic Acids Res, 2014

doi:10.1093/nar/gkt1115.

Data standardization and sharing-the work of the HUPO-PSI.

Orchard S.

Biochim Biophys Acta, 2014

doi:10.1016/j.bbapap.2013.03.011.

Controlled vocabularies and ontologies in proteomics: overview, principles and practice.

Mayer G, Jones AR, Binz PA, Deutsch EW, Orchard S, Montecchi-Palazzi L, Vizcaíno JA, Hermjakob H, Oveillero D, Julian R, Stephan C, Meyer HE, Eisenacher M.

Biochim Biophys Acta, 2014

doi:10.1016/j.bbapap.2013.02.017.

Preparing to work with big data in proteomics - a report on the HUPO-PSI Spring Workshop: April 15-17, 2013, Liverpool, UK.

Orchard S, Binz PA, Jones AR, Vizcaino JA, Deutsch EW, Hermjakob H.

Proteomics, 2013

doi:10.1002/pmic.201370166.

Capturing cooperative interactions with the PSI-MI format.

Van Roey K, Orchard S, Kerrien S, Dumousseau M, Ricard-Blum S, Hermjakob H, Gibson TJ.

Database (Oxford), 2013

doi:10.1093/database/bat066.

A new reference implementation of the PSICQUIC web service.

del-Toro N, Dumousseau M, Orchard S, Jimenez RC, Galeota E, Launay G, Goll J, Breuer K, Ono K, Salwinski L, Hermjakob H.

Nucleic Acids Res, 2013

doi:10.1093/nar/gkt392.

The HUPO proteomics standards initiative- mass spectrometry controlled vocabulary.

Mayer G, Montecchi-Palazzi L, Ovelleiro D, Jones AR, Binz PA, Deutsch EW, Chambers M, Kallhardt M, Levander F, Shofstahl J, Orchard S, Vizcaíno JA, Hermjakob H, Stephan C, Meyer HE, Eisenacher M, HUPO-PSI Group.

Database (Oxford), 2013

doi:10.1093/database/bat009.

BioJS: an open source JavaScript framework for biological data visualization.

Gómez J, García LJ, Salazar GA, Villaveces J, Gore S, García A, Martín MJ, Launay G, Alcántara R, Del-Toro N, Dumousseau M, Orchard S, Velankar S, Hermjakob H, Zong C, Ping P, Corpas M, Jiménez RC.

Bioinformatics, 2013

doi:10.1093/bioinformatics/btt100.

IntAct: Molecular Interactions at the EBI

Orchard S.

2012

doi:10.6019/tol.inta-t.2012.00001.1.

Shouldn't enantiomeric purity be included in the minimum information about a bioactive entity? Response from the MIABE group

Orchard S, Al-Lazikani B, Bryant S, Clark D, Calder E, Dix I, Engkvist O, Forster M, Gaulton A, Gilson M, Glen R, Grigorov M, Hammond-Kosack K, Harland L, Hopkins A, Larminie C, Lynch N, Mann RK, Murray-Rust P, Piparo EL, Southan C, Steinbeck C, Wishart D, Hermjakob H, Overington J, Thornton J.

Nat Rev Drug Discov, 2012

doi:10.1038/nrd3503-c2.

Ten years of standardizing proteomic data: a report on the HUPO-PSI Spring Workshop: April 12-14th, 2012, San Diego, USA.

Orchard S, Binz PA, Borchers C, Gilson MK, Jones AR, Nicola G, Vizcaino JA, Deutsch EW, Hermjakob H.

Proteomics, 2012

doi:10.1002/pmic.201270126.

Molecular interaction databases.

Orchard S.

Proteomics, 2012

doi:10.1002/pmic.201100484.

Protein interaction data curation: the International Molecular Exchange (IMEx) consortium.

Orchard S, Kerrien S, Abbani S, Aranda B, Bhate J, Bidwell S, Bridge A, Briganti L, Brinkman FS, Cesareni G, Chatr-aryamontri A, Chautard E, Chen C, Dumousseau M, Goll J, Hancock RE, Hannick LI, Jurisica I, Khadake J, Lynn DJ, Mahadevan U, Perfetto L, Raghunath A, Ricard-Blum S, Roechert B, Salwinski L, Stümpflen V, Tyers M, Uetz P, Xenarios I, Hermjakob H.

Nat Methods, 2012

doi:10.1038/nmeth.1931.

Correction: Conserved BK Channel-Protein Interactions Reveal Signals Relevant to Cell Death and Survival

PLoS One, 2012

doi:.

Analyzing protein-protein interaction networks.

Koh GC, Porras P, Aranda B, Hermjakob H, Orchard SE.

J Proteome Res, 2012

doi:10.1021/pr201211w.

From proteomics data representation to public data flow: a report on the HUPO-PSI workshop September 2011, Geneva, Switzerland.

Orchard S, Albar JP, Deutsch EW, Eisenacher M, Binz PA, Martinez-Bartolomé S, Vizcaíno JA, Hermjakob H.

Proteomics, 2012

doi:10.1002/pmic.201290016.

The IntAct molecular interaction database in 2012.

