The release focuses on organisms with a UniProt reference proteome that are relevant to Neglected Tropical Disease or antimicrobial resistance. The selection was based on priority lists compiled by the World Health Organisation.
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AlphaFold database – January 2022 update
- Number of new proteomes: 27 (17 relevant for neglected tropical diseases and 10 for antimicrobial resistance)
- Total proteins provided for the 27 new proteomes: 199,251
- Total proteins in the AlphaFold database: 992,316
The freshly-added proteomes are (in alphabetical order):
Neglected tropical diseases:
- Brugia malayi (Lymphatic filariasis)
- Cladophialophora carrionii (Chromoblastomycosis)
- Dracunculus medinensis (Dracunculiasis)
- Fonsecaea pedrosoi (Chromoblastomycosis)
- Histoplasma capsulatum (Histoplasmosis)
- Madurella mycetomatis (Mycetoma)
- Mycobacterium leprae (Leprosy)
- Mycobacterium ulcerans (Buruli ulcer)
- Nocardia brasiliensis (Mycetoma)
- Onchocerca volvulus (River blindness)
- Paracoccidioides lutzii (Paracoccidioidomycosis)
- Schistosoma mansoni (Schistosomiasis)
- Sporothrix schenckii (Sporotrichosis)
- Strongyloides stercoralis (Parasitic worm)
- Trichuris trichiura (Parasitic worm)
- Trypanosoma brucei (subspecies brucei) (model for Human African trypanosomiasis)
- Wuchereria bancrofti (Lymphatic filariasis)
AMR:
- Campylobacter jejuni
- Enterococcus faecium
- Haemophilus influenzae
- Helicobacter pylori
- Klebsiella pneumoniae
- Neisseria gonorrhoeae
- Pseudomonas aeruginosa
- Salmonella typhimurium
- Shigella dysenteriae
- Streptococcus pneumoniae
The above are added to five other global health related proteomes from the original release:
- Plasmodium falciparum
- Trypanosoma cruzi
- Leishmania infantum
- Mycobacterium tuberculosis
- Staphylococcus aureus
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