Discovery of a non-canonical prototype long-chain monoacylglycerol lipase through a structure-based endogenous reaction intermediate complex.

Pinotsis N, Krüger A, Tomas N, Chatziefthymiou SD, Litz C, Mortensen SA, Daffé M, Marrakchi H, Antranikian G, Wilmanns M

Nature communications, 2023

doi:10.1038/s41467-023-43354-4.

Titin domains with reduced core hydrophobicity cause dilated cardiomyopathy.

Martinez-Martin I, Crousilles A, Ochoa JP, Velazquez-Carreras D, Mortensen SA, Herrero-Galan E, Delgado J, Dominguez F, Garcia-Pavia P, de Sancho D, Wilmanns M, Alegre-Cebollada J

Cell reports, 2023

doi:10.1016/j.celrep.2023.113490.

Structural basis of domain destabilization by dilated-cardiomyopathy-causing missense mutations in titin.

Martinez-Martin I, Crousilles A, Herrero-Galan E, Velazquez-Carreras D, Mortensen SA, Pablo Ochoa J, Garcia-Pavia P, de Sancho D, Wilmanns M, Alegre-Cebollada J

Biophysical journal, 2023

doi:10.1016/j.bpj.2022.11.1077.

Structure of the mycobacterial ESX-5 type VII secretion system pore complex.

Beckham KSH, Ritter C, Chojnowski G, Ziemianowicz DS, Mullapudi E, Rettel M, Savitski MM, Mortensen SA, Kosinski J, Wilmanns M

Science advances, 2021

doi:10.1126/sciadv.abg9923.

Across scales: novel insights into kidney health and disease by structural biology.

Tomas NM, Mortensen SA, Wilmanns M, Huber TB

Kidney international, 2021

doi:10.1016/j.kint.2021.03.042.

Structure and assembly of ESCRT-III helical Vps24 filaments.

Huber ST, Mostafavi S, Mortensen SA, Sachse C

Science advances, 2020

doi:10.1126/sciadv.aba4897.

Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake.

Jakobi AJ, Huber ST, Mortensen SA, Schultz SW, Palara A, Kuhm T, Shrestha BK, Lamark T, Hagen WJH, Wilmanns M, Johansen T, Brech A, Sachse C

Nature communications, 2020

doi:10.1038/s41467-020-14343-8.

Cross-linker-mediated regulation of actin network organization controls tissue morphogenesis.

Krueger D, Quinkler T, Mortensen SA, Sachse C, De Renzis S

The Journal of cell biology, 2019

doi:10.1083/jcb.201811127.

The SSRP1 subunit of the histone chaperone FACT is required for seed dormancy in Arabidopsis.

Michl-Holzinger P, Mortensen SA, Grasser KD

JOURNAL OF PLANT PHYSIOLOGY, 2019

doi:10.1016/j.jplph.2019.03.006.

Models of the complement C1 complex

Simon A. Mortensen, Bjørn Sander, Rasmus K. Jensen, Jan S. Pedersen, Monika M. Golas, Steffen Thiel, and Gregers R. Andersen

Proceedings of the National Academy of Sciences of the United States of America, 2018

doi:10.1073/pnas.1803577115.

Reply to Arlaud et al.: Structure of the C1 complex and the unbound C1r2s2 tetramer.

Simon A. Mortensen, Bjørn Sander, Rasmus K. Jensen, Jan S. Pedersen, Monika M. Golas, Steffen Thiel, and Gregers R. Andersen

Proceedings of the National Academy of Sciences of the United States of America, 2017

doi:10.1073/pnas.1704353114.

Structure and activation of C1, the complex initiating the classical pathway of the complement cascade.

Simon A. Mortensen, Bjørn Sander, Rasmus K. Jensen, Jan S. Pedersen, Monika M. Golas, Steffen Thiel, and Gregers R. Andersen

Proceedings of the National Academy of Sciences of the United States of America, 2017

doi:10.1073/pnas.1616998114.

Endogenous natural complement inhibitor regulates cardiac development.

Simon A. Mortensen, Louise L. Skov, Kasper Kjaer-Sorensen, Annette G. Hansen, Søren Hansen, Frederik Dagnæs-Hansen, Jens C. Jensenius, Claus Oxvig, Steffen Thiel and Søren E. Degn

Journal of immunology (Baltimore, Md. : 1950), 2017

doi:10.4049/jimmunol.1601958.

The composition of the arabidopsis RNA polymerase II transcript elongation complex reveals the interplay between elongation and mRNA processing factors.

Wojciech Antosz, Alexander Pfab, Hans F. Ehrnsberger, Philipp Holzinger, Karin Köllen, Simon A. Mortensen, Astrid Bruckmann, Thomas Schubert, Gernot Längst, Joachim Griesenbeck, Veit Schubert, Marion Grasser, Klaus D. Grasser

The Plant cell, 2017

doi:10.1105/tpc.16.00735.

Mannan-binding lectin (MBL) associated serine proteases in mice.

Simon A. Mortensen, Annette G. Hansen, Esben Axelgaard, Frederik D. Hansen, Steffen Thiel, Jens C.Jensenius

Immunobiology, 2016

doi:10.1016/j.imbio.2016.06.199.

Targeted inhibition by RNA interference-mediated gene silencing of mannan-binding lectin-associated serine protease (MASP)-1/3 expression attenuates collagen antibody-induced arthritis (CAIA).

Banda NK, Acharya S, Scheinman RI, Mehta G, Takahashi M, Mortensen S, Thiel S, Sekine H, Fujita T, Holers VM

IMMUNOBIOLOGY, 2016

doi:10.1016/j.imbio.2016.06.017.

The seed dormancy defect of Arabidopsis mutants lacking the transcript elongation factor TFIIS is caused by reduced expression of the DOG1 gene.

Simon A. Mortensen & Klaus D. Grasser

FEBS letters, 2014

doi:10.1016/j.febslet.2013.10.047.

Structural insights into the mechanism of negative regulation of single-box high mobility group proteins by the acidic tail domain.

Stott K, Watson M, Bostock MJ, Mortensen SA, Travers A, Grasser KD, Thomas JO

The Journal of Biological Chemistry, 2014

doi:10.1074/jbc.m114.591115.

Plant proteins containing high mobility group box DNA-binding domains modulate different nuclear processes.

Martin Antosch, Simon A. Mortensen, Klaus D. Grasser

Plant physiology, 2012

doi:10.1104/pp.112.198283.

Reduced expression of the DOG1 gene in Arabidopsis mutant seeds lacking the transcript elongation factor TFIIS.

Mortensen Simon A., Sønderkær M, Lynggaard C, Grasser M, Nielsen KL, Grasser KD

FEBS letters, 2011

doi:10.1016/j.febslet.2011.04.077.