Regulation of the COPII secretory machinery via focal adhesions and extracellular matrix signaling.

Jung J, Khan MM, Landry J, Halavatyi A, Machado P, Reiss M, Pepperkok R

The Journal of cell biology, 2022

doi:10.1083/jcb.202110081.

Glucocorticoids exacerbate TGFß1 mediated fibrotic signalling in lung fibroblasts by inhibition of metalloproteinase expression and activity.

Khan MM, Zukowska-Kasprzyk J, Neumann B, Halavatyi A, Tischer C, Haberkant P, Stein F, Jung F, Landry J, Lewis J, Pepperkok R

ERJ open research, 2021

doi:10.1183/23120541.lsc-2021.33.

Regulatory function of sympathetic innervation on the endo/lysosomal trafficking of acetylcholine receptor.

Straka T, Schroder C, Roos A, Kollipara L, Sickmann A, Williams MPI, Hafner M, Khan MM, Rudolf R

FRONTIERS IN PHYSIOLOGY, 2021

doi:10.3389/fphys.2021.626707.

A high throughput SEC23 functional interaction screen reveals a role for focal adhesion and extracellular matrix signalling in the regulation of COPII subunit SEC23A

Jung J, Khan MM, Landry J, Halavatyi A, Machado P, Reiss M, Pepperkok R

2021

doi:10.1101/2021.03.16.435679.

An integrated multiomic and quantitative label-free microscopy-based approach to study pro-fibrotic signalling in ex vivo human precision-cut lung slices.

Khan MM, Poeckel D, Halavatyi A, Zukowska-Kasprzyk J, Stein F, Vappiani J, Sevin DC, Tischer C, Zinn N, Eley JD, Gudmann NS, Muley T, Winter H, Fisher AJ, Nanthakumar CB, Bergamini G, Pepperkok R

The European respiratory journal, 2020

doi:10.1183/13993003.00221-2020.

α-Calcitonin gene-related peptide inhibits autophagy and calpain systems and maintains the stability of neuromuscular junction in denervated muscles.

Machado J, Silveira WA, Gonçalves DA, Schavinski AZ, Khan MM, Zanon NM, Diaz MB, Rudolf R, Kettelhut IC, Navegantes LC

Molecular metabolism, 2019

doi:10.1016/j.molmet.2019.06.024.

Evidence for the subsynaptic zone as a preferential site for CHRN recycling at neuromuscular junctions.

Wild F, Khan MM, Rudolf R

Small GTPases, 2019

doi:10.1080/21541248.2017.1324939.

Motor endplate-anatomical, functional, and molecular concepts in the historical perspective.

Rudolf R, Khan MM, Witzemann V

Cells, 2019

doi:10.3390/cells8050387.

GFPT1 deficiency in muscle leads to myasthenia and myopathy in mice.

Issop Y, Hathazi D, Khan MM, Rudolf R, Weis J, Spendiff S, Slater CR, Roos A, Lochmüller H

Human molecular genetics, 2018

doi:10.1093/hmg/ddy225.

Postnatal development and distribution of sympathetic innervation in mouse skeletal muscle.

Straka T, Vita V, Prokshi K, Hörner SJ, Khan MM, Pirazzini M, Williams MPI, Hafner M, Zaglia T, Rudolf R

International journal of molecular sciences, 2018

doi:10.3390/ijms19071935.

Reduced muscle strength in ether lipid-deficient mice is accompanied by altered development and function of the neuromuscular junction.

Dorninger F, Herbst R, Kravic B, Camurdanoglu BZ, Macinkovic I, Zeitler G, Forss-Petter S, Strack S, Khan MM, Waterham HR, Rudolf R, Hashemolhosseini S, Berger J

Journal of neurochemistry, 2017

doi:10.1111/jnc.14082.

Progress of endocytic CHRN to autophagic degradation is regulated by RAB5-GTPase and T145 phosphorylation of SH3GLB1 at mouse neuromuscular junctions in vivo.

Wild F, Khan MM, Straka T, Rudolf R

Autophagy, 2016

doi:10.1080/15548627.2016.1234564.

Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I.