Kerrien S, Aranda B, Breuza L, Bridge A, Broackes-Carter F, Chen C, Duesbury M, Dumousseau M, Feuermann M, Hinz U, Jandrasits C, Jimenez RC, Khadake J, Mahadevan U, Masson P, Pedruzzi I, Pfeiffenberger E, Porras P, Raghunath A, Roechert B, Orchard S, Hermjakob H.

Nucleic Acids Res, 2012

doi:10.1093/nar/gkr1088.

Reorganizing the protein space at the Universal Protein Resource (UniProt).

UniProt Consortium.

Nucleic Acids Res, 2012

doi:10.1093/nar/gkr981.

IntAct quick tour

Porras P.

2011

doi:10.6019/tol.inta-qt.2011.00001.1.

Proteomics: An introduction to EMBL-EBI resources

Orchard S, Charles PD.

2011

doi:10.6019/tol.pms.2011.00001.1.

Conserved BK channel-protein interactions reveal signals relevant to cell death and survival.

Sokolowski B, Orchard S, Harvey M, Sridhar S, Sakai Y.

PLoS One, 2011

doi:10.1371/journal.pone.0028532.

Enabling BioSharing - a report on the Annual Spring Workshop of the HUPO-PSI April 11-13, 2011, EMBL-Heidelberg, Germany.

Orchard S, Albar JP, Deutsch EW, Eisenacher M, Vizcaíno JA, Hermjakob H.

Proteomics, 2011

doi:10.1002/pmic.201190117.

Minimum information about a bioactive entity (MIABE).

Orchard S, Al-Lazikani B, Bryant S, Clark D, Calder E, Dix I, Engkvist O, Forster M, Gaulton A, Gilson M, Glen R, Grigorov M, Hammond-Kosack K, Harland L, Hopkins A, Larminie C, Lynch N, Mann RK, Murray-Rust P, Lo Piparo E, Southan C, Steinbeck C, Wishart D, Hermjakob H, Overington J, Thornton J.

Nat Rev Drug Discov, 2011

doi:10.1038/nrd3503.

PSICQUIC and PSISCORE: accessing and scoring molecular interactions.

Aranda B, Blankenburg H, Kerrien S, Brinkman FS, Ceol A, Chautard E, Dana JM, De Las Rivas J, Dumousseau M, Galeota E, Gaulton A, Goll J, Hancock RE, Isserlin R, Jimenez RC, Kerssemakers J, Khadake J, Lynn DJ, Michaut M, O'Kelly G, Ono K, Orchard S, Prieto C, Razick S, Rigina O, Salwinski L, Simonovic M, Velankar S, Winter A, Wu G, Bader GD, Cesareni G, Donaldson IM, Eisenberg D, Kleywegt GJ, Overington J, Ricard-Blum S, Tyers M, Albrecht M, Hermjakob H.

Nat Methods, 2011

doi:10.1038/nmeth.1637.

UniProt Knowledgebase: a hub of integrated protein data.

Magrane M, UniProt Consortium.

Database (Oxford), 2011

doi:10.1093/database/bar009.

Omics technologies, data and bioinformatics principles.

Schneider MV, Orchard S.

Methods Mol Biol, 2011

doi:10.1007/978-1-61779-027-0_1.

Towards BioDBcore: a community-defined information specification for biological databases.

Gaudet P, Bairoch A, Field D, Sansone SA, Taylor C, Attwood TK, Bateman A, Blake JA, Bult CJ, Cherry JM, Chisholm RL, Cochrane G, Cook CE, Eppig JT, Galperin MY, Gentleman R, Goble CA, Gojobori T, Hancock JM, Howe DG, Imanishi T, Kelso J, Landsman D, Lewis SE, Karsch Mizrachi I, Orchard S, Ouellette BF, Ranganathan S, Richardson L, Rocca-Serra P, Schofield PN, Smedley D, Southan C, Tan TW, Tatusova T, Whetzel PL, White O, Yamasaki C, BioDBCore Working Group.

Database (Oxford), 2011

doi:10.1093/database/baq027.

Proteomic temporal profile of human brain endothelium after oxidative stress.

Ning M, Sarracino DA, Kho AT, Guo S, Lee SR, Krastins B, Buonanno FS, Vizcaíno JA, Orchard S, McMullin D, Wang X, Lo EH.

Stroke, 2011

doi:10.1161/strokeaha.110.585703.

Towards BioDBcore: a community-defined information specification for biological databases.

Gaudet P, Bairoch A, Field D, Sansone SA, Taylor C, Attwood TK, Bateman A, Blake JA, Bult CJ, Cherry JM, Chisholm RL, Cochrane G, Cook CE, Eppig JT, Galperin MY, Gentleman R, Goble CA, Gojobori T, Hancock JM, Howe DG, Imanishi T, Kelso J, Landsman D, Lewis SE, Mizrachi IK, Orchard S, Ouellette BF, Ranganathan S, Richardson L, Rocca-Serra P, Schofield PN, Smedley D, Southan C, Tan TW, Tatusova T, Whetzel PL, White O, Yamasaki C, BioDBCore Working Group.

Nucleic Acids Res, 2011

doi:10.1093/nar/gkq1173.

Preparing molecular interaction data for publication.

Orchard S, Hermjakob H.

Methods Mol Biol, 2011

doi:10.1007/978-1-60761-977-2_15.

Data standardization by the HUPO-PSI: how has the community benefitted?

