Systematic analysis of drug combinations against Gram-positive bacteria.

Cacace E, Kim V, Varik V, Knopp M, Tietgen M, Brauer-Nikonow A, Inecik K, Mateus A, Milanese A, Mårli MT, Mitosch K, Selkrig J, Brochado AR, Kuipers OP, Kjos M, Zeller G, Savitski MM, Göttig S, Huber W, Typas A

Nature microbiology, 2023

doi:10.1038/s41564-023-01486-9.

The ribosomal A-site finger is crucial for binding and activation of the stringent factor RelA.

Kudrin P, Dzhygyr I, Ishiguro K, Beljantseva J, Maksimova E, Oliveira SRA, Varik V, Payoe R, Konevega AL, Tenson T, Suzuki T, Hauryliuk V

Nucleic acids research, 2018

doi:10.1093/nar/gky023.

HPLC-based quantification of bacterial housekeeping nucleotides and alarmone messengers ppGpp and pppGpp.

Varik V, Oliveira SRA, Hauryliuk V, Tenson T

Scientific reports, 2017

doi:10.1038/s41598-017-10988-6.

Subinhibitory concentrations of bacteriostatic antibiotics induce relA-dependent and relA-independent tolerance to β-lactams.

Kudrin P, Varik V, Oliveira SR, Beljantseva J, Del Peso Santos T, Dzhygyr I, Rejman D, Cava F, Tenson T, Hauryliuk V

Antimicrobial agents and chemotherapy, 2017

doi:10.1128/AAC.02173-16.

Molecular mutagenesis of ppGpp: turning a RelA activator into an inhibitor.

Beljantseva J, Kudrin P, Jimmy S, Ehn M, Pohl R, Varik V, Tozawa Y, Shingler V, Tenson T, Rejman D, Hauryliuk V

Scientific reports, 2017

doi:10.1038/srep41839.

Auxotrophy-based High Throughput Screening assay for the identification of Bacillus subtilis stringent response inhibitors.

Andresen L, Varik V, Tozawa Y, Jimmy S, Lindberg S, Tenson T, Hauryliuk V

Scientific reports, 2016

doi:10.1038/srep35824.

Evaluation of the characteristics of leucyl-tRNA synthetase (LeuRS) inhibitor AN3365 in combination with different antibiotic classes.

Monteferrante CG, Jirgensons A, Varik V, Hauryliuk V, Goessens WHF, Hays JP

2016

doi:10.1007/s10096-016-2738-1.

Composition of the outgrowth medium modulates wake-up kinetics and ampicillin sensitivity of stringent and relaxed Escherichia coli.

Varik V, Oliveira SRA, Hauryliuk V, Tenson T

2016

doi:10.1038/srep22308.

Phenotypic heterogeneity enables uropathogenic Escherichia coli to evade killing by antibiotics and serum complement.

Putrinš M, Kogermann K, Lukk E, Lippus M, Varik V, Tenson T

2015

doi:10.1128/IAI.02725-14.