Genetic dissection of a super enhancer controlling the Nppa-Nppb cluster in the heart.

Man JCK, van Duijvenboden K, Krijger PHL, Hooijkaas IB, van der Made I, de Gier-de Vries C, Wakker V, Creemers EE, de Laat W, Boukens BJ, Christoffels VM

Circulation research, 2021

doi:10.1161/CIRCRESAHA.120.317045.

Variant intronic enhancer controls SCN10A-short expression and heart conduction.

Man JCK, Bosada FM, Scholman KT, Offerhaus JA, Walsh R, van Duijvenboden K, van Eif VWW, Bezzina CR, Verkerk AO, Boukens BJ, Barnett P, Christoffels VM

2021

doi:10.1161/CIRCULATIONAHA.121.054083.

An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo.

Man JCK, Mohan RA, van den Boogaard M, Hilvering CRE, Jenkins C, Wakker V, Bianchi V, de Laat W, Barnett P, Boukens BJ, Christoffels VM

NATURE COMMUNICATIONS, 2019

doi:10.1038/s41467-019-12856-5.

Conserved NPPB plus border zone switches from MEF2-to AP-1-driven gene program.

van Duijvenboden K, de Bakker DEM, Man JCK, Janssen R, Gunthe M, Hill MC, Hooijkaas IB, van der Made I, van der Kraak PH, Vink A, Creemers EE, Martin JF, Barnett P, Bakkers J, Christoffels VM

CIRCULATION, 2019

doi:10.1161/CIRCULATIONAHA.118.038944.

Structure and function of the Nppa-Nppb cluster locus during heart development and disease.

Man J, Barnett P, Christoffels VM

CELLULAR AND MOLECULAR LIFE SCIENCES, 2018

doi:10.1007/s00018-017-2737-0.

Inhibiting the clathrin-mediated endocytosis pathway rescues K(IR)2.1 downregulation by pentamidine.

Varkevisser R, Houtman MJC, Waasdorp M, Man JCK, Heukers R, Takanari H, Tieland RG, Henegouwen PMPVE, Vos MA, van der Heyden MAG

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2013

doi:10.1007/s00424-012-1189-5.