Orchard S, Hermjakob H.

Methods Mol Biol, 2011

doi:10.1007/978-1-60761-987-1_9.

Ongoing and future developments at the Universal Protein Resource.

UniProt Consortium.

Nucleic Acids Res, 2011

doi:10.1093/nar/gkq1020.

Meeting Report from the Second "Minimum Information for Biological and Biomedical Investigations" (MIBBI) workshop.

Kettner C, Field D, Sansone SA, Taylor C, Aerts J, Binns N, Blake A, Britten CM, de Marco A, Fostel J, Gaudet P, González-Beltrán A, Hardy N, Hellemans J, Hermjakob H, Juty N, Leebens-Mack J, Maguire E, Neumann S, Orchard S, Parkinson H, Piel W, Ranganathan S, Rocca-Serra P, Santarsiero A, Shotton D, Sterk P, Untergasser A, Whetzel PL.

Stand Genomic Sci, 2010

doi:10.4056/sigs.147362.

Meeting Report: BioSharing at ISMB 2010.

Field D, Sansone S, Delong EF, Sterk P, Friedberg I, Gaudet P, Lewis S, Kottmann R, Hirschman L, Garrity G, Cochrane G, Wooley J, Meyer F, Hunter S, White O, Bramlett B, Gregurick S, Lapp H, Orchard S, Rocca-Serra P, Ruttenberg A, Shah N, Taylor C, Thessen A.

Stand Genomic Sci, 2010

doi:10.4056/sigs/1403501.

Tackling quantitation: a report on the annual Spring Workshop of the HUPO-PSI 28-30 March 2010, Seoul, South Korea.

Orchard S, Jones A, Albar JP, Cho SY, Kwon KH, Lee C, Hermjakob H.

Proteomics, 2010

doi:10.1002/pmic.201090075.

implementing data standards: a report on the HUPOPSI workshop September 2009, Toronto, Canada.

Orchard S, Albar JP, Deutsch EW, Eisenacher M, Binz PA, Hermjakob H.

Proteomics, 2010

doi:10.1002/pmic.201090034.

Minimum information about a protein affinity reagent (MIAPAR).

Bourbeillon J, Orchard S, Benhar I, Borrebaeck C, de Daruvar A, Dübel S, Frank R, Gibson F, Gloriam D, Haslam N, Hiltker T, Humphrey-Smith I, Hust M, Juncker D, Koegl M, Konthur Z, Korn B, Krobitsch S, Muyldermans S, Nygren PA, Palcy S, Polic B, Rodriguez H, Sawyer A, Schlapshy M, Snyder M, Stoevesandt O, Taussig MJ, Templin M, Uhlen M, van der Maarel S, Wingren C, Hermjakob H, Sherman D.

Nat Biotechnol, 2010

doi:10.1038/nbt0710-650.

The publication and database deposition of molecular interaction data.

Orchard S, Aranda B, Hermjakob H.

Curr Protoc Protein Sci, 2010

doi:10.1002/0471140864.ps2503s60.

A domain level interaction network of amyloid precursor protein and Abeta of Alzheimer's disease.

Perreau VM, Orchard S, Adlard PA, Bellingham SA, Cappai R, Ciccotosto GD, Cowie TF, Crouch PJ, Duce JA, Evin G, Faux NG, Hill AF, Hung YH, James SA, Li QX, Mok SS, Tew DJ, White AR, Bush AI, Hermjakob H, Masters CL.

Proteomics, 2010

doi:10.1002/pmic.200900773.

From protein sequences to 3D-structures and beyond: the example of the UniProt knowledgebase.

Hinz U, UniProt Consortium.

Cell Mol Life Sci, 2010

doi:10.1007/s00018-009-0229-6.

Molecular interactions and data standardisation.

Orchard S, Kerrien S.

Methods Mol Biol, 2010

doi:10.1007/978-1-60761-444-9_21.

The IntAct molecular interaction database in 2010.

Aranda B, Achuthan P, Alam-Faruque Y, Armean I, Bridge A, Derow C, Feuermann M, Ghanbarian AT, Kerrien S, Khadake J, Kerssemakers J, Leroy C, Menden M, Michaut M, Montecchi-Palazzi L, Neuhauser SN, Orchard S, Perreau V, Roechert B, van Eijk K, Hermjakob H.

Nucleic Acids Res, 2010

doi:10.1093/nar/gkp878.

The Universal Protein Resource (UniProt) in 2010.

UniProt Consortium.

Nucleic Acids Res, 2010

doi:10.1093/nar/gkp846.

A community standard format for the representation of protein affinity reagents.

Gloriam DE, Orchard S, Bertinetti D, Björling E, Bongcam-Rudloff E, Borrebaeck CA, Bourbeillon J, Bradbury AR, de Daruvar A, Dübel S, Frank R, Gibson TJ, Gold L, Haslam N, Herberg FW, Hiltke T, Hoheisel JD, Kerrien S, Koegl M, Konthur Z, Korn B, Landegren U, Montecchi-Palazzi L, Palcy S, Rodriguez H, Schweinsberg S, Sievert V, Stoevesandt O, Taussig MJ, Ueffing M, Uhlén M, van der Maarel S, Wingren C, Woollard P, Sherman DJ, Hermjakob H.

