Structure of the human 20S U5 snRNP.

Schneider S, Brandina I, Peter D, Lagad S, Fraudeau A, Portell-Montserrat J, Tholen J, Zhao J, Galej WP

Nature structural & molecular biology, 2024

doi:10.1038/s41594-024-01250-5.

Monovalent metal ion binding promotes the first transesterification reaction in the spliceosome.

Aupič J, Borišek J, Fica SM, Galej WP, Magistrato A

Nature communications, 2023

doi:10.1038/s41467-023-44174-2.

Characterization of the SF3B1-SUGP1 interface reveals how numerous cancer mutations cause mRNA missplicing.

Zhang J, Xie J, Huang J, Liu X, Xu R, Tholen J, Galej WP, Tong L, Manley JL, Liu Z

Genes & development, 2023

doi:10.1101/gad.351154.123.

PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection.

Fisch D, Pfleiderer MM, Anastasakou E, Mackie GM, Wendt F, Liu X, Clough B, Lara-Reyna S, Encheva V, Snijders AP, Bando H, Yamamoto M, Beggs AD, Mercer J, Shenoy AR, Wollscheid B, Maslowski KM, Galej WP, Frickel EM

Science (New York, N.Y.), 2023

doi:10.1126/science.adg2253.

A combinatorial approach to uncover an additional Integrator subunit.

Offley SR, Pfleiderer MM, Zucco A, Fraudeau A, Welsh SA, Razew M, Galej WP, Gardini A

Cell reports, 2023

doi:10.1016/j.celrep.2023.112244.

Structural studies of the spliceosome: bridging the gaps.

Tholen J, Galej WP

Current opinion in structural biology, 2022

doi:10.1016/j.sbi.2022.102461.

What's NEXT for the exosome?

Razew M, Galej WP

Molecular cell, 2022

doi:10.1016/j.molcel.2022.06.017.

Emerging insights into the function and structure of the Integrator complex.

Pfleiderer MM, Galej WP

Transcription, 2022

doi:10.1080/21541264.2022.2047583.

Structural basis of branch site recognition by the human spliceosome.

Tholen J, Razew M, Weis F, Galej WP

Science (New York, N.Y.), 2021

doi:10.1126/science.abm4245.

Structural basis for conformational equilibrium of the catalytic spliceosome.

Wilkinson ME, Fica SM, Galej WP, Nagai K

Molecular cell, 2021

doi:10.1016/j.molcel.2021.02.021.

Structure of the catalytic core of the Integrator complex.

Pfleiderer MM, Galej WP

Molecular cell, 2021

doi:10.1016/j.molcel.2021.01.005.

Inhibition of bacterial ubiquitin ligases by SidJ-calmodulin-catalysed glutamylation.

Bhogaraju S, Bonn F, Mukherjee R, Adams M, Pfleiderer MM, Galej WP, Matkovic V, Lopez-Mosqueda J, Kalayil S, Shin D, Dikic I

Nature, 2019

doi:10.1038/s41586-019-1440-8.

Structural studies of the spliceosome: past, present and future perspectives.

Galej WP

Biochemical Society transactions, 2018

doi:10.1042/BST20170240.

Molecular Mechanism and Evolution of Nuclear Pre-mRNA and Group II Intron Splicing: Insights from Cryo-Electron Microscopy Structures.

Galej WP, Toor N, Newman AJ, Nagai K

Chemical reviews, 2018

doi:10.1021/acs.chemrev.7b00499.

Postcatalytic spliceosome structure reveals mechanism of 3'-splice site selection.

Wilkinson ME, Fica SM, Galej WP, Norman CM, Newman AJ, Nagai K

Science (New York, N.Y.), 2017

doi:10.1126/science.aar3729.

Structure of a spliceosome remodelled for exon ligation.

Fica SM, Oubridge C, Galej WP, Wilkinson ME, Bai XC, Newman AJ, Nagai K

Nature, 2017

doi:10.1038/nature21078.

Cryo-EM structure of the spliceosome immediately after branching.

Galej WP, Wilkinson ME, Fica SM, Oubridge C, Newman AJ, Nagai K

Nature, 2016

doi:10.1038/nature19316.

Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 A resolution.

Nguyen TH, Galej WP, Bai XC, Oubridge C, Newman AJ, Scheres SH, Nagai K

Nature, 2016

doi:10.1038/nature16940.

CryoEM structures of two spliceosomal complexes: starter and dessert at the spliceosome feast.

Nguyen TH, Galej WP, Fica SM, Lin PC, Newman AJ, Nagai K

Current opinion in structural biology, 2016

doi:10.1016/j.sbi.2015.12.005.

The architecture of the spliceosomal U4/U6.U5 tri-snRNP.

Nguyen TH, Galej WP, Bai XC, Savva CG, Newman AJ, Scheres SH, Nagai K

Nature, 2015

doi:10.1038/nature14548.

Structural studies of the spliceosome: zooming into the heart of the machine.

Galej WP, Nguyen TH, Newman AJ, Nagai K

Current opinion in structural biology, 2014

doi:10.1016/j.sbi.2013.12.002.

Structural basis of Brr2-Prp8 interactions and implications for U5 snRNP biogenesis and the spliceosome active site.

Nguyen TH, Li J, Galej WP, Oshikane H, Newman AJ, Nagai K

Structure (London, England : 1993), 2013

doi:10.1016/j.str.2013.04.017.

Crystal structure of Prp8 reveals active site cavity of the spliceosome.

Galej WP, Oubridge C, Newman AJ, Nagai K

Nature, 2013

doi:10.1038/nature11843.