Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.

Bloch Y, Felix J, Merceron R, Provost M, Symakani RA, De Backer R, Lambert E, Mehdipour AR, Savvides SN

Nature structural & molecular biology, 2024

doi:10.1038/s41594-023-01190-6.

Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27.

Skladanowska K, Bloch Y, Strand J, White KF, Hua J, Aldridge D, Welin M, Logan DT, Soete A, Merceron R, Murphy C, Provost M, Bazan JF, Hunter CA, Hill JA, Savvides SN

Cell Reports, 2022

doi:10.1016/j.celrep.2022.111490.

Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity.

Detry S, Andries J, Bloch Y, Gabay C, Clancy DM, Savvides SN

Journal of biological chemistry, 2022

doi:10.1016/j.jbc.2022.101908.

Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding.

Timmermans S, Verhoog NJD, Van Looveren K, Dewaele S, Hochepied T, Eggermont M, Gilbert B, Boerema-de Munck A, Vanderhaeghen T, Vanden Berghe J, Gonzalez NG, Vandewalle J, Bloch Y, Provost M, Savvides SN, De Bosscher K, Declercq W, Rottier RJ, Louw A, Libert C

The Journal of biological chemistry, 2022

doi:10.1016/j.jbc.2022.101574.

Structural basis of cytokine-mediated activation of ALK family receptors.

De Munck S, Provost M, Kurikawa M, Omori I, Mukohyama J, Felix J, Bloch Y, Abdel-Wahab O, Bazan JF, Yoshimi A, Savvides SN

Nature , 2021

doi:10.1038/s41586-021-03959-5.

Distinct EH domains of the endocytic TPLATE complex confer lipid and protein binding.

Yperman K, Papageorgiou AC, Merceron R, De Munck S, Bloch Y, Eeckhout D, Jiang QH, Tack P, Grigoryan R, Evangelidis T, Van Leene J, Vincze L, Vandenabeele P, Vanhaecke F, Potocky M, De Jaeger G, Savvides SN, Tripsianes K, Pleskot R, Van Damme D

Nature Communications, 2021

doi:10.1038/s41467-021-23314-6.

Homogeneously N-glycosylated proteins derived from the GlycoDelete HEK293 cell line enable diffraction-quality crystallogenesis.

Kozak S, Bloch Y, De Munck S, Mikula A, Bento I, Savvides SN, Meijers R

Acta crystallographica. Section D, Structural biology, 2020

doi:10.1107/S2059798320013753.

Pathophysiology and inhibition of IL-23 signaling in psoriatic arthritis: a molecular insight.

Nguyen CT, Bloch Y, Skladanowska K, Savvides SN, Adamopoulos IE

Clinical Immunology, 2019

doi:10.1016/j.clim.2018.09.002.

Revisiting the combinatorial potential of cytokine subunits in the IL-12 family.

Detry S, Skladanowska K, Vuylsteke M, Savvides SN, Bloch Y

Biochemical Pharmacology, 2019

doi:10.1016/j.bcp.2019.03.026.

Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.

Verschueren KHG, Blanchet C, Felix J, Dansercoer A, De Vos D, Bloch Y, Van Beeumen J, Svergun D, Gutsche I, Savvides SN, Verstraete K

Nature, 2019

doi:10.1038/s41586-019-1095-5.

Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha.

Govindarajan S, Gaublomme D, Van der Cruyssen R, Verheugen E, Van Gassen S, Saeys Y, Tavernier S, Iwawaki T, Bloch Y, Savvides SN, Lambrecht BN, Janssens S, Elewaut D, Drennan MB

Nature Communications, 2018

doi:10.1038/s41467-018-07758-x.

Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12R beta 1.

Bloch Y, Bouchareychas L, Merceron R, Skladanowska K, Van den Bossche L, Detry S, Govindarajan S, Elewaut D, Haerynck F, Dullaers M, Adamopoulos IE, Savvides SN

Immunity , 2018

doi:10.1016/j.immuni.2017.12.008.

Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF.

Felix J, Kandiah E, De Munck S, Bloch Y, van Zundert GCP, Pauwels K, Dansercoer A, Novanska K, Read RJ, Bonvin AMJJ, Vergauwen B, Verstraete K, Gutsche I, Savvides SN

Nature Communications, 2016

doi:10.1038/ncomms13228.

Structural basis of IL-23 antagonism by an Alphabody protein scaffold.

Desmet J, Verstraete K, Bloch Y, Lorent E, Wen YR, Devreese B, Vandenbroucke K, Loverix S, Hettmann T, Deroo S, Somers K, Henderikx P, Lasters I, Savvides SN

Nature Communications, 2014

doi:10.1038/ncomms6237.

Structural basis of the proinflammatory signaling complex mediated by TSLP.

Verstraete K, van Schie L, Vyncke L, Bloch Y, Tavernier J, Pauwels E, Peelman F, Savvides SN

Nature Structural and Molecular Biology, 2014

doi:10.1038/nsmb.2794.