Mol Cell Proteomics, 2010

doi:10.1074/mcp.m900185-mcp200.

Annual spring meeting of the Proteomics Standards Initiative.

Orchard S, Deutsch EW, Binz PA, Jones AR, Creasy D, Montechi-Palazzi L, Corthals G, Hermjakob H.

Proteomics, 2009

doi:10.1002/pmic.200900407.

Second Joint HUPO publication and Proteomics Standards Initiative workshop.

Orchard S, Binz PA, Hermjakob H.

Proteomics, 2009

doi:10.1002/pmic.200900406.

Ending the "publish and vanish" culture: how the data standardization process will assist in data harvesting.

Orchard S.

J Proteome Res, 2009

doi:10.1021/pr900527r.

A protein interaction network for the large conductance Ca(2+)-activated K(+) channel in the mouse cochlea.

Kathiresan T, Harvey M, Orchard S, Sakai Y, Sokolowski B.

Mol Cell Proteomics, 2009

doi:10.1074/mcp.m800495-mcp200.

Nucleoside diphosphate kinase (NDPK, NM23, AWD): recent regulatory advances in endocytosis, metastasis, psoriasis, insulin release, fetal erythroid lineage and heart failure; translational medicine exemplified.

Mehta A, Orchard S.

Mol Cell Biochem, 2009

doi:10.1007/s11010-009-0114-5.

HUPO World Congress Publication Committee meeting. August 2008, Amsterdam, The Netherlands.

Orchard S, Ping P.

Proteomics, 2009

doi:10.1002/pmic.200800839.

Debunking minimum information myths: one hat need not fit all.

Orchard S, Taylor CF.

N Biotechnol, 2009

doi:10.1016/j.nbt.2008.12.001.

Managing the data explosion. A report on the HUPO-PSI Workshop. August 2008, Amsterdam, The Netherlands.

Orchard S, Hoogland C, Bairoch A, Eisenacher M, Kraus HJ, Binz PA.

Proteomics, 2009

doi:10.1002/pmic.200800838.

The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative.

Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U.

Chem Biol Interact, 2009

doi:10.1016/j.cbi.2008.10.040.

The Universal Protein Resource (UniProt) 2009.

UniProt Consortium.

Nucleic Acids Res, 2009

doi:10.1093/nar/gkn664.

The Protein Feature Ontology: a tool for the unification of protein feature annotations.

Reeves GA, Eilbeck K, Magrane M, O'Donovan C, Montecchi-Palazzi L, Harris MA, Orchard S, Jimenez RC, Prlic A, Hubbard TJ, Hermjakob H, Thornton JM.

Bioinformatics, 2008

doi:10.1093/bioinformatics/btn528.

MINT and IntAct contribute to the Second BioCreative challenge: serving the text-mining community with high quality molecular interaction data.

Chatr-aryamontri A, Kerrien S, Khadake J, Orchard S, Ceol A, Licata L, Castagnoli L, Costa S, Derow C, Huntley R, Aranda B, Leroy C, Thorneycroft D, Apweiler R, Cesareni G, Hermjakob H.

Genome Biol, 2008

doi:10.1186/gb-2008-9-s2-s5.

Minimum reporting guidelines for proteomics released by the Proteomics Standards Initiative.

Jones AR, Orchard S.

Mol Cell Proteomics, 2008

doi:10.1074/mcp.h800010-mcp200.

Annual spring meeting of the Proteomics Standards Initiative 23-25 April 2008, Toledo, Spain.

Orchard S, Albar JP, Deutsch EW, Binz PA, Jones AR, Creasy D, Hermjakob H.

Proteomics, 2008

doi:10.1002/pmic.200800555.

Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project.

Taylor CF, Field D, Sansone SA, Aerts J, Apweiler R, Ashburner M, Ball CA, Binz PA, Bogue M, Booth T, Brazma A, Brinkman RR, Michael Clark A, Deutsch EW, Fiehn O, Fostel J, Ghazal P, Gibson F, Gray T, Grimes G, Hancock JM, Hardy NW, Hermjakob H, Julian RK, Kane M, Kettner C, Kinsinger C, Kolker E, Kuiper M, Le Novère N, Leebens-Mack J, Lewis SE, Lord P, Mallon AM, Marthandan N, Masuya H, McNally R, Mehrle A, Morrison N, Orchard S, Quackenbush J, Reecy JM, Robertson DG, Rocca-Serra P, Rodriguez H, Rosenfelder H, Santoyo-Lopez J, Scheuermann RH, Schober D, Smith B, Snape J, Stoeckert CJ, Tipton K, Sterk P, Untergasser A, Vandesompele J, Wiemann S.

Nat Biotechnol, 2008

doi:10.1038/nbt.1411.

The annotation of both human and mouse kinomes in UniProtKB/Swiss-Prot: one small step in manual annotation, one giant leap for full comprehension of genomes.

Braconi Quintaje S, Orchard S.

Mol Cell Proteomics, 2008

doi:10.1074/mcp.r700001-mcp200.

Charting plant interactomes: possibilities and challenges.

Morsy M, Gouthu S, Orchard S, Thorneycroft D, Harper JF, Mittler R, Cushman JC.

Trends Plant Sci, 2008

doi:10.1016/j.tplants.2008.01.006.