Bogomolovas J, Fleming JR, Anderson BR, Williams R, Lange S, Simon B, Khan MM, Rudolf R, Franke B, Bullard B, Rigden DJ, Granzier H, Labeit S, Mayans O

Open biology, 2016

doi:10.1098/rsob.160114.

A compact unc45b-promoter drives muscle-specific expression in zebrafish and mouse.

Rudeck S, Etard C, Khan MM, Rottbauer W, Rudolf R, Strähle U, Just S

Genesis (New York, N.Y. : 2000), 2016

doi:10.1002/dvg.22953.

The impact of autophagy on peripheral synapses in health and disease.

Rudolf R, Khan MM, Wild F, Hashemolhosseini S

Frontiers in bioscience (Landmark edition), 2016

doi:10.2741/4467.

Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease.

Khan MM, Lustrino D, Silveira WA, Wild F, Straka T, Issop Y, O'Connor E, Cox D, Reischl M, Marquardt T, Labeit D, Labeit S, Benoit E, Molgó J, Lochmüller H, Witzemann V, Kettelhut IC, Navegantes LC, Pozzan T, Rudolf R

Proceedings of the National Academy of Sciences of the United States of America, 2016

doi:10.1073/pnas.1524272113.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky DJ et al

Autophagy, 2016

doi:10.1080/15548627.2015.1100356.

Turnover of acetylcholine receptors at the endplate revisited: novel insights into nerve-dependent behavior.

Strack S, Khan MM, Wild F, Rall A, Rudolf R

Journal of muscle research and cell motility, 2015

doi:10.1007/s10974-015-9418-0.

Degeneration of neuromuscular junction in age and dystrophy.

Rudolf R, Khan MM, Labeit S, Deschenes MR

Frontiers in aging neuroscience, 2014

doi:10.3389/fnagi.2014.00099.

Autophagy impairment in muscle induces neuromuscular junction degeneration and precocious aging.

Carnio S, LoVerso F, Baraibar MA, Longa E, Khan MM, Maffei M, Reischl M, Canepari M, Loefler S, Kern H, Blaauw B, Friguet B, Bottinelli R, Rudolf R, Sandri M

Cell reports, 2014

doi:10.1016/j.celrep.2014.07.061.

Molecular basis for the fold organization and sarcomeric targeting of the muscle atrogin MuRF1.

Franke B, Gasch A, Rodriguez D, Chami M, Khan MM, Rudolf R, Bibby J, Hanashima A, Bogomolovas J, von Castelmur E, Rigden DJ, Uson I, Labeit S, Mayans O

Open biology, 2014

doi:10.1098/rsob.130172.

Role of autophagy, SQSTM1, SH3GLB1, and TRIM63 in the turnover of nicotinic acetylcholine receptors.

Khan MM, Strack S, Wild F, Hanashima A, Gasch A, Brohm K, Reischl M, Carnio S, Labeit D, Sandri M, Labeit S, Rudolf R

Autophagy, 2014

doi:10.4161/auto.26841.

Alterations of cAMP-dependent signaling in dystrophic skeletal muscle.

Rudolf R, Khan MM, Lustrino D, Labeit S, Kettelhut IC, Navegantes LC

Frontiers in physiology, 2013

doi:10.3389/fphys.2013.00290.

Regulation of nicotinic acetylcholine receptor turnover by MuRF1 connects muscle activity to endo/lysosomal and atrophy pathways.

Rüdiger Rudolf , Julius Bogomolovas, Siegfried Strack, Kyeong-Rok Choi, Muzamil Majid Khan, Anika Wagner, Kathrin Brohm, Akira Hanashima, Alexander Gasch, Dittmar Labeit, Siegfried Labeit

2013

doi:10.1007/s11357-012-9468-9.

Participation of myosin Va and Pka type I in the regeneration of neuromuscular junctions.

Ira Verena Röder, Siegfried Strack, Markus Reischl, Oliver Dahley, Muzamil Majid Khan, Olivier Kassel, Manuela Zaccolo, Rüdiger Rudolf

2012

doi:10.1371/journal.pone.0040860.