6th HUPO Annual World Congress - Proteomics Standards Initiative Workshop 6-10 October 2007, Seoul, Korea.

Orchard S, Martens L, Tasman J, Binz PA, Albar JP, Hermjakob H.

Proteomics, 2008

doi:10.1002/pmic.200701086.

The HUPO proteomics standards initiative--easing communication and minimizing data loss in a changing world.

Orchard S, Hermjakob H.

Brief Bioinform, 2008

doi:10.1093/bib/bbm061.

Rintact: enabling computational analysis of molecular interaction data from the IntAct repository.

Chiang T, Li N, Orchard S, Kerrien S, Hermjakob H, Gentleman R, Huber W.

Bioinformatics, 2008

doi:10.1093/bioinformatics/btm518.

Human Proteome Organization Proteomics Standards Initiative: Data Standardization, a View on Developments and Policy.

Martens L, Orchard S, Apweiler R, Hermjakob H.

Mol Cell Proteomics , 2007

doi:.

Proteomics: from technology development to biomarker applications.

Orchard S.

Expert Rev Proteomics, 2007

doi:10.1586/14789450.4.6.709.

Broadening the horizon--level 2.5 of the HUPO-PSI format for molecular interactions.

Kerrien S, Orchard S, Montecchi-Palazzi L, Aranda B, Quinn AF, Vinod N, Bader GD, Xenarios I, Wojcik J, Sherman D, Tyers M, Salama JJ, Moore S, Ceol A, Chatr-Aryamontri A, Oesterheld M, Stümpflen V, Salwinski L, Nerothin J, Cerami E, Cusick ME, Vidal M, Gilson M, Armstrong J, Woollard P, Hogue C, Eisenberg D, Cesareni G, Apweiler R, Hermjakob H.

BMC Biol, 2007

doi:10.1186/1741-7007-5-44.

Five years of progress in the Standardization of Proteomics Data 4th Annual Spring Workshop of the HUPO-Proteomics Standards Initiative April 23-25, 2007 Ecole Nationale Supérieure (ENS), Lyon, France.

Orchard S, Montechi-Palazzi L, Deutsch EW, Binz PA, Jones AR, Paton N, Pizarro A, Creasy DM, Wojcik J, Hermjakob H.

Proteomics, 2007

doi:10.1002/pmic.200700658.

Submit your interaction data the IMEx way: a step by step guide to trouble-free deposition.

Orchard S, Kerrien S, Jones P, Ceol A, Chatr-Aryamontri A, Salwinski L, Nerothin J, Hermjakob H.

Proteomics, 2007

doi:10.1002/pmic.200700286.

Human Proteome Organization Proteomics Standards Initiative: data standardization, a view on developments and policy.

Martens L, Orchard S, Apweiler R, Hermjakob H.

Mol Cell Proteomics, 2007

doi:10.1016/s1535-9476(20)31973-3.

The minimum information required for reporting a molecular interaction experiment (MIMIx).

Orchard S, Salwinski L, Kerrien S, Montecchi-Palazzi L, Oesterheld M, Stümpflen V, Ceol A, Chatr-aryamontri A, Armstrong J, Woollard P, Salama JJ, Moore S, Wojcik J, Bader GD, Vidal M, Cusick ME, Gerstein M, Gavin AC, Superti-Furga G, Greenblatt J, Bader J, Uetz P, Tyers M, Legrain P, Fields S, Mulder N, Gilson M, Niepmann M, Burgoon L, De Las Rivas J, Prieto C, Perreau VM, Hogue C, Mewes HW, Apweiler R, Xenarios I, Eisenberg D, Cesareni G, Hermjakob H.

Nat Biotechnol, 2007

doi:10.1038/nbt1324.

The implications of alternative splicing in the ENCODE protein complement.

Tress ML, Martelli PL, Frankish A, Reeves GA, Wesselink JJ, Yeats C, Olason PI, Albrecht M, Hegyi H, Giorgetti A, Raimondo D, Lagarde J, Laskowski RA, López G, Sadowski MI, Watson JD, Fariselli P, Rossi I, Nagy A, Kai W, Størling Z, Orsini M, Assenov Y, Blankenburg H, Huthmacher C, Ramírez F, Schlicker A, Denoeud F, Jones P, Kerrien S, Orchard S, Antonarakis SE, Reymond A, Birney E, Brunak S, Casadio R, Guigo R, Harrow J, Hermjakob H, Jones DT, Lengauer T, Orengo CA, Patthy L, Thornton JM, Tramontano A, Valencia A.

Proc Natl Acad Sci U S A, 2007

doi:10.1073/pnas.0700800104.

Publication Committee meeting. HUPO 5th annual World Congress. Long Beach, CA, USA 30 October 2006.

Orchard S, Heck A, Uhlen M, Ping P.

Proteomics, 2007

doi:10.1002/pmic.200700015.

The HUPO pre-congress Proteomics Standards Initiative workshop. HUPO 5th annual World Congress. Long Beach, CA, USA 28 October-1 November 2006.

Orchard S, Jones AR, Stephan C, Binz PA.

Proteomics, 2007

doi:10.1002/pmic.200700014.

Entering the implementation era: a report on the HUPO-PSI Fall workshop 25-27 September 2006, Washington DC, USA.

Orchard S, Taylor CF, Jones P, Montechi-Palazzo L, Binz PA, Jones AR, Pizarro A, Julian RK, Hermjakob H.

Proteomics, 2007

doi:10.1002/pmic.200600915.

New developments in the InterPro database.

Mulder NJ, Apweiler R, Attwood TK, Bairoch A, Bateman A, Binns D, Bork P, Buillard V, Cerutti L, Copley R, Courcelle E, Das U, Daugherty L, Dibley M, Finn R, Fleischmann W, Gough J, Haft D, Hulo N, Hunter S, Kahn D, Kanapin A, Kejariwal A, Labarga A, Langendijk-Genevaux PS, Lonsdale D, Lopez R, Letunic I, Madera M, Maslen J, McAnulla C, McDowall J, Mistry J, Mitchell A, Nikolskaya AN, Orchard S, Orengo C, Petryszak R, Selengut JD, Sigrist CJ, Thomas PD, Valentin F, Wilson D, Wu CH, Yeats C.

Nucleic Acids Res, 2007

doi:10.1093/nar/gkl841.

Proteomic data exchange and storage: the need for common standards and public repositories.

Orchard S, Jones P, Taylor C, Zhu W, Julian RK, Hermjakob H, Apweiler R.

Methods Mol Biol, 2007

doi:10.1385/1-59745-275-0:261.

IntAct--open source resource for molecular interaction data.

Kerrien S, Alam-Faruque Y, Aranda B, Bancarz I, Bridge A, Derow C, Dimmer E, Feuermann M, Friedrichsen A, Huntley R, Kohler C, Khadake J, Leroy C, Liban A, Lieftink C, Montecchi-Palazzi L, Orchard S, Risse J, Robbe K, Roechert B, Thorneycroft D, Zhang Y, Apweiler R, Hermjakob H.

Nucleic Acids Res, 2007

doi:10.1093/nar/gkl958.

Guilt by association: using protein interactions and expression patterns to predict protein function

Orchard S, Hermjakob H.

2006

doi:.

Proteomic Data Standardization, Deposition and Exchange

Orchard S, Hermjakob H, Pruess M, Apweiler R.

2006

doi:10.1002/3527608230.ch2.

Proteomics and Beyond: a report on the 3rd Annual Spring Workshop of the HUPO-PSI 21-23 April 2006, San Francisco, CA, USA.

Orchard S, Apweiler R, Barkovich R, Field D, Garavelli JS, Horn D, Jones A, Jones P, Julian R, McNally R, Nerothin J, Paton N, Pizarro A, Seymour S, Taylor C, Wiemann S, Hermjakob H.

Proteomics, 2006

doi:10.1002/pmic.200600452.

HUPO Publications Committee Meeting: 21 April 2006, San Francisco, CA, USA.

Orchard S, Ping P.

Proteomics, 2006

doi:10.1002/pmic.200600453.

Autumn 2005 Workshop of the Human Proteome Organisation Proteomics Standards Initiative (HUPO-PSI) Geneva, September, 4-6, 2005.

Orchard S, Hermjakob H, Taylor C, Binz PA, Hoogland C, Julian R, Garavelli JS, Aebersold R, Apweiler R.

Proteomics, 2006

doi:10.1002/pmic.200500868.

Data standardization and the HUPO proteomics standards initiative.

Taylor C, Hermjakob H, Apweiler R, Orchard S, Zhu W.

2005

doi:.

Human Proteome Organisation Proteomics Standards Initiative. Pre-Congress Initiative.

Orchard S, Hermjakob H, Taylor C, Aebersold R, Apweiler R.

Proteomics, 2005

doi:10.1002/pmic.200500727.

Further steps in standardisation. Report of the second annual Proteomics Standards Initiative Spring Workshop (Siena, Italy 17-20th April 2005).

Orchard S, Hermjakob H, Taylor CF, Potthast F, Jones P, Zhu W, Julian RK, Apweiler R.

Proteomics, 2005

doi:10.1002/pmic.200500626.

Second proteomics standards initiative spring workshop.

Orchard S, Hermjakob H, Taylor CF, Potthast F, Jones P, Zhu W, Julian RK, Apweiler R.

Expert Rev Proteomics, 2005

doi:10.1586/14789450.2.3.287.

Annotating the human proteome.

Orchard S, Hermjakob H, Apweiler R.

Mol Cell Proteomics, 2005

doi:10.1074/mcp.r500003-mcp200.

The use of common ontologies and controlled vocabularies to enable data exchange and deposition for complex proteomic experiments.

Orchard S, Montecchi-Palazzi L, Hermjakob H, Apweiler R.

Pac Symp Biocomput, 2005

doi:.

Further steps towards data standardisation: the Proteomic Standards Initiative HUPO 3(rd) annual congress, Beijing 25-27(th) October, 2004.

Orchard S, Hermjakob H, Binz PA, Hoogland C, Taylor CF, Zhu W, Julian RK, Apweiler R.

Proteomics, 2005

doi:10.1002/pmic.200401158.

InterPro, progress and status in 2005.

Mulder NJ, Apweiler R, Attwood TK, Bairoch A, Bateman A, Binns D, Bradley P, Bork P, Bucher P, Cerutti L, Copley R, Courcelle E, Das U, Durbin R, Fleischmann W, Gough J, Haft D, Harte N, Hulo N, Kahn D, Kanapin A, Krestyaninova M, Lonsdale D, Lopez R, Letunic I, Madera M, Maslen J, McDowall J, Mitchell A, Nikolskaya AN, Orchard S, Pagni M, Ponting CP, Quevillon E, Selengut J, Sigrist CJ, Silventoinen V, Studholme DJ, Vaughan R, Wu CH.

Nucleic Acids Res, 2005

doi:10.1093/nar/gki106.

InterPro -prediction of protein families, domains and functional sites.

Apweiler R, Attwood TK, Bairoch A, Bateman A, Binns D, Bradley P, Bordoli L, Bucher P, Courcelle E, Das U, Durbin R, Flegel V, Fleischmann W, Gouzy J, Griffiths-Jones, S, Haft D, Harte N, Hulo N, Kahn D, Kanapin A, Krestyaninova M, Lonsdale D, Lopez R, McDowall J, Mulder N, Nikolskaya AN, Orchard S, Peyruc D, Quevillon E, Servant F, Sigrist CJ, Silventoinen V, Studholme DJ, Wu CH.

2004

doi:.

Proteomics and data standardisation

Orchard S, Hermjakob H, Apweiler R.

Drug Discov Today Biosilico, 2004

doi:10.1016/s1741-8364(04)02405-9.

Current status of proteomic standards development.

Orchard S, Taylor C, Hermjakob H, Zhu W, Julian R, Apweiler R.

Expert Rev Proteomics, 2004

doi:10.1586/14789450.1.2.179.

Advances in the development of common interchange standards for proteomic data.

Orchard S, Taylor CF, Hermjakob H, Weimin-Zhu, Julian RK, Apweiler R.

Proteomics, 2004

doi:10.1002/pmic.200400884.

IntAct: an open source molecular interaction database.

Hermjakob H, Montecchi-Palazzi L, Lewington C, Mudali S, Kerrien S, Orchard S, Vingron M, Roechert B, Roepstorff P, Valencia A, Margalit H, Armstrong J, Bairoch A, Cesareni G, Sherman D, Apweiler R.

Nucleic Acids Res, 2004

doi:10.1093/nar/gkh052.

Common interchange standards for proteomics data: Public availability of tools and schema.

Orchard S, Hermjakob H, Julian RK, Runte K, Sherman D, Wojcik J, Zhu W, Apweiler R.

Proteomics, 2004

doi:10.1002/pmic.200300694.

The HUPO PSI's molecular interaction format--a community standard for the representation of protein interaction data.

Hermjakob H, Montecchi-Palazzi L, Bader G, Wojcik J, Salwinski L, Ceol A, Moore S, Orchard S, Sarkans U, von Mering C, Roechert B, Poux S, Jung E, Mersch H, Kersey P, Lappe M, Li Y, Zeng R, Rana D, Nikolski M, Husi H, Brun C, Shanker K, Grant SG, Sander C, Bork P, Zhu W, Pandey A, Brazma A, Jacq B, Vidal M, Sherman D, Legrain P, Cesareni G, Xenarios I, Eisenberg D, Steipe B, Hogue C, Apweiler R.

Nat Biotechnol, 2004

doi:10.1038/nbt926.

InterPro -prediction of protein families, domains and functional sites

Apweiler R, Attwood TK, Bairoch A, Bateman A, Binns D, Bradley P, Bordoli L, Bucher P, Courcelle E, Das U, Durbin R, Flegel V, Fleischmann W, Griffiths-Jones S, Haft D, Harte N, Hulo N, Kahn D, Kanapin A, Krestyaninova M, Lonsdale D, Lopez R, Maslen J, McDowall J, Mulder N, Nikolskaya AN, Orchard S, Quevillon E, Servant F, Sigrist CJA, Silventoinen V, Studholme DJ, Wu CH.

2003

doi:.

Progress in Establishing Common Standards for Exchanging Proteomics Data: The Second Meeting of the HUPO Proteomics Standards Initiative.

Orchard S, Kersey P, Zhu W, Montecchi-Palazzi L, Hermjakob H, Apweiler R.

Comp Funct Genomics, 2003

doi:10.1002/cfg.279.

The HUPO Proteomics Standards Initiative Meeting: Towards Common Standards for Exchanging Proteomics Data.

Orchard S, Kersey P, Hermjakob H, Apweiler R.

Comp Funct Genomics, 2003

doi:10.1002/cfg.232.

Further advances in the development of a data interchange standard for proteomics data.

Orchard S, Zhu W, Julian RK, Hermjakob H, Apweiler R.

Proteomics, 2003

doi:10.1002/pmic.200300588.

The InterPro Database, 2003 brings increased coverage and new features.

Mulder NJ, Apweiler R, Attwood TK, Bairoch A, Barrell D, Bateman A, Binns D, Biswas M, Bradley P, Bork P, Bucher P, Copley RR, Courcelle E, Das U, Durbin R, Falquet L, Fleischmann W, Griffiths-Jones S, Haft D, Harte N, Hulo N, Kahn D, Kanapin A, Krestyaninova M, Lopez R, Letunic I, Lonsdale D, Silventoinen V, Orchard SE, Pagni M, Peyruc D, Ponting CP, Selengut JD, Servant F, Sigrist CJ, Vaughan R, Zdobnov EM.

Nucleic Acids Res, 2003

doi:10.1093/nar/gkg046.

The proteomics standards initiative.

Orchard S, Hermjakob H, Apweiler R.

Proteomics, 2003

doi:10.1002/pmic.200300496.

Kinases as targets: prospects for chronic therapy.

Orchard S.

Curr Opin Drug Discov Devel, 2002

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InterPro: an integrated documentation resource for protein families, domains and functional sites.

Mulder NJ, Apweiler R, Attwood TK, Bairoch A, Bateman A, Binns D, Biswas M, Bradley P, Bork P, Bucher P, Copley R, Courcelle E, Durbin R, Falquet L, Fleischmann W, Gouzy J, Griffith-Jones S, Haft D, Hermjakob H, Hulo N, Kahn D, Kanapin A, Krestyaninova M, Lopez R, Letunic I, Orchard S, Pagni M, Peyruc D, Ponting CP, Servant F, Sigrist CJ, InterPro Consortium.

Brief Bioinform, 2002

doi:10.1093/bib/3.3.225.

T-cell signal transduction and the role of protein kinase C.

Wilkinson SE, Nixon JS.

Cell Mol Life Sci, 1998

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Ro 09-2210 exhibits potent anti-proliferative effects on activated T cells by selectively blocking MKK activity.

Williams DH, Wilkinson SE, Purton T, Lamont A, Flotow H, Murray EJ.

Biochemistry, 1998

doi:10.1021/bi972914c.

Substrate specificity and inhibitor profile of human recombinant p56lck from a baculovirus expression vector.

Flotow H, Purton TJ, Whitaker DP, Williams DH, Wilkinson SE.

Inflamm Res, 1996

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Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function.

Bubeck Wardenburg J, Fu C, Jackman JK, Flotow H, Wilkinson SE, Williams DH, Johnson R, Kong G, Chan AC, Findell PR.

J Biol Chem, 1996

doi:10.1074/jbc.271.33.19641.

Protein kinase C. Measurement of translocation, activation, and role in cellular responses.

Wilkinson SE, Hallam TJ.

Methods Mol Biol, 1995

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Protein kinase C: is its pivotal role in cellular activation over-stated?

Wilkinson SE, Hallam TJ.

Trends Pharmacol Sci, 1994

doi:10.1016/0165-6147(94)90110-4.

Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C.

Wilkinson SE, Parker PJ, Nixon JS.

Biochem J, 1993

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Therapeutic potential of protein kinase C inhibitors.

Bradshaw D, Hill CH, Nixon JS, Wilkinson SE.

Agents Actions, 1993

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Second messengers in inflammation. 9th Meeting of the British Inflammation Research Association, March 14, 1991, Beckenham, Kent.

Wilkinson SE, Wadsworth J.

Agents Actions, 1992

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Inhibitors of protein kinase C. 2. Substituted bisindolylmaleimides with improved potency and selectivity.

Davis PD, Elliott LH, Harris W, Hill CH, Hurst SA, Keech E, Kumar MK, Lawton G, Nixon JS, Wilkinson SE.

J Med Chem, 1992

doi:10.1021/jm00084a004.

Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides.

Davis PD, Hill CH, Lawton G, Nixon JS, Wilkinson SE, Hurst SA, Keech E, Turner SE.

J Med Chem, 1992

doi:10.1021/jm00079a024.

Modulation of cellular processes by H7, a non-selective inhibitor of protein kinases.

Nixon JS, Wilkinson SE, Davis PD, Sedgwick AD, Wadsworth J, Westmacott D.

Agents Actions, 1991

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Potent collagenase inhibitors prevent interleukin-1-induced cartilage degradation in vitro.

Nixon JS, Bottomley KM, Broadhurst MJ, Brown PA, Johnson WH, Lawton G, Marley J, Sedgwick AD, Wilkinson SE.

Int J Tissue React, 1991

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A novel conformationally restricted protein kinase C inhibitor, Ro 31-8425, inhibits human neutrophil superoxide generation by soluble, particulate and post-receptor stimuli.

Muid RE, Dale MM, Davis PD, Elliott LH, Hill CH, Kumar H, Lawton G, Twomey BM, Wadsworth J, Wilkinson SE.

FEBS Lett, 1991

doi:10.1016/0014-5793(91)81178-b.

The effect of new potent selective inhibitors of protein kinase C on the neutrophil respiratory burst.

Twomey B, Muid RE, Nixon JS, Sedgwick AD, Wilkinson SE, Dale MM.

Biochem Biophys Res Commun, 1990

doi:10.1016/0006-291x(90)90795-o.

K252a is a potent and selective inhibitor of phosphorylase kinase.

Elliott LH, Wilkinson SE, Sedgwick AD, Hill CH, Lawton G, Davis PD, Nixon JS.

Biochem Biophys Res Commun, 1990

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Potent selective inhibitors of protein kinase C.

Davis PD, Hill CH, Keech E, Lawton G, Nixon JS, Sedgwick AD, Wadsworth J, Westmacott D, Wilkinson SE.

FEBS Lett, 1989

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The inhibitory profiles of hog pancreatic and human rheumatoid synovial cell phospholipases A2.

Nixon JS, Wilkinson SE, Davis P, Bloxham DP.

Agents Actions, 1